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Conserved domains on  [gi|55953125|ref|NP_057188|]
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RWD domain-containing protein 1 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWD_DRWD_ELF-like super family cl45901
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 1-23 3.01e-08

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


The actual alignment was detected with superfamily member cd23816:

Pssm-ID: 480265  Cd Length: 118  Bit Score: 48.83  E-value: 3.01e-08
                        10        20
                ....*....|....*....|...
gi 55953125   1 MVMIFTLVTAVQEKLNEIVDQIK 23
Cdd:cd23816  96 MVMVFTIVSAVQEKLNEIVDQIK 118
DFRP_C super family cl37909
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 48-101 1.80e-04

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


The actual alignment was detected with superfamily member pfam16543:

Pssm-ID: 465167  Cd Length: 89  Bit Score: 38.34  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 55953125    48 TPVTIENFLNWKAKfdaELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSD 101
Cdd:pfam16543  20 TPVTPETFAKWKKK---RIDKKEAEEEAERKKKKADGLSGRELFEFNPDLFEDD 70
 
Name Accession Description Interval E-value
RWD_RWDD1 cd23816
RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called ...
 1-23 3.01e-08

RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called DRG family-regulatory protein 2 (DFRP2), or PTD013, interacts with DRG2 and protects DRG2 from proteolytic degradation. It is an androgen receptor-interacting protein that functions as a coactivator of androgen-dependent transcription.


Pssm-ID: 467652  Cd Length: 118  Bit Score: 48.83  E-value: 3.01e-08
                        10        20
                ....*....|....*....|...
gi 55953125   1 MVMIFTLVTAVQEKLNEIVDQIK 23
Cdd:cd23816  96 MVMVFTIVSAVQEKLNEIVDQIK 118
DFRP_C pfam16543
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 48-101 1.80e-04

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


Pssm-ID: 465167  Cd Length: 89  Bit Score: 38.34  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 55953125    48 TPVTIENFLNWKAKfdaELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSD 101
Cdd:pfam16543  20 TPVTPETFAKWKKK---RIDKKEAEEEAERKKKKADGLSGRELFEFNPDLFEDD 70
COG5252 COG5252
Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function ...
 48-102 6.75e-03

Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227577 [Multi-domain]  Cd Length: 299  Bit Score: 35.45  E-value: 6.75e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 55953125  48 TPVTIENFLNWK-AKFDAELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSDI 102
Cdd:COG5252 212 TPLTEENFKEWKdGRRLRILKQKEEKESARKVKGRATGTKGVELFETRRDLFKDDV 267
 
Name Accession Description Interval E-value
RWD_RWDD1 cd23816
RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called ...
 1-23 3.01e-08

RWD domain of RWD domain-containing protein 1 (RWDD1) and related proteins; RWDD1, also called DRG family-regulatory protein 2 (DFRP2), or PTD013, interacts with DRG2 and protects DRG2 from proteolytic degradation. It is an androgen receptor-interacting protein that functions as a coactivator of androgen-dependent transcription.


Pssm-ID: 467652  Cd Length: 118  Bit Score: 48.83  E-value: 3.01e-08
                        10        20
                ....*....|....*....|...
gi 55953125   1 MVMIFTLVTAVQEKLNEIVDQIK 23
Cdd:cd23816  96 MVMVFTIVSAVQEKLNEIVDQIK 118
DFRP_C pfam16543
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 48-101 1.80e-04

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


Pssm-ID: 465167  Cd Length: 89  Bit Score: 38.34  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 55953125    48 TPVTIENFLNWKAKfdaELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSD 101
Cdd:pfam16543  20 TPVTPETFAKWKKK---RIDKKEAEEEAERKKKKADGLSGRELFEFNPDLFEDD 70
COG5252 COG5252
Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function ...
 48-102 6.75e-03

Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227577 [Multi-domain]  Cd Length: 299  Bit Score: 35.45  E-value: 6.75e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 55953125  48 TPVTIENFLNWK-AKFDAELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSDI 102
Cdd:COG5252 212 TPLTEENFKEWKdGRRLRILKQKEEKESARKVKGRATGTKGVELFETRRDLFKDDV 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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