NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|61744467|ref|NP_059992|]
View 

low-density lipoprotein receptor-related protein 8 isoform 3 precursor [Homo sapiens]

Protein Classification

LDL receptor domain-containing protein( domain architecture ID 10819178)

Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; similar to Bos taurus CD320 antigen

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-463 1.84e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 64.87  E-value: 1.84e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61744467   423 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 463
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 360-402 1.10e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61744467    360 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 402
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 47-81 8.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 8.01e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 61744467  47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 447-489 4.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 4.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61744467    447 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 85-117 2.01e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.01e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467     85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
169-204 3.32e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.32e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61744467   169 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 510-550 2.97e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 2.97e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 61744467   510 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 550
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 211-245 1.34e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61744467   211 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 245
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 127-163 9.44e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 9.44e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 61744467 127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
247-277 2.59e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 2.59e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467    247 DIDECKDPDACSQ--ICVNYKGYFKCECYPGYE 277
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
298-432 1.19e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 298 TNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSayMDKASDPKEQEVLIDEQlhsPEGLAVDW 377
Cdd:COG3391  87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAG---PHGIAVDP 161

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61744467 378 VHKHIYWTDSGNKTIS--VATVDGGRRRTLFSRNL-SEPRAIAVDPLRGFMYWSDWGD 432
Cdd:COG3391 162 DGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGS 219
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 568-605 1.12e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 61744467   568 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 605
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-463 1.84e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 64.87  E-value: 1.84e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61744467   423 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 463
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 360-402 1.10e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61744467    360 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 402
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 381-420 2.07e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 2.07e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61744467   381 HIYWTDSGNK-TISVATVDGGRRRTLFSRNLSEPRAIAVDP 420
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 47-81 8.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 8.01e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 61744467  47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 403-446 1.45e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.45e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 61744467    403 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGdQAKIEKSGLNGVDR 446
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 447-489 4.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 4.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61744467    447 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 85-117 2.01e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.01e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467     85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 47-78 2.66e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 2.66e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 61744467     47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE 78
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
169-204 3.32e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.32e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61744467   169 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 364-548 5.83e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 5.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 364 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRT-----LFSRNLSEPRAIAVDPlRGFMYWSDWGDQaKIEK 438
Cdd:cd05819  51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 439 SGLNGVDRQTLVSDNIEW-----PNGITLDlLSQRLYWVDSKLHQLSSIDfSGGNRKTLISSTDF----LSHPFGIAVFE 509
Cdd:cd05819 128 FDPDGEFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQVFD-PDGNFLTTFGSTGTgpgqFNYPTGIAVDS 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 61744467 510 D-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 548
Cdd:cd05819 206 DgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 86-117 9.37e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 9.37e-09
                        10        20        30
                ....*....|....*....|....*....|..
gi 61744467  86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 170-204 9.46e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 9.46e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 61744467 170 CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
379-536 1.32e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 1.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 379 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNlSEPRAIAVDPLRGFMYWSDWGDQAkieksgLNGVDRQTL-VSDNI--- 454
Cdd:COG3391  79 GRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR------VSVIDTATGkVVATIpvg 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 455 EWPNGITLDLLSQRLYWVDSKLHQLS----SIDFSGGnrkTLISSTDFLSHPFGIAVFED--KVFWTDLENEaifSANRL 528
Cdd:COG3391 152 AGPHGIAVDPDGKRLYVANSGSNTVSvivsVIDTATG---KVVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGG 225


                ....*...
gi 61744467 529 NGlEISIL 536
Cdd:COG3391 226 SN-TVSVI 232
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
45-81 1.99e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.99e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 61744467    45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 510-550 2.97e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 2.97e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 61744467   510 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 550
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 169-201 5.80e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 5.80e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467    169 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 201
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 467-509 6.71e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 6.71e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 61744467   467 QRLYWVDSKLHQ-LSSIDFSGGNRKTLIssTDFLSHPFGIAVFE 509
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
84-117 7.04e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 7.04e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 61744467    84 KTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 211-245 1.34e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61744467   211 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 245
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 127-163 9.44e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 9.44e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 61744467 127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
247-277 2.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 2.59e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467    247 DIDECKDPDACSQ--ICVNYKGYFKCECYPGYE 277
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
127-163 3.89e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 3.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 61744467   127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 127-160 4.56e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 4.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 61744467    127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 160
Cdd:smart00192   2 CPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
298-432 1.19e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 298 TNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSayMDKASDPKEQEVLIDEQlhsPEGLAVDW 377
Cdd:COG3391  87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAG---PHGIAVDP 161

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61744467 378 VHKHIYWTDSGNKTIS--VATVDGGRRRTLFSRNL-SEPRAIAVDPLRGFMYWSDWGD 432
Cdd:COG3391 162 DGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGS 219
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 247-277 1.49e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.49e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 61744467 247 DIDECKDPDACS--QICVNYKGYFKCECYPGYE 277
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 316-351 1.60e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 61744467    316 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 351
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 568-605 1.12e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 61744467   568 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 605
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 333-377 1.71e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 1.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 61744467   333 NRIYWCDLSYRKIYSayMDKASDpKEQEVLIDEQLHSPEGLAVDW 377
Cdd:pfam00058   1 GRLYWTDSSLRASIS--SADLNG-SDRKTLFTDDLQHPNAIAVDP 42
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-463 1.84e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 64.87  E-value: 1.84e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61744467   423 GFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLD 463
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 360-402 1.10e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61744467    360 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 402
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 381-420 2.07e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 2.07e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 61744467   381 HIYWTDSGNK-TISVATVDGGRRRTLFSRNLSEPRAIAVDP 420
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 47-81 8.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 8.01e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 61744467  47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 403-446 1.45e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 1.45e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 61744467    403 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGdQAKIEKSGLNGVDR 446
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 447-489 4.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 4.14e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 61744467    447 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 85-117 2.01e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 2.01e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467     85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 47-78 2.66e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 2.66e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 61744467     47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE 78
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
169-204 3.32e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.32e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61744467   169 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 364-548 5.83e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 5.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 364 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRT-----LFSRNLSEPRAIAVDPlRGFMYWSDWGDQaKIEK 438
Cdd:cd05819  51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 439 SGLNGVDRQTLVSDNIEW-----PNGITLDlLSQRLYWVDSKLHQLSSIDfSGGNRKTLISSTDF----LSHPFGIAVFE 509
Cdd:cd05819 128 FDPDGEFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQVFD-PDGNFLTTFGSTGTgpgqFNYPTGIAVDS 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 61744467 510 D-KVFWTDLENEAIFSANRLNGLEISI-----LAENLNNPHDIVI 548
Cdd:cd05819 206 DgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 86-117 9.37e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 9.37e-09
                        10        20        30
                ....*....|....*....|....*....|..
gi 61744467  86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 170-204 9.46e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 9.46e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 61744467 170 CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 364-548 1.17e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.56  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 364 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRTLFSR-----NLSEPRAIAVDPlRGFMYWSDWG------- 431
Cdd:cd05819   4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFgsgdgQFNEPAGVAVDS-DGNLYVADTGnhriqkf 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 432 --DQAKIEKSGLNGVDRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFSGGNRKTL---ISSTDFLSHPFGIA 506
Cdd:cd05819  82 dpDGNFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgsgGSGPGQFNGPTGVA 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 61744467 507 VF-EDKVFWTDLENEAI--FSAnrlNGLEISILAEN------LNNPHDIVI 548
Cdd:cd05819 156 VDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
379-536 1.32e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 1.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 379 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNlSEPRAIAVDPLRGFMYWSDWGDQAkieksgLNGVDRQTL-VSDNI--- 454
Cdd:COG3391  79 GRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR------VSVIDTATGkVVATIpvg 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 455 EWPNGITLDLLSQRLYWVDSKLHQLS----SIDFSGGnrkTLISSTDFLSHPFGIAVFED--KVFWTDLENEaifSANRL 528
Cdd:COG3391 152 AGPHGIAVDPDGKRLYVANSGSNTVSvivsVIDTATG---KVVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGG 225


                ....*...
gi 61744467 529 NGlEISIL 536
Cdd:COG3391 226 SN-TVSVI 232
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
45-81 1.99e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.99e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 61744467    45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 510-550 2.97e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.85  E-value: 2.97e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 61744467   510 DKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVIFH 550
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 169-201 5.80e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 5.80e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467    169 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 201
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 467-509 6.71e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 6.71e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 61744467   467 QRLYWVDSKLHQ-LSSIDFSGGNRKTLIssTDFLSHPFGIAVFE 509
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
84-117 7.04e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 7.04e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 61744467    84 KTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 211-245 1.34e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61744467   211 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 245
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 364-516 2.87e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 52.32  E-value: 2.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 364 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN-----LSEPRAIAVDPlRGFMYWSDWGDQaKIEK 438
Cdd:cd05819  98 DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVDS-DGNIYVADTGNH-RIQV 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 439 SGLNGvDRQTLVSDNIEW------PNGITLDlLSQRLYWVDSKLHQLSSIDFSGGNRKTL---ISSTDFLSHPFGIAVFE 509
Cdd:cd05819 175 FDPDG-NFLTTFGSTGTGpgqfnyPTGIAVD-SDGNIYVADSGNNRVQVFDPDGAGFGGNgnfLGSDGQFNRPSGLAVDS 252


                ....*...
gi 61744467 510 D-KVFWTD 516
Cdd:cd05819 253 DgNLYVAD 260
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 127-163 9.44e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.66  E-value: 9.44e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 61744467 127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 366-448 7.38e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 48.05  E-value: 7.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 366 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATVDGGRRRTLFSR-----NLSEPRAIAVDPLrGFMYWSD-WGDqaKIEKS 439
Cdd:cd14956  11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86


                ....*....
gi 61744467 440 GLNGVDRQT 448
Cdd:cd14956  87 TLTGELQTI 95
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 333-522 1.33e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.29  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 333 NRIYWCDLSYRKIysaymdKASDPKEQEVLI-------DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGGRRRTL 405
Cdd:cd14963 112 GKLYVSDVKKHKV------IVFDLEGKLLLEfgkpgsePGELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKEL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 406 -----FSRNLSEPRAIAVDPlrgfmywsDWGdqakieksglngvdrqtlvsdniewpngitldllsqrLYWVDSKLHQLS 480
Cdd:cd14963 185 ngspdGKSGFVNPRGIAVDP--------DGN-------------------------------------LYVVDNLSHRVY 219

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 61744467 481 SIDFSGGNRKTLISS---TDFLSHPFGIAVFEDKVFW-TDLENEAI 522
Cdd:cd14963 220 VFDEQGKELFTFGGRgkdDGQFNLPNGLFIDDDGRLYvTDRENNRV 265
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 331-507 2.07e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 46.81  E-value: 2.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 331 ATNRIYWCDLSYRKIYSAymdkasDPKEQEV-LIDEQLHSPEGLAVD-----WVhkhiywTDSGNKtISVATVDGGRRRT 404
Cdd:COG3386  17 PDGRLYWVDIPGGRIHRY------DPDGGAVeVFAEPSGRPNGLAFDpdgrlLV------ADHGRG-LVRFDPADGEVTV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 405 L---FSRNLSEPRAIAVDPlRGFMYWSDWGDQA------KIEKSGlngvdRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 475
Cdd:COG3386  84 LadeYGKPLNRPNDGVVDP-DGRLYFTDMGEYLptgalyRVDPDG-----SLRVLADGLTFPNGIAFSPDGRTLYVADTG 157

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 61744467 476 LHQLSSIDFSG----GNRKTLISSTDFLSHPFGIAV 507
Cdd:COG3386 158 AGRIYRFDLDAdgtlGNRRVFADLPDGPGGPDGLAV 193
EGF_CA smart00179
Calcium-binding EGF-like domain;
247-277 2.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 2.59e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 61744467    247 DIDECKDPDACSQ--ICVNYKGYFKCECYPGYE 277
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
127-163 3.89e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 3.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 61744467   127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 163
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 127-160 4.56e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 4.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 61744467    127 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 160
Cdd:smart00192   2 CPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
298-432 1.19e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 298 TNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSayMDKASDPKEQEVLIDEQlhsPEGLAVDW 377
Cdd:COG3391  87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAG---PHGIAVDP 161

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61744467 378 VHKHIYWTDSGNKTIS--VATVDGGRRRTLFSRNL-SEPRAIAVDPLRGFMYWSDWGD 432
Cdd:COG3391 162 DGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGS 219
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 247-277 1.49e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.49e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 61744467 247 DIDECKDPDACS--QICVNYKGYFKCECYPGYE 277
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 316-351 1.60e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 61744467    316 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 351
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
369-473 2.32e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 2.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 369 SPEGLAVDWVHKHIYWTDSGNKTISVatVDGGRRRTLFSRNL-SEPRAIAVDPLRGFMYWSDWGDQ--AKIeksgLNGVD 445
Cdd:COG3391 111 GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSNtvSVI----VSVID 184

                        90       100       110
                ....*....|....*....|....*....|..
gi 61744467 446 RQTL-VSDNIEW---PNGITLDLLSQRLYWVD 473
Cdd:COG3391 185 TATGkVVATIPVgggPVGVAVSPDGRRLYVAN 216
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 568-605 1.12e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 1.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 61744467   568 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 605
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 333-377 1.71e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 1.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 61744467   333 NRIYWCDLSYRKIYSayMDKASDpKEQEVLIDEQLHSPEGLAVDW 377
Cdd:pfam00058   1 GRLYWTDSSLRASIS--SADLNG-SDRKTLFTDDLQHPNAIAVDP 42
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 363-569 3.26e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.95  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 363 IDEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDGG----RRRTLFSRNLSEPRAIAVDPLrgfmywsdwGDQAKIEK 438
Cdd:cd14961  94 VRKSFSLPWGVAVN-PSGEILVTDSEAGKLFVLTVDFKlgilKKGQKLCSQLCRPRFVAVSRL---------GAVAVTEH 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 439 SGLNGVDRQtlvsdniewpngitldllSQRLYWVDSKLHQLSSIDFSGGNrktlISSTDFLsHPFGIAV-FEDKVFWTDL 517
Cdd:cd14961 164 LFANGTRSS------------------STRVKVFSSGGQLLGQIDSFGLN----LVFPSLI-CASGVAFdSEGNVIVADT 220

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 61744467 518 ENEAIFSANRLNGleISILaenlnnphDIVIFHELKQPRApdaceLSVQPNG 569
Cdd:cd14961 221 GSGAILCLGKPEG--FPIL--------KPIVTQGLSRPVG-----LAVTPDG 257
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 366-522 9.26e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 38.67  E-value: 9.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 366 QLHSPEGLAVDwVHKHIYWTDSGNKTISVATVDG------GRRRTLFSRN-------LSEPRAIAVDPlRGFMYWSDWGD 432
Cdd:cd14953 130 QFNYPTGVAVD-AAGNLYVADTGNHRIRKITPDGvvttvaGTGGAGYAGDgpataaqFNNPTGVAVDA-AGNLYVADRGN 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61744467 433 QA--KIEKSGL------NGV----DRQTLVSDNIEWPNGITLDllSQ-RLYWVDSKLHQLSSIDFSGGNRKTLISSTDF- 498
Cdd:cd14953 208 HRirKITPDGVvttvagTGTagfsGDGGATAAQLNNPTGVAVD--AAgNLYVADSGNHRIRKITPAGVVTTVAGGGAGFs 285

                       170       180       190
                ....*....|....*....|....*....|....*
gi 61744467 499 ----------LSHPFGIAV-FEDKVFWTDLENEAI 522
Cdd:cd14953 286 gdggpatsaqFNNPTGVAVdAAGNLYVADTGNNRI 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH