|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
5-1035 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 1448.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 5 KGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKgKYFVTFPYPYMNGRLHLGHTFSLSKCE------------- 71
Cdd:PLN02959 7 KSTARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPPKPGE-KFFGNFPYPYMNGLLHLGHAFSLSKLEfaaayhrlrganv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 72 --------------ACADKLKREIELYGCPPDFP--DEEEEEEETSVKTEDI---IIKDKAKGKKSKAAAKAGSSKYQWG 132
Cdd:PLN02959 86 llpfafhctgmpikASADKLAREIQQYGNPPVFPeeDEDEAAAVAAAKAEAEaaaAPPDKFKGKKSKAVAKSGTQKYQWE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 133 IMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTI 212
Cdd:PLN02959 166 IMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKKGKIVKDKRYTI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 213 YSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETV 292
Cdd:PLN02959 246 YSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLPPFPGKLKALEGKKVFLAAATLRPETMYGQTNCWVLPDGKYGAYEIN 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 293 NGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDD 372
Cdd:PLN02959 326 DTEVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTILTDKGTGVVTSVPSDSPDD 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 373 IAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLV 452
Cdd:PLN02959 406 YMALSDLKAKPALRAKYGVKDEWVLPFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKLAEAKRLTYLKGFTDGTMLV 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 453 DGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRR 532
Cdd:PLN02959 486 GEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWKKKAEKCLSKMNLYSDETRH 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 533 NFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPlgIRPQQMTKEVWDYVF 612
Cdd:PLN02959 566 GFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGGDMYGKDKSS--IKPEQMTDEVWDFVF 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 613 FKeAPFPKT-QIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEqsDKWPTAVRANGHLLLNSEKMS 691
Cdd:PLN02959 644 CG-GPLPKSsDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAE--EHWPRGFRCNGHLMLNSEKMS 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 692 KSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFA 771
Cdd:PLN02959 721 KSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAAESSLRTGPPSTYADRVFE 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 772 SELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYR-ELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIW-TLLGK 849
Cdd:PLN02959 801 NEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRlSCGSGGMNRDLVWRFMDVQTRLITPICPHYAEHVWrEILKK 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 850 PDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCT---IYVAKNYPPWQHTTLS 926
Cdd:PLN02959 881 EGFAVTAGWPVAGEPDLTLKRANKYLQDSIVSFRKLLQKQLAGSKKAKKGGAPVTLPEKKLaglIYVAEKYDGWKEECLR 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 927 VLRKHFEANNGKL-PDNKVIA----SELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLT 1001
Cdd:PLN02959 961 ILQSKFDSQSRTFaPDAEILEalkeSSVGQEANFKQVQKLCMPFVKFKKDEAIAVGPQALDLKLPFDEIEVLQENLELIK 1040
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....
gi 964751021 1002 NSLELEHIEVKFASEAEDKIR----------EDCCPGKPLNVFR 1035
Cdd:PLN02959 1041 RQLGLEEVEILSASDPDAVAKagahasllkqNPPSPGNPVAIFV 1084
|
|
| leuS_arch |
TIGR00395 |
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ... |
14-1030 |
0e+00 |
|
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273056 [Multi-domain] Cd Length: 938 Bit Score: 805.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 14 KKIEKEIQQKWDTERVFEVNASNLEKqtskgkYFVTFPYPYMNGRLHLGHTFSLSKCE---------------------- 71
Cdd:TIGR00395 1 IAIEKKWQKRWEEAHIFEADPDDREK------FFLTMAYPYLNGVMHAGHCRTFTIPEvsarfermkgknvlfplgfhvt 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 72 -----ACADKLKREIELYGcppdfpdeeeeeeetsvktediiikdkakgkkskaaakagsskyqWGIMKSLGLSDEEIVK 146
Cdd:TIGR00395 75 gtpilGLAELIKRRDELTI---------------------------------------------KNYTEVHAIPREELLK 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 147 FSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDR 226
Cdd:TIGR00395 110 FTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCPKDGNPVEDHDL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 227 QTGEGVGPQEYTLLKLKVLEpypsklsglkgKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFEtVNGDIFICTQKAARN 306
Cdd:TIGR00395 188 LSGEGVTIVEYILIKFELED-----------GAFYFVAATLRPETVYGVTNCWVNPTITYVIAE-VGGEKWITSKEAFEN 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 307 MSYQGFTkdngvVPVVKELMGEEILGASLSAPLTsYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALr 386
Cdd:TIGR00395 256 LSYQKLK-----YKPIEEVPGKQFIGKKVHNPVV-GPEVPILPAEFVDTTKGTGVVMSVPAHAPDDYIALEDLLHDPEY- 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 387 akYGIRDdMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIML--VDGFKGQKVQDVK 464
Cdd:TIGR00395 329 --LGIKP-VVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIynIPPYKGMKVSEAK 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 465 KTIQKKMIDAGDALIYMEP-EKQVMSRSSDECVVALC-DQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQ 542
Cdd:TIGR00395 406 EKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKVVeDQWFVKYSDESWKELAHECLEGMRIIPEEVKNAFEGKIDWLK 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 543 EHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNlhgqaesplgIRPQQMTKEVWDYVFFKEAPFPKTQ 622
Cdd:TIGR00395 486 DWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDY----------YGNEQMTDEFFDYIFLGKGDVKNTN 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 623 IAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEqsDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQ 702
Cdd:TIGR00395 556 IPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPE--KFWPRGIVVNGYVMLEGKKMSKSKGNVLTLEQ 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 703 AIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEmVANWDSLRSGPASTFNDRVFASELNAGIIKTD 782
Cdd:TIGR00395 634 AVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEE-ITKESNLETGEETSFIDRWLESRMNAAIKETY 712
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 783 QNYEKMMFKEALKTGFFEFQAAKDKYRElAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAG 862
Cdd:TIGR00395 713 EAMENFQTRKAVKYALFDLQADVDWYRR-RGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEVGNEGFVSLAKFPEAS 791
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 863 --PVNEVLIHSSQYLMEVTHDLRlrlknymmpaKGKKTDKqplQKPSHCTIYVAknyPPWQHTTLSVLRKHFEANNGKlp 940
Cdd:TIGR00395 792 epAVDKEVEAAEEYLRNLVRDIQ----------EIAKIDA---SKPKRVYLYTS---EDWKSQCLKIVAELFGEDTGE-- 853
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 941 DNKVIASElgsmPELKKYMKKVMPFVAMIKENLEKmgprilDLQLEFDEKAVLMENIVYLTNSLELEHI-EVKFASEAED 1019
Cdd:TIGR00395 854 DMKKVMEE----PEERKRGKEVISLVKQIIKDEKK------EDELQISEIEVLKAAARFIKKEVGALVIiEFSADSFPEN 923
|
1050
....*....|.
gi 964751021 1020 KiREDCCPGKP 1030
Cdd:TIGR00395 924 K-KRNAVPGKP 933
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
133-1030 |
0e+00 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 722.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 133 IMKSL-GLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYT 211
Cdd:PRK12300 56 LYKSLyGIPEEELEKFKDPEYIVEYFSEEAKEDMKRIGYSIDWRREFTTTD--PEYSKFIEWQFRKLKEKGLIVKGSHPV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 212 IYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKvlepypsklsglKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFEt 291
Cdd:PRK12300 134 RYCPNDNNPVGDHDLLDGEEPEIVEYTLIKFE------------ESEDLILPAATLRPETIFGVTNLWVNPDATYVKAE- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 292 VNGDIFICTQKAARNMSYQGFTkdngvVPVVKELMGEEILGASLSAPLTSYKVIyVLPMLTIKEDKGTGVVTSVPSDSPD 371
Cdd:PRK12300 201 VDGEKWIVSKEAAEKLSFQDRD-----VEIIEEIKGSELIGKKVKNPVTGKEVP-ILPADFVDPDNGTGVVMSVPAHAPY 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 372 DIAALRDLKKKQALRAKygirddmvlpFEPVPVIEIPGFGNLSAVTICDELKIQSQNDReKLAEAKEKIYLKGFYEGIML 451
Cdd:PRK12300 275 DYVALRDLKKNKELLDV----------IEPIPLIEVEGYGEFPAKEVVEKLGIKSQEDP-ELEEATKEVYRAEFHKGVLK 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 452 VD--GFKGQKVQDVKKTIQKKMIDAGDALIYME-PEKQVMSRSSDECVVA-LCDQWYLDYGEENWKKQTSQCLKNLETFC 527
Cdd:PRK12300 344 ENtgEYAGKPVREAREKITKDLIEKGIADIMYEfSNRPVYCRCGTECVVKvVKDQWFIDYSDPEWKELAHKALDNMEIIP 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 528 EETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGnlhgqaesplGIRPQQMTKEV 607
Cdd:PRK12300 424 EEYRKEFENTIDWLKDRACARRRGLGTRLPWDEEWIIESLSDSTIYMAYYTIAHKIREY----------GIKPEQLTPEF 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 608 WDYVF----FKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEqsDKWPTAVRANGHL 683
Cdd:PRK12300 494 FDYVFlgkgDPEEVSKKTGIPKEILEEMREEFLYWYPVDWRHSGKDLIPNHLTFFIFNHVAIFPE--EKWPRGIVVNGFV 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 684 LLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLytwvEWVKEMVANWDSLRSGPAS 763
Cdd:PRK12300 572 LLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQL----ERFYELAKELIEIGGEEEL 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 764 TFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELaVEGMHRELVFRFIEVQTLLLAPFCPHLCEHI 843
Cdd:PRK12300 648 RFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWYLRR-VGEANNKVLREVLEIWIRLLAPFTPHLAEEL 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 844 WTLLGKPDSIMNASWPVAGP--VNEVLIHSSQYLMEVTHDLRlRLKNYmmpAKGkktdkqplqKPSHCTIYVAknyPPWQ 921
Cdd:PRK12300 727 WHKLGGEGFVSLEKWPEPDEskIDEEAELAEEYVKRLIEDIR-EILKV---AKI---------KPKKVYIYVA---PDWK 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 922 HTTLSVLRkhfeanngKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDL-QLEFDEKAVLMENIVYL 1000
Cdd:PRK12300 791 YEVLEIAA--------ENGDVKEAIKELMKDEELRKHGKEVAKLAQKIVKEVLKLDKEVRKLiLKNIDEEEVLEEAKDFL 862
|
890 900 910
....*....|....*....|....*....|.
gi 964751021 1001 TNSLELEhIEVKFASEAE-DKIREDCCPGKP 1030
Cdd:PRK12300 863 EKELGVE-VEIYGADDPGkKKKKKKALPLKP 892
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
498-730 |
1.93e-72 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 243.69 E-value: 1.93e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 498 ALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGwlqehaCSRTYGLGTHLPWdeQWLIESLSDSTIYMAFY 577
Cdd:cd00812 127 KLLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARY 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 578 TVAHLLQggnlhgqaesplgirpqqmtkevwdyvffkeapfpktQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSY 657
Cdd:cd00812 199 TDAHNLE-------------------------------------QPYEGDLEFDREEFEYWYPVDIYIGGKEHAPNHLLY 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 964751021 658 YLYNHVAMWPEQ--SDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDtvEDANFVE 730
Cdd:cd00812 242 SRFNHKALFDEGlvTDEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
728-847 |
6.33e-51 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 175.09 E-value: 6.33e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 728 FVEAMADAGILRLYTWVEWVKEMVANWDSLrsgPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDK 807
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEGEL---EELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLDW 77
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 964751021 808 YRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLL 847
Cdd:cd07959 78 YRERGGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
469-717 |
3.12e-20 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 92.87 E-value: 3.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 469 KKMIDAGdaLIYmepekqvmsrsSDECVVALCDQWYLDYGEenWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSR 548
Cdd:cd00668 121 SRLYEKG--LIY-----------RGTHPVRITEQWFFDMPK--FKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISR 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 549 TYGLGTHLPwdeQWLIESLSDSTIYMAFYTvahllqgGNLHGqaesplgirpqqmtkevwdyvffkeapfpktqiakekl 628
Cdd:cd00668 186 QRYWGTPLP---EDVFDVWFDSGIGPLGSL-------GYPEE-------------------------------------- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 629 dqlKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEqsdKWPTAVRANGHLLLN-SEKMSKSTGNFLTLTQAIDKF 707
Cdd:cd00668 218 ---KEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGE---IPPKNLLVHGFVLDEgGQKMSKSKGNVIDPSDVVEKY 291
|
250
....*....|
gi 964751021 708 SADGMRLALA 717
Cdd:cd00668 292 GADALRYYLT 301
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
14-1025 |
2.25e-17 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 87.81 E-value: 2.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 14 KKIEKEIQQKWDTERVFEVNASnlekqTSKGKYFVTFPYPYMNGRLHLGHTFSLSkceaCADKLKREIELYGCPPDF-PD 92
Cdd:TIGR00422 8 HEVEKKWYKKWEKSGFFKPDGN-----SNKPPFCIDIPPPNVTGSLHIGHALNWS----IQDIIARYKRMKGYNVLWlPG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 93 EEEEEEETSVKTEDIIikdkakgkkskaaakagsskyqWGIMKSLG-LSDEEIVKfsEAEHWLDYFPPLAIQDLKRMGLK 171
Cdd:TIGR00422 79 TDHAGIATQVKVEKKL----------------------GAEGKTKHdLGREEFRE--KIWEWKEESGGTIKNQIKRLGAS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 172 VDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKvlepypsk 251
Cdd:TIGR00422 135 LDWSRERFTMD--EGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLA-------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 252 lsglKGKNIFLVAATLRPETMFGQTNCWVRP-DMKYigfetvngdifictqkaarnmsyqgftkdngvvpvvKELMGEEI 330
Cdd:TIGR00422 205 ----NGSKDYLVVATTRPETMFGDTAVAVHPeDERY------------------------------------KHLIGKKV 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 331 LgaslsAPLTSYKViyvlPMLT---IKEDKGTGVVTSVPSDSPDDIAalrdLKKKQALrakygirddmvlpfEPVPVIEI 407
Cdd:TIGR00422 245 I-----LPLTGRKI----PIIAdeyVDMEFGTGAVKVTPAHDFNDYE----WGKRHNL--------------EFINILDE 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 408 PGFGNLSAvticdeLKIQSQndreKLAEAKEKIylkgfyegimlvdgfkgqkVQDVKKtiQKKmidagdaLIYMEPEKQ- 486
Cdd:TIGR00422 298 DGLLNENA------GKYQGL----TRFEARKKI-------------------VEDLKE--EGL-------LVKIEPHTHn 339
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 487 --VMSRSSDECVVALCDQWYLDYgeENWKKQTSQCLKNLE-TFCEEtrrNFEATL-GWLQEHA--C-SRTYGLGTHLPwd 559
Cdd:TIGR00422 340 vgTCWRSGTVVEPLLSKQWFVKV--EKLADKALEAAEEGEiKFVPK---RMEKRYlNWLRNIKdwCiSRQLIWGHRIP-- 412
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 560 eqwlieslsdstiymAFYTVahllQGGNLHGQAESPLGIRPQQMT--------KEVWDyVFFKEA--PFPKTQIAKEKLD 629
Cdd:TIGR00422 413 ---------------VWYCK----ECGEVYVAKEEPLPDDKTNTGpsveleqdTDVLD-TWFSSSlwPFSTLGWPDETKD 472
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 630 qlkqeFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMwpEQSDKWPTA-----VR-ANGHlllnseKMSKSTGNFLTLTQA 703
Cdd:TIGR00422 473 -----LKKFYPTDLLVTGYDIIFFWVARMIFRSLAL--TGQVPFKEVyihglVRdEQGR------KMSKSLGNVIDPLDV 539
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 704 IDKFSADGMRLALADAGDTVEDANFVEAMADAG---ILRLYTWVEWVKEMVANWDSLrSGPASTFN--DRVFASELNAGI 778
Cdd:TIGR00422 540 IEKYGADALRFTLASLVTPGDDINFDWKRVESArnfLNKLWNASRFVLMNLSDDLEL-SGGEEKLSlaDRWILSKLNRTI 618
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 779 IKTDQNYEKMMFKEALKtGFFEF----------QAAK--DKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIW-T 845
Cdd:TIGR00422 619 KEVRKALDKYRFAEAAK-ALYEFiwndfcdwyiELVKyrLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWqH 697
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 846 LLGKPDSIMNASWPVAGP--VNEVLIHSSQYLMEVTHDLRLRLKNYMMPAkgkktdKQPLQKpshCTIYVAKNYPPWQHT 923
Cdd:TIGR00422 698 FKEGADSIMLQSYPVVDAefVDEEAEKAFELLKEIIVSIRNLKAESNIPP------NAPLKV---LLIYTEAETAERLKL 768
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 924 TLSVLRKHFEANNGKLpdnkviaseLGSMPELKKYMKKVMPFVAMI--KENLEKMGPRILDLQLEFDEKavLMENIVyLT 1001
Cdd:TIGR00422 769 NAVDIKGAINFSEVEV---------VIEKPEVTEAVVELVPGFEIIipVKGLINKAKELARLQKQLDKE--KKEVIR-IE 836
|
1050 1060
....*....|....*....|....
gi 964751021 1002 NSLELEHIEVKFASEAEDKIREDC 1025
Cdd:TIGR00422 837 GKLENEGFVKKAPKEVIEKEKEKL 860
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
767-883 |
6.22e-17 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 78.60 E-value: 6.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 767 DRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQ---------AAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCP 837
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWndlsdwyleLIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 964751021 838 HLCEHIWtllgKPDSIMNASWPVAGPVNEVLIHSS-QYLMEVTHDLR 883
Cdd:pfam08264 81 FITEELW----QKESIHLAPWPEDAELEEAELEEAfELRQEIVQAIR 123
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
647-861 |
2.18e-16 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 84.01 E-value: 2.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 647 GKDLVpnhlsyylYNHVAMWP---EQSD-KWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDT 722
Cdd:COG0143 289 GKDII--------RFHAIIWPamlMAAGlPLPKKVFAHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPF 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 723 VEDANFveamadagilrlyTWVEWV----KEMVANWDSL--RS--------------GPASTFNDRVFASELNAGIIKTD 782
Cdd:COG0143 361 GQDGDF-------------SWEDFVarvnSDLANDLGNLasRTlsmihkyfdgkvpePGELTEADEELLAEAEAALEEVA 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 783 QNYEKMMFKEALKT---------GFFEFQA----AKDKYRELAVEGMHREL-VFRFIevqTLLLAPFCPHLCEHIWTLLG 848
Cdd:COG0143 428 EAMEAFEFRKALEEimalaraanKYIDETApwklAKDEDPERLATVLYTLLeALRIL---AILLKPFLPETAEKILEQLG 504
|
250
....*....|....*.
gi 964751021 849 KPDSIMN---ASWPVA 861
Cdd:COG0143 505 LEGDELTwedAGWPLP 520
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
20-728 |
3.04e-16 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 83.61 E-value: 3.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 20 IQQKWDTERVFEvnaSNLEKQTSKGKYFVTFPYPYMNGRLHLGHtfslskceACADKLKreielygcppdfpdeeeeeee 99
Cdd:pfam00133 2 IYEFWDEQGYFK---PELEKRKGKPSFTIHDGPPNATGSLHIGH--------ALAKTLK--------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 100 tsvkteDIIIKdkakgkksKAAAKAGSSKYQWG-----------IMKSLGLSDEEIV-KFSEAEH------WLDYFPPLA 161
Cdd:pfam00133 50 ------DIVIR--------YKRMKGYYVLWVPGwdhhglpteqvVEKKLGIKEKKTRhKYGREEFrekcreWKMEYADEI 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 162 IQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLK 241
Cdd:pfam00133 116 RKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEYKDVKGPSIHVAFP 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 242 LKVlepypsklsglkGKNIFLVAATLRPETMFGQTNCWVRPDMKYIgfetVNGDIFICTQKAARNMSYQGFTKDngvvpV 321
Cdd:pfam00133 194 LAD------------DEGASLVIWTTTPWTLPGNTAVAVNPEFDYV----ITGEGYILAEALLKSLYKKGTDKK-----I 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 322 VKELMGEEILGASLSAPLTSYKViyvlPMLT---IKEDKGTGVVTSVPSDSPDDIAALRdlkkkqalraKYGIrdDMVLP 398
Cdd:pfam00133 253 LEDFRGKELEGKEAIHPFVNREI----PIITddyVDMEFGTGAVHIAPAHGENDYEVGQ----------RHNL--EVINP 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 399 FEPVPVIeipgfgnlsavticdelkiqsqndREKLAEakekiylkgfyegimlvdgFKGQKVQDVKKTIQKKMIDAGdal 478
Cdd:pfam00133 317 VDDDGTF------------------------TEEAPD-------------------FQGVYRFDARKKIVELLTEKG--- 350
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 479 IYMEPEKQVMS-----RSSDECVVALCDQWYLdygeeNWKKQTSQCLKNLE--TFCEETRRN-FEATLGWLQEHACSRTY 550
Cdd:pfam00133 351 LLLKIEPFTHSypfcwRSGTPIIPRATPQWFV-----RMDELADQALEAVEkvQFVPKSGEKrYFNWLANIQDWCISRQR 425
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 551 GLGTHLPWdeqWLIESLSDstIYMA---FYTVAHLLQGG----NLHGQAESPLGIRPQQMTK--EVWDyVFFKEAPFPKT 621
Cdd:pfam00133 426 WWGHPIPA---WVSKDTEE--VVCRgelFELVAGRFEEEgsikWLHREAKDKLGYGKGTLEQdeDVLD-TWFSSGSWPFS 499
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 622 QIakEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKwptAVRANGhLLLNSE--KMSKSTGNFLT 699
Cdd:pfam00133 500 TL--GWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFK---NVLVHG-LVRDEQgrKMSKSLGNVID 573
|
730 740
....*....|....*....|....*....
gi 964751021 700 LTQAIDKFSADGMRLALADAgDTVEDANF 728
Cdd:pfam00133 574 PLDVIDKYGADALRLWLANS-DYGRDINL 601
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
675-861 |
2.20e-12 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 71.62 E-value: 2.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 675 TAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL------------ADAGdtVEDAN-FVEamadagilRLY 741
Cdd:COG0495 575 LEVGKDGVVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRLFEmfagpperdlewSDSG--VEGAYrFLN--------RVW 644
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 742 TwvewvkeMVANWDSLRSGPASTFN--DRVFASELNAGIIKTDQNYEKMMFKEA------LKTGFFEFQAAKDKYRELAV 813
Cdd:COG0495 645 R-------LVVDEAEALKLDVADLSeaDKELRRALHKTIKKVTEDIERLRFNTAiaalmeLVNALYKAKDSGEADRAVLR 717
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 964751021 814 EGMhrelvfrfiEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVA 861
Cdd:COG0495 718 EAL---------ETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEA 756
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
45-202 |
3.19e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 68.81 E-value: 3.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 45 KYFVTFPYPYMNGRLHLGHTFSLSKCEACAdKLKReieLYGCPPDFP---DeeeeeeETSVKTEDIIIKdkakgkkskaa 121
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIA-RYKR---MQGYNVLFPmgfD------AFGLPAENAAIK----------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 122 akagsskyqwgimksLGLSDEEIVKFSEAEhwldyfpplAIQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRER 201
Cdd:cd00812 60 ---------------IGRDPEDWTEYNIKK---------MKEQLKRMGFSYDWRREFTTCD--PEYYKFTQWLFLKLYEK 113
|
.
gi 964751021 202 N 202
Cdd:cd00812 114 G 114
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
635-861 |
1.23e-10 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 65.98 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 635 FEFWYPVDLRVSGKDLVPNHL------SYYLYNHVAmwpeqsdkWpTAVRANGHLL-LNSEKMSKSTGNFLTLTQAIDKF 707
Cdd:PRK13208 481 FEKVFPMDLRPQGHDIIRTWLfytilrAYLLTGKLP--------W-KNIMISGMVLdPDGKKMSKSKGNVVTPEELLEKY 551
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 708 SADGMRLALADA--GDtveDANFVEAMADAG-------------ILRLYTWVEWVKEMVANwdslrsgPAstfnDRVFAS 772
Cdd:PRK13208 552 GADAVRYWAASArlGS---DTPFDEKQVKIGrrlltklwnasrfVLHFSADPEPDKAEVLE-------PL----DRWILA 617
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 773 ELNAGIIKTDQNYEKMMFKEALKT--GFF--EFqaaKDKYRELA--------VEGMHRELVF---RFIEVQTLLLAPFCP 837
Cdd:PRK13208 618 KLAKVVEKATEALENYDFAKALEEieSFFwhVF---CDDYLELVksraygedEEEEQKSARYtlyTVLDTLLRLLAPFLP 694
|
250 260
....*....|....*....|....
gi 964751021 838 HLCEHIWTLLGKpDSIMNASWPVA 861
Cdd:PRK13208 695 FITEEVWSWLYG-GSVHRASWPEP 717
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
647-851 |
1.81e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 65.17 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 647 GKDLVpnhlsyylYNHVAMWP---EQSD-KWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALA-DAGD 721
Cdd:PRK00133 291 GKDII--------YFHTLFWPamlEGAGyRLPTNVFAHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAaKLPE 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 722 TVEDANFveamadagilrlyTWVEWVK----EMVANWDSL--RS----------GPASTFNDRVFASELNAGIIKTDQNY 785
Cdd:PRK00133 363 TIDDLDF-------------NWEDFQQrvnsELVGKVVNFasRTagfinkrfdgKLPDALADPELLEEFEAAAEKIAEAY 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 786 EKMMFKEALKT---------GFFEFQA----AKDKYRELAvEGMHREL-VFRFIevqTLLLAPFCPHLCEHIWTLLGKPD 851
Cdd:PRK00133 430 EAREFRKALREimaladfanKYVDDNEpwklAKQDGERLQ-AVCSVGLnLFRAL---AIYLKPVLPELAERAEAFLNLEE 505
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
608-863 |
4.02e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 64.46 E-value: 4.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 608 WDYVFFKEAPFPKTQIAKEKLdqlkqefEFWYPVDLRVSGKDLVPNHLSY------YLYN--------------HVAM-- 665
Cdd:PLN02563 591 WYYLRFMDPKNSNALVDKEKE-------KYWMPVDLYVGGAEHAVLHLLYarfwhkVLYDigvvstkepfqclvNQGMil 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 666 -------WPEQSDKWPTAVRANGHLLLNSE-----------------------------KMSKSTGNFLTLTQAIDKFSA 709
Cdd:PLN02563 664 geveytaFKDSDGEYVSADTADRLGELQQEkipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGA 743
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 710 DGMRLaladagdtvedanFVEAMadaGILR-LYTW----VEWVKEMVAN-WDSLRSGPAS--TFNDRVFASE-------- 773
Cdd:PLN02563 744 DSLRL-------------YEMFM---GPLRdSKTWstsgVEGVHRFLGRtWRLVVGAPLPdgSFRDGTVVTDeepsleql 807
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 774 --LNAGIIKTDQNYEKMMFKEALkTGFFEFQAAKDKYRELAVEgmhrelvfrFIEVQTLLLAPFCPHLCEHIWTLLGKPD 851
Cdd:PLN02563 808 rlLHKCIAKVTEEIESTRFNTAI-SAMMEFTNAAYKWDKVPRE---------AIEPFVLLLSPYAPHLAEELWFRLGHSN 877
|
330
....*....|..
gi 964751021 852 SIMNASWPVAGP 863
Cdd:PLN02563 878 SLAYEPWPEANP 889
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
689-897 |
4.93e-10 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 63.97 E-value: 4.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 689 KMSKSTGNF---LTLtqaIDKFSADGMRLALAdagdtvedanfveAMADAGI-LRL-YTWVE---------W-----VKE 749
Cdd:PRK05729 520 KMSKSKGNVidpLDL---IDKYGADALRFTLA-------------ALASPGRdIRFdEERVEgyrnfanklWnasrfVLM 583
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 750 MVANWDSLRSGPASTFN--DRVFASELNAGIIKTDQNYEKMMFKEALKT--GFF--EF-----QAAKDKYRELAVEGMHR 818
Cdd:PRK05729 584 NLEGADVGELPDPEELSlaDRWILSRLNRTVAEVTEALDKYRFDEAARAlyEFIwnEFcdwylELAKPVLQEAAKRATRA 663
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 819 ELVfRFIEvQTL-LLAPFCPHLCEHIWTLL---GKPDSIMNASWPVAGPV-NEVLIHSSQYLMEVTHDLRlRLKNYMMPA 893
Cdd:PRK05729 664 TLA-YVLE-QILrLLHPFMPFITEELWQKLaplGIEESIMLAPWPEADEAiDEAAEAEFEWLKELITAIR-NIRAEMNIP 740
|
....
gi 964751021 894 KGKK 897
Cdd:PRK05729 741 PSKK 744
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
689-883 |
1.19e-09 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 62.76 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 689 KMSKSTGNF---LTLtqaIDKFSADGMRLALAdagdtvedanfveAMADAGI-LRLYT-WVE------------------ 745
Cdd:COG0525 522 KMSKSKGNVidpLDL---IDKYGADALRFTLA-------------ALASPGRdIKFDEeRVEgyrnfanklwnasrfvlm 585
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 746 WVKEMVANWDSLRSgpASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKT--GFF--EFQaakDKYRELA-------VE 814
Cdd:COG0525 586 NLEGFDPGLDPDPE--ELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQAlyDFVwnEFC---DWYLELAkprlyggDE 660
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 964751021 815 GMHRELVFRFIEV--QTL-LLAPFCPHLCEHIWTLLGKP---DSIMNASWPVAGP--VNEVLIHSSQYLMEVTHDLR 883
Cdd:COG0525 661 AAKRETRATLVYVleQILrLLHPFMPFITEEIWQKLPPRkegESIMLAPWPEADEelIDEEAEAEFEWLKEVISAIR 737
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
610-728 |
1.70e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 61.15 E-value: 1.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 610 YVFFkEAPFPKTQIAKEkLDQLKQEFEFWYPVDLRVS-----GKDLVpnhlsyylYNHVAMWP----EQSDKWPTAVRAN 680
Cdd:pfam09334 246 YVWL-DAPIGYISATKE-LSGNEEKWKEWWPNDPDTElvhfiGKDII--------YFHTIFWPamllGAGYRLPTTVFAH 315
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 964751021 681 GHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANF 728
Cdd:pfam09334 316 GYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDF 363
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
637-853 |
2.60e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 61.05 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 637 FWyPVDLRVSGKDLVPNHLSYylynhvamWPEQ--SD--KWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGM 712
Cdd:PRK11893 252 YW-PADVHLIGKDILRFHAVY--------WPAFlmAAglPLPKRVFAHGFLTLDGEKMSKSLGNVIDPFDLVDEYGVDAV 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 713 RLALA-------DaGDTVED----------ANFVEAMADAgilrlytwvewVKEMVANW--DSLRSGPASTFNDRVFASE 773
Cdd:PRK11893 323 RYFLLreipfgqD-GDFSREafinrinadlANDLGNLAQR-----------TLSMIAKNfdGKVPEPGALTEADEALLEA 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 774 LNAGIIKTDQNYEKMMFKEALK---------TGFFEFQA----AKDKYRELAVEGMHRELVFRFIevqTLLLAPFCPHLC 840
Cdd:PRK11893 391 AAALLERVRAAMDNLAFDKALEailalvraaNKYIDEQApwslAKTDPERLATVLYTLLEVLRGI---AVLLQPVMPELA 467
|
250
....*....|...
gi 964751021 841 EHIWTLLGKPDSI 853
Cdd:PRK11893 468 AKILDQLGVEEDE 480
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
666-866 |
6.71e-09 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 60.39 E-value: 6.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 666 WPEQSDK----WPTAVRANGHLLL--------------------------------NSEKMSKSTGNFLTLTQAIDKFSA 709
Cdd:PRK14900 479 WPEQTDTlrtfYPTSVMETGHDIIffwvarmmmmglhfmgevpfrtvylhpmvrdeKGQKMSKTKGNVIDPLVITEQYGA 558
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 710 DGMRLALAD----------AGDTVEDAN-FVEAMADAGILRLYTWVEWVKEMVanwDSLRSgpASTFNDRVFASELNAGI 778
Cdd:PRK14900 559 DALRFTLAAltaqgrdiklAKERIEGYRaFANKLWNASRFALMNLSGYQERGE---DPARL--ARTPADRWILARLQRAV 633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 779 IKTDQNYEKMMFKEALKTGF-FEFQAAKDKYRELAVEGMH----------RELVFRFIEVQTLLLAPFCPHLCEHIWTLL 847
Cdd:PRK14900 634 NETVEALEAFRFNDAANAVYaFVWHELCDWYIELAKEALAsedpearrsvQAVLVHCLQTSYRLLHPFMPFITEELWHVL 713
|
250 260
....*....|....*....|....*.
gi 964751021 848 -------GKPDSIMNASWPVAGPVNE 866
Cdd:PRK14900 714 raqvgasAWADSVLAAEYPRKGEADE 739
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
610-728 |
1.32e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 57.93 E-value: 1.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 610 YVFFkEAPFPKTQIAKEKLDQLKQEFEFWY--PVDLRVSGKDLVPNHlsyylynhVAMWP---EQSDKW-PTAVRANGHL 683
Cdd:cd00814 204 YVWF-DALIGYISATGYYNEEWGNSWWWKDgwPELVHFIGKDIIRFH--------AIYWPamlLGAGLPlPTRIVAHGYL 274
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 964751021 684 LLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANF 728
Cdd:cd00814 275 TVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
680-716 |
2.18e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 58.19 E-value: 2.18e-08
10 20 30
....*....|....*....|....*....|....*..
gi 964751021 680 NGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 716
Cdd:COG0215 256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFL 292
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
680-716 |
1.86e-07 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 52.97 E-value: 1.86e-07
10 20 30
....*....|....*....|....*....|....*..
gi 964751021 680 NGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 716
Cdd:cd00672 165 TGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
639-719 |
1.22e-05 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 48.52 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 639 YPVDLRVSGKDLV-PNHlsyylYNHVAMWPEQSDK-WPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 716
Cdd:pfam01406 206 DQIDIHGGGIDLAfPHH-----ENEIAQSEAAFDKqLANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFL 280
|
...
gi 964751021 717 ADA 719
Cdd:pfam01406 281 LSV 283
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
630-728 |
1.64e-05 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 48.40 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 630 QLKQEFEFWYPVDLRVSGKDLvpnhLSYYLYNHVAMWPEQSDKWP-TAVRANGhLLLNSE--KMSKSTGNFLTLTQAIDK 706
Cdd:cd00817 286 EETKDLKKFYPTSLLVTGHDI----IFFWVARMIMRGLKLTGKLPfKEVYLHG-LVRDEDgrKMSKSLGNVIDPLDVIDG 360
|
90 100
....*....|....*....|..
gi 964751021 707 FSADGMRLALADAGDTVEDANF 728
Cdd:cd00817 361 YGADALRFTLASAATQGRDINL 382
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
681-714 |
2.36e-05 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 48.49 E-value: 2.36e-05
10 20 30
....*....|....*....|....*....|....
gi 964751021 681 GHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRL 714
Cdd:PTZ00399 307 GHLHIKGLKMSKSLKNFITIRQALSKYTARQIRL 340
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
689-905 |
3.37e-05 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 48.15 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 689 KMSKSTGNFLTLTQAIDKFSADGMRLALAdAGDTVEDANF----VEAMADAgILRLY-TWV---------EWVKEMVA-- 752
Cdd:COG0060 603 KMSKSLGNVVDPQEVIDKYGADILRLWVA-SSDYWGDLRFsdeiLKEVRDV-YRRLRnTYRfllanlddfDPAEDAVPye 680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 753 NWDSLrsgpastfnDRVFASELNAGIIKTDQNYEKMMFKEALKT--GF-------FEFQAAKD---------KYRELAVE 814
Cdd:COG0060 681 DLPEL---------DRWILSRLNELIKEVTEAYDNYDFHRAYRAlhNFcvedlsnWYLDISKDrlyteaadsLDRRAAQT 751
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 815 GMHRELvfrfiEVQTLLLAPFCPHLCEHIWTLL--GKPDSIMNASWPVA--GPVNEVLIHSSQYLMEVTHDLRLRLKNym 890
Cdd:COG0060 752 TLYEVL-----ETLVRLLAPILPFTAEEIWQNLpgEAEESVHLADWPEVdeELIDEELEAKWDLVREVRSAVLKALEA-- 824
|
250
....*....|....*
gi 964751021 891 mpAKGKKTDKQPLQK 905
Cdd:COG0060 825 --ARKEKLIRQPLEA 837
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
13-63 |
3.44e-04 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 45.07 E-value: 3.44e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 964751021 13 LKKIEKEIQQKWDTERVFEvnasNLEKQTSKGKYFVtF---PyPYMNGRLHLGH 63
Cdd:COG0060 18 LPKREPEILKFWEENDIYE----KSREARAGRPKFV-LhdgP-PYANGDIHIGH 65
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
808-847 |
4.14e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 41.05 E-value: 4.14e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 964751021 808 YRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLL 847
Cdd:cd07958 78 YKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
639-716 |
5.86e-04 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 43.77 E-value: 5.86e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 964751021 639 YPVDLRVSGKDLV-PNHLSYYLYNHVAMWPEQSDKWPtavrANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 716
Cdd:PLN02946 276 HSFDIHGGGMDLVfPHHENEIAQSCAACCDSNISYWI----HNGFVTVDSEKMSKSLGNFFTIRQVIDLYHPLALRLFL 350
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
689-863 |
1.41e-03 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 42.84 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 689 KMSKSTGNFLTLTQAID---------KFSADGMRLALAD---AGDTVEDANFVEAMADA-----GILR--LYTWVEWVKE 749
Cdd:PLN02843 611 KMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWVASvdyTGDVLIGPQILKQMSDIyrklrGTLRylLGNLHDWKPD 690
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 750 MVANWDSLrsgPAStfnDRVFASELNAGIIKTDQNYEKMMFKEALKT---------GFFEFQAAKDKyreLAVEGMHRel 820
Cdd:PLN02843 691 NAVPYEDL---PSI---DKYALFQLENVVNEIEESYDNYQFFKIFQIlqrftivdlSNFYLDVAKDR---LYVGGTTS-- 759
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 964751021 821 vFRFIEVQTLL----------LAPFCPHLCEHIWTLL------GKPDSIMNASWPVAGP 863
Cdd:PLN02843 760 -FTRRSCQTVLaahllsllraIAPILPHLAEDAWQNLpfqedgSAAESVFEAGWPTPNE 817
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
627-725 |
1.84e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 42.39 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751021 627 KLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYlynhVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDK 706
Cdd:PLN02224 308 KQQNLETAVSFGWPASLHLIGKDILRFHAVYW----PAMLMSAGLELPKMVFGHGFLTKDGMKMGKSLGNTLEPFELVQK 383
|
90 100
....*....|....*....|....*
gi 964751021 707 FSADGMR------LALADAGDTVED 725
Cdd:PLN02224 384 FGPDAVRyfflreVEFGNDGDYSED 408
|
|
| |
