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Conserved domains on  [gi|8393446|ref|NP_059001|]
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glutamate--cysteine ligase regulatory subunit [Rattus norvegicus]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 86-211 2.23e-12

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19071:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 251  Bit Score: 65.20  E-value: 2.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFIvGSNSSSSTRNAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLQPyWEELENLVQSKKIVAIGTS 165
Cdd:cd19071  54 REELFITTKLWP-TDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLET-WRALEELVDEGLVRSIGVS 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 8393446  166 DLDKTQLEQLYQWAQVKPNSNQVNLASCCVmPPDLTAFAKQFDIQL 211
Cdd:cd19071 132 NFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVV 176
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 86-211 2.23e-12

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 65.20  E-value: 2.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFIvGSNSSSSTRNAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLQPyWEELENLVQSKKIVAIGTS 165
Cdd:cd19071  54 REELFITTKLWP-TDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLET-WRALEELVDEGLVRSIGVS 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 8393446  166 DLDKTQLEQLYQWAQVKPNSNQVNLASCCVmPPDLTAFAKQFDIQL 211
Cdd:cd19071 132 NFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVV 176
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 83-211 2.60e-05

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 44.61  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446     83 PDEREEMKVSAKL-FIVGSNSSSSTRNAVDMACSV----LGVAQLDSVIMASP----PIEDGvnlslehlqpyWEELENL 153
Cdd:pfam00248  58 PVKRDKVVIATKVpDGDGPWPSGGSKENIRKSLEEslkrLGTDYIDLYYLHWPdpdtPIEET-----------WDALEEL 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 8393446    154 VQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPP-DLTAFAKQFDIQL 211
Cdd:pfam00248 127 KKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPL 185
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 147-211 9.76e-05

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 42.73  E-value: 9.76e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8393446  147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV--NLASccvMPPDLTAFAKQFDIQL 211
Cdd:COG0656 110 WRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVelHPYL---QQRELLAFCREHGIVV 173
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 86-211 2.23e-12

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 65.20  E-value: 2.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFIvGSNSSSSTRNAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLQPyWEELENLVQSKKIVAIGTS 165
Cdd:cd19071  54 REELFITTKLWP-TDHGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGGSKEARLET-WRALEELVDEGLVRSIGVS 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 8393446  166 DLDKTQLEQLYQWAQVKPNSNQVNLASCCVmPPDLTAFAKQFDIQL 211
Cdd:cd19071 132 NFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVV 176
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 86-221 2.71e-10

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 59.55  E-value: 2.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFivgsNSSSSTRNAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLqpyWEELENLVQSKKIVAIGTS 165
Cdd:cd19120  65 REDLFITTKVS----PGIKDPREALRKSLAKLGVDYVDLYLIHSPFFAKEGGPTLAEA---WAELEALKDAGLVRSIGVS 137

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8393446  166 DLDKTQLEQLYQWAQVKPNSNQVNLASCCVMP-PDLTAFAKQFDIQL--------LTHNDPKELL 221
Cdd:cd19120 138 NFRIEDLEELLDTAKIKPAVNQIEFHPYLYPQqPALLEYCREHGIVVsaysplspLTRDAGGPLD 202
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 86-210 3.38e-08

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 53.10  E-value: 3.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFiVGSNSSSSTRNAVDMACSVLGVAQLDSVIMASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTS 165
Cdd:cd19135  66 REDLFLTTKLW-PSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKNVKETRAETWRALEELYDEGLCRAIGVS 144

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 8393446  166 DLDKTQLEQLYQWAQVKPNSNQVNLaSCCVMPPDLTAFAKQFDIQ 210
Cdd:cd19135 145 NFLIEHLEQLLEDCSVVPHVNQVEF-HPFQNPVELIEYCRDNNIV 188
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 102-211 9.24e-06

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 45.70  E-value: 9.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446  102 SSSSTRNAVDMACSVLGVAQLDSVIMASP-----PIEDGVNLSLEHLQpyWEELENLVQSKKIVAIGTSDLDKTQLEQLY 176
Cdd:cd19136  74 GYEKARAACLGSLERLGTDYLDLYLIHWPgvqglKPSDPRNAELRRES--WRALEDLYKEGKLRAIGVSNYTVRHLEELL 151

                        90       100       110
                ....*....|....*....|....*....|....*
gi 8393446  177 QWAQVKPNSNQVNLASCCVMpPDLTAFAKQFDIQL 211
Cdd:cd19136 152 KYCEVPPAVNQVEFHPHLVQ-KELLKFCKDHGIHL 185
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 86-209 1.96e-05

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 44.97  E-value: 1.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFIVgSNSSSSTRNAVDMACSVLGVAQLDSVIMASPP--IEDGVNLSLEHLQP----Y---WEELENLVQS 156
Cdd:cd19116  69 REDLFITTKLWNS-YHEREQVEPALRESLKRLGLDYVDLYLIHWPVafKENNDSESNGDGSLsdidYletWRGMEDLVKL 147

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 8393446  157 KKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNlasccVMP----PDLTAFAKQFDI 209
Cdd:cd19116 148 GLTRSIGVSNFNSEQINRLLSNCNIKPAVNQIE-----VHPtltqEKLVAYCQSNGI 199
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 83-211 2.60e-05

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 44.61  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446     83 PDEREEMKVSAKL-FIVGSNSSSSTRNAVDMACSV----LGVAQLDSVIMASP----PIEDGvnlslehlqpyWEELENL 153
Cdd:pfam00248  58 PVKRDKVVIATKVpDGDGPWPSGGSKENIRKSLEEslkrLGTDYIDLYYLHWPdpdtPIEET-----------WDALEEL 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 8393446    154 VQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPP-DLTAFAKQFDIQL 211
Cdd:pfam00248 127 KKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPL 185
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 141-190 4.14e-05

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 44.15  E-value: 4.14e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 8393446  141 EHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNL 190
Cdd:cd19122 139 ENPEPTWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEI 188
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 86-190 6.58e-05

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 43.33  E-value: 6.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFIvgSNSS-SSTRNAVDMACSVLGVAQLDsvimasppiedgvnLSLEHlQPY------WEELENLVQSKK 158
Cdd:cd19133  63 REELFITTKLWI--QDAGyEKAKKAFERSLKRLGLDYLD--------------LYLIH-QPFgdvygaWRAMEELYKEGK 125

                        90       100       110
                ....*....|....*....|....*....|..
gi 8393446  159 IVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNL 190
Cdd:cd19133 126 IRAIGVSNFYPDRLVDLILHNEVKPAVNQIET 157
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 86-211 6.75e-05

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 43.19  E-value: 6.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFivgsNS---SSSTRNAVDMACSVLGVAQLDSVIMASPpiedgvnlSLEHLQPYWEELENLVQSKKIVAI 162
Cdd:cd19126  63 REELFVTTKLW----NDdqrARRTEDAFQESLDRLGLDYVDLYLIHWP--------GKDKFIDTWKALEKLYASGKVKAI 130

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 8393446  163 GTSDLDKTQLEQLYQWAQVKPNSNQVNLaSCCVMPPDLTAFAKQFDIQL 211
Cdd:cd19126 131 GVSNFQEHHLEELLAHADVVPAVNQVEF-HPYLTQKELRGYCKSKGIVV 178
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 147-211 9.76e-05

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 42.73  E-value: 9.76e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8393446  147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV--NLASccvMPPDLTAFAKQFDIQL 211
Cdd:COG0656 110 WRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVelHPYL---QQRELLAFCREHGIVV 173
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 85-190 2.25e-04

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 41.62  E-value: 2.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   85 EREEMKVSAKLFIVgSNSSSSTRNAVDMACSVLGVAQLDSVIMASPpiedgVNLSLEHLQPYWEELENLVQSKKIVAIGT 164
Cdd:cd19127  61 DRSDIFVTTKLWIS-DYGYDKALRGFDASLRRLGLDYVDLYLLHWP-----VPNDFDRTIQAYKALEKLLAEGRVRAIGV 134

                        90       100
                ....*....|....*....|....*.
gi 8393446  165 SDLDKTQLEQLYQWAQVKPNSNQVNL 190
Cdd:cd19127 135 SNFTPEHLERLIDATTVVPAVNQVEL 160
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 86-211 2.70e-04

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 41.61  E-value: 2.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFiVGSNSSSSTRNAVDMACSVLGVAQLDSVIMASPpiedGVNLSLEHlqpyWEELENLVQSKKIVAIGTS 165
Cdd:cd19157  64 REELFITSKVW-NADQGYDSTLKAFEASLERLGLDYLDLYLIHWP----VKGKYKET----WKALEKLYKDGRVRAIGVS 134

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 8393446  166 DLDKTQLEQLYQWAQVKPNSNQVNLAScCVMPPDLTAFAKQFDIQL 211
Cdd:cd19157 135 NFQVHHLEDLLADAEIVPMVNQVEFHP-RLTQKELRDYCKKQGIQL 179
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 86-190 3.11e-04

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 41.20  E-value: 3.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFivgsNSSS---STRNAVDMACSVLGVAQLDSVIMASP-PIEDgvnlsleHLQPYWEELENLVQSKKIVA 161
Cdd:cd19131  63 REELFITTKLW----NSDQgydSTLRAFDESLRKLGLDYVDLYLIHWPvPAQD-------KYVETWKALIELKKEGRVKS 131

                        90       100
                ....*....|....*....|....*....
gi 8393446  162 IGTSDLDKTQLEQLYQWAQVKPNSNQVNL 190
Cdd:cd19131 132 IGVSNFTIEHLQRLIDETGVVPVVNQIEL 160
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 147-188 3.31e-04

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 41.18  E-value: 3.31e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 8393446  147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 188
Cdd:cd19125 135 WKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVARVPPAVNQV 176
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 86-190 5.12e-04

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 40.59  E-value: 5.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFivgsnsSSSTRN---AVDMACSVLGVAQLDSVIM-------------ASPPIEDG---VNLSLEHLQPy 146
Cdd:cd19121  68 REDLFVTTKLW------STYHRRvelCLDRSLKSLGLDYVDLYLVhwpvllnpngnhdLFPTLPDGsrdLDWDWNHVDT- 140

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 8393446  147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNL 190
Cdd:cd19121 141 WKQMEKVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVEN 184
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 86-209 5.42e-04

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 40.58  E-value: 5.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFivgsNSSS---STRNAVDMACSVLGVaqldsvimasppieDGVNLSLEH------LQPYWEELENLVQS 156
Cdd:cd19156  63 REEVFVTTKLW----NSDQgyeSTLAAFEESLEKLGL--------------DYVDLYLIHwpvkgkFKDTWKAFEKLYKE 124

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 8393446  157 KKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMPPdLTAFAKQFDI 209
Cdd:cd19156 125 KKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHPLLTQEP-LRKFCKEKNI 176
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 147-209 6.86e-04

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 40.47  E-value: 6.86e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8393446  147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLAscCVMP-PDLTAFAKQFDI 209
Cdd:cd19154 141 WRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECH--LYFPqKELVEFCKKHNI 202
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 133-211 1.02e-03

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 39.70  E-value: 1.02e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8393446  133 EDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLaSCCVMPPDLTAFAKQFDIQL 211
Cdd:cd19123 126 EDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVEL-HPYLQQPELLAFCRDNGIHL 203
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 133-256 1.21e-03

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 39.43  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446  133 EDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASccVMPPD-LTAFAKQFDIQL 211
Cdd:cd19128 116 NQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQIECHP--YFQNDkLIKFCIENNIHV 193

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 8393446  212 LTHN-------DPKELLSEASFQEALQE----SIPDIEAQEWVPLWLLRYSVIVKS 256
Cdd:cd19128 194 TAYRplggsygDGNLTFLNDSELKALATkyntTPPQVIIAWHLQKWPKNYSVIPKS 249
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 86-211 1.28e-03

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 39.74  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446   86 REEMKVSAKLFivgsNSSSSTRN---AVDMACSVLGVAQLDSVIMASP------PIE----------DGVNLSLEH--LQ 144
Cdd:cd19113  68 REELFLTSKLW----NNFHDPKNvetALNKTLSDLKLDYVDLFLIHFPiafkfvPIEekyppgfycgDGDNFVYEDvpIL 143

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8393446  145 PYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQVNLASCCVMpPDLTAFAKQFDIQL 211
Cdd:cd19113 144 DTWKALEKLVDAGKIKSIGVSNFPGALILDLLRGATIKPAVLQIEHHPYLQQ-PKLIEYAQKAGITI 209
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 133-188 2.87e-03

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 38.59  E-value: 2.87e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 8393446  133 EDGVNLSlehlqPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 188
Cdd:cd19129 127 DDGVTLL-----DTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAARIKPAVVQV 177
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 106-214 5.26e-03

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 37.57  E-value: 5.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8393446  106 TRNAVDMACSVLGVAQLDSVimasppiedgvnlslehlQPYW------------EELENLVQSKKIVAIGTSDLDKTQLE 173
Cdd:cd19101  90 VEAAIDRSLKRLGVDRLDLV------------------QFHWwdysdpgyldaaKHLAELQEEGKIRHLGLTNFDTERLR 151

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 8393446  174 QLYQwAQVKPNSNQVNLaSCCVMPPD--LTAFAKQFDIQLLTH 214
Cdd:cd19101 152 EILD-AGVPIVSNQVQY-SLLDRRPEngMAALCEDHGIKLLAY 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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