NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|156142186|ref|NP_057070|]
View 

cytokine receptor-like factor 3 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 181-265 1.10e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156142186 181 PPVQIEELIEKPGGIIVRWCKVDDDFTA-QDYRLQFRKCTSNHFEDVYV--GSETEFIVLHIDPNVDYQFRVCARGDGrq 257
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVNGG-- 80


                 ....*...
gi 156142186 258 EWSPWSVP 265
Cdd:cd00063   81 GESPPSES 88
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 181-265 1.10e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156142186 181 PPVQIEELIEKPGGIIVRWCKVDDDFTA-QDYRLQFRKCTSNHFEDVYV--GSETEFIVLHIDPNVDYQFRVCARGDGrq 257
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVNGG-- 80


                 ....*...
gi 156142186 258 EWSPWSVP 265
Cdd:cd00063   81 GESPPSES 88
fn3 pfam00041
Fibronectin type III domain;
181-260 5.15e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156142186  181 PPVQIEELIEK-PGGIIVRW---CKVDDDFTaqDYRLQFRKCTSNHFEDVY--VGSETEFIVLHIDPNVDYQFRVCAR-G 253
Cdd:pfam00041   1 SAPSNLTVTDVtSTSLTVSWtppPDGNGPIT--GYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAVnG 78


                  ....*..
gi 156142186  254 DGRQEWS 260
Cdd:pfam00041  79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 181-252 4.96e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 4.96e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156142186   181 PPVQIEELIEKPGGIIVRWCKVDDDFTAQD---YRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCAR 252
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYivgYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 181-265 1.10e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156142186 181 PPVQIEELIEKPGGIIVRWCKVDDDFTA-QDYRLQFRKCTSNHFEDVYV--GSETEFIVLHIDPNVDYQFRVCARGDGrq 257
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPiTGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVNGG-- 80


                 ....*...
gi 156142186 258 EWSPWSVP 265
Cdd:cd00063   81 GESPPSES 88
fn3 pfam00041
Fibronectin type III domain;
181-260 5.15e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156142186  181 PPVQIEELIEK-PGGIIVRW---CKVDDDFTaqDYRLQFRKCTSNHFEDVY--VGSETEFIVLHIDPNVDYQFRVCAR-G 253
Cdd:pfam00041   1 SAPSNLTVTDVtSTSLTVSWtppPDGNGPIT--GYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAVnG 78


                  ....*..
gi 156142186  254 DGRQEWS 260
Cdd:pfam00041  79 GGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 181-252 4.96e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.05  E-value: 4.96e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156142186   181 PPVQIEELIEKPGGIIVRWCKVDDDFTAQD---YRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCAR 252
Cdd:smart00060   3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYivgYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH