NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|269846904|ref|NP_060085|]
View 

non-structural maintenance of chromosomes element 4 homolog A isoform 1 [Homo sapiens]

Protein Classification

non-structural maintenance of chromosomes element 4 family protein( domain architecture ID 10634160)

non-structural maintenance of chromosomes (non-SMC) element 4 (NSE4) family protein has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
285-374 3.77e-35

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


:

Pssm-ID: 462585  Cd Length: 89  Bit Score: 124.18  E-value: 3.77e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846904  285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWEEIV 364
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKELI 79
                          90
                  ....*....|
gi 269846904  365 KTFEISEPVI 374
Cdd:pfam08743  80 EAFDITEPMI 89
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
133-187 2.01e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


:

Pssm-ID: 464708  Cd Length: 56  Bit Score: 58.76  E-value: 2.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269846904  133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
285-374 3.77e-35

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 124.18  E-value: 3.77e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846904  285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWEEIV 364
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKELI 79
                          90
                  ....*....|
gi 269846904  365 KTFEISEPVI 374
Cdd:pfam08743  80 EAFDITEPMI 89
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
231-374 1.76e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 69.65  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846904 231 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 310
Cdd:COG5125  130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269846904 311 IIRDGFARIRLDQDRLPVIEPVSIneenegFEHNTqvrNQGIIALSYRDWEEIVKTFEISEPVI 374
Cdd:COG5125  204 LLKEGKAFLEFDEDGTLYVVSEGS------EGAST---GHLVVEMTYDEYLRIVERMGISKAMI 258
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
133-187 2.01e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


Pssm-ID: 464708  Cd Length: 56  Bit Score: 58.76  E-value: 2.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269846904  133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Name Accession Description Interval E-value
Nse4_C pfam08743
Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges ...
285-374 3.77e-35

Nse4 C-terminal; Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5.


Pssm-ID: 462585  Cd Length: 89  Bit Score: 124.18  E-value: 3.77e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846904  285 PMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQvRNQGIIALSYRDWEEIV 364
Cdd:pfam08743   1 PINLFKFVINPKSFAQTVENLFYLSFLVKDGRVGIELDEDGLPVLEPVAPPEEEEAKEGGVS-RNQAVFSLDMKTWKELI 79
                          90
                  ....*....|
gi 269846904  365 KTFEISEPVI 374
Cdd:pfam08743  80 EAFDITEPMI 89
COG5125 COG5125
Uncharacterized conserved protein [Function unknown];
231-374 1.76e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227454 [Multi-domain]  Cd Length: 259  Bit Score: 69.65  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269846904 231 PRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQtyfredPDTPMSFFDFVVDPHSFPRTVENIFHVSF 310
Cdd:COG5125  130 PSRRRAQSQRSRQTLPETEVPTNITRQEDSVEEPKILAQISRLLA------EKGRTNYFKFIIDPRSFSKTIENLFYLSF 203
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269846904 311 IIRDGFARIRLDQDRLPVIEPVSIneenegFEHNTqvrNQGIIALSYRDWEEIVKTFEISEPVI 374
Cdd:COG5125  204 LLKEGKAFLEFDEDGTLYVVSEGS------EGAST---GHLVVEMTYDEYLRIVERMGISKAMI 258
Nse4-Nse3_bdg pfam15412
Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that ...
133-187 2.01e-11

Binding domain of Nse4/EID3 to Nse3-MAGE; This family includes Nse4 and EID3 members, that bind over this region to the Nse3 pocket, in MAGE family pfam01454.


Pssm-ID: 464708  Cd Length: 56  Bit Score: 58.76  E-value: 2.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269846904  133 DAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDS 187
Cdd:pfam15412   1 DSRLLVLASDLGAEKARNLKSGGGGFDVDEFVSKLKTFMGGNRLEGAGEEDDDDD 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH