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Conserved domains on  [gi|20302166|ref|NP_057694|]
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toll-like receptor 8 isoform 1 [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
483-793 3.24e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 3.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  483 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 562
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  563 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 637
Cdd:COG4886   83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  638 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 717
Cdd:COG4886  148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20302166  718 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 793
Cdd:COG4886  217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
898-1040 2.23e-16

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 76.98  E-value: 2.23e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166     898 YDAYISYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 977
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20302166     978 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1040
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-460 1.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   81 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 158
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  159 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 236
Cdd:COG4886  152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  237 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 315
Cdd:COG4886  204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  316 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 395
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20302166  396 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 460
Cdd:COG4886  329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 760-847 1.32e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.78  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    760 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 839
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....*...
gi 20302166    840 CVSDVTAV 847
Cdd:TIGR00864   78 SGCDEEYV 85
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
483-793 3.24e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 3.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  483 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 562
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  563 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 637
Cdd:COG4886   83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  638 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 717
Cdd:COG4886  148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20302166  718 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 793
Cdd:COG4886  217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
898-1040 2.23e-16

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 76.98  E-value: 2.23e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166     898 YDAYISYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 977
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20302166     978 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1040
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 591-792 3.91e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 3.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  591 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 660
Cdd:cd21340    4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  661 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 740
Cdd:cd21340   72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 20302166  741 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 792
Cdd:cd21340  131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-460 1.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   81 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 158
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  159 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 236
Cdd:COG4886  152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  237 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 315
Cdd:COG4886  204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  316 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 395
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20302166  396 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 460
Cdd:COG4886  329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 301-790 4.32e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 4.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   301 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 377
Cdd:PLN00113  114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   378 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 433
Cdd:PLN00113  188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   434 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 513
Cdd:PLN00113  258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   514 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 590
Cdd:PLN00113  299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   591 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 653
Cdd:PLN00113  374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   654 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 728
Cdd:PLN00113  449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20302166   729 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 790
Cdd:PLN00113  519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 898-1042 4.89e-11

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 62.38  E-value: 4.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    898 YDAYISYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 973
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    974 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1032
Cdd:pfam01582   76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150

                          170
                   ....*....|
gi 20302166   1033 WQTLRNVVLT 1042
Cdd:pfam01582  151 WKKIAYDISN 160
LRR_8 pfam13855
Leucine rich repeat;
658-718 2.26e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 2.26e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20302166    658 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 718
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-615 8.68e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 8.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    83 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 161
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   162 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 240
Cdd:PLN00113  138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   241 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 306
Cdd:PLN00113  211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   307 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 386
Cdd:PLN00113  286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   387 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 447
Cdd:PLN00113  363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   448 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 527
Cdd:PLN00113  440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   528 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 604
Cdd:PLN00113  504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570

                         570
                  ....*....|....
gi 20302166   605 KVL---NLSHNNIY 615
Cdd:PLN00113  571 ESLvqvNISHNHLH 584
LRR_8 pfam13855
Leucine rich repeat;
305-367 1.55e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.55e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20302166    305 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 367
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 130-339 1.66e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  130 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 205
Cdd:cd21340   10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  206 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 272
Cdd:cd21340   80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  273 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 339
Cdd:cd21340  129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 760-847 1.32e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.78  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    760 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 839
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....*...
gi 20302166    840 CVSDVTAV 847
Cdd:TIGR00864   78 SGCDEEYV 85
LRRCT smart00082
Leucine rich repeat C-terminal domain;
790-835 5.88e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.34  E-value: 5.88e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 20302166     790 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 835
Cdd:smart00082    1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
483-793 3.24e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 3.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  483 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 562
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  563 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 637
Cdd:COG4886   83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  638 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 717
Cdd:COG4886  148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20302166  718 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 793
Cdd:COG4886  217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
TIR smart00255
Toll - interleukin 1 - resistance;
898-1040 2.23e-16

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 76.98  E-value: 2.23e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166     898 YDAYISYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 977
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20302166     978 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1040
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
502-790 1.03e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  502 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 581
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSN 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  582 NshyfRIAGVTHHLEfiqNFTNLKVLNLSHNNIYTLTDKYNlESKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 661
Cdd:COG4886  192 N----QITDLPEPLG---NLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQL---------TDLPELGNLTNLEE 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  662 LDLSLNRLKHIPNEAFLnlpASLTELHINDNMLKFFNWTLLQ--QFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH 739
Cdd:COG4886  255 LDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKELEllLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 20302166  740 NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 790
Cdd:COG4886  332 GLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 591-792 3.91e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 3.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  591 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 660
Cdd:cd21340    4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  661 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 740
Cdd:cd21340   72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 20302166  741 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 792
Cdd:cd21340  131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-460 1.19e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   81 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 158
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  159 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 236
Cdd:COG4886  152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  237 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 315
Cdd:COG4886  204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  316 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 395
Cdd:COG4886  261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20302166  396 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 460
Cdd:COG4886  329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
502-787 1.57e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  502 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 581
Cdd:COG4886  139 KELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  582 NshyfriaGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 661
Cdd:COG4886  215 N-------QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNL--TNLEELDLSNNQL---------TDLPPLANLTNLKT 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  662 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNR 741
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 20302166  742 ISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLEL 787
Cdd:COG4886  357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
122-451 1.75e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  122 NGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYF 201
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  202 NKVCEKTNIEDgvFETLTNLELLSLSFNSlshvPPKLPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfna 281
Cdd:COG4886   81 LLSLLLLGLTD--LGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNN------- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  282 pfpcvpcdggaSINIDRFAFQNLTQLRYLNLSSTSLRKINaAWFKNMPHLKVLDLEFNYLvGEIasGAFLTMLPRLEILD 361
Cdd:COG4886  147 -----------QLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI-TDL--PEPLGNLTNLEELD 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  362 LSFNYIKgsypqhiNISRNFSKLLSLRALHLRGYVFQELREddfqpLMQLPNLSTINLGINFIKQIDFklFQNFSNLEII 441
Cdd:COG4886  212 LSGNQLT-------DLPEPLANLTNLETLDLSNNQLTDLPE-----LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                        330
                 ....*....|
gi 20302166  442 YLSENRISPL 451
Cdd:COG4886  278 DLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-559 3.24e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 3.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  103 GLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQlpqiPSGLPESLTELSLIQNNIYNITKE 182
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  183 gISRLINLKNLYLAWNcyfnkvcektNIEDgvfetltnlellslsfnslshVPPKLPS--SLRKLFLSNTQIKYISEEdF 260
Cdd:COG4886  132 -LANLTNLKELDLSNN----------QLTD---------------------LPEPLGNltNLKSLDLSNNQLTDLPEE-L 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  261 KGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF--AFQNLTQLRYLNLSSTSLRKINAAwFKNMPHLKVLDLEF 338
Cdd:COG4886  179 GNLTNLKELDLSNN--------------------QITDLpePLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  339 NylvgEIASGAFLTMLPRLEILDLSFNYIKgsypqhinisrnfskllslralhlrgyvfqelredDFQPLMQLPNLSTIN 418
Cdd:COG4886  238 N----QLTDLPELGNLTNLEELDLSNNQLT-----------------------------------DLPPLANLTNLKTLD 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  419 LGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYhftrpLIKPQCA 498
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL-----LALLTLL 353

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20302166  499 AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNR 559
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 301-790 4.32e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 4.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   301 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 377
Cdd:PLN00113  114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   378 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 433
Cdd:PLN00113  188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   434 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 513
Cdd:PLN00113  258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   514 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 590
Cdd:PLN00113  299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   591 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 653
Cdd:PLN00113  374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   654 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 728
Cdd:PLN00113  449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20302166   729 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 790
Cdd:PLN00113  519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 898-1042 4.89e-11

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 62.38  E-value: 4.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    898 YDAYISYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 973
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    974 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1032
Cdd:pfam01582   76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150

                          170
                   ....*....|
gi 20302166   1033 WQTLRNVVLT 1042
Cdd:pfam01582  151 WKKIAYDISN 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-274 6.32e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 6.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   68 SNRRLQEVPQTVG--KYVTELDLSDNFITHItNESFQGLQNLTKINLNHNpnvqhqngnpgiqsnglNITD--GAFLNLK 143
Cdd:COG4886  121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-----------------QLTDlpEELGNLT 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  144 NLRELLLEDNQLPQIPSGL--PESLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgvFETLTNL 221
Cdd:COG4886  183 NLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----------QLTD--LPELGNL 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 20302166  222 ellslsfnslshvppklpSSLRKLFLSNTQIKYISEEdfKGLINLTLLDLSGN 274
Cdd:COG4886  250 ------------------TNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNN 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 327-792 4.55e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   327 NMPHLKVLDLEFNYLVGEIASGAFltMLPRLEILDLSFNYIKGSYPQHInisrnFSKLLSLRALHLRGYVFQelredDFQ 406
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIF--RLPYIQTINLSNNQLSGPIPDDI-----FTTSSSLRYLNLSNNNFT-----GSI 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   407 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENrisPLVKDTRQSYANSSSFQ--------------RHIRKR 472
Cdd:PLN00113  135 PRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN---VLVGKIPNSLTNLTSLEfltlasnqlvgqipRELGQM 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   473 RSTDFEFDPHSNFYHFTrPLIKPQCAAYGKaLDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSaIPHVKY 552
Cdd:PLN00113  212 KSLKWIYLGYNNLSGEI-PYEIGGLTSLNH-LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS-LQKLIS 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   553 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQ-------NFT-----------NLKVLNLSHNNI 614
Cdd:PLN00113  289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQvlqlwsnKFSgeipknlgkhnNLTVLDLSTNNL 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   615 YTLTDKYNLESKSLVELVFSGNRLDilwndddnryISIFKGL---KNLTRLDLSLNRLKHIPNEAFLNLPAsLTELHIND 691
Cdd:PLN00113  369 TGEIPEGLCSSGNLFKLILFSNSLE----------GEIPKSLgacRSLRRVRLQDNSFSGELPSEFTKLPL-VYFLDISN 437

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   692 NMLKFFNWTLLQQFPRLELLDLRGNKLLfltDSLSDFTSS--LRTLLLSHNRISH-LPSGFLSeVSSLKHLDLSSNLLKT 768
Cdd:PLN00113  438 NNLQGRINSRKWDMPSLQMLSLARNKFF---GGLPDSFGSkrLENLDLSRNQFSGaVPRKLGS-LSELMQLKLSENKLSG 513

                         490       500
                  ....*....|....*....|....
gi 20302166   769 INKSalETKTTTKLSMLELHGNPF 792
Cdd:PLN00113  514 EIPD--ELSSCKKLVSLDLSHNQL 535
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 901-1012 1.38e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 56.94  E-value: 1.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    901 YISYDTKDASVTDWVINELryhleESRDKNVLLclEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYL 980
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-----EAAGYRVWL--DRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 20302166    981 ALQRLMDENmdVIIFILLE-----PVLQHSQYLRLRQ 1012
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
LRR_8 pfam13855
Leucine rich repeat;
658-718 2.26e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 2.26e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20302166    658 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 718
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-615 8.68e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 8.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    83 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 161
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   162 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 240
Cdd:PLN00113  138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   241 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 306
Cdd:PLN00113  211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   307 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 386
Cdd:PLN00113  286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   387 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 447
Cdd:PLN00113  363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   448 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 527
Cdd:PLN00113  440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   528 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 604
Cdd:PLN00113  504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570

                         570
                  ....*....|....
gi 20302166   605 KVL---NLSHNNIY 615
Cdd:PLN00113  571 ESLvqvNISHNHLH 584
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
234-740 2.19e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 2.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  234 VPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLS 313
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  314 STSLRKINAAWFKNMPHLKVLDLEFNylvgeiasgAFLTMLPRLEILDLSFNYIKgsypqhiNISRNFSKLLSLRALHLR 393
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLT-------DLPEELANLTNLKELDLS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  394 GYVFQELREddfqPLMQLPNLSTINLGINFIKQIDfKLFQNFSNLEIIYLSENRISPLvkdtrqsyansssfqrhirkrr 473
Cdd:COG4886  145 NNQLTDLPE----PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---------------------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  474 stdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYL 553
Cdd:COG4886  198 ------------------------------------------PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETL 233

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  554 DLTNNRLDfdNASALTELSDLEVLDLSYNshyfRIAgvthHLEFIQNFTNLKVLNLSHNNIYTLtdkyNLESKSLVELVF 633
Cdd:COG4886  234 DLSNNQLT--DLPELGNLTNLEELDLSNN----QLT----DLPPLANLTNLKTLDLSNNQLTDL----KLKELELLLGLN 299

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  634 SGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDL 713
Cdd:COG4886  300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379

                        490       500
                 ....*....|....*....|....*..
gi 20302166  714 RGNKLLFLTDSLSDFTSSLRTLLLSHN 740
Cdd:COG4886  380 LTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 504-719 2.87e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.59  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  504 LDLSLNSIFFIGPNQFENLPDIACL-NLSANSNAQVLSGTEFSA------IPHVKYLDLTNNRLD----FDNASALTELS 572
Cdd:cd00116   86 LDLSDNALGPDGCGVLESLLRSSSLqELKLNNNGLGDRGLRLLAkglkdlPPALEKLVLGRNRLEgascEALAKALRANR 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  573 DLEVLDLSYNShyFRIAGVTHHLEFIQNFTNLKVLNLSHNniyTLTDKynlESKSLVElvfsgnrldilwndddnryisI 652
Cdd:cd00116  166 DLKELNLANNG--IGDAGIRALAEGLKANCNLEVLDLNNN---GLTDE---GASALAE---------------------T 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20302166  653 FKGLKNLTRLDLSLNRLKHIP----NEAFLNLPASLTELHINDNMLKFFNW----TLLQQFPRLELLDLRGNKLL 719
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDAGaaalASALLSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRGNKFG 291
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 238-694 9.68e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 9.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   238 LPSSLRKLFLSNTqikyiseeDFKGLI------NLTLLDLSGN-----CPRCFNAPFPCVPCDGGASINIDRF--AFQNL 304
Cdd:PLN00113  116 TSSSLRYLNLSNN--------NFTGSIprgsipNLETLDLSNNmlsgeIPNDIGSFSSLKVLDLGGNVLVGKIpnSLTNL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   305 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINisrNFSKL 384
Cdd:PLN00113  188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYNNLTGPIPSSLG---NLKNL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   385 LSLralhlrgYVFQELREDDFQP-LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYAN-- 461
Cdd:PLN00113  263 QYL-------FLYQNKLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRlq 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   462 -----SSSFQRHIRKrrstdfEFDPHSNFyhftrplikpqcaaygKALDLSLNS------------------IFFIGPNQ 518
Cdd:PLN00113  336 vlqlwSNKFSGEIPK------NLGKHNNL----------------TVLDLSTNNltgeipeglcssgnlfklILFSNSLE 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   519 FENLPDI-AC-----LNLSANSNAQVLSgTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFriagvt 592
Cdd:PLN00113  394 GEIPKSLgACrslrrVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFG------ 466

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   593 hhlEFIQNF--TNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDdnryisiFKGLKNLTRLDLSLNRLK 670
Cdd:PLN00113  467 ---GLPDSFgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE-------LSSCKKLVSLDLSHNQLS 536

                         490       500
                  ....*....|....*....|....*
gi 20302166   671 -HIPnEAFLNLPAsLTELHINDNML 694
Cdd:PLN00113  537 gQIP-ASFSEMPV-LSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
305-367 1.55e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.55e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20302166    305 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 367
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 130-339 1.66e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  130 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 205
Cdd:cd21340   10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  206 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 272
Cdd:cd21340   80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  273 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 339
Cdd:cd21340  129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
730-792 1.97e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.97e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20302166    730 SSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALEtkTTTKLSMLELHGNPF 792
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
706-766 2.59e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.59e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20302166    706 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLL 766
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
530-766 2.84e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   530 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHyfriaGVTHHLEFIQNftNLKVLNL 609
Cdd:PRK15370  176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSN-----QLTSIPATLPD--TIQEMEL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   610 SHNNIYTLTDKynLESkSLVELVFSGNRLDILWND--DDNRYISIFKglknltrldlslNRLKHIPNeaflNLPASLTEL 687
Cdd:PRK15370  249 SINRITELPER--LPS-ALQSLDLFHNKISCLPENlpEELRYLSVYD------------NSIRTLPA----HLPSGITHL 309

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20302166   688 HINDNMLKFFNWTLLqqfPRLELLDLRGNKLLFLTDSLSdftSSLRTLLLSHNRISHLPSGFlseVSSLKHLDLSSNLL 766
Cdd:PRK15370  310 NVQSNSLTALPETLP---PGLKTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPETL---PPTITTLDVSRNAL 379
LRR_8 pfam13855
Leucine rich repeat;
83-155 3.06e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 3.06e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20302166     83 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiqsNGLNITDGAFLNLKNLRELLLEDNQL 155
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN--------------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 523-768 1.14e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  523 PDIACLNLSANSNAQVLSGTE-----FSAIPHVKYLDLTNNRLDFDNA---SALTELSDLEVLDLSYNSH-----YFRIA 589
Cdd:cd00116   51 PSLKELCLSLNETGRIPRGLQsllqgLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLgdrglRLLAK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  590 GVTHHLEfiqnftNLKVLNLSHNNIY--TLTDKYNLESK--SLVELVFSGNRLdilwNDDDNRYIS-IFKGLKNLTRLDL 664
Cdd:cd00116  131 GLKDLPP------ALEKLVLGRNRLEgaSCEALAKALRAnrDLKELNLANNGI----GDAGIRALAeGLKANCNLEVLDL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  665 SLNRLKHIPNEAF---LNLPASLTELHINDNmlkffnwtllqqfprleLLDLRGnkLLFLTDSLSDFTSSLRTLLLSHNR 741
Cdd:cd00116  201 NNNGLTDEGASALaetLASLKSLEVLNLGDN-----------------NLTDAG--AAALASALLSPNISLLTLSLSCND 261

                        250       260       270
                 ....*....|....*....|....*....|.
gi 20302166  742 ISHLPSGFLSEV----SSLKHLDLSSNLLKT 768
Cdd:cd00116  262 ITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 760-847 1.32e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.78  E-value: 1.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    760 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 839
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....*...
gi 20302166    840 CVSDVTAV 847
Cdd:TIGR00864   78 SGCDEEYV 85
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 529-742 1.63e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 51.71  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  529 NLSANSNAQVLSGTefsaiPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNL 604
Cdd:COG5238  222 DEGAEILAEALKGN-----KSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGN--QIGAEGAIALAKALQGNTTL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  605 KVLNLSHNNIytlTDK------YNLE-SKSLVELVFSGNRLDilwnddDNRYISIFKGLK---NLTRLDLSLNRLKHIPN 674
Cdd:COG5238  295 TSLDLSVNRI---GDEgaialaEGLQgNKTLHTLNLAYNGIG------AQGAIALAKALQentTLHSLDLSDNQIGDEGA 365

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20302166  675 EAFLNLPASLTELHindnmlkffnwtllqqfprleLLDLRGNKL-----LFLTDSLSdfTSSLRTLLLSHNRI 742
Cdd:COG5238  366 IALAKYLEGNTTLR---------------------ELNLGKNNIgkqgaEALIDALQ--TNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
295-341 2.09e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 20302166    295 NIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL 341
Cdd:pfam13855   15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
657-769 3.14e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   657 KNLTRLDLSLNRLKHIPNeaflNLPASLTELHINDNMLKFFNWTLLQQfprLELLDLRGNKLLFLTDSLSdftSSLRTLL 736
Cdd:PRK15370  199 EQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSIPATLPDT---IQEMELSINRITELPERLP---SALQSLD 268

                          90       100       110
                  ....*....|....*....|....*....|...
gi 20302166   737 LSHNRISHLPSGFLSEvssLKHLDLSSNLLKTI 769
Cdd:PRK15370  269 LFHNKISCLPENLPEE---LRYLSVYDNSIRTL 298
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 547-764 3.34e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  547 IPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTD--- 619
Cdd:cd00116   22 LLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvl 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  620 KYNLESKSLVELVFSGNRLDilwnDDDNRYISifKGLK----NLTRLDLSLNRLKHIPNEAFLN-LPA--SLTELHINDN 692
Cdd:cd00116  102 ESLLRSSSLQELKLNNNGLG----DRGLRLLA--KGLKdlppALEKLVLGRNRLEGASCEALAKaLRAnrDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  693 MLKFFNWTLLQQ----FPRLELLDLRGNKL-----LFLTDSLSDfTSSLRTLLLSHNRI-----SHLPSGFLSEVSSLKH 758
Cdd:cd00116  176 GIGDAGIRALAEglkaNCNLEVLDLNNNGLtdegaSALAETLAS-LKSLEVLNLGDNNLtdagaAALASALLSPNISLLT 254


                 ....*.
gi 20302166  759 LDLSSN 764
Cdd:cd00116  255 LSLSCN 260
LRR_8 pfam13855
Leucine rich repeat;
602-694 5.63e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 5.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    602 TNLKVLNLSHNNIYTLTDkynleskslvelvfsgnrldilwndddnryiSIFKGLKNLTRLDLSLNRLKHIPNEAFLNLP 681
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDD-------------------------------GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49

                           90
                   ....*....|...
gi 20302166    682 aSLTELHINDNML 694
Cdd:pfam13855   50 -SLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
790-835 5.88e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.34  E-value: 5.88e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 20302166     790 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 835
Cdd:smart00082    1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
LRR_8 pfam13855
Leucine rich repeat;
548-614 3.33e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 3.33e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20302166    548 PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNShyfriagvthhLEFI-----QNFTNLKVLNLSHNNI 614
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-----------LTTLspgafSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-199 3.75e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   84 TELDLSDNFITHITNesFQGLQNLTKINLNHNPnvqhqngnpgIQS-NGLNitdgaflNLKNLRELLLEDNQL------- 155
Cdd:cd21340   49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNR----------ISVvEGLE-------NLTNLEELHIENQRLppgeklt 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 20302166  156 --PQIPSGLPESLTELSLIQNNIYNItkEGISRLINLKNLYLAWNC 199
Cdd:cd21340  110 fdPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
LRR_8 pfam13855
Leucine rich repeat;
240-317 8.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 8.37e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20302166    240 SSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCfnapfpcvpcdggasinIDRFAFQNLTQLRYLNLSSTSL 317
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
141-284 2.81e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   141 NLK-NLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLknlylawNCYFNKV-CEKTNIEDGVfETL 218
Cdd:PRK15370  217 NLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL-------DLFHNKIsCLPENLPEEL-RYL 288

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20302166   219 TnlellsLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEedfKGLINLTLLDLSGNCPRCFNAPFP 284
Cdd:PRK15370  289 S------VYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLP 345
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 579-791 2.93e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  579 LSYNSHYFRIAGVTHHLEFIQNftnLKVLNLSHNNIYTLTDKY---NLESK-SLVELVFSGNRLDilwNDDDN--RYISI 652
Cdd:cd00116    3 LSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGEEAAKAlasALRPQpSLKELCLSLNETG---RIPRGlqSLLQG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  653 FKGLKNLTRLDLSLNRLKHIPNEAFLNL--PASLTELHINDNML-----KFFNWTLLQQFPRLELLDLRGNKL-LFLTDS 724
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPDGCGVLESLlrSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLeGASCEA 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20302166  725 LSD---FTSSLRTLLLSHNRISHlpSGF------LSEVSSLKHLDLSSNLLKTINKSALET--KTTTKLSMLELHGNP 791
Cdd:cd00116  157 LAKalrANRDLKELNLANNGIGD--AGIralaegLKANCNLEVLDLNNNGLTDEGASALAEtlASLKSLEVLNLGDNN 232
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 537-775 3.33e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  537 QVLSGTEFSAIPHVKYLDLTNNRLDFDN----ASALTELSDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNLKVLNLSHN 612
Cdd:COG5238  169 AAISMAKALQNNSVETVYLGCNQIGDEGieelAEALTQNTTVTTLWLKRN--PIGDEGAEILAEALKGNKSLTTLDLSNN 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  613 NIytlTD-------KYNLESKSLVELVFSGNRLdilwndDDNRYISIFKGL---KNLTRLDLSLNRlkhIPNEAFLNL-- 680
Cdd:COG5238  247 QI---GDegvialaEALKNNTTVETLYLSGNQI------GAEGAIALAKALqgnTTLTSLDLSVNR---IGDEGAIALae 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166  681 ----PASLTELHINDNMLKFFNWTLL----QQFPRLELLDLRGNKL-----LFLTDSLSDFTsSLRTLLLSHNRIShlPS 747
Cdd:COG5238  315 glqgNKTLHTLNLAYNGIGAQGAIALakalQENTTLHSLDLSDNQIgdegaIALAKYLEGNT-TLRELNLGKNNIG--KQ 391

                        250       260       270
                 ....*....|....*....|....*....|...
gi 20302166  748 GFLSEVSSLKH-----LDLSSNLLKTINKSALE 775
Cdd:COG5238  392 GAEALIDALQTnrlhtLILDGNLIGAEAQQRLE 424
LRR_8 pfam13855
Leucine rich repeat;
329-394 3.77e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 3.77e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20302166    329 PHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYIKGSYPQHinisrnFSKLLSLRALHLRG 394
Cdd:pfam13855    1 PNLRSLDLSNNRLTS-LDDGAFKG-LSNLKVLDLSNNLLTTLSPGA------FSGLPSLRYLDLSG 58
PLN03150 PLN03150
hypothetical protein; Provisional
 304-372 3.97e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 3.97e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20302166   304 LTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAsgAFLTMLPRLEILDLSFNYIKGSYP 372
Cdd:PLN03150  441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP--ESLGQLTSLRILNLNGNSLSGRVP 507
LRR_8 pfam13855
Leucine rich repeat;
504-560 4.96e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.96e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 20302166    504 LDLSLNSIFFIGPNQFENLPDIACLNLSaNSNAQVLSGTEFSAIPHVKYLDLTNNRL 560
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLS-NNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
528-582 5.48e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 5.48e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 20302166    528 LNLSANsNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 582
Cdd:pfam13855    6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 284-394 6.03e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 6.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   284 PCVPCD---GGASINIDRFAFQNLtqLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIaSGAFLTMlPRLEIL 360
Cdd:PLN03150  396 PCVPQQhpwSGADCQFDSTKGKWF--IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNI-PPSLGSI-TSLEVL 471

                          90       100       110
                  ....*....|....*....|....*....|....
gi 20302166   361 DLSFNYIKGSYPQHInisrnfSKLLSLRALHLRG 394
Cdd:PLN03150  472 DLSYNSFNGSIPESL------GQLTSLRILNLNG 499
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 604-674 1.89e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20302166  604 LKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLDilwndDDNRYISIFKGLKNLTRLDLSLNRLKHIPN 674
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPL--RNLEQLDASNNQIS-----DLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-193 2.30e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 41.99  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166    41 ELCAEENFSRSYPcdEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN------H 114
Cdd:PRK15370  224 TLYANSNQLTSIP--ATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSirtlpaH 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   115 NPN-VQHQNgnpgIQSNGLNITDGAFLnlKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIY--------NITKEGIS 185
Cdd:PRK15370  302 LPSgITHLN----VQSNSLTALPETLP--PGLKTLEAGENALTSLPASLPPELQVLDVSKNQITvlpetlppTITTLDVS 375

                         170
                  ....*....|.
gi 20302166   186 R--LINL-KNL 193
Cdd:PRK15370  376 RnaLTNLpENL 386
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
143-380 3.29e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 41.61  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   143 KNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNItKEGISRliNLKNLYLAWNcyfnkvcEKTNIEDGVFETLtnlE 222
Cdd:PRK15370  178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSN-------QLTSIPATLPDTI---Q 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   223 LLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDlsgNCPRCFNAPFPcvpcdggasinidrfafq 302
Cdd:PRK15370  245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPAHLP------------------ 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20302166   303 nlTQLRYLNLSSTSLRKINAAWfknMPHLKVLDLEFNYLVGEIASgafltMLPRLEILDLSFNYIK---GSYP---QHIN 376
Cdd:PRK15370  304 --SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPAS-----LPPELQVLDVSKNQITvlpETLPptiTTLD 373


                  ....
gi 20302166   377 ISRN 380
Cdd:PRK15370  374 VSRN 377
PLN03150 PLN03150
hypothetical protein; Provisional
 541-612 4.79e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 4.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20302166   541 GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAgvthhlEFIQNFTNLKVLNLSHN 612
Cdd:PLN03150  435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP------ESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
412-449 9.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 9.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 20302166    412 PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRIS 449
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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