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Conserved domains on  [gi|291190781|ref|NP_060110|]
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F-actin-uncapping protein LRRC16A isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 786-1078 3.34e-122

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


:

Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 381.81  E-value: 3.34e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   786 AENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLA 865
Cdd:pfam16000    1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   866 DHFSRRGKTLPQQESL-EIELAEEKPVKRSIITVEeltEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEM-EFDLD 943
Cdd:pfam16000   81 RHLSQRGRTLLEPESLpDGDRPESSPLGPGKRHEG---EIERLEELETPMATLKSKRKSIHSRKLRPVSVAFSVsELDLD 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   944 KALEEVPIHIED----PPFPSLRQEK------RSSGFISELPSeEGKKLEHFTKLRPKRNKKQQPTQAAVCAAniVSQDG 1013
Cdd:pfam16000  158 KAPEEVPIHVEDassgPPLPSSSPSEpelsasESLDSLSELPT-EGQKLQHLTKGRPKRNKTRAPTRPPGKVG--PAQDG 234

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  1014 EQNGLMGRVDEGVDEFFTKKVTKMDSKkwSTRGSESHELNEGGDEKKKRDSRKsSGFLNLIKSRS 1078
Cdd:pfam16000  235 EQNGLSGRVDEGLEDFFSKKVIKLSTP--TSPTSEPSSSSLFPDSPKKRKKRK-SGFFNFIKPRS 296
Carm_PH pfam17888
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ...
 38-119 9.91e-36

Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.


:

Pssm-ID: 436119  Cd Length: 94  Bit Score: 130.87  E-value: 9.91e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781    38 GDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKI 117
Cdd:pfam17888   13 GDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHILTALKKI 92


                   ..
gi 291190781   118 FP 119
Cdd:pfam17888   93 FP 94
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 429-658 2.88e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.00  E-value: 2.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  429 INLSGTKLSPEPLKALLLGLACNHNLKGvsLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL-ESDLSTLIVWLSK 507
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTT--LWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIgDEGVIALAEALKN 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  508 NRSIQHLALGKN---------FNNM--KSKNLTPVLDNLVQmIQDE-----------ESPLQSLSLADSKLKTEVTI-II 564
Cdd:COG5238   263 NTTVETLYLSGNqigaegaiaLAKAlqGNTTLTSLDLSVNR-IGDEgaialaeglqgNKTLHTLNLAYNGIGAQGAIaLA 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  565 NALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKN--YTLRFMPIPMYDASQA 642
Cdd:COG5238   342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNrlHTLILDGNLIGAEAQQ 421

                         250
                  ....*....|....*.
gi 291190781  643 lktnpeKTEDALQKIE 658
Cdd:COG5238   422 ------RLEQLLERIK 431
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 229-373 1.56e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 70.08  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  229 KLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNsgLHTINLAGNPLEDRGVSSLSIQFAKLPKgLK 308
Cdd:cd00116   148 RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN--LEVLDLNNNGLTDEGASALAETLASLKS-LE 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  309 HLNLSKTSLSPKGVNSLsqsLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLS 373
Cdd:cd00116   225 VLNLGDNNLTDAGAAAL---ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLR 286
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1182-1320 1.26e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781 1182 AQKKLgndAVSQDSSSPALSGVERSDGGGAVPKLHPGLPENRFGLGTPEKNTKA-----EPKAEAGSRSRSSSSTPTSPK 1256
Cdd:PTZ00449  492 SKKKL---APIEEEDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEpkeggKPGETKEGEVGKKPGPAKEHK 568

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781 1257 PllqSPKPSLAARPVIPQKPRTASRPDDiPDSPSSPKVALLP--------PVLKKVP-SDKERDGQSSPQ--PSP 1320
Cdd:PTZ00449  569 P---SKIPTLSKKPEFPKDPKHPKDPEE-PKKPKRPRSAQRPtrpkspklPELLDIPkSPKRPESPKSPKrpPPP 639
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 786-1078 3.34e-122

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 381.81  E-value: 3.34e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   786 AENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLA 865
Cdd:pfam16000    1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   866 DHFSRRGKTLPQQESL-EIELAEEKPVKRSIITVEeltEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEM-EFDLD 943
Cdd:pfam16000   81 RHLSQRGRTLLEPESLpDGDRPESSPLGPGKRHEG---EIERLEELETPMATLKSKRKSIHSRKLRPVSVAFSVsELDLD 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   944 KALEEVPIHIED----PPFPSLRQEK------RSSGFISELPSeEGKKLEHFTKLRPKRNKKQQPTQAAVCAAniVSQDG 1013
Cdd:pfam16000  158 KAPEEVPIHVEDassgPPLPSSSPSEpelsasESLDSLSELPT-EGQKLQHLTKGRPKRNKTRAPTRPPGKVG--PAQDG 234

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  1014 EQNGLMGRVDEGVDEFFTKKVTKMDSKkwSTRGSESHELNEGGDEKKKRDSRKsSGFLNLIKSRS 1078
Cdd:pfam16000  235 EQNGLSGRVDEGLEDFFSKKVIKLSTP--TSPTSEPSSSSLFPDSPKKRKKRK-SGFFNFIKPRS 296
Carm_PH pfam17888
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ...
 38-119 9.91e-36

Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.


Pssm-ID: 436119  Cd Length: 94  Bit Score: 130.87  E-value: 9.91e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781    38 GDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKI 117
Cdd:pfam17888   13 GDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHILTALKKI 92


                   ..
gi 291190781   118 FP 119
Cdd:pfam17888   93 FP 94
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 429-658 2.88e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.00  E-value: 2.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  429 INLSGTKLSPEPLKALLLGLACNHNLKGvsLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL-ESDLSTLIVWLSK 507
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTT--LWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIgDEGVIALAEALKN 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  508 NRSIQHLALGKN---------FNNM--KSKNLTPVLDNLVQmIQDE-----------ESPLQSLSLADSKLKTEVTI-II 564
Cdd:COG5238   263 NTTVETLYLSGNqigaegaiaLAKAlqGNTTLTSLDLSVNR-IGDEgaialaeglqgNKTLHTLNLAYNGIGAQGAIaLA 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  565 NALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKN--YTLRFMPIPMYDASQA 642
Cdd:COG5238   342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNrlHTLILDGNLIGAEAQQ 421

                         250
                  ....*....|....*.
gi 291190781  643 lktnpeKTEDALQKIE 658
Cdd:COG5238   422 ------RLEQLLERIK 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 229-373 1.56e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 70.08  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  229 KLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNsgLHTINLAGNPLEDRGVSSLSIQFAKLPKgLK 308
Cdd:cd00116   148 RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN--LEVLDLNNNGLTDEGASALAETLASLKS-LE 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  309 HLNLSKTSLSPKGVNSLsqsLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLS 373
Cdd:cd00116   225 VLNLGDNNLTDAGAAAL---ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLR 286
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 281-595 2.31e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 69.69  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  281 INLAGNPLEDRGVSSLSiQFAKLPKGLKHLNLS--KTSLSPKGVNSLSQSLSANPLtastLVHLDLSGNVLrGDDLSHMY 358
Cdd:cd00116    28 LRLEGNTLGEEAAKALA-SALRPQPSLKELCLSlnETGRIPRGLQSLLQGLTKGCG----LQELDLSDNAL-GPDGCGVL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  359 NFLAQPNAIVHLDLSNTECS---LDMVCGALlRGCLQYLAVLNLSRTVFSHRKGKEVppsfKQFFSSSLALMHINLSGTK 435
Cdd:cd00116   102 ESLLRSSSLQELKLNNNGLGdrgLRLLAKGL-KDLPPALEKLVLGRNRLEGASCEAL----AKALRANRDLKELNLANNG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  436 LSPEPLKALLLGLACNHNLKgvSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLesdlstlivwlsKNRSIQHLA 515
Cdd:cd00116   177 IGDAGIRALAEGLKANCNLE--VLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL------------TDAGAAALA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  516 LGknfnnMKSKNLTpvldnlvqmiqdeespLQSLSLADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKA 594
Cdd:cd00116   243 SA-----LLSPNIS----------------LLTLSLSCNDITDDgAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301


                  .
gi 291190781  595 L 595
Cdd:cd00116   302 L 302
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 244-352 3.75e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 3.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  244 RSNRLEELVLENAGLRTDFAQKLASALAHNPNsgLHTINLAGNPLEDRGVSSLsIQFAKLPKGLKHLNLSKTSLSPKGVN 323
Cdd:COG5238   318 GNKTLHTLNLAYNGIGAQGAIALAKALQENTT--LHSLDLSDNQIGDEGAIAL-AKYLEGNTTLRELNLGKNNIGKQGAE 394

                          90       100
                  ....*....|....*....|....*....
gi 291190781  324 SLSQSLSANPLTAstlvhLDLSGNVLRGD 352
Cdd:COG5238   395 ALIDALQTNRLHT-----LILDGNLIGAE 418
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 231-583 1.13e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  231 STDVCEQILRVVSRSNRLEELVLENaglrTDFAQKLASALAHNPNsgLHTINLAGNPLEdrgvSSLSIQFAKLPKGLKHL 310
Cdd:PLN00113   54 SADVCLWQGITCNNSSRVVSIDLSG----KNISGKISSAIFRLPY--IQTINLSNNQLS----GPIPDDIFTTSSSLRYL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  311 NLSKTSLS---PKGVNSLSQSL--SANPLTA---------STLVHLDLSGNVLRGddlsHMYNFLAQPNAIVHLDLSNTE 376
Cdd:PLN00113  124 NLSNNNFTgsiPRGSIPNLETLdlSNNMLSGeipndigsfSSLKVLDLGGNVLVG----KIPNSLTNLTSLEFLTLASNQ 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  377 C--SLDMVCGALLRGCLQYLAVLNLSrtvfshrkgKEVPPSFKQFFS-SSLALMHINLSGtklsPEPlkalllglacnhn 453
Cdd:PLN00113  200 LvgQIPRELGQMKSLKWIYLGYNNLS---------GEIPYEIGGLTSlNHLDLVYNNLTG----PIP------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  454 lkgVSL-DLSNCELRSGGAQVLEGCIA----EIHNITSLDISDNGLESDLSTLIVWLsKNRSIQHLalgknFNNMKSKNL 528
Cdd:PLN00113  254 ---SSLgNLKNLQYLFLYQNKLSGPIPpsifSLQKLISLDLSDNSLSGEIPELVIQL-QNLEILHL-----FSNNFTGKI 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  529 TPVLDNLVQmiqdeespLQSLSLADSKLKTEvtiIINALGSNTSLTKVDISGNGM 583
Cdd:PLN00113  325 PVALTSLPR--------LQVLQLWSNKFSGE---IPKNLGKHNNLTVLDLSTNNL 368
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1182-1320 1.26e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781 1182 AQKKLgndAVSQDSSSPALSGVERSDGGGAVPKLHPGLPENRFGLGTPEKNTKA-----EPKAEAGSRSRSSSSTPTSPK 1256
Cdd:PTZ00449  492 SKKKL---APIEEEDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEpkeggKPGETKEGEVGKKPGPAKEHK 568

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781 1257 PllqSPKPSLAARPVIPQKPRTASRPDDiPDSPSSPKVALLP--------PVLKKVP-SDKERDGQSSPQ--PSP 1320
Cdd:PTZ00449  569 P---SKIPTLSKKPEFPKDPKHPKDPEE-PKKPKRPRSAQRPtrpkspklPELLDIPkSPKRPESPKSPKrpPPP 639
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 786-1078 3.34e-122

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 381.81  E-value: 3.34e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   786 AENLCPNVMKKAHIRQDLIHASTEKISIPRTFVKNVLLEQSGIDILNKISEVKLTVASFLSDRIVDEILDALSHCHHKLA 865
Cdd:pfam16000    1 AESLCPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLLEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   866 DHFSRRGKTLPQQESL-EIELAEEKPVKRSIITVEeltEIERLEDLDTCMMTPKSKRKSIHSRMLRPVSRAFEM-EFDLD 943
Cdd:pfam16000   81 RHLSQRGRTLLEPESLpDGDRPESSPLGPGKRHEG---EIERLEELETPMATLKSKRKSIHSRKLRPVSVAFSVsELDLD 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781   944 KALEEVPIHIED----PPFPSLRQEK------RSSGFISELPSeEGKKLEHFTKLRPKRNKKQQPTQAAVCAAniVSQDG 1013
Cdd:pfam16000  158 KAPEEVPIHVEDassgPPLPSSSPSEpelsasESLDSLSELPT-EGQKLQHLTKGRPKRNKTRAPTRPPGKVG--PAQDG 234

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  1014 EQNGLMGRVDEGVDEFFTKKVTKMDSKkwSTRGSESHELNEGGDEKKKRDSRKsSGFLNLIKSRS 1078
Cdd:pfam16000  235 EQNGLSGRVDEGLEDFFSKKVIKLSTP--TSPTSEPSSSSLFPDSPKKRKKRK-SGFFNFIKPRS 296
Carm_PH pfam17888
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ...
 38-119 9.91e-36

Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.


Pssm-ID: 436119  Cd Length: 94  Bit Score: 130.87  E-value: 9.91e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781    38 GDKVENKVLVLTSCRAFLVTARIPTKLELTFSYLEIHGVVCSKSAQMIVETEKCSISMKMASPEDVSEVLAHIGTCLRKI 117
Cdd:pfam17888   13 GDKVEDRILVLTPWRLFLLSAKVPTKVERTFHFLEIRAINSRNPNQVIVETDKSNYSLKLASEEDVDHVVGHILTALKKI 92


                   ..
gi 291190781   118 FP 119
Cdd:pfam17888   93 FP 94
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 429-658 2.88e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.00  E-value: 2.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  429 INLSGTKLSPEPLKALLLGLACNHNLKGvsLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL-ESDLSTLIVWLSK 507
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTT--LWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIgDEGVIALAEALKN 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  508 NRSIQHLALGKN---------FNNM--KSKNLTPVLDNLVQmIQDE-----------ESPLQSLSLADSKLKTEVTI-II 564
Cdd:COG5238   263 NTTVETLYLSGNqigaegaiaLAKAlqGNTTLTSLDLSVNR-IGDEgaialaeglqgNKTLHTLNLAYNGIGAQGAIaLA 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  565 NALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKN--YTLRFMPIPMYDASQA 642
Cdd:COG5238   342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNrlHTLILDGNLIGAEAQQ 421

                         250
                  ....*....|....*.
gi 291190781  643 lktnpeKTEDALQKIE 658
Cdd:COG5238   422 ------RLEQLLERIK 431
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 250-624 1.17e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.91  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  250 ELVLENAGLRTDFAQKLASALAH----NPNSGLHTINLAGNPLEDRGVSSLSIQFAKlPKGLKHLNLSKTSLSPKGVNSL 325
Cdd:COG5238   150 PLGGNAVHLLGLAARLGLLAAISmakaLQNNSVETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKRNPIGDEGAEIL 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  326 SQSLSANPltasTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDlsntecsldmvcgallrgclqylavlnlsrtvfs 405
Cdd:COG5238   229 AEALKGNK----SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLY---------------------------------- 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  406 hrkgkevppsfkqffssslalmhinLSGTKLSPEPLKALLLGLACNHNLKgvSLDLSNCELRSGGAQVLEGCIAEIHNIT 485
Cdd:COG5238   271 -------------------------LSGNQIGAEGAIALAKALQGNTTLT--SLDLSVNRIGDEGAIALAEGLQGNKTLH 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  486 SLDISDNGLESDLSTLIvwlsknrsIQHLALGKNfnnmksknltpvldnlvqmiqdeespLQSLSLADSKLKTE-VTIII 564
Cdd:COG5238   324 TLNLAYNGIGAQGAIAL--------AKALQENTT--------------------------LHSLDLSDNQIGDEgAIALA 369

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  565 NALGSNTSLTKVDISGNGMGDMGAKMLAKALQINtKLRTVIWDKNNITAQGFQDIAVAME 624
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 441-651 6.16e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 75.60  E-value: 6.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  441 LKALLLGLACNHNLKGV------SLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGL-ESDLSTLIVWLSKNRSIQH 513
Cdd:COG5238   161 LAARLGLLAAISMAKALqnnsveTVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgDEGAEILAEALKGNKSLTT 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  514 LALGKNfnNMKSKNLTPVLDNLvqmiqDEESPLQSLSLADSKLKTEVTI-IINALGSNTSLTKVDISGNGMGDMGAKMLA 592
Cdd:COG5238   241 LDLSNN--QIGDEGVIALAEAL-----KNNTTVETLYLSGNQIGAEGAIaLAKALQGNTTLTSLDLSVNRIGDEGAIALA 313

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 291190781  593 KALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRF---MPIPMYDAS-----QALKTNPEKTE 651
Cdd:COG5238   314 EGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSldlSDNQIGDEGaialaKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 451-630 7.42e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 72.52  E-value: 7.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  451 NHNLKGV-SLDLSNCELRSGGAQVLEGCIAEI-HNITSLDISDNGLESD-LSTLIVWLSKNRSIQHLALGKNfnNMKSKN 527
Cdd:COG5238   147 LKDPLGGnAVHLLGLAARLGLLAAISMAKALQnNSVETVYLGCNQIGDEgIEELAEALTQNTTVTTLWLKRN--PIGDEG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  528 LtpvlDNLVQMIQDEESpLQSLSLADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIW 606
Cdd:COG5238   225 A----EILAEALKGNKS-LTTLDLSNNQIGDEgVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDL 299

                         170       180
                  ....*....|....*....|....
gi 291190781  607 DKNNITAQGFQDIAVAMEKNYTLR 630
Cdd:COG5238   300 SVNRIGDEGAIALAEGLQGNKTLH 323
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 229-373 1.56e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 70.08  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  229 KLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNsgLHTINLAGNPLEDRGVSSLSIQFAKLPKgLK 308
Cdd:cd00116   148 RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN--LEVLDLNNNGLTDEGASALAETLASLKS-LE 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  309 HLNLSKTSLSPKGVNSLsqsLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLS 373
Cdd:cd00116   225 VLNLGDNNLTDAGAAAL---ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLR 286
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 281-595 2.31e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 69.69  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  281 INLAGNPLEDRGVSSLSiQFAKLPKGLKHLNLS--KTSLSPKGVNSLSQSLSANPLtastLVHLDLSGNVLrGDDLSHMY 358
Cdd:cd00116    28 LRLEGNTLGEEAAKALA-SALRPQPSLKELCLSlnETGRIPRGLQSLLQGLTKGCG----LQELDLSDNAL-GPDGCGVL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  359 NFLAQPNAIVHLDLSNTECS---LDMVCGALlRGCLQYLAVLNLSRTVFSHRKGKEVppsfKQFFSSSLALMHINLSGTK 435
Cdd:cd00116   102 ESLLRSSSLQELKLNNNGLGdrgLRLLAKGL-KDLPPALEKLVLGRNRLEGASCEAL----AKALRANRDLKELNLANNG 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  436 LSPEPLKALLLGLACNHNLKgvSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLesdlstlivwlsKNRSIQHLA 515
Cdd:cd00116   177 IGDAGIRALAEGLKANCNLE--VLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL------------TDAGAAALA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  516 LGknfnnMKSKNLTpvldnlvqmiqdeespLQSLSLADSKLKTE-VTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKA 594
Cdd:cd00116   243 SA-----LLSPNIS----------------LLTLSLSCNDITDDgAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301


                  .
gi 291190781  595 L 595
Cdd:cd00116   302 L 302
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
310-634 2.90e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  310 LNLSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTECSLDmvcgallrg 389
Cdd:COG4886    41 SLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN--------- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  390 cLQYLAVLNLSRTvfshrKGKEVPPSFKQFFSsslaLMHINLSGTKLS--PEPLKALllglacnHNLKgvSLDLSNCELR 467
Cdd:COG4886   112 -LTNLESLDLSGN-----QLTDLPEELANLTN----LKELDLSNNQLTdlPEPLGNL-------TNLK--SLDLSNNQLT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  468 SggaqvLEGCIAEIHNITSLDISDNGLeSDLSTlivWLSKNRSIQHLALGKN--------FNNMKskNLT---------- 529
Cdd:COG4886   173 D-----LPEELGNLTNLKELDLSNNQI-TDLPE---PLGNLTNLEELDLSGNqltdlpepLANLT--NLEtldlsnnqlt 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  530 --PVLDNLVQmiqdeespLQSLSLADSKLKTevtiiINALGSNTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWD 607
Cdd:COG4886   242 dlPELGNLTN--------LEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                         330       340
                  ....*....|....*....|....*..
gi 291190781  608 KNNITAQGFQDIAVAMEKNYTLRFMPI 634
Cdd:COG4886   309 NLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 221-466 4.85e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 65.84  E-value: 4.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  221 TKLSSKDLKLSTDVCeQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPnSGLHTINLAGNPLEDRGVSSLSIQF 300
Cdd:cd00116    84 QELDLSDNALGPDGC-GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLP-PALEKLVLGRNRLEGASCEALAKAL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  301 AKLPKgLKHLNLSKTSLSPKGVNSLSQSLSANPLtastLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNteCSLD 380
Cdd:cd00116   162 RANRD-LKELNLANNGIGDAGIRALAEGLKANCN----LEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD--NNLT 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  381 MVCGALL----RGCLQYLAVLNLSRTVFSHRKGKevppSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNHNlKG 456
Cdd:cd00116   235 DAGAAALasalLSPNISLLTLSLSCNDITDDGAK----DLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN-EL 309

                         250
                  ....*....|
gi 291190781  457 VSLDLSNCEL 466
Cdd:cd00116   310 ESLWVKDDSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 244-352 3.75e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 3.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  244 RSNRLEELVLENAGLRTDFAQKLASALAHNPNsgLHTINLAGNPLEDRGVSSLsIQFAKLPKGLKHLNLSKTSLSPKGVN 323
Cdd:COG5238   318 GNKTLHTLNLAYNGIGAQGAIALAKALQENTT--LHSLDLSDNQIGDEGAIAL-AKYLEGNTTLRELNLGKNNIGKQGAE 394

                          90       100
                  ....*....|....*....|....*....
gi 291190781  324 SLSQSLSANPLTAstlvhLDLSGNVLRGD 352
Cdd:COG5238   395 ALIDALQTNRLHT-----LILDGNLIGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 217-481 4.24e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 4.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  217 NQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQKLASALAHNPNsgLHTINLAGNPLEDRGVSSL 296
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS--LTTLDLSNNQIGDEGVIAL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  297 sIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPltasTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNte 376
Cdd:COG5238   257 -AEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNT----TLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAY-- 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  377 CSLDMVCGALLRGCLQY---LAVLNLSrtvfSHRKGKEVPPSFKQFFSSSLALMHINLSGTKLSPEPLKALLLGLACNhN 453
Cdd:COG5238   330 NGIGAQGAIALAKALQEnttLHSLDLS----DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-R 404

                         250       260
                  ....*....|....*....|....*...
gi 291190781  454 LKgvSLDLSNCELRSGGAQVLEGCIAEI 481
Cdd:COG5238   405 LH--TLILDGNLIGAEAQQRLEQLLERI 430
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 280-632 1.06e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.60  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  280 TINLAGNPLEDRGVSSLsiqFAKLPKgLKHLNLSKTSLSPKGVNSLSQSLSANPltasTLVHLDLSGNVLRGDD--LSHM 357
Cdd:cd00116     2 QLSLKGELLKTERATEL---LPKLLC-LQVLRLEGNTLGEEAAKALASALRPQP----SLKELCLSLNETGRIPrgLQSL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  358 YNFLAQPNAIVHLDLSNTECSLDMVcgALLRGCLQylavlnlsrtvfshrkgkevppsfkqffSSSLALMHINLSGTKLS 437
Cdd:cd00116    74 LQGLTKGCGLQELDLSDNALGPDGC--GVLESLLR----------------------------SSSLQELKLNNNGLGDR 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  438 PEPLKALLLgLACNHNLKgvSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLstlivwlsknrsIQHLALG 517
Cdd:cd00116   124 GLRLLAKGL-KDLPPALE--KLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG------------IRALAEG 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  518 knfnnMKsknltpvldnlvqmiqdEESPLQSLSLADSKL-KTEVTIIINALGSNTSLTKVDISGNGMGDMGAKMLAKAL- 595
Cdd:cd00116   189 -----LK-----------------ANCNLEVLDLNNNGLtDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALl 246

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 291190781  596 QINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFM 632
Cdd:cd00116   247 SPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLEL 283
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 457-647 4.96e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.59  E-value: 4.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  457 VSLDLSNCELRSGGAQVLEGCIAEIHNITSLDISDNGLESDLSTLIVWLS---KNRSIQHLALgknFNNMKSKNLTPVLD 533
Cdd:cd00116    26 QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQgltKGCGLQELDL---SDNALGPDGCGVLE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  534 NLVQmiqdeESPLQSLSLADSKL-KTEVTIIINALGSNT-SLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNI 611
Cdd:cd00116   103 SLLR-----SSSLQELKLNNNGLgDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGI 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 291190781  612 TAQGFQDIAVAMEKNYTLR--------FMPIPMYDASQALKTNP 647
Cdd:cd00116   178 GDAGIRALAEGLKANCNLEvldlnnngLTDEGASALAETLASLK 221
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 187-347 1.52e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.57  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  187 LTQDT--RELNLQDfSHLDHRDLIPIIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEELVLENAGLRTDFAQ 264
Cdd:COG5238   204 LTQNTtvTTLWLKR-NPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAI 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  265 KLASALAHNPNsgLHTINLAGNPLEDRGVSSLsIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSANPltasTLVHLDL 344
Cdd:COG5238   283 ALAKALQGNTT--LTSLDLSVNRIGDEGAIAL-AEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENT----TLHSLDL 355


                  ...
gi 291190781  345 SGN 347
Cdd:COG5238   356 SDN 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 231-583 1.13e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  231 STDVCEQILRVVSRSNRLEELVLENaglrTDFAQKLASALAHNPNsgLHTINLAGNPLEdrgvSSLSIQFAKLPKGLKHL 310
Cdd:PLN00113   54 SADVCLWQGITCNNSSRVVSIDLSG----KNISGKISSAIFRLPY--IQTINLSNNQLS----GPIPDDIFTTSSSLRYL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  311 NLSKTSLS---PKGVNSLSQSL--SANPLTA---------STLVHLDLSGNVLRGddlsHMYNFLAQPNAIVHLDLSNTE 376
Cdd:PLN00113  124 NLSNNNFTgsiPRGSIPNLETLdlSNNMLSGeipndigsfSSLKVLDLGGNVLVG----KIPNSLTNLTSLEFLTLASNQ 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  377 C--SLDMVCGALLRGCLQYLAVLNLSrtvfshrkgKEVPPSFKQFFS-SSLALMHINLSGtklsPEPlkalllglacnhn 453
Cdd:PLN00113  200 LvgQIPRELGQMKSLKWIYLGYNNLS---------GEIPYEIGGLTSlNHLDLVYNNLTG----PIP------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781  454 lkgVSL-DLSNCELRSGGAQVLEGCIA----EIHNITSLDISDNGLESDLSTLIVWLsKNRSIQHLalgknFNNMKSKNL 528
Cdd:PLN00113  254 ---SSLgNLKNLQYLFLYQNKLSGPIPpsifSLQKLISLDLSDNSLSGEIPELVIQL-QNLEILHL-----FSNNFTGKI 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 291190781  529 TPVLDNLVQmiqdeespLQSLSLADSKLKTEvtiIINALGSNTSLTKVDISGNGM 583
Cdd:PLN00113  325 PVALTSLPR--------LQVLQLWSNKFSGE---IPKNLGKHNNLTVLDLSTNNL 368
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1182-1320 1.26e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781 1182 AQKKLgndAVSQDSSSPALSGVERSDGGGAVPKLHPGLPENRFGLGTPEKNTKA-----EPKAEAGSRSRSSSSTPTSPK 1256
Cdd:PTZ00449  492 SKKKL---APIEEEDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEpkeggKPGETKEGEVGKKPGPAKEHK 568

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190781 1257 PllqSPKPSLAARPVIPQKPRTASRPDDiPDSPSSPKVALLP--------PVLKKVP-SDKERDGQSSPQ--PSP 1320
Cdd:PTZ00449  569 P---SKIPTLSKKPEFPKDPKHPKDPEE-PKKPKRPRSAQRPtrpkspklPELLDIPkSPKRPESPKSPKrpPPP 639
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1089-1341 2.33e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781 1089 TEEPSSPKGAvrSPPVDCPRKDTKAAEHNGNSERIEEIKTPDSFEESQGEEIGKVERSDSKSSPQAGRRYGVQVMGSGLL 1168
Cdd:PHA03307  182 TARAPSSPPA--EPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPR 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781 1169 AEMKAKQEKRAACAqkklGNDAVSQDSSSPALSGVERSDGGGAVPK--LHPGLPENRFGLGTPEKNTKAEPKAEAGSRSR 1246
Cdd:PHA03307  260 PAPITLPTRIWEAS----GWNGPSSRPGPASSSSSPRERSPSPSPSspGSGPAPSSPRASSSSSSSRESSSSSTSSSSES 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190781 1247 SSSSTPTSPKPLLQSPKPSLAARPVIPQKPRTASRPDDIPDSPSSPKVALLPPVLKKVPSDKERdGQSSPQPSPRTFSQE 1326
Cdd:PHA03307  336 SRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRAR-RRDATGRFPAGRPRP 414

                         250
                  ....*....|....*
gi 291190781 1327 VSRRSWGQQAQEYQE 1341
Cdd:PHA03307  415 SPLDAGAASGAFYAR 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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