NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|8392885|ref|NP_058831|]
View 

adenylate kinase 4, mitochondrial isoform 1 [Rattus norvegicus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492251)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 7-211 4.21e-94

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


:

Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 274.11  E-value: 4.21e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885      7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-- 84
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEng 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     85 WLLDGFPRTLVQAEALDRICD--VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDD 162
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 8392885    163 KPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGT-ETNRIWPYVYTLFS 211
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
 
Name Accession Description Interval E-value
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 7-211 4.21e-94

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 274.11  E-value: 4.21e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885      7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-- 84
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEng 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     85 WLLDGFPRTLVQAEALDRICD--VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDD 162
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 8392885    163 KPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGT-ETNRIWPYVYTLFS 211
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK pfam00406
Adenylate kinase;
10-188 2.09e-93

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 271.10  E-value: 2.09e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELE-TRSAQHWLLD 88
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     89 GFPRTLVQAEALDR----ICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDDKP 164
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 8392885    165 EALAARLRRYKDAAKPVIELYKSR 188
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 7-197 4.01e-81

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 241.18  E-value: 4.01e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMmselETRSAQH-- 84
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLV----KERLAQPdc 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885   85 ---WLLDGFPRTLVQAEALDRICD-----VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPL 156
Cdd:COG0563  78 angFILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGEL 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 8392885  157 VQQEDDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGT 197
Cdd:COG0563 158 VQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 7-199 2.95e-79

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 235.59  E-value: 2.95e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-W 85
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKgF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885   86 LLDGFPRTLVQAEALDRICD----VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNldfnppqvLGVDDITGEPLVQQED 161
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYH--------LGKDDVTGEPLSQRSD 152

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 8392885  162 DKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTET 199
Cdd:cd01428 153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
adk PRK00279
adenylate kinase; Reviewed
 6-197 3.99e-76

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 228.50  E-value: 3.99e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     6 LRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH- 84
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    85 WLLDGFPRTLVQAEALDRIC-----DVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQ 159
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 8392885   160 EDDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGT 197
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
 
Name Accession Description Interval E-value
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 7-211 4.21e-94

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 274.11  E-value: 4.21e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885      7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-- 84
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEng 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     85 WLLDGFPRTLVQAEALDRICD--VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDD 162
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 8392885    163 KPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGT-ETNRIWPYVYTLFS 211
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
ADK pfam00406
Adenylate kinase;
10-188 2.09e-93

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 271.10  E-value: 2.09e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELE-TRSAQHWLLD 88
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     89 GFPRTLVQAEALDR----ICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDDKP 164
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 8392885    165 EALAARLRRYKDAAKPVIELYKSR 188
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 7-197 4.01e-81

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 241.18  E-value: 4.01e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMmselETRSAQH-- 84
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLV----KERLAQPdc 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885   85 ---WLLDGFPRTLVQAEALDRICD-----VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPL 156
Cdd:COG0563  78 angFILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGEL 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 8392885  157 VQQEDDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGT 197
Cdd:COG0563 158 VQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 7-199 2.95e-79

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 235.59  E-value: 2.95e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-W 85
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKgF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885   86 LLDGFPRTLVQAEALDRICD----VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNldfnppqvLGVDDITGEPLVQQED 161
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYH--------LGKDDVTGEPLSQRSD 152

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 8392885  162 DKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTET 199
Cdd:cd01428 153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
adk PRK00279
adenylate kinase; Reviewed
 6-197 3.99e-76

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 228.50  E-value: 3.99e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     6 LRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH- 84
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    85 WLLDGFPRTLVQAEALDRIC-----DVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQ 159
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 8392885   160 EDDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGT 197
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
PLN02674 PLN02674
adenylate kinase
 7-193 8.76e-56

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 177.77  E-value: 8.76e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-W 85
Cdd:PLN02674  33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKgF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    86 LLDGFPRTLVQAEALDRICD-----VDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQE 160
Cdd:PLN02674 113 ILDGFPRTVVQAQKLDEMLAkqgakIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRK 192

                        170       180       190
                 ....*....|....*....|....*....|...
gi 8392885   161 DDKPEALAARLRRYKDAAKPVIELYKSRGVLHQ 193
Cdd:PLN02674 193 DDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVAN 225
PRK14530 PRK14530
adenylate kinase; Provisional
 1-203 5.33e-50

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 161.88  E-value: 5.33e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     1 MASKllRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLREN-----LKTNTEVgDVAKQYLEKGLLVPDHVITRLMMS 75
Cdd:PRK14530   1 MSQP--RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANkqmdiSDMDTEY-DTPGEYMDAGELVPDAVVNEIVEE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    76 ELEtrSAQHWLLDGFPRTLVQAEALDRICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEP 155
Cdd:PRK14530  78 ALS--DADGFVLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 8392885   156 LVQQEDDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTET-NRIW 203
Cdd:PRK14530 156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTpDEVW 204
PLN02842 PLN02842
nucleotide kinase
 9-187 1.30e-40

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 144.62  E-value: 1.30e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     9 VILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH--WL 86
Cdd:PLN02842   1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEkgWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    87 LDGFPRTLVQAEALDRI-CDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQvlgvDDITGEPLVQQEDDKPE 165
Cdd:PLN02842  81 LDGYPRSFAQAQSLEKLkIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----SEEIKARLITRPDDTEE 156

                        170       180
                 ....*....|....*....|..
gi 8392885   166 ALAARLRRYKDAAKPVIELYKS 187
Cdd:PLN02842 157 KVKARLQIYKKNAEAILSTYSD 178
PRK14526 PRK14526
adenylate kinase; Provisional
 6-185 5.17e-40

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 136.52  E-value: 5.17e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     6 LRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELET-RSAQH 84
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTiKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    85 WLLDGFPRTLVQAEALDRICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQEDDKP 164
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKE 160

                        170       180
                 ....*....|....*....|.
gi 8392885   165 EALAARLRRYKDAAKPVIELY 185
Cdd:PRK14526 161 ESLKTRLQEYKLQTKPLIEFY 181
PLN02459 PLN02459
probable adenylate kinase
 9-194 1.58e-36

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 128.81  E-value: 1.58e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     9 VILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQ---HW 85
Cdd:PLN02459  33 VFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgesGF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    86 LLDGFPRTLVQAEALDRICDVDLVISLNIPFETLKDR-LSRRwIHPSSGRVYNL-DFNPPQVLGVDDITGEPL------- 156
Cdd:PLN02459 113 ILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKcLGRR-ICSECGKNFNVaDIDLKGEDGRPGIVMPPLlpppeca 191

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 8392885   157 ---VQQEDDKPEALAARLRRYKDAAKPVIELYKSRGVLHQF 194
Cdd:PLN02459 192 sklITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEF 232
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 10-193 3.03e-34

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 120.69  E-value: 3.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRL----MMSELETrsAQHW 85
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLlkdaMVAALGT--SKGF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     86 LLDGFPRTLVQAEALD-RICDVDLVISLNIPFETLKDRLSRRwiHPSSGRVynldfnppqvlgvdditgeplvqqeDDKP 164
Cdd:TIGR01360  86 LIDGYPREVKQGEEFErRIGPPTLVLYFDCSEDTMVKRLLKR--AETSGRV-------------------------DDNE 138

                         170       180
                  ....*....|....*....|....*....
gi 8392885    165 EALAARLRRYKDAAKPVIELYKSRGVLHQ 193
Cdd:TIGR01360 139 KTIKKRLETYYKATEPVIAYYETKGKLRK 167
PRK14527 PRK14527
adenylate kinase; Provisional
 7-199 1.04e-33

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 119.51  E-value: 1.04e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     7 RAVI-LGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHW 85
Cdd:PRK14527   7 KVVIfLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    86 LLDGFPRTLVQAEALDRICD-----VDLVISLNIPFETLKDRLSRRwihpssGRvynldfnppqvlgvdditgepLVQQE 160
Cdd:PRK14527  87 IFDGFPRTLAQAEALDRLLEelgarLLAVVLLEVPDEELIRRIVER------AR---------------------QEGRS 139

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 8392885   161 DDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTET 199
Cdd:PRK14527 140 DDNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGT 178
adk PRK02496
adenylate kinase; Provisional
 7-199 2.63e-33

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 118.31  E-value: 2.63e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-W 85
Cdd:PRK02496   3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANgW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    86 LLDGFPRTLVQAEALDRICD-----VDLVISLNIPFETLKDRLSRRwihpssGRvynldfnppqvlgvdditgeplvqqE 160
Cdd:PRK02496  83 ILDGFPRKVTQAAFLDELLQeigqsGERVVNLDVPDDVVVERLLAR------GR-------------------------K 131

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 8392885   161 DDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTET 199
Cdd:PRK02496 132 DDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQS 170
PRK13808 PRK13808
adenylate kinase; Provisional
 6-188 3.57e-32

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 119.22  E-value: 3.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     6 LRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELE-TRSAQH 84
Cdd:PRK13808   1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEqPDAANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    85 WLLDGFPRTLVQAEALDRIC-----DVDLVISLNIPFETLKDRLSRRwIHPSSGRvynldfnppqvlgvdditGEPLvqQ 159
Cdd:PRK13808  81 FILDGFPRTVPQAEALDALLkdkqlKLDAVVELRVNEGALLARVETR-VAEMRAR------------------GEEV--R 139

                        170       180
                 ....*....|....*....|....*....
gi 8392885   160 EDDKPEALAARLRRYKDAAKPVIELYKSR 188
Cdd:PRK13808 140 ADDTPEVLAKRLASYRAQTEPLVHYYSEK 168
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 10-211 4.79e-32

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 115.16  E-value: 4.79e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTN-TEVGDVAKQYLEKGLLVPDHVITRLMMSEL-ETRSAQHWLL 87
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAIqEDGSSKKFLI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     88 DGFPRTLVQAEALDRICD----VDLVISLNIPFETLKDRLSRRwiHPSSGRVynldfnppqvlgvdditgeplvqqeDDK 163
Cdd:TIGR01359  84 DGFPRNEENLEAWEKLMDnkvnFKFVLFFDCPEETMIKRLLKR--GQTSGRV-------------------------DDN 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 8392885    164 PEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTET-NRIWPYVYTLFS 211
Cdd:TIGR01359 137 IETLKKRFRTYNEETLPIIEHFENKGKVKEINAEGSvEEVFEDVEKIFA 185
PRK14531 PRK14531
adenylate kinase; Provisional
 1-191 9.27e-32

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 114.14  E-value: 9.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     1 MASKLLravILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETR 80
Cdd:PRK14531   1 MKQRLL---FLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    81 SAQHWLLDGFPRTLVQAEALDricdvDLVISLNIPFETlkdrlsrrwihpssgrVYNLDFNppqvlgvDDITGEPLVQ-- 158
Cdd:PRK14531  78 NSGGWLLDGFPRTVAQAEALE-----PLLEELKQPIEA----------------VVLLELD-------DAVLIERLLArg 129

                        170       180       190
                 ....*....|....*....|....*....|...
gi 8392885   159 QEDDKPEALAARLRRYKDAAKPVIELYKSRGVL 191
Cdd:PRK14531 130 RADDNEAVIRNRLEVYREKTAPLIDHYRQRGLL 162
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 6-190 3.20e-31

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 114.13  E-value: 3.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     6 LRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH- 84
Cdd:PTZ00088   7 LKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTDDCf 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    85 --WLLDGFPRTLVQAEALDRICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNL------DFNPPQVL---GVDDITG 153
Cdd:PTZ00088  87 kgFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIahirsdPYDMPPILppaDCEGCKG 166

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 8392885   154 EP-LVQQEDDKPEALAARLRRYKDAAKPVIELYKSRGV 190
Cdd:PTZ00088 167 NPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14528 PRK14528
adenylate kinase; Provisional
 7-199 5.13e-31

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 112.41  E-value: 5.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     7 RAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSEL-ETRSAQHW 85
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIrEADCKNGF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    86 LLDGFPRTLVQAEALDRIC-----DVDLVISLNIPFETLKDRLsrrwihpssgrvynldfnppqvLGVDDITGeplvqQE 160
Cdd:PRK14528  83 LLDGFPRTVEQADALDALLknegkSIDKAINLEVPDGELLKRL----------------------LGRAEIEG-----RA 135

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 8392885   161 DDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTET 199
Cdd:PRK14528 136 DDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGS 174
PRK14529 PRK14529
adenylate kinase; Provisional
 9-151 2.48e-29

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 109.04  E-value: 2.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     9 VILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHWLLD 88
Cdd:PRK14529   4 LIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKNGWLLD 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8392885    89 GFPRTLVQAEALDRI-----CDVDLVISLNIPFETLKDRLSRRwihpssgRVYNLDFNPPQVLGVDDI 151
Cdd:PRK14529  84 GFPRNKVQAEKLWEAlqkegMKLDYVIEILLPREVAKNRIMGR-------RLCKNDNNHPNNIFIDAI 144
PLN02200 PLN02200
adenylate kinase family protein
 10-211 8.88e-29

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 108.06  E-value: 8.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHWLLDG 89
Cdd:PLN02200  48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNKFLIDG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    90 FPRTLVQAEALDRI--CDVDLVISLNIPFETLKDRLSRRwihpSSGRVynldfnppqvlgvdditgeplvqqeDDKPEAL 167
Cdd:PLN02200 128 FPRTEENRIAFERIigAEPNVVLFFDCPEEEMVKRVLNR----NQGRV-------------------------DDNIDTI 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 8392885   168 AARLRRYKDAAKPVIELYKSRGVLHQFSGTET-NRIWPYVYTLFS 211
Cdd:PLN02200 179 KKRLKVFNALNLPVIDYYSKKGKLYTINAVGTvDEIFEQVRPIFA 223
PRK14532 PRK14532
adenylate kinase; Provisional
 9-196 1.08e-28

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 106.44  E-value: 1.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     9 VILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLLVPDHVITRLMMSEL-ETRSAQHWLL 87
Cdd:PRK14532   4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLpEAEAAGGAIF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    88 DGFPRTLVQAEALDRICD-----VDLVISLNIPFETLKDRLSRRWihPSSGRvynldfnppqvlgvdditgeplvqqEDD 162
Cdd:PRK14532  84 DGFPRTVAQAEALDKMLAsrgqkIDVVIRLKVDDEALIERIVKRF--EEQGR-------------------------PDD 136

                        170       180       190
                 ....*....|....*....|....*....|....
gi 8392885   163 KPEALAARLRRYKDAAKPVIELYKSRGVLHQFSG 196
Cdd:PRK14532 137 NPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDG 170
AAA_17 pfam13207
AAA domain;
11-136 2.21e-26

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 98.85  E-value: 2.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885     11 LGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENLKTNTevGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQH-WLLDG 89
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGgVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 8392885     90 FPRTLVQAEALD-------RICDVDLVISLNIPFETLKDRLSRRwihPSSGRVY 136
Cdd:pfam13207  79 HPRIKTPAGYLPglpvevlRELKPDAIILLEADPEEILERRLKD---RTRGRDD 129
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 126-161 6.15e-15

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 65.95  E-value: 6.15e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 8392885    126 RWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQED 161
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 9-42 1.28e-07

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 49.73  E-value: 1.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 8392885      9 VILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRE 42
Cdd:TIGR02173   4 TISGPPGSGKTTVAKILAEKLSLKLISAGDIFRE 37
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 10-54 3.35e-07

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 48.25  E-value: 3.35e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 8392885   10 ILGPPGSGKGTVCERIAQNFGLQHLSSGhLLRENlktntEVGDVA 54
Cdd:cd02020   4 IDGPAGSGKSTVAKLLAKKLGLPYLDTG-GIRTE-----EVGKLA 42
PRK04182 PRK04182
cytidylate kinase; Provisional
 6-42 1.48e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 46.72  E-value: 1.48e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 8392885     6 LRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRE 42
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
AAA_18 pfam13238
AAA domain;
9-126 1.99e-06

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 45.50  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885      9 VILGPPGSGKGTVCERIAqnfglQHLSSGHLLRENLKTNTEVGDVAKQYLEKGLL---VPDHVITRLMMSELETrSAQHW 85
Cdd:pfam13238   2 LITGTPGVGKTTLAKELS-----KRLGFGDNVRDLALENGLVLGDDPETRESKRLdedKLDRLLDLLEENAALE-EGGNL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 8392885     86 LLDGFPRTLVQAEALDRicdvdLVISLNIPFETLKDRLSRR 126
Cdd:pfam13238  76 IIDGHLAELEPERAKDL-----VGIVLRASPEELLERLEKR 111
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 10-41 1.22e-05

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 44.60  E-value: 1.22e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 8392885     10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLR 41
Cdd:pfam02224   3 IDGPSGSGKSTVARILARKLGYKYLDTGAMYR 34
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 10-41 1.87e-04

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 41.26  E-value: 1.87e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 8392885     10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLR 41
Cdd:TIGR00017   7 IDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYR 38
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
10-41 3.17e-04

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 41.19  E-value: 3.17e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 8392885    10 ILGPPGSGKGTVCERIAQNFGLQHLSSGHLLR 41
Cdd:PRK11860 447 IDGPTASGKGTVAARVAEALGYHYLDSGALYR 478
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
12-37 4.20e-04

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 40.01  E-value: 4.20e-04
                        10        20
                ....*....|....*....|....*.
gi 8392885   12 GPPGSGKGTVCERIAQNFGLQHLSSG 37
Cdd:COG0283   7 GPAGSGKSTVAKALAKRLGYHYLDTG 32
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
12-126 5.54e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 39.13  E-value: 5.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885   12 GPPGSGKGTVCERIAQNFGLQHLSS---------------GHLLRENLKTNTEVGDVAKQYLEKGLlvpdHVItrlmmse 76
Cdd:COG0645   6 GLPGSGKSTLARALAERLGAVRLRSdvvrkrlfgaglaplERSPEATARTYARLLALARELLAAGR----SVI------- 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 8392885   77 letrsaqhwlLD-GFPRTL--VQAEALDRICDVDLV-ISLNIPFETLKDRLSRR 126
Cdd:COG0645  75 ----------LDaTFLRRAqrEAFRALAEEAGAPFVlIWLDAPEEVLRERLEAR 118
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 9-129 1.54e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 37.62  E-value: 1.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885    9 VILGPPGSGKGTVCERIAQNFGLQHL--------------SSGHLLREnlktntevGDVAKqYLEKgllvpdhvitrlmm 74
Cdd:cd02021   3 VVMGVSGSGKSTVGKALAERLGAPFIdgddlhppaniakmAAGIPLND--------EDRWP-WLQA-------------- 59

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8392885   75 selETRSAQHWLLDGFPRTLVQAEALDRI---------CDVDLVIS-LNIPFETLKDRLSRRWIH 129
Cdd:cd02021  60 ---LTDALLAKLASAGEGVVVACSALKRIyrdilrggaANPRVRFVhLDGPREVLAERLAARKGH 121
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 9-126 3.08e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 36.90  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885      9 VIL--GPPGSGKGTVCERIAQNFGLQHLSSGHLLR----------ENLKTNTE-VGDVAKQYLEKGLLVPDHVI---TRL 72
Cdd:pfam13671   1 LILlvGLPGSGKSTLARRLLEELGAVRLSSDDERKrlfgegrpsiSYYTDATDrTYERLHELARIALRAGRPVIldaTNL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 8392885     73 MmseletRSAQHWLLDGFPRTLVQAEALDriCDVDLvislnipfETLKDRLSRR 126
Cdd:pfam13671  81 R------RDERARLLALAREYGVPVRIVV--FEAPE--------EVLRERLAAR 118
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 6-41 4.08e-03

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 37.85  E-value: 4.08e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 8392885     6 LRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLR 41
Cdd:PRK09518   2 IIVAIDGPAGVGKSSVSRALAQYLGYAYLDTGAMYR 37
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
12-126 8.46e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 35.96  E-value: 8.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392885   12 GPPGSGKGTVCERIAQNFGLQHLsSGHLLRE-------NLKTNTEVGDVAKQYLEKGLLVPD-------HVITRLMMSE- 76
Cdd:COG1102   7 REPGSGGTTIAKRLAEKLGLPLY-DGEILREaakerglSEEEFEKLDEKAPSLLYRDTAEEDeidraldKVIRELARKGn 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 8392885   77 --LETRSAqHWLLDGFPRTL---VQA---EALDRICDVDlvislNIPFETLKDRLSRR 126
Cdd:COG1102  86 cvIVGRLA-DWILRDRPNVLkvfLTApleVRVKRIAERE-----GISEEEAEKEIKKR 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH