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Conserved domains on  [gi|23199995|ref|NP_059998|]
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probable 18S rRNA (guanine-N(7))-methyltransferase isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 204-279 7.84e-21

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


:

Pssm-ID: 432656  Cd Length: 81  Bit Score: 84.22  E-value: 7.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995   204 LFSGP-STFIPEGLS-ENQDEVEPRESV-FTNERFPLRMSRRG--MVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRK 278
Cdd:pfam12589   1 LFVGGvQQQLPKGLGeDGEECSEEQNTVkYERRRRPRKKRKKKgkKAVKGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 23199995   279 P 279
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 42-184 1.03e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.73  E-value: 1.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  42 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG2226  13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23199995 118 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 184
Cdd:COG2226  90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 204-279 7.84e-21

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 84.22  E-value: 7.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995   204 LFSGP-STFIPEGLS-ENQDEVEPRESV-FTNERFPLRMSRRG--MVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRK 278
Cdd:pfam12589   1 LFVGGvQQQLPKGLGeDGEECSEEQNTVkYERRRRPRKKRKKKgkKAVKGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 23199995   279 P 279
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 42-184 1.03e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.73  E-value: 1.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  42 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG2226  13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23199995 118 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 184
Cdd:COG2226  90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-156 1.72e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.59  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995    58 LDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnan 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|....
gi 23199995   133 kksenPAKRLYCFFASLFSVLVRG 156
Cdd:pfam13649  77 -----PDPDLEAALREIARVLKPG 95
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 34-130 1.85e-12

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 65.55  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995   34 DIQTRMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMgQGIPFKP 113
Cdd:PRK10258  25 ELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDI-ESLPLAT 101

                         90
                 ....*....|....*..
gi 23199995  114 GTFDGCISISAVQWlCN 130
Cdd:PRK10258 102 ATFDLAWSNLAVQW-CG 117
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-164 2.30e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 2.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  57 LLDIGCGTGLSGSYL-SDEGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKPGTFDGCISISAVQWLcn 130
Cdd:cd02440   2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 23199995 131 ankksenpAKRLYCFFASLFSVLVRGSRAVLQLY 164
Cdd:cd02440  80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 35-153 2.66e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 59.22  E-value: 2.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995    35 IQTRMAGRALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEGHY--WVGLDISPAMLDEAVDREIEGDL-LLGDMGQgIP 110
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 23199995   111 FKPGTFDGCISISAVQWLCNANKksenpakrlycFFASLFSVL 153
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 204-279 7.84e-21

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 84.22  E-value: 7.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995   204 LFSGP-STFIPEGLS-ENQDEVEPRESV-FTNERFPLRMSRRG--MVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRK 278
Cdd:pfam12589   1 LFVGGvQQQLPKGLGeDGEECSEEQNTVkYERRRRPRKKRKKKgkKAVKGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 23199995   279 P 279
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 42-184 1.03e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.73  E-value: 1.03e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  42 RALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG2226  13 ALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDAED-LPFPDGSFD 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23199995 118 GCISISAVQWLcnankksENPAKrlycFFASLFSVLVRGSR-AVLQLYPENSEQLELIttqATKAGFS 184
Cdd:COG2226  90 LVISSFVLHHL-------PDPER----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
38-118 2.59e-15

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 72.34  E-value: 2.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  38 RMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQgIPFKPGTFD 117
Cdd:COG4976  33 LLAEELLARL--PPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLAD-LAEPDGRFD 109


                .
gi 23199995 118 G 118
Cdd:COG4976 110 L 110
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-156 1.72e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.59  E-value: 1.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995    58 LDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR----EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnan 132
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|....
gi 23199995   133 kksenPAKRLYCFFASLFSVLVRG 156
Cdd:pfam13649  77 -----PDPDLEAALREIARVLKPG 95
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 58-161 2.30e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 64.61  E-value: 2.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995    58 LDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDL--LLGDMGQgIPFKPGTFDGCISISAVQWLcnankks 135
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLtfVVGDAED-LPFPDNSFDLVLSSEVLHHV------- 72

                          90       100
                  ....*....|....*....|....*.
gi 23199995   136 ENPAKrlycFFASLFSVLVRGSRAVL 161
Cdd:pfam08241  73 EDPER----ALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 40-183 5.98e-13

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 66.09  E-value: 5.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  40 AGRALELLYLPENKPcyLLDIGCGTGLSGSYLSDEGHYWV-GLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKP 113
Cdd:COG0500  15 AALLALLERLPKGGR--VLDLGCGTGRNLLALAARFGGRViGIDLSPEAIALARARAAKAglgnvEFLVADLAELDPLPA 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995 114 GTFDGCISISAVQWLcnankkseNPAKRLYcFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGF 183
Cdd:COG0500  93 ESFDLVVAFGVLHHL--------PPEEREA-LLRELARALKPGGVLLLSASDAAAALSLARLLLLATASL 153
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 57-161 9.40e-13

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 63.88  E-value: 9.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  57 LLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR--EIEGDLLLGDMgQGIPFKPGTFDGCISISAVQWLcnankk 134
Cdd:COG2227  28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERaaELNVDFVQGDL-EDLPLEDGSFDLVICSEVLEHL------ 100

                        90       100
                ....*....|....*....|....*..
gi 23199995 135 sENPAKrlycFFASLFSVLVRGSRAVL 161
Cdd:COG2227 101 -PDPAA----LLRELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
58-162 1.22e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 1.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  58 LDIGCGTGLSGSYLSDE--GHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPfkPGTFDGCISISAVQWLcnankks 135
Cdd:COG4106   6 LDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDP--PEPFDLVVSNAALHWL------- 76

                        90       100
                ....*....|....*....|....*..
gi 23199995 136 ENPAKrlycFFASLFSVLVRGSRAVLQ 162
Cdd:COG4106  77 PDHAA----LLARLAAALAPGGVLAVQ 99
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 34-130 1.85e-12

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 65.55  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995   34 DIQTRMAGRALELLylPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMgQGIPFKP 113
Cdd:PRK10258  25 ELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDI-ESLPLAT 101

                         90
                 ....*....|....*..
gi 23199995  114 GTFDGCISISAVQWlCN 130
Cdd:PRK10258 102 ATFDLAWSNLAVQW-CG 117
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 36-162 6.15e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 59.56  E-value: 6.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  36 QTRMAGRALELLYLPENKPcyLLDIGCGTGLSGSYLSDE-GHYWVGLDISPAMLDEAVDR-EIEG-----DLLLGDMGQg 108
Cdd:COG2230  36 QEAKLDLILRKLGLKPGMR--VLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERaAEAGladrvEVRLADYRD- 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 23199995 109 iPFKPGTFDGCISISAVQWLCNANKKSenpakrlycFFASLFSVLVRGSRAVLQ 162
Cdd:COG2230 113 -LPADGQFDAIVSIGMFEHVGPENYPA---------YFAKVARLLKPGGRLLLH 156
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-164 2.30e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 2.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995  57 LLDIGCGTGLSGSYL-SDEGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDMGQGIPFKPGTFDGCISISAVQWLcn 130
Cdd:cd02440   2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 23199995 131 ankksenpAKRLYCFFASLFSVLVRGSRAVLQLY 164
Cdd:cd02440  80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 35-153 2.66e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 59.22  E-value: 2.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995    35 IQTRMAGRALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEGHY--WVGLDISPAMLDEAVDREIEGDL-LLGDMGQgIP 110
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 23199995   111 FKPGTFDGCISISAVQWLCNANKksenpakrlycFFASLFSVL 153
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
PRK08317 PRK08317
hypothetical protein; Provisional
 58-161 4.60e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 58.41  E-value: 4.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995   58 LDIGCGTGLSGSYLSD----EGHYwVGLDISPAMLDEAVDReIEGDLL-----LGDmGQGIPFKPGTFDGCISISAVQWL 128
Cdd:PRK08317  24 LDVGCGPGNDARELARrvgpEGRV-VGIDRSEAMLALAKER-AAGLGPnvefvRGD-ADGLPFPDGSFDAVRSDRVLQHL 100

                         90       100       110
                 ....*....|....*....|....*....|...
gi 23199995  129 cnankksENPAKRLycffASLFSVLVRGSRAVL 161
Cdd:PRK08317 101 -------EDPARAL----AEIARVLRPGGRVVV 122
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 58-128 4.01e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.67  E-value: 4.01e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23199995    58 LDIGCGTGLSGSYLSDEGHYW--VGLDISPAMLDEAVDREIEGDLLLGDM-----GQGIPFKPGTFDGCISISAVQWL 128
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeyTGLDISPAALEAARERLAALGLLNAVRvelfqLDLGELDPGSFDVVVASNVLHHL 78
BchM-ChlM TIGR02021
magnesium protoporphyrin O-methyltransferase; This model represents the ...
 35-94 3.05e-05

magnesium protoporphyrin O-methyltransferase; This model represents the S-adenosylmethionine-dependent O-methyltransferase responsible for methylation of magnesium protoporphyrin IX. This step is essentiasl for the biosynthesis of both chlorophyll and bacteriochlorophyll. This model encompasses two closely related clades, from cyanobacteria (and plants) where it is called ChlM and other photosynthetic bacteria where it is known as BchM. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273930 [Multi-domain]  Cd Length: 219  Bit Score: 44.02  E-value: 3.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23199995    35 IQTRMAGRALELLYLPENKPC--YLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR 94
Cdd:TIGR02021  35 REGRAAMRRKLLDWLPKDPLKgkRVLDAGCGTGLLSIELAKRGAIVKAVDISEQMVQMARNR 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 57-123 3.61e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.99  E-value: 3.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23199995   57 LLDIGCGTG-LSGSY---LSDEGHYWvGLDISPAMLDEAVDREIEG------DLLLGDmGQGIPFKPGTFDgCISIS 123
Cdd:PRK00216  55 VLDLACGTGdLAIALakaVGKTGEVV-GLDFSEGMLAVGREKLRDLglsgnvEFVQGD-AEALPFPDNSFD-AVTIA 128
PRK14968 PRK14968
putative methyltransferase; Provisional
 58-117 4.41e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.27  E-value: 4.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23199995   58 LDIGCGTGLSGSYLSDEGHYWVGLDISPamldEAVDREIEGDLLLGDMGQGI---------PFKPGTFD 117
Cdd:PRK14968  28 LEVGTGSGIVAIVAAKNGKKVVGVDINP----YAVECAKCNAKLNNIRNNGVevirsdlfePFRGDKFD 92
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 40-125 1.86e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.18  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995    40 AGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMldeaVDREIEGDLLLGDMGQGIPFKPGTFDgC 119
Cdd:pfam13489   9 LADLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIA----IERALLNVRFDQFDEQEAAVPAGKFD-V 83


                  ....*.
gi 23199995   120 ISISAV 125
Cdd:pfam13489  84 IVAREV 89
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 43-128 3.41e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 38.00  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199995   43 ALELL-YLPENKPCYLLDIGCGTGLSGSYLSDEghyW-----VGLDISPAMLDEAVDREIEGDLLLGDMGQgipFKPGTF 116
Cdd:PRK01683  20 ARDLLaRVPLENPRYVVDLGCGPGNSTELLVER---WpaariTGIDSSPAMLAEARSRLPDCQFVEADIAS---WQPPQA 93

                         90
                 ....*....|...
gi 23199995  117 DGCISISAV-QWL 128
Cdd:PRK01683  94 LDLIFANASlQWL 106
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 51-91 3.69e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 37.01  E-value: 3.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 23199995    51 ENKPCYLLDIGCGTG----LSGSYLSDEGHYwVGLDISPAMLDEA 91
Cdd:pfam13847   1 IDKGMRVLDLGCGTGhlsfELAEELGPNAEV-VGIDISEEAIEKA 44
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 24-94 4.80e-03

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 37.51  E-value: 4.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23199995   24 RKYVRNSRmidiqTRMAGRALEllYLPEN---KPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDR 94
Cdd:PRK07580  38 RATVRAGH-----QRMRDTVLS--WLPADgdlTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARER 104
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
58-123 5.91e-03

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 37.42  E-value: 5.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23199995    58 LDIGCGTGLSGSYLSD---EGHYWVGLDISPAMLDEAVDREIEG-----DLLLGDmGQGIPFKPGTFDgCISIS 123
Cdd:pfam01209  47 LDVAGGTGDWTFGLSDsagSSGKVVGLDINENMLKEGEKKAKEEgkyniEFLQGN-AEELPFEDDSFD-IVTIS 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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