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Conserved domains on  [gi|8394456|ref|NP_059138|]
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toll-like receptor 9 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-504 5.54e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   113 TIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNcyyknpcrqALEVAP 192
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN---------QLTDLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   193 GALLGLGNLTHLSLKYNNLTVVPRNLPS--SLEYLLLSYNRIVKLaPEDLANLTALRVLDVGGNcrrcdhapnpcmecpr 270
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN---------------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   271 hfpQLH--PDTFSHLSRLEGLVLKDSSLSWLNASwFRGLGNLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNyqkr 348
Cdd:COG4886  193 ---QITdlPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN---- 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   349 vsfaHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS 428
Cdd:COG4886  261 ----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8394456   429 GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
Cdd:COG4886  337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-739 9.63e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKldlyhehSFTELPRLEALDLSYNSqpfgmqgVGHNFSFVAHL 574
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-------LTDLPEELANL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   575 RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTlLPQTLRNLpKS 654
Cdd:COG4886  136 TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITD-LPEPLGNL-TN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   655 LQVLRLRDNYLAFFKwWSLHFLPKLEVLDLAGNQLKALTngSLPAGTRLRRLDVSCNSISFVAPgfFSKAKELRELNLSA 734
Cdd:COG4886  207 LEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSN 281


                 ....*
gi 8394456   735 NALKT 739
Cdd:COG4886  282 NQLTD 286
SEFIR super family cl23749
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 870-1009 2.11e-08

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


The actual alignment was detected with superfamily member smart00255:

Pssm-ID: 474043 [Multi-domain]  Cd Length: 140  Bit Score: 53.87  E-value: 2.11e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456      870 YDAFVVFdktqsAVADWVYNELRGQLEECRGRwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAH--TDrvSGLL 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRG--YGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPnyAE--SEWC 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8394456      948 RASFLLAQQRLLEDRKDVVVLVILSPDGR--RSRYVRLRQRLcRQSVLLWPHQPSGQrsFWAQL 1009
Cdd:smart00255   73 LDELVAALENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKA 133
LRR_8 pfam13855
Leucine rich repeat;
64-135 1.23e-07

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8394456      64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPSTFLAVPTLEELNLSYNNI 135
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LT--------TLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-504 5.54e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   113 TIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNcyyknpcrqALEVAP 192
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN---------QLTDLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   193 GALLGLGNLTHLSLKYNNLTVVPRNLPS--SLEYLLLSYNRIVKLaPEDLANLTALRVLDVGGNcrrcdhapnpcmecpr 270
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN---------------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   271 hfpQLH--PDTFSHLSRLEGLVLKDSSLSWLNASwFRGLGNLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNyqkr 348
Cdd:COG4886  193 ---QITdlPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN---- 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   349 vsfaHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS 428
Cdd:COG4886  261 ----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8394456   429 GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
Cdd:COG4886  337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-739 9.63e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKldlyhehSFTELPRLEALDLSYNSqpfgmqgVGHNFSFVAHL 574
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-------LTDLPEELANL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   575 RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTlLPQTLRNLpKS 654
Cdd:COG4886  136 TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITD-LPEPLGNL-TN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   655 LQVLRLRDNYLAFFKwWSLHFLPKLEVLDLAGNQLKALTngSLPAGTRLRRLDVSCNSISFVAPgfFSKAKELRELNLSA 734
Cdd:COG4886  207 LEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSN 281


                 ....*
gi 8394456   735 NALKT 739
Cdd:COG4886  282 NQLTD 286
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 200-737 2.77e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.68  E-value: 2.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    200 NLTHLSLKYNNLT-VVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCrRCDHAPNpcmecprhfpqlhpd 278
Cdd:PLN00113  119 SLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-LVGKIPN--------------- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    279 TFSHLSRLEGLVL--------------KDSSLSWLNASW----------FRGLGNLRVLDLSENFLYKCITKTkafqgLT 334
Cdd:PLN00113  183 SLTNLTSLEFLTLasnqlvgqiprelgQMKSLKWIYLGYnnlsgeipyeIGGLTSLNHLDLVYNNLTGPIPSS-----LG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    335 QLRKLNLSFNYQKRVSFahlSLAPSFGSLVALKELDMHGiffRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAF 414
Cdd:PLN00113  258 NLKNLQYLFLYQNKLSG---PIPPSIFSLQKLISLDLSD---NSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSL 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    415 PGLRYVDLSDNRISGasELTATMGEADggekvwlqpgdlapapvdtpssedfrpncstlNFT-LDLSRNNLVTVQPEMFA 493
Cdd:PLN00113  332 PRLQVLQLWSNKFSG--EIPKNLGKHN--------------------------------NLTvLDLSTNNLTGEIPEGLC 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    494 QLSHLQCLRLSHNCISQAVNGSqFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQpfgmqgVGHNFSFVAH 573
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL------QGRINSRKWD 450

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    574 LRTLRHLSLAHNNihsqvsqqlcstslraldFSGNalghmwaegdlyLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPK 653
Cdd:PLN00113  451 MPSLQMLSLARNK------------------FFGG------------LPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE 500

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    654 SLQvLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLkaltNGSLPAGTR----LRRLDVSCNSISFVAPGFFSKAKELRE 729
Cdd:PLN00113  501 LMQ-LKLSENKLSGEIPDELSSCKKLVSLDLSHNQL----SGQIPASFSempvLSQLDLSQNQLSGEIPKNLGNVESLVQ 575


                  ....*...
gi 8394456    730 LNLSANAL 737
Cdd:PLN00113  576 VNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 401-737 1.77e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    401 NFINQAQLGIFRaFPGLRYVDLSDNRISGaseltatmgeadggekvwlqpgdlapapvdtPSSEDFRPNCSTLNFtLDLS 480
Cdd:PLN00113   80 NISGKISSAIFR-LPYIQTINLSNNQLSG-------------------------------PIPDDIFTTSSSLRY-LNLS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    481 RNNLVTVQPEMFaqLSHLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNsqpfg 560
Cdd:PLN00113  127 NNNFTGSIPRGS--IPNLETLDLSNNMLSGEIP-NDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN----- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    561 mQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCS-TSLRALDFSGNAL-GHMWAE-GDL----YLHFFQ-------- 625
Cdd:PLN00113  199 -QLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGlTSLNHLDLVYNNLtGPIPSSlGNLknlqYLFLYQnklsgpip 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    626 ----GLSGLIWLDLSQNRLHTLLPQTLRNLpKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGT 701
Cdd:PLN00113  278 psifSLQKLISLDLSDNSLSGEIPELVIQL-QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHN 356

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 8394456    702 RLRRLDVSCNSISFVAPGFFSKAKELRELNLSANAL 737
Cdd:PLN00113  357 NLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL 392
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 393-422 9.22e-13

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 63.13  E-value: 9.22e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 8394456     393 LQTLRLQMNFINQAQLGIFRAFPGLRYVDL 422
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
LRR_8 pfam13855
Leucine rich repeat;
496-555 8.10e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 8.10e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     496 SHLQCLRLSHNCIsQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYN 555
Cdd:pfam13855    1 PNLRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
TIR smart00255
Toll - interleukin 1 - resistance;
870-1009 2.11e-08

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 53.87  E-value: 2.11e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456      870 YDAFVVFdktqsAVADWVYNELRGQLEECRGRwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAH--TDrvSGLL 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRG--YGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPnyAE--SEWC 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8394456      948 RASFLLAQQRLLEDRKDVVVLVILSPDGR--RSRYVRLRQRLcRQSVLLWPHQPSGQrsFWAQL 1009
Cdd:smart00255   73 LDELVAALENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKA 133
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 143-344 3.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   143 KSLISLSLSHTNILMLDSasLAGLHALRFLFMDGNCYYKNPcrqalevapgALLGLGNLTHLSLKYNNLTVVP--RNLPS 220
Cdd:cd21340    2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE----------NLEFLTNLTHLYLQNNQIEKIEnlENLVN 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   221 sLEYLLLSYNRIVKLapEDLANLTALRVLDVGGNCRRCDHapnpcmecprhfpQLHPDTFSHLSRLEglvlkdsSLSWLN 300
Cdd:cd21340   70 -LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPGE-------------KLTFDPRSLAALSN-------SLRVLN 126

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 8394456   301 AS--------WFRGLGNLRVLDLSENFL--YKCITKTkaFQGLTQLRKLNLSFN 344
Cdd:cd21340  127 ISgnnidslePLAPLRNLEQLDASNNQIsdLEELLDL--LSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
64-135 1.23e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8394456      64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPSTFLAVPTLEELNLSYNNI 135
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LT--------TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 476-739 1.65e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   476 TLDLSRNNL------VTVQPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPL----TGLQVLDLSHNKLDLYHEH----SF 541
Cdd:cd00116   55 ELCLSLNETgriprgLQSLLQGLTKGCGLQELDLSDNALGPD--GCGVLESllrsSSLQELKLNNNGLGDRGLRllakGL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   542 TEL-PRLEALDLSYNS-QPFGMQGVGHNFSfvaHLRTLRHLSLAHNNIHSQVSQQLC-----STSLRALDFSGNALGHmw 614
Cdd:cd00116  133 KDLpPALEKLVLGRNRlEGASCEALAKALR---ANRDLKELNLANNGIGDAGIRALAeglkaNCNLEVLDLNNNGLTD-- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   615 aEGDlylhffqglsgliwldlsqnrlhTLLPQTLRNLpKSLQVLRLRDNylaffkwwslhflpkleVLDLAGnqLKALTN 694
Cdd:cd00116  208 -EGA-----------------------SALAETLASL-KSLEVLNLGDN-----------------NLTDAG--AAALAS 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 8394456   695 GSLPAGTRLRRLDVSCNSISFVAPGFFSKA----KELRELNLSANALKT 739
Cdd:cd00116  244 ALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 870-997 6.89e-04

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 41.58  E-value: 6.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     870 YDAFVVFdkTQSAVADWVYNELRGQLEECRgrwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLlra 949
Cdd:pfam01582    1 YDVFLSF--RGSDTREWFVSHLLKELKQKG----IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGW--- 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     950 sFLLAQQRLLEDRKD---VVVLVILSPDGRRSR---------YVRLRQRLCRQSVLLWPH 997
Cdd:pfam01582   72 -CLDELVKILECALDlgqKVIPIFYEVDPSDVRkqtgsfgkaFKKHKKVLTEEKVLKWRG 130
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-504 5.54e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 5.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   113 TIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNcyyknpcrqALEVAP 192
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN---------QLTDLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   193 GALLGLGNLTHLSLKYNNLTVVPRNLPS--SLEYLLLSYNRIVKLaPEDLANLTALRVLDVGGNcrrcdhapnpcmecpr 270
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN---------------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   271 hfpQLH--PDTFSHLSRLEGLVLKDSSLSWLNASwFRGLGNLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNyqkr 348
Cdd:COG4886  193 ---QITdlPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN---- 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   349 vsfaHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS 428
Cdd:COG4886  261 ----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8394456   429 GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
Cdd:COG4886  337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
495-739 9.63e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKldlyhehSFTELPRLEALDLSYNSqpfgmqgVGHNFSFVAHL 574
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQ-------LTDLPEELANL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   575 RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTlLPQTLRNLpKS 654
Cdd:COG4886  136 TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-------LGNLTNLKELDLSNNQITD-LPEPLGNL-TN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   655 LQVLRLRDNYLAFFKwWSLHFLPKLEVLDLAGNQLKALTngSLPAGTRLRRLDVSCNSISFVAPgfFSKAKELRELNLSA 734
Cdd:COG4886  207 LEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSN 281


                 ....*
gi 8394456   735 NALKT 739
Cdd:COG4886  282 NQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
23-254 2.09e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 2.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    23 TLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAprgNVTSLSLSSNRIHHLhDSDFAHLPSLRHLNLKWNcppvg 102
Cdd:COG4886   76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT---NLESLDLSGNQLTDL-PEELANLTNLKELDLSNN----- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   103 lspmhfpcHMTIEPSTFLAVPTLEELNLSYNNIMTVPA----LPKsLISLSLSHTNILMLdSASLAGLHALRFLFMDGNc 178
Cdd:COG4886  147 --------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITDL-PEPLGNLTNLEELDLSGN- 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8394456   179 yyknpcrqALEVAPGALLGLGNLTHLSLKYNNLTVVPR--NLPsSLEYLLLSYNRIVKLAPedLANLTALRVLDVGGN 254
Cdd:COG4886  216 --------QLTDLPEPLANLTNLETLDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPP--LANLTNLKTLDLSNN 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 200-737 2.77e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.68  E-value: 2.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    200 NLTHLSLKYNNLT-VVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCrRCDHAPNpcmecprhfpqlhpd 278
Cdd:PLN00113  119 SLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV-LVGKIPN--------------- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    279 TFSHLSRLEGLVL--------------KDSSLSWLNASW----------FRGLGNLRVLDLSENFLYKCITKTkafqgLT 334
Cdd:PLN00113  183 SLTNLTSLEFLTLasnqlvgqiprelgQMKSLKWIYLGYnnlsgeipyeIGGLTSLNHLDLVYNNLTGPIPSS-----LG 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    335 QLRKLNLSFNYQKRVSFahlSLAPSFGSLVALKELDMHGiffRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAF 414
Cdd:PLN00113  258 NLKNLQYLFLYQNKLSG---PIPPSIFSLQKLISLDLSD---NSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSL 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    415 PGLRYVDLSDNRISGasELTATMGEADggekvwlqpgdlapapvdtpssedfrpncstlNFT-LDLSRNNLVTVQPEMFA 493
Cdd:PLN00113  332 PRLQVLQLWSNKFSG--EIPKNLGKHN--------------------------------NLTvLDLSTNNLTGEIPEGLC 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    494 QLSHLQCLRLSHNCISQAVNGSqFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQpfgmqgVGHNFSFVAH 573
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL------QGRINSRKWD 450

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    574 LRTLRHLSLAHNNihsqvsqqlcstslraldFSGNalghmwaegdlyLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPK 653
Cdd:PLN00113  451 MPSLQMLSLARNK------------------FFGG------------LPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE 500

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    654 SLQvLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLkaltNGSLPAGTR----LRRLDVSCNSISFVAPGFFSKAKELRE 729
Cdd:PLN00113  501 LMQ-LKLSENKLSGEIPDELSSCKKLVSLDLSHNQL----SGQIPASFSempvLSQLDLSQNQLSGEIPKNLGNVESLVQ 575


                  ....*...
gi 8394456    730 LNLSANAL 737
Cdd:PLN00113  576 VNISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
476-707 2.63e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 2.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   476 TLDLSRNNLVTVqPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPLTGLQVLDLSHNKLdlyhehsfTELPrlealdlsyn 555
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQL--------TDLP---------- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   556 sqpfgmqgvghnfSFVAHLRTLRHLSLAHNNIhSQVSQQLCS-TSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLD 634
Cdd:COG4886  176 -------------EELGNLTNLKELDLSNNQI-TDLPEPLGNlTNLEELDLSGNQLTDLPEP-------LANLTNLETLD 234

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8394456   635 LSQNRLHTlLPQtLRNLPKsLQVLRLRDNYLAFFKwwSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLD 707
Cdd:COG4886  235 LSNNQLTD-LPE-LGNLTN-LEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
567-762 2.97e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 2.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   567 NFSFVAHLRTLRHLSLAHNNIHSQVsqqlcsTSLRALDFSGNALGHMWAEgdlylhfFQGLSGLIWLDLSQNRLHTLlPQ 646
Cdd:COG4886   88 GLTDLGDLTNLTELDLSGNEELSNL------TNLESLDLSGNQLTDLPEE-------LANLTNLKELDLSNNQLTDL-PE 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   647 TLRNLPKsLQVLRLRDNYLAFFKWWSLHfLPKLEVLDLAGNQLKALTNgSLPAGTRLRRLDVSCNSISFVaPGFFSKAKE 726
Cdd:COG4886  154 PLGNLTN-LKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTN 229

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 8394456   727 LRELNLSANALKTVdhSWFGPLaSALQILDVSANPL 762
Cdd:COG4886  230 LETLDLSNNQLTDL--PELGNL-TNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-588 5.30e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.36  E-value: 5.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     65 VTSLSLSSNRIH-HLHDSDFAHLPSLRHLNLKWNcppvglspmHFPCHMtiePSTFLavPTLEELNLSyNNIMT--VPAL 141
Cdd:PLN00113   95 IQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN---------NFTGSI---PRGSI--PNLETLDLS-NNMLSgeIPND 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    142 PKSLISLSLSHT--NILMLD-SASLAGLHALRFLFMDGNCYYKNPCRQALEVA----------------PGALLGLGNLT 202
Cdd:PLN00113  160 IGSFSSLKVLDLggNVLVGKiPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKslkwiylgynnlsgeiPYEIGGLTSLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    203 HLSLKYNNLT-VVPRNLP--SSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNcrrcdhapNPCMECPRHFPQLH--- 276
Cdd:PLN00113  240 HLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN--------SLSGEIPELVIQLQnle 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    277 -------------PDTFSHLSRLEGLVLKDSSLSwlnASWFRGLG---NLRVLDLSENFLYKCITKTKAFQGltQLRKLN 340
Cdd:PLN00113  312 ilhlfsnnftgkiPVALTSLPRLQVLQLWSNKFS---GEIPKNLGkhnNLTVLDLSTNNLTGEIPEGLCSSG--NLFKLI 386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    341 LsfnyqkrvsfahlslapsfgslvalkeldmhgiFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
Cdd:PLN00113  387 L---------------------------------FSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFL 433

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    421 DLSDNRISGASEltatmgeadggEKVW----LQPGDLAPAPVDTPSSEDFRpncSTLNFTLDLSRNNLVTVQPEMFAQLS 496
Cdd:PLN00113  434 DISNNNLQGRIN-----------SRKWdmpsLQMLSLARNKFFGGLPDSFG---SKRLENLDLSRNQFSGAVPRKLGSLS 499

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    497 HLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNsqpfgmQGVGHNFSFVAHLRT 576
Cdd:PLN00113  500 ELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN------QLSGEIPKNLGNVES 572

                         570
                  ....*....|..
gi 8394456    577 LRHLSLAHNNIH 588
Cdd:PLN00113  573 LVQVNISHNHLH 584
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
476-732 3.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   476 TLDLSRNNLVTVqPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPLTGLQVLDLSHNKL-DLyhEHSFTELPRLEALDLSY 554
Cdd:COG4886  140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQItDL--PEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   555 NsqpfgmqGVGHNFSFVAHLRTLRHLSLAHNNIhSQVSQQLCSTSLRALDFSGNALGHmwaegdlyLHFFQGLSGLIWLD 634
Cdd:COG4886  215 N-------QLTDLPEPLANLTNLETLDLSNNQL-TDLPELGNLTNLEELDLSNNQLTD--------LPPLANLTNLKTLD 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   635 LSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSIS 714
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                        250
                 ....*....|....*...
gi 8394456   715 FVAPGFFSKAKELRELNL 732
Cdd:COG4886  359 LSLLLTLLLTLGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
283-671 1.26e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   283 LSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENflykcitktKAFQGLTQLRKLNLSFNyqkRVSfahlSLAPSFGS 362
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGN---QLT----DLPEELAN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   363 LVALKELDMHGIFFRSLDEttlrPLARLPMLQTLRLQMNFINQAQLGIFRaFPGLRYVDLSDNRISgasELTATMGEADG 442
Cdd:COG4886  135 LTNLKELDLSNNQLTDLPE----PLGNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQIT---DLPEPLGNLTN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   443 GEKVWLQPGDLAPAPVDTPssedfrpNCSTLNfTLDLSRNNLVTVqPEmFAQLSHLQCLRLSHNCISQAvngSQFLPLTG 522
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLA-------NLTNLE-TLDLSNNQLTDL-PE-LGNLTNLEELDLSNNQLTDL---PPLANLTN 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   523 LQVLDLSHNKLdlyhehSFTELPRLEALDLSYNSQPFGMQGVGHNfsFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRA 602
Cdd:COG4886  274 LKTLDLSNNQL------TDLKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8394456   603 LDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWW 671
Cdd:COG4886  346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 401-737 1.77e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.35  E-value: 1.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    401 NFINQAQLGIFRaFPGLRYVDLSDNRISGaseltatmgeadggekvwlqpgdlapapvdtPSSEDFRPNCSTLNFtLDLS 480
Cdd:PLN00113   80 NISGKISSAIFR-LPYIQTINLSNNQLSG-------------------------------PIPDDIFTTSSSLRY-LNLS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    481 RNNLVTVQPEMFaqLSHLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNsqpfg 560
Cdd:PLN00113  127 NNNFTGSIPRGS--IPNLETLDLSNNMLSGEIP-NDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN----- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    561 mQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCS-TSLRALDFSGNAL-GHMWAE-GDL----YLHFFQ-------- 625
Cdd:PLN00113  199 -QLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGlTSLNHLDLVYNNLtGPIPSSlGNLknlqYLFLYQnklsgpip 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    626 ----GLSGLIWLDLSQNRLHTLLPQTLRNLpKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGT 701
Cdd:PLN00113  278 psifSLQKLISLDLSDNSLSGEIPELVIQL-QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHN 356

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 8394456    702 RLRRLDVSCNSISFVAPGFFSKAKELRELNLSANAL 737
Cdd:PLN00113  357 NLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-647 2.73e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.50  E-value: 2.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNcppvglsPMHFPchmtIEPSTFLAVPTLEELNLSYNNIMTvpALPKS 144
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN-------QLSGP----IPDDIFTTSSSLRYLNLSNNNFTG--SIPRG 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    145 LIS----LSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNpcrqalevAPGALLGLGNLTHLSLKYNNLT-VVPRNLP 219
Cdd:PLN00113  138 SIPnletLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGK--------IPNSLTNLTSLEFLTLASNQLVgQIPRELG 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    220 S--SLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNcrrcdhapnpcmecprHFPQLHPDTFSHLSRLEGLVLKDSSLS 297
Cdd:PLN00113  210 QmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN----------------NLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    298 WLNASWFRGLGNLRVLDLSENFLYKCITKTkafqgltqlrklnlsfnyqkrvsfahlslapsfgsLVALKELDMHGIFFR 377
Cdd:PLN00113  274 GPIPPSIFSLQKLISLDLSDNSLSGEIPEL-----------------------------------VIQLQNLEILHLFSN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    378 SLDETTLRPLARLPMLQTLRLQMNFIN---QAQLGifrAFPGLRYVDLSDNRISGasELTATMGEAdggekvwlqpGDLA 454
Cdd:PLN00113  319 NFTGKIPVALTSLPRLQVLQLWSNKFSgeiPKNLG---KHNNLTVLDLSTNNLTG--EIPEGLCSS----------GNLF 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    455 PAPVDTPSSEDFRP----NCSTLNfTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNgSQFLPLTGLQVLDLSH 530
Cdd:PLN00113  384 KLILFSNSLEGEIPkslgACRSLR-RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRIN-SRKWDMPSLQMLSLAR 461

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    531 NKLdlyhehsFTELP------RLEALDLSYNsqpfgmQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCS-TSLRAL 603
Cdd:PLN00113  462 NKF-------FGGLPdsfgskRLENLDLSRN------QFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSScKKLVSL 528

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8394456    604 DFSGNAL-GHMWAE-------GDLYLHFFQgLSG-----------LIWLDLSQNRLHTLLPQT 647
Cdd:PLN00113  529 DLSHNQLsGQIPASfsempvlSQLDLSQNQ-LSGeipknlgnvesLVQVNISHNHLHGSLPST 590
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-433 5.02e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 5.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   132 YNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNL 211
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   212 TVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNcrrcdhapnpcmecprhfpQLH--PDTFSHLSRLEGL 289
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGN-------------------QLTdlPEELANLTNLKEL 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   290 VLKDSSLSWLNASwFRGLGNLRVLDLSENFLYKCitkTKAFQGLTQLRKLNLSFNyqkRVSfahlSLAPSFGSLVALKEL 369
Cdd:COG4886  142 DLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNN---QIT----DLPEPLGNLTNLEEL 210

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8394456   370 DMHGIFFRSLDEttlrPLARLPMLQTLRLQMNFINqaQLGIFRAFPGLRYVDLSDNRISGASEL 433
Cdd:COG4886  211 DLSGNQLTDLPE----PLANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLPPL 268
LRR_12 pfam18837
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 393-422 9.22e-13

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408607  Cd Length: 30  Bit Score: 63.13  E-value: 9.22e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 8394456     393 LQTLRLQMNFINQAQLGIFRAFPGLRYVDL 422
Cdd:pfam18837    1 LQTLHLQMNFINQAQLSIFGAFPGLRFVDL 30
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
24-240 2.32e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     24 LALGTLPAFLPCELQPHGLVNCNwlfLKSVPHfsmaAPRGNVTSLSLSSNRIHHLHDSdfahLP-SLRHLNLKWN----C 98
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNE---LKSLPE----NLQGNIKTLYANSNQLTSIPAT----LPdTIQEMELSINriteL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     99 P---PVGLSPMHFPCH-MTIEPSTflaVPT-LEELNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLAGLhalRFL 172
Cdd:PRK15370  257 PerlPSALQSLDLFHNkISCLPEN---LPEeLRYLSVYDNSIRTLPAhLPSGITHLNVQSNSLTALPETLPPGL---KTL 330

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8394456    173 FMDGN---CYYKN--PCRQALEVAPGALLGLG-----NLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLaPEDL 240
Cdd:PRK15370  331 EAGENaltSLPASlpPELQVLDVSKNQITVLPetlppTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL-PESL 407
LRR_8 pfam13855
Leucine rich repeat;
496-555 8.10e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 8.10e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     496 SHLQCLRLSHNCIsQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYN 555
Cdd:pfam13855    1 PNLRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
476-533 1.09e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.09e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 8394456     476 TLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQaVNGSQFLPLTGLQVLDLSHNKL 533
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSGNRL 61
TIR smart00255
Toll - interleukin 1 - resistance;
870-1009 2.11e-08

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 53.87  E-value: 2.11e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456      870 YDAFVVFdktqsAVADWVYNELRGQLEECRGRwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAH--TDrvSGLL 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRG--YGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPnyAE--SEWC 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8394456      948 RASFLLAQQRLLEDRKDVVVLVILSPDGR--RSRYVRLRQRLcRQSVLLWPHQPSGQrsFWAQL 1009
Cdd:smart00255   73 LDELVAALENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKA 133
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
592-762 2.81e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 2.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   592 SQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNylaffkwW 671
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------E 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   672 SLHFLPKLEVLDLAGNQLKALTNgSLPAGTRLRRLDVSCNSISFVaPGFFSKAKELRELNLSANALKTVDhSWFGPLaSA 751
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNL-TN 183

                        170
                 ....*....|.
gi 8394456   752 LQILDVSANPL 762
Cdd:COG4886  184 LKELDLSNNQI 194
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 143-344 3.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   143 KSLISLSLSHTNILMLDSasLAGLHALRFLFMDGNCYYKNPcrqalevapgALLGLGNLTHLSLKYNNLTVVP--RNLPS 220
Cdd:cd21340    2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE----------NLEFLTNLTHLYLQNNQIEKIEnlENLVN 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   221 sLEYLLLSYNRIVKLapEDLANLTALRVLDVGGNCRRCDHapnpcmecprhfpQLHPDTFSHLSRLEglvlkdsSLSWLN 300
Cdd:cd21340   70 -LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPGE-------------KLTFDPRSLAALSN-------SLRVLN 126

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 8394456   301 AS--------WFRGLGNLRVLDLSENFL--YKCITKTkaFQGLTQLRKLNLSFN 344
Cdd:cd21340  127 ISgnnidslePLAPLRNLEQLDASNNQIsdLEELLDL--LSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
701-762 3.52e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 3.52e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8394456     701 TRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASaLQILDVSANPL 762
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
284-344 1.19e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8394456     284 SRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLyKCITKtKAFQGLTQLRKLNLSFN 344
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSP-GAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
64-135 1.23e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 1.23e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8394456      64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPSTFLAVPTLEELNLSYNNI 135
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LT--------TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 476-739 1.65e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   476 TLDLSRNNL------VTVQPEMFAQLSHLQCLRLSHNCISQAvnGSQFLPL----TGLQVLDLSHNKLDLYHEH----SF 541
Cdd:cd00116   55 ELCLSLNETgriprgLQSLLQGLTKGCGLQELDLSDNALGPD--GCGVLESllrsSSLQELKLNNNGLGDRGLRllakGL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   542 TEL-PRLEALDLSYNS-QPFGMQGVGHNFSfvaHLRTLRHLSLAHNNIHSQVSQQLC-----STSLRALDFSGNALGHmw 614
Cdd:cd00116  133 KDLpPALEKLVLGRNRlEGASCEALAKALR---ANRDLKELNLANNGIGDAGIRALAeglkaNCNLEVLDLNNNGLTD-- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   615 aEGDlylhffqglsgliwldlsqnrlhTLLPQTLRNLpKSLQVLRLRDNylaffkwwslhflpkleVLDLAGnqLKALTN 694
Cdd:cd00116  208 -EGA-----------------------SALAETLASL-KSLEVLNLGDN-----------------NLTDAG--AAALAS 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 8394456   695 GSLPAGTRLRRLDVSCNSISFVAPGFFSKA----KELRELNLSANALKT 739
Cdd:cd00116  244 ALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
127-318 8.70e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 8.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    127 ELNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSaslaGLHalrflfmdgncyyknpcrqalevapgallglGNLTHLS 205
Cdd:PRK15370  182 ELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE----NLQ-------------------------------GNIKTLY 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    206 LKYNNLTVVPRNLPSSLEYLLLSYNRIVKLaPEDLAnlTALRVLDVGGNCRRC--DHAP----------NPCMECPRHFP 273
Cdd:PRK15370  227 ANSNQLTSIPATLPDTIQEMELSINRITEL-PERLP--SALQSLDLFHNKISClpENLPeelrylsvydNSIRTLPAHLP 303

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 8394456    274 Q--LHPDTFSHL---------SRLEGLVLKDSSLSWLNASWfrgLGNLRVLDLSEN 318
Cdd:PRK15370  304 SgiTHLNVQSNSltalpetlpPGLKTLEAGENALTSLPASL---PPELQVLDVSKN 356
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 510-737 9.41e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 9.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   510 QAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTEL----PRLEALDLSYNsqPFGMQGVGHNFSFVAHLRTLRHLSLAHN 585
Cdd:COG5238  169 AAISMAKALQNNSVETVYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRN--PIGDEGAEILAEALKGNKSLTTLDLSNN 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   586 NIHSQVSQQL-----CSTSLRALDFSGNALGHmwaEGDLYL-HFFQGLSGLIWLDLSQNRLHTllpQTLRNLPKSLQVLR 659
Cdd:COG5238  247 QIGDEGVIALaealkNNTTVETLYLSGNQIGA---EGAIALaKALQGNTTLTSLDLSVNRIGD---EGAIALAEGLQGNK 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   660 lrdnylaffkwwslhflpKLEVLDLAGNQL-----KALTNgSLPAGTRLRRLDVSCNSISFVAPGFFSKA----KELREL 730
Cdd:COG5238  321 ------------------TLHTLNLAYNGIgaqgaIALAK-ALQENTTLHSLDLSDNQIGDEGAIALAKYlegnTTLREL 381


                 ....*..
gi 8394456   731 NLSANAL 737
Cdd:COG5238  382 NLGKNNI 388
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-373 1.41e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   198 LGNLTHLSLKYNNLTVVP---------------------RNLPS--SLEYLLLSYNRIVKLapEDLANLTALRVLDVGGN 254
Cdd:cd21340    1 LKRITHLYLNDKNITKIDnlslcknlkvlylydnkitkiENLEFltNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   255 CrrcdhapnpcmecprhfpqlhpdtfshLSRLEGL---------------VLKDSSLSWLNASWFRGLGNLRVLDLSENf 319
Cdd:cd21340   79 R---------------------------ISVVEGLenltnleelhienqrLPPGEKLTFDPRSLAALSNSLRVLNISGN- 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 8394456   320 lykCITKTKAFQGLTQLRKLNLSFNYQKRVSfahlSLAPSFGSLVALKELDMHG 373
Cdd:cd21340  131 ---NIDSLEPLAPLRNLEQLDASNNQISDLE----ELLDLLSSWPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
677-737 2.60e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 2.60e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8394456     677 PKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANAL 737
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
200-254 3.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 3.13e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 8394456     200 NLTHLSLKYNNLTVVP----RNLPSsLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGN 254
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 494-638 4.75e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 4.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   494 QLSHLQCLRLSHNCISQAVNgsqFLPLTGLQVLDLSHNKLdlyhehSFTE----LPRLEALDLSYNSQPFGMQGVGHNFS 569
Cdd:cd21340   44 FLTNLTHLYLQNNQIEKIEN---LENLVNLKKLYLGGNRI------SVVEglenLTNLEELHIENQRLPPGEKLTFDPRS 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8394456   570 FVAHLRTLRHLSLAHNNIhSQVSQQLCSTSLRALDFSGNALGHMwaeGDLyLHFFQGLSGLIWLDLSQN 638
Cdd:cd21340  115 LAALSNSLRVLNISGNNI-DSLEPLAPLRNLEQLDASNNQISDL---EEL-LDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 650-760 8.66e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 8.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   650 NLPKSLQVLRLRDNYLAFFKwwSLHFLPKLEVLDLAGNQLKALTN-GSLPagtRLRRLDVSCNSISFVApGfFSKAKELR 728
Cdd:cd21340   21 SLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENlENLV---NLKKLYLGGNRISVVE-G-LENLTNLE 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 8394456   729 ELNLSANALKTVDHSWFGP-----LASALQILDVSAN 760
Cdd:cd21340   94 ELHIENQRLPPGEKLTFDPrslaaLSNSLRVLNISGN 130
LRR_8 pfam13855
Leucine rich repeat;
598-665 1.19e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.19e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8394456     598 TSLRALDFSGNALGHmwaegdLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPkSLQVLRLRDNYL 665
Cdd:pfam13855    1 PNLRSLDLSNNRLTS------LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 477-556 1.27e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.04  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    477 LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSqFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNS 556
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPS-LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501
LRR_8 pfam13855
Leucine rich repeat;
628-689 1.51e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8394456     628 SGLIWLDLSQNRLHTLLPQTLRNLPkSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQL 689
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 133-255 2.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   133 NNIMTVPALP--KSLISLSLSHTNILMLDSasLAGLHALRFLFMDGNCyyknpcrqaLEVAPGaLLGLGNLTHLSLKYNN 210
Cdd:cd21340   34 NKITKIENLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR---------ISVVEG-LENLTNLEELHIENQR 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 8394456   211 L------TVVPRNLPS---SLEYLLLSYNRIVKLapEDLANLTALRVLDVGGNC 255
Cdd:cd21340  102 LppgeklTFDPRSLAAlsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 573-714 2.98e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   573 HLRTLRHLSLAHNNIhsQVSQQLCS-TSLRALDFSGNALGHMwaEGdlylhfFQGLSGLIWLDLSQNRL---HTLL--PQ 646
Cdd:cd21340   44 FLTNLTHLYLQNNQI--EKIENLENlVNLKKLYLGGNRISVV--EG------LENLTNLEELHIENQRLppgEKLTfdPR 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   647 TLRNLPKSLQVLRLRDNYLAFFKwwSLHFLPKLEVLDLAGNQLKALTN--GSLPAGTRLRRLDVSCNSIS 714
Cdd:cd21340  114 SLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
521-587 3.98e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.98e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8394456     521 TGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSqpfgMQGVgHNFSFVaHLRTLRHLSLAHNNI 587
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL----LTTL-SPGAFS-GLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
275-318 4.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 4.61e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 8394456     275 LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSEN 318
Cdd:pfam13855   16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
123-177 6.13e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.13e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 8394456     123 PTLEELNLSYNNIMTVPAL----PKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGN 177
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 599-777 4.86e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   599 SLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKS--LQVLRLRDNYLAF----FKWWS 672
Cdd:cd00116   52 SLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSssLQELKLNNNGLGDrglrLLAKG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   673 L-HFLPKLEVLDLAGNQLkalTNGS-------LPAGTRLRRLDVSCNSISfvAPGF------FSKAKELRELNLSANALK 738
Cdd:cd00116  132 LkDLPPALEKLVLGRNRL---EGAScealakaLRANRDLKELNLANNGIG--DAGIralaegLKANCNLEVLDLNNNGLT 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 8394456   739 TVDHSWFG---PLASALQILDVSANPLHCACGAAFMDFLLEV 777
Cdd:cd00116  207 DEGASALAetlASLKSLEVLNLGDNNLTDAGAAALASALLSP 248
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 469-555 5.20e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 5.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   469 NCSTLNfTLDLSRNNL-----VTVQPE-MFAQLSHLQCLRLSHNCISqavNGSQFLPLTGLQVLDLSHNKLDLYHE--HS 540
Cdd:cd21340   88 NLTNLE-ELHIENQRLppgekLTFDPRsLAALSNSLRVLNISGNNID---SLEPLAPLRNLEQLDASNNQISDLEEllDL 163

                         90
                 ....*....|....*
gi 8394456   541 FTELPRLEALDLSYN 555
Cdd:cd21340  164 LSSWPSLRELDLTGN 178
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 870-997 6.89e-04

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 41.58  E-value: 6.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     870 YDAFVVFdkTQSAVADWVYNELRGQLEECRgrwaLRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLlra 949
Cdd:pfam01582    1 YDVFLSF--RGSDTREWFVSHLLKELKQKG----IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGW--- 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     950 sFLLAQQRLLEDRKD---VVVLVILSPDGRRSR---------YVRLRQRLCRQSVLLWPH 997
Cdd:pfam01582   72 -CLDELVKILECALDlgqKVIPIFYEVDPSDVRkqtgsfgkaFKKHKKVLTEEKVLKWRG 130
LRR_8 pfam13855
Leucine rich repeat;
190-232 7.53e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 7.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 8394456     190 VAPGALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRI 232
Cdd:pfam13855   16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 64-254 1.50e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    64 NVTSLSLSSNRIHHLhdSDFAHLPSLRHLNLKWNCppvgLSpmhfpchmTIEPstFLAVPTLEELNLSYNNIMTVpalpk 143
Cdd:cd21340   25 NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQ----IE--------KIEN--LENLVNLKKLYLGGNRISVV----- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   144 slislslshtnilmldsASLAGLHALRFLFMDGNcyyKNPCRQALEVAPGALLGLGN-LTHLSLKYNNLTVVpRNLP--S 220
Cdd:cd21340   84 -----------------EGLENLTNLEELHIENQ---RLPPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAplR 142

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 8394456   221 SLEYLLLSYNRIVKLAP--EDLANLTALRVLDVGGN 254
Cdd:cd21340  143 NLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
654-713 2.73e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.73e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456     654 SLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSI 713
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 633-719 2.76e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    633 LDLSQNRLHTLLPQTLRNLpKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLkaltNGSLPAG----TRLRRLDV 708
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKL-RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF----NGSIPESlgqlTSLRILNL 497

                          90
                  ....*....|.
gi 8394456    709 SCNSISFVAPG 719
Cdd:PLN03150  498 NGNSLSGRVPA 508
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 476-611 2.89e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456   476 TLDLSRNNlVTVQ-----PEMFAQLSHLQCLRLSHNCISQ--AVNGSQFLPLT-GLQVLDLSHNKLD-----LYHEHsFT 542
Cdd:COG5238  268 TLYLSGNQ-IGAEgaialAKALQGNTTLTSLDLSVNRIGDegAIALAEGLQGNkTLHTLNLAYNGIGaqgaiALAKA-LQ 345

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8394456   543 ELPRLEALDLSYNsqPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQ----VSQQLCSTSLRALDFSGNALG 611
Cdd:COG5238  346 ENTTLHSLDLSDN--QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQgaeaLIDALQTNRLHTLILDGNLIG 416
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 309-346 4.07e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 4.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 8394456     309 NLRVLDLSENflykCITKTKAFQGLTQLRKLNLSFNYQ 346
Cdd:pfam12799    2 NLEVLDLSNN----QITDIPPLAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 198-254 8.10e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 8.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8394456    198 LGNLTHLSLKYNNLT-VVPRNLPS--SLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGN 254
Cdd:PLN03150  441 LRHLQSINLSGNSIRgNIPPSLGSitSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
309-373 9.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 9.93e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8394456     309 NLRVLDLSENFLYKciTKTKAFQGLTQLRKLNLSFNYQKRVSfahlslAPSFGSLVALKELDMHG 373
Cdd:pfam13855    2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLS------PGAFSGLPSLRYLDLSG 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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