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Conserved domains on  [gi|662236770|ref|NP_059977|]
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zinc finger protein 823 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-502 1.19e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770  65 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 141
Cdd:COG5048    6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 142 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 219
Cdd:COG5048   86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 220 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 296
Cdd:COG5048  166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 297 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 367
Cdd:COG5048  236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 368 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 432
Cdd:COG5048  316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 662236770 433 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 502
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
498-522 1.87e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*
gi 662236770  498 LLRHERIHTGEKPYECLQCGKAFTR 522
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-502 1.19e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770  65 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 141
Cdd:COG5048    6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 142 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 219
Cdd:COG5048   86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 220 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 296
Cdd:COG5048  166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 297 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 367
Cdd:COG5048  236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 368 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 432
Cdd:COG5048  316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 662236770 433 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 502
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-382 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....
gi 662236770  359 FQRHERTHTGEKPYQCKQCGKAFS 382
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
498-522 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*
gi 662236770  498 LLRHERIHTGEKPYECLQCGKAFTR 522
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
65-502 1.19e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770  65 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 141
Cdd:COG5048    6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 142 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 219
Cdd:COG5048   86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 220 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 296
Cdd:COG5048  166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 297 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 367
Cdd:COG5048  236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 368 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 432
Cdd:COG5048  316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 662236770 433 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 502
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-561 6.92e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 147 PYKCKLCGKAFVWPSLFHLHERTHTGEKPYEC--KQCSKAFPFYSSYLRHERIHTGEKAYEC-KQCSKAFPDYSTYLRHE 223
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 224 RTHTGEKPYKCTQCGKAFSCYYYTRLHERTHTGEQPYACKQCgkTFYHHTSFRRHMIRHTGDGPHKCKICGKgfdcPSSV 303
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN--NSSSVNTPQSNSLHPPLPANSLSKDPSS----NLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 304 RNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDGPQKCKICGkaFGCPSLFQRHERTHTGEKpyqckqcgkafsl 383
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSS------------- 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 384 agslrrHEATHTGVKPYKCQCGKAFSDLSSFQNHETTHTG-EKPYECKECGKAFSCFKYLSQHKRT--HTVE--KPYEC- 457
Cdd:COG5048  252 ------DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCp 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 458 -KTCRKAFSHFSNLKVHERIHSGEKPYECKEC-------GKAFSWLTCLLRHERIHTGEKPYECL--QCGKAFTRSRFLR 527
Cdd:COG5048  326 ySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 662236770 528 GHEKTHTGEKLYECK--ECGKALSSLRSLHRHKRTH 561
Cdd:COG5048  406 LHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
230-513 1.76e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 230 KPYKCTQCGKAFSCYYYTRLHERTHTGEQPYAC--KQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG--FDCPSSVRN 305
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 306 HETTHTGEKPYECkQCGKVLSHSSSFRSHMITHTGDGPQKCKICGKAFG----------------------CPSLFQRHE 363
Cdd:COG5048  112 SSSSNSNDNNLLS-SHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 364 RTHTGEKPYQCKQCG----KAFSLAGSLRRHEAThTGVKPYKCQCGKAFSDLSSFQNHETthtgeKPYECKECGKAFSCF 439
Cdd:COG5048  191 NVSTSIPSSSENSPLsssySIPSSSSDQNLENSS-SSLPLTTNSQLSPKSLLSQSPSSLS-----SSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 440 KYLSQHKRTHTVE----------KPYECKTCRKAFSHFSNLKVHER--IHSGE--KPYECKE--CGKAFSWLTCLLRHER 503
Cdd:COG5048  265 LPTASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 662236770 504 IHTGEKPYEC 513
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-392 2.58e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 208 QCSKAFPDYSTYLRHERTHTG-EKPYKCTQCGKAFSCYYYTRLHERT--HTGE--QPYAC--KQCGKTFYHHTSFRRHMI 280
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236770 281 RHTGDGPHKCKICGKGFD-------CPSSVRNHETTHTGEKPYEC--KQCGKVLSHSSSFRSHMITHTGDGP--QKCKIC 349
Cdd:COG5048  345 LHTSISPAKEKLLNSSSKfspllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 662236770 350 GKAFGCPSLFQRHERTHTGEKPYQCKQCGKAFSLAGSLRRHEA 392
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-382 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....
gi 662236770  359 FQRHERTHTGEKPYQCKQCGKAFS 382
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-493 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 662236770  469 NLKVHERIHSGEKPYECKECGKAFS 493
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
221-243 1.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|...
gi 662236770  221 RHERTHTGEKPYKCTQCGKAFSC 243
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
498-522 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*
gi 662236770  498 LLRHERIHTGEKPYECLQCGKAFTR 522
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-466 3.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 662236770  441 YLSQHKRTHTVEKPYECKTCRKAFSH 466
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
134-158 5.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.75e-03
                          10        20
                  ....*....|....*....|....*
gi 662236770  134 NLRRHMAAHHGDGPYKCKLCGKAFV 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-438 8.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 662236770  413 SFQNHETTHTGEKPYECKECGKAFSC 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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