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Conserved domains on  [gi|20336270|ref|NP_057278|]
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guanine nucleotide-binding protein subunit beta-5 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-395 1.60e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.60e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  98 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 172
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 173 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNsDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetg 251
Cdd:cd00200  77 LWDLETGE------CVRTLTGHTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 252 NTFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgas 329
Cdd:cd00200 147 GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN--- 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20336270 330 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-395 1.60e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.60e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  98 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 172
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 173 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNsDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetg 251
Cdd:cd00200  77 LWDLETGE------CVRTLTGHTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 252 NTFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgas 329
Cdd:cd00200 147 GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN--- 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20336270 330 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
96-394 1.53e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.30  E-value: 1.53e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  96 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 175
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 176 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 255
Cdd:COG2319 191 LATGK------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 256 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIifGASSVDFSL 335
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSP 340

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20336270 336 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 256-394 4.18e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 4.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  256 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYyPSGDA--FASGSDDATCRLYDLRADREVA-IYSKESIifgaSSVD 332
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDY-SSADPtlLASGSDDGSVKLWSINQGVSIGtIKTKANI----CCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20336270  333 F-SLSGRLLFAGYNDYTINVWDvLKGSRVSI--LFGHENRVSTLRVSpDGTAFCSGSWDHTLRVW 394
Cdd:PLN00181 625 FpSESGRSLAFGSADHKVYYYD-LRNPKLPLctMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-133 1.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.16e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20336270     95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 133
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
357-394 8.60e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 8.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20336270   357 GSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-395 1.60e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.60e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  98 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 172
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 173 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNsDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetg 251
Cdd:cd00200  77 LWDLETGE------CVRTLTGHTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 252 NTFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgas 329
Cdd:cd00200 147 GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN--- 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20336270 330 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 395
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
96-394 1.53e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.30  E-value: 1.53e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  96 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 175
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 176 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 255
Cdd:COG2319 191 LATGK------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 256 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIifGASSVDFSL 335
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSP 340

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20336270 336 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
98-394 1.90e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 200.91  E-value: 1.90e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  98 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYplt 177
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--- 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 178 fdkneNMAAKK--KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 255
Cdd:COG2319 148 -----DLATGKllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKLLA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 256 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSL 335
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSP 298

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20336270 336 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:COG2319 299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
98-394 7.89e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 7.89e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  98 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLT 177
Cdd:COG2319  29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 178 fdknenMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFVSG 257
Cdd:COG2319 109 ------TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 258 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSLSG 337
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS--GSVRSVAFSPDG 258

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 20336270 338 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
96-354 4.93e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 4.93e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  96 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYp 175
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW- 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 176 ltfdkneNMAAKK--KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNT 253
Cdd:COG2319 232 -------DLATGKllRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD--GKL 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 254 FVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIifGASSVDF 333
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG--AVTSVAF 380

                       250       260
                ....*....|....*....|.
gi 20336270 334 SLSGRLLFAGYNDYTINVWDV 354
Cdd:COG2319 381 SPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
96-311 2.06e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 2.06e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  96 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 175
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 176 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTFV 255
Cdd:COG2319 275 LATGE------LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--DGKTLA 346

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20336270 256 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 311
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 229-394 1.95e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 1.95e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 229 LLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 308
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPD--GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 309 DLRADREVAIYS--KESIifgaSSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGS 386
Cdd:cd00200  79 DLETGECVRTLTghTSYV----SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154


                ....*...
gi 20336270 387 WDHTLRVW 394
Cdd:cd00200 155 QDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
96-270 1.95e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 1.95e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  96 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYp 175
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW- 315

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 176 ltfdkneNMAAKK--KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLclDLAPSETGNT 253
Cdd:COG2319 316 -------DLATGKllRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRT 386

                       170
                ....*....|....*..
gi 20336270 254 FVSGGCDKKAMVWDMRS 270
Cdd:COG2319 387 LASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
209-394 2.47e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 2.47e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 209 QILTASGDGTCALWDVESGQLLQSFHGHGADVLclDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVR 288
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 289 YYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHEN 368
Cdd:COG2319  86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                       170       180
                ....*....|....*....|....*.
gi 20336270 369 RVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-267 1.24e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 1.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDsfttnkehavtmpctwvmacayapsgcaiacggLDNKCSVY 174
Cdd:cd00200 167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---------------------------------LSTGKCLG 213

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 175 PLTFdknenmaakkksvamHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTF 254
Cdd:cd00200 214 TLRG---------------HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP--DGKRL 276

                       170
                ....*....|...
gi 20336270 255 VSGGCDKKAMVWD 267
Cdd:cd00200 277 ASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 256-394 4.18e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 4.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  256 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYyPSGDA--FASGSDDATCRLYDLRADREVA-IYSKESIifgaSSVD 332
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDY-SSADPtlLASGSDDGSVKLWSINQGVSIGtIKTKANI----CCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20336270  333 F-SLSGRLLFAGYNDYTINVWDvLKGSRVSI--LFGHENRVSTLRVSpDGTAFCSGSWDHTLRVW 394
Cdd:PLN00181 625 FpSESGRSLAFGSADHKVYYYD-LRNPKLPLctMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-133 1.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.16e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20336270     95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 133
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-394 5.19e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.19e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 20336270    356 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
357-394 8.60e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 8.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20336270   357 GSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
95-133 1.19e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 20336270    95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 270-309 1.77e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.77e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 20336270    270 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 207-317 2.46e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 2.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  207 DMQILTASGDGTCALWDVESGQLLQS-------FHGHGADVLCLDLAPSeTGNTFVSGGCDKKAMVWDMRSGQCVQAFET 279
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPS-AMNVLASAGADMVVNVWDVERGKAVEVIKC 166

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 20336270  280 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA 317
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS 204
WD40 COG2319
WD40 repeat [General function prediction only];
292-394 2.83e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 2.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270 292 SGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 371
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100
                ....*....|....*....|...
gi 20336270 372 TLRVSPDGTAFCSGSWDHTLRVW 394
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLW 105
WD40 pfam00400
WD domain, G-beta repeat;
271-309 4.42e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 20336270   271 GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 150-354 6.56e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 6.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  150 VMACAYAPSGCAIACGGLDNKCSVYPLT--FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 227
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECEsiIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  228 QLLQSFHGHGADVLCLDLAPSETgNTFVSGGCDKKAMVWDMRSGQCVQAFEThESDINSVRyYPS--GDAFASGSDDATC 305
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADP-TLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQ-FPSesGRSLAFGSADHKV 642

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 20336270  306 RLYDLRADR----EVAIYSKEsiifgASSVDFSLSGRLLfAGYNDYTINVWDV 354
Cdd:PLN00181 643 YYYDLRNPKlplcTMIGHSKT-----VSYVRFVDSSTLV-SSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-267 2.50e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.50e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 20336270    226 SGQLLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 334-393 7.61e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 7.61e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270  334 SLSGRLLFAGYnDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRV 393
Cdd:PTZ00421 136 SAMNVLASAGA-DMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
227-267 9.47e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 9.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 20336270   227 GQLLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWD 267
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
WD40_like pfam17005
WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat ...
 282-362 3.97e-03

WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia and related species.


Pssm-ID: 407205 [Multi-domain]  Cd Length: 301  Bit Score: 38.88  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336270   282 SDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--KESIIFgassVDFsLSGRLLFAGYNDYTINVWDVLKGSR 359
Cdd:pfam17005   1 TEIYSIDISKKGSYILYGGKDDTCTVYDFENLDLVSIVEgfSDSVIF----CKF-LDDDLILVVTLDGTIMESLLKNDQE 75


                  ...
gi 20336270   360 VSI 362
Cdd:pfam17005  76 IEN 78
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 194-223 4.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 20336270    194 HTNYLSACSFTNSDMQILTASGDGTCALWD 223
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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