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Conserved domains on  [gi|42544121|ref|NP_060154|]
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intermembrane lipid transfer protein VPS13C isoform 1A [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1323 1.15e-94

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 345.33  E-value: 1.15e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043    2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIE---EALQKAAEkdKPKEAKKDTFVEKLATQVIKNVQVKITDIH 159
Cdd:COG5043   82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEilrETLEESSS--SPNISRKQSFIESLITKLIDNIQIYIEDIH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  160 IKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNE 238
Cdd:COG5043  160 LRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  239 ILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 317
Cdd:COG5043  237 QPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKY 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  318 KPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIKKHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVf 396
Cdd:COG5043  315 RPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL- 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  397 niilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGLWGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG---- 470
Cdd:COG5043  392 ------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGLWNGKPQA---------QDEDTLASTDKTAAELTDQEqkdf 456

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  471 YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEILKIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDI 549
Cdd:COG5043  457 FSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVR 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  550 VPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEI 627
Cdd:COG5043  537 ESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTL 616

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  628 KERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEKSDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKF 706
Cdd:COG5043  617 TRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPKSPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRF 695

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  707 DVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLM 786
Cdd:COG5043  696 TISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLM 774

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  787 NSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDTVESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELI 866
Cdd:COG5043  775 SNI-LPTISVDEINGDYQQF-----------------SSASLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQI 828

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  867 NLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL 945
Cdd:COG5043  829 FAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNN 907

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  946 --DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLNLLLQTQALVASINYL--TTIIPSDDQSISVAKEVQISTeK 1019
Cdd:COG5043  908 fdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIrsTFTSPNDEYMIGEDPELTRKI-S 982

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1020 QQKNSTLPKAIVS------SRDSDIIDFRLFAKLNAFCVIVCNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTD 1093
Cdd:COG5043  983 DVENIKIEDANVRldnndiFLYDCIQLFATVLSYGAFMHMEEREKFFL-QLRLMDLE--------------LKNHEKSNN 1047

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1094 VDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSKVDGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLS 1172
Cdd:COG5043 1048 PD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFS 1111

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1173 AATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQssistnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvq 1252
Cdd:COG5043 1112 SIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD--------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN--- 1175

                       1290      1300      1310      1320      1330      1340      1350
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544121 1253 lTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1323
Cdd:COG5043 1176 -SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLTIDANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3280-3457 7.19e-75

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


:

Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 247.46  E-value: 7.19e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   3280 SFFEHFHISPVKLHLSLSLGSGGEESDKEKQEmfavHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVV 3359
Cdd:pfam16909    2 IYFELLHLQPIKLHLSFSRSERVNLEESLEKS----NPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   3360 RHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3439
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 42544121   3440 GSVGKGLAAITMDKEYQQ 3457
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3141-3619 6.77e-52

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 204.35  E-value: 6.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3141 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDsEPKPFIDVSVITRFNEYSKVLQFKYFMV 3220
Cdd:COG5043 2020 NVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEI-ENHLLPSRKFAVVKDSDSAVTYDKYVTI 2098

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3221 LIQEMALKIDQGFLGAIIALFTPttdPEAERRRTKLIQQDIdalnaELMETSMTDMSILSFFEHFHISPVKLHLSLSLGS 3300
Cdd:COG5043 2099 LLQELSIELDEDLALAYLEKLKF---PGSKYMDDKKFDDEI-----ELPDIIINKSGSNIYFEFLHLQPTRLHISFSRSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3301 GGEESD-KEKQEMFA-VHSVNLLLKSIGatltdvddlifKLAYYEIRYQFYKRDQLIWS-------VVRHYSEQFLKQMY 3371
Cdd:COG5043 2171 ESSGEDgKVVPSSNSySDFYGMLAMTLG-----------NINDAPVRLNSLLMDNARVSlpelfdlIASHYLQQVEYQIY 2239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3372 VLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQG--AVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAI 3449
Cdd:COG5043 2240 KILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLV 2319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3450 TMDKEYQQKRREELSR-QPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIV 3528
Cdd:COG5043 2320 TSDPELQSSRRLVRRRnRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFL 2399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3529 DMASSTFQGIQR--AAESTEEVSSLRPPRLIHEDGIIRPYDRQESEGSDLLENHI-KKLEGETYRYHCAIPG-----SKK 3600
Cdd:COG5043 2400 DLTSNDSEGIKNttTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDaGKYPLDEYKFHDIINNvaviiSRD 2479

                        490
                 ....*....|....*....
gi 42544121 3601 TILMVTNRRVLCIKEVEIL 3619
Cdd:COG5043 2480 IHAIVTSKILILKDYIPSK 2498
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2723-2899 4.31e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.42  E-value: 4.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   2723 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2794
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   2795 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2869
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 42544121   2870 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2899
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1003-2569 1.48e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 78.00  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1003 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1082
Cdd:COG5043  435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1083 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1154
Cdd:COG5043  515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1155 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1221
Cdd:COG5043  586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1222 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1288
Cdd:COG5043  662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1289 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1368
Cdd:COG5043  740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1369 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1443
Cdd:COG5043  811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1444 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1523
Cdd:COG5043  891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1524 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1597
Cdd:COG5043  964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1598 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1674
Cdd:COG5043 1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1675 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1751
Cdd:COG5043 1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1752 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1831
Cdd:COG5043 1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1832 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1906
Cdd:COG5043 1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1907 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 1986
Cdd:COG5043 1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1987 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2066
Cdd:COG5043 1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2067 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2143
Cdd:COG5043 1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2144 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2219
Cdd:COG5043 1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2220 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2298
Cdd:COG5043 1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2299 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2378
Cdd:COG5043 1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2379 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2454
Cdd:COG5043 1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2455 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2530
Cdd:COG5043 1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                       1610      1620      1630      1640
                 ....*....|....*....|....*....|....*....|
gi 42544121 2531 RPEEEFHVPLD-SYRCQLFIQPAGilEHQYKESTTYISWK 2569
Cdd:COG5043 1893 SPEESCSLPIEtAYLYSIRIRPVS--EDKFNWSSQAISWK 1930
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1323 1.15e-94

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 345.33  E-value: 1.15e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043    2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIE---EALQKAAEkdKPKEAKKDTFVEKLATQVIKNVQVKITDIH 159
Cdd:COG5043   82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEilrETLEESSS--SPNISRKQSFIESLITKLIDNIQIYIEDIH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  160 IKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNE 238
Cdd:COG5043  160 LRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  239 ILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 317
Cdd:COG5043  237 QPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKY 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  318 KPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIKKHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVf 396
Cdd:COG5043  315 RPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL- 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  397 niilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGLWGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG---- 470
Cdd:COG5043  392 ------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGLWNGKPQA---------QDEDTLASTDKTAAELTDQEqkdf 456

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  471 YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEILKIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDI 549
Cdd:COG5043  457 FSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVR 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  550 VPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEI 627
Cdd:COG5043  537 ESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTL 616

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  628 KERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEKSDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKF 706
Cdd:COG5043  617 TRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPKSPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRF 695

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  707 DVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLM 786
Cdd:COG5043  696 TISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLM 774

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  787 NSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDTVESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELI 866
Cdd:COG5043  775 SNI-LPTISVDEINGDYQQF-----------------SSASLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQI 828

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  867 NLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL 945
Cdd:COG5043  829 FAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNN 907

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  946 --DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLNLLLQTQALVASINYL--TTIIPSDDQSISVAKEVQISTeK 1019
Cdd:COG5043  908 fdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIrsTFTSPNDEYMIGEDPELTRKI-S 982

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1020 QQKNSTLPKAIVS------SRDSDIIDFRLFAKLNAFCVIVCNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTD 1093
Cdd:COG5043  983 DVENIKIEDANVRldnndiFLYDCIQLFATVLSYGAFMHMEEREKFFL-QLRLMDLE--------------LKNHEKSNN 1047

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1094 VDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSKVDGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLS 1172
Cdd:COG5043 1048 PD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFS 1111

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1173 AATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQssistnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvq 1252
Cdd:COG5043 1112 SIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD--------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN--- 1175

                       1290      1300      1310      1320      1330      1340      1350
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544121 1253 lTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1323
Cdd:COG5043 1176 -SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLTIDANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 139-370 1.45e-89

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 291.86  E-value: 1.45e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    139 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNV 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    219 NC---SMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPISASAKLYMNPYAESElKTPKLDCNIEIQNIAIELTKPQY 295
Cdd:pfam16908   81 DSeslELLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42544121    296 LSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYtQMWSWSNIKKHRQLLKSYKIAYK 370
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERR-RKWSWDYIKKRRDDRKEYIELYK 233
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3280-3457 7.19e-75

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 247.46  E-value: 7.19e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   3280 SFFEHFHISPVKLHLSLSLGSGGEESDKEKQEmfavHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVV 3359
Cdd:pfam16909    2 IYFELLHLQPIKLHLSFSRSERVNLEESLEKS----NPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   3360 RHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3439
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 42544121   3440 GSVGKGLAAITMDKEYQQ 3457
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3141-3619 6.77e-52

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 204.35  E-value: 6.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3141 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDsEPKPFIDVSVITRFNEYSKVLQFKYFMV 3220
Cdd:COG5043 2020 NVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEI-ENHLLPSRKFAVVKDSDSAVTYDKYVTI 2098

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3221 LIQEMALKIDQGFLGAIIALFTPttdPEAERRRTKLIQQDIdalnaELMETSMTDMSILSFFEHFHISPVKLHLSLSLGS 3300
Cdd:COG5043 2099 LLQELSIELDEDLALAYLEKLKF---PGSKYMDDKKFDDEI-----ELPDIIINKSGSNIYFEFLHLQPTRLHISFSRSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3301 GGEESD-KEKQEMFA-VHSVNLLLKSIGatltdvddlifKLAYYEIRYQFYKRDQLIWS-------VVRHYSEQFLKQMY 3371
Cdd:COG5043 2171 ESSGEDgKVVPSSNSySDFYGMLAMTLG-----------NINDAPVRLNSLLMDNARVSlpelfdlIASHYLQQVEYQIY 2239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3372 VLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQG--AVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAI 3449
Cdd:COG5043 2240 KILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLV 2319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3450 TMDKEYQQKRREELSR-QPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIV 3528
Cdd:COG5043 2320 TSDPELQSSRRLVRRRnRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFL 2399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3529 DMASSTFQGIQR--AAESTEEVSSLRPPRLIHEDGIIRPYDRQESEGSDLLENHI-KKLEGETYRYHCAIPG-----SKK 3600
Cdd:COG5043 2400 DLTSNDSEGIKNttTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDaGKYPLDEYKFHDIINNvaviiSRD 2479

                        490
                 ....*....|....*....
gi 42544121 3601 TILMVTNRRVLCIKEVEIL 3619
Cdd:COG5043 2480 IHAIVTSKILILKDYIPSK 2498
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2723-2899 4.31e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.42  E-value: 4.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   2723 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2794
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   2795 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2869
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 42544121   2870 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2899
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1003-2569 1.48e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 78.00  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1003 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1082
Cdd:COG5043  435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1083 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1154
Cdd:COG5043  515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1155 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1221
Cdd:COG5043  586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1222 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1288
Cdd:COG5043  662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1289 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1368
Cdd:COG5043  740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1369 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1443
Cdd:COG5043  811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1444 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1523
Cdd:COG5043  891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1524 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1597
Cdd:COG5043  964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1598 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1674
Cdd:COG5043 1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1675 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1751
Cdd:COG5043 1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1752 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1831
Cdd:COG5043 1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1832 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1906
Cdd:COG5043 1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1907 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 1986
Cdd:COG5043 1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1987 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2066
Cdd:COG5043 1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2067 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2143
Cdd:COG5043 1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2144 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2219
Cdd:COG5043 1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2220 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2298
Cdd:COG5043 1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2299 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2378
Cdd:COG5043 1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2379 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2454
Cdd:COG5043 1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2455 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2530
Cdd:COG5043 1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                       1610      1620      1630      1640
                 ....*....|....*....|....*....|....*....|
gi 42544121 2531 RPEEEFHVPLD-SYRCQLFIQPAGilEHQYKESTTYISWK 2569
Cdd:COG5043 1893 SPEESCSLPIEtAYLYSIRIRPVS--EDKFNWSSQAISWK 1930
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 3464-3539 1.26e-10

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 60.60  E-value: 1.26e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42544121   3464 SRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQ 3539
Cdd:pfam09333    5 ANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1647-1839 9.99e-07

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 52.90  E-value: 9.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   1647 SKVDGKLSFKVGCIQIVYVHKFFMSLLNFL---NNFQTAKEALSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKA 1719
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDFFkppESHLELIGALMAAAEATLEgikeQTRAGLEYALEEHKTLDLDIDLQA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   1720 PVIIIPQS--SVSPNAVIADLGLIRVENKfsLVPMEHYS--------------LPPVI----DKMNIEL--TQLKLSRTI 1777
Cdd:pfam16910   88 PLIIVPEDytSKDSPCLILDAGHISVTSD--LVDKSTIKeikskqsqqyteedLKELEslmyDKFSLKLsdTQVLIGPSG 165

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42544121   1778 --LQASLPQNDIE---ILKPVNMLLSIQRNLAAAwYVQIPGMEIKGKLKPMQVALSEDDLTVLMKIL 1839
Cdd:pfam16910  166 edWKEALTEDDSSplhILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
 
Name Accession Description Interval E-value
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3-1323 1.15e-94

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 345.33  E-value: 1.15e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:COG5043    2 LEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   83 LEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIE---EALQKAAEkdKPKEAKKDTFVEKLATQVIKNVQVKITDIH 159
Cdd:COG5043   82 IEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEilrETLEESSS--SPNISRKQSFIESLITKLIDNIQIYIEDIH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  160 IKYED-DVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWnvnCSMSYQRSREQILDQLKNE 238
Cdd:COG5043  160 LRFEDnLSADLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYW---CEISPCITTEDIDSYLENF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  239 ILTSGNIPPNY-QYIFQPISASAKLYMNPYAESELktPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 317
Cdd:COG5043  237 QPMIAEKSPAYnEYILKPVRGTAKVSINKLPTDEI--PRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLKY 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  318 KPYLPLHTNGRRWWKYAIDSVL-EVHIRRYtqMWSWSNIKKHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVf 396
Cdd:COG5043  315 RPKSTPKEKPLEWFKYIILVVLdSIHEKRY--HWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDL- 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  397 niilarQQAQVEVIRSGQKLRKKSA--DTGEKRGGWFSGLWGKKESKkkdeeslipETIDDLMTPEEKDKLFTAIG---- 470
Cdd:COG5043  392 ------IKYRSRLFRSLAKRRNSIYlkPQTHKLQGWFSGLWNGKPQA---------QDEDTLASTDKTAAELTDQEqkdf 456

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  471 YSESTHNLTLPKQYVAHIMTLKLVSTSVTIRENKNIPEILKIQIIGLGTQVS-QRPGAQALKVEAKLEHWYITGLRQQDI 549
Cdd:COG5043  457 FSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSlNKLDLFDGATNPELKPYRSIRNKPKVR 536

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  550 VPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQS--NKGLDLEQITSATLMKLEEI 627
Cdd:COG5043  537 ESESLQEIEEESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPsrTKIEHVSEWVYSAAATVMTL 616

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  628 KERTATGLTHIIETRKVLDLRINLKPSYLVVPQtGFHHEKSDLLILDFGTFQLNSKDQGLQKT-TNSSLEEIMDKAYDKF 706
Cdd:COG5043  617 TRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPKSPTLFLDAGRISIHSQLVEDAIIkKFRELQTLENLMYDRF 695

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  707 DVEIKNVQLLFARAEETWKKCRfQHPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLM 786
Cdd:COG5043  696 TISLFNVRCLIGPDYEGKRELP-KGKCDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQYKVIINLM 774

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  787 NSIpLPQKSSAQSPERQVSSipiisggtkgllgtsllLDTVESESDDEYFDAEDGEPQTCKSmkgselkkAAEVPNEELI 866
Cdd:COG5043  775 SNI-LPTISVDEINGDYQQF-----------------SSASLPPPFFDIKDNFQIENHANEQ--------TAAKFHAQQI 828

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  867 NLLLkFEIKEVILEFTKQQKEEDTI-LVFNVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGL 945
Cdd:COG5043  829 FAFY-FKVDYFICSGLDSRSENYLVpVLRARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPSSLCDNLLSRSSPKPKNN 907

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121  946 --DLLKVEY--IKADKNGpsfqTAFGKTEQTVKVAFSSLNLLLQTQALVASINYL--TTIIPSDDQSISVAKEVQISTeK 1019
Cdd:COG5043  908 fdDTVFIEYksIDYDVLD----SVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIrsTFTSPNDEYMIGEDPELTRKI-S 982

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1020 QQKNSTLPKAIVS------SRDSDIIDFRLFAKLNAFCVIVCNEKNNIaEIKIQGLDsslslqsrkqslfaRLENIIVTD 1093
Cdd:COG5043  983 DVENIKIEDANVRldnndiFLYDCIQLFATVLSYGAFMHMEEREKFFL-QLRLMDLE--------------LKNHEKSNN 1047

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1094 VDpktvhKKAVSIMGNEVFRFNLDLYpdategDLYTDMSKVDGVLSLNVGCiqivyLHK-FLMSLLNFLNNFQTAKESLS 1172
Cdd:COG5043 1048 PD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGS-----LHFyFIESYFNFLSKFKRFKVSFS 1111

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1173 AATAQAAeraatSVKDLAQRSFRVSINIDLKAPVIVIPQssistnavVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMdvq 1252
Cdd:COG5043 1112 SIRYAAY-----YKAYGNKVSNNYKFELRIKHPIVQFPD--------VLGERNCRMQLIIKPGSFYAFSKCPVVEKN--- 1175

                       1290      1300      1310      1320      1330      1340      1350
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544121 1253 lTKLTLYRTVIQPGIYHPD-------IQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRI 1323
Cdd:COG5043 1176 -SKLSIFSCELRKGEFSTAvpssghhDVLLEELNIHLDLTIDANPTTGENAYVFKATGDLDPVILNLCQSQHLILLDL 1252
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 139-370 1.45e-89

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 291.86  E-value: 1.45e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    139 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNV 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    219 NC---SMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPISASAKLYMNPYAESElKTPKLDCNIEIQNIAIELTKPQY 295
Cdd:pfam16908   81 DSeslELLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42544121    296 LSMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYtQMWSWSNIKKHRQLLKSYKIAYK 370
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERR-RKWSWDYIKKRRDDRKEYIELYK 233
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 569-790 1.92e-79

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 263.22  E-value: 1.92e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    569 FETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLD--LEQITSATLMKLEEIKERTATGLTHIIETRKVLD 646
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121    647 LRINLKPSYLVVPQtGFHHEKSDLLILDFGTFQLNS-----------KDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQL 715
Cdd:pfam16910   81 LDIDLQAPLIIVPE-DYTSKDSPCLILDAGHISVTSdlvdkstikeiKSKQSQQYTEEDLKELESLMYDKFSLKLSDTQV 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42544121    716 LFARAEETWKKCRFQ-HPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLM-NSIP 790
Cdd:pfam16910  160 LIGPSGEDWKEALTEdDSSPLHILEPINLDLTLEKSILPKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLIdVSIP 236
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 3280-3457 7.19e-75

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 247.46  E-value: 7.19e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   3280 SFFEHFHISPVKLHLSLSLGSGGEESDKEKQEmfavHSVNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVV 3359
Cdd:pfam16909    2 IYFELLHLQPIKLHLSFSRSERVNLEESLEKS----NPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   3360 RHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3439
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 42544121   3440 GSVGKGLAAITMDKEYQQ 3457
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3141-3619 6.77e-52

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 204.35  E-value: 6.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3141 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDsEPKPFIDVSVITRFNEYSKVLQFKYFMV 3220
Cdd:COG5043 2020 NVGIGLRFIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPTEISQEEKEI-ENHLLPSRKFAVVKDSDSAVTYDKYVTI 2098

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3221 LIQEMALKIDQGFLGAIIALFTPttdPEAERRRTKLIQQDIdalnaELMETSMTDMSILSFFEHFHISPVKLHLSLSLGS 3300
Cdd:COG5043 2099 LLQELSIELDEDLALAYLEKLKF---PGSKYMDDKKFDDEI-----ELPDIIINKSGSNIYFEFLHLQPTRLHISFSRSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3301 GGEESD-KEKQEMFA-VHSVNLLLKSIGatltdvddlifKLAYYEIRYQFYKRDQLIWS-------VVRHYSEQFLKQMY 3371
Cdd:COG5043 2171 ESSGEDgKVVPSSNSySDFYGMLAMTLG-----------NINDAPVRLNSLLMDNARVSlpelfdlIASHYLQQVEYQIY 2239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3372 VLVLGLDVLGNPFGLIRGLSEGVEALFYEPFQG--AVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAI 3449
Cdd:COG5043 2240 KILGSADFLGNPVGLFETVSSGVSDLFYEPYQGrfLVDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLV 2319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3450 TMDKEYQQKRREELSR-QPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIV 3528
Cdd:COG5043 2320 TSDPELQSSRRLVRRRnRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFL 2399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 3529 DMASSTFQGIQR--AAESTEEVSSLRPPRLIHEDGIIRPYDRQESEGSDLLENHI-KKLEGETYRYHCAIPG-----SKK 3600
Cdd:COG5043 2400 DLTSNDSEGIKNttTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDaGKYPLDEYKFHDIINNvaviiSRD 2479

                        490
                 ....*....|....*....
gi 42544121 3601 TILMVTNRRVLCIKEVEIL 3619
Cdd:COG5043 2480 IHAIVTSKILILKDYIPSK 2498
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 3-115 9.34e-42

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 150.02  E-value: 9.34e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121      3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKLTLKIPWKNLYGEAVVAT 82
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVIE 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 42544121     83 LEGLYLLVVPGA-SIKYDAVKEEKSLQDVKQKEL 115
Cdd:pfam12624   81 IEDVYLLAVPKDeSEEYDEEEEEKRELAAKKEKL 114
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2723-2899 4.31e-14

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 75.42  E-value: 4.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   2723 LSVFSPYWLINKTTRVLQYRSEDIHVKHPADF------RDII--LFSFkKKNIFTKNKVQLKISTSAWSSSFSLDTVGSY 2794
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGNKNKAAGTLesheggRRLIplMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   2795 GCVKCPANN--MEYLVGVSIKMSS--FNLSRIVTLTPFCTIANKSSLELevgEIASDGSmptNKWNYIASSECLPF-WPE 2869
Cdd:pfam06650   82 NDVVLPSPNgqNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDL---EIREPGS---SKIISLPPGELIPLhWLR 155

                          170       180       190
                   ....*....|....*....|....*....|..
gi 42544121   2870 SLSGK-LCVRVVG-CEGSSKPFFYNrqDNGTL 2899
Cdd:pfam06650  156 NVEEKqLCIRFPGsNSQWSSPFNIS--DVGST 185
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1003-2569 1.48e-13

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 78.00  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1003 DDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSL 1082
Cdd:COG5043  435 EDTLASTDKTAAELTDQEQKDFFSEIEPVGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSKFSLNKLDL 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1083 FarleniivtDVDPKTVHKKAVSIMGNEVFR--FNLDLYPDATEGDLYTDM--SKVDGVLSLNVGC----IQIVYLHKFL 1154
Cdd:COG5043  515 F---------DGATNPELKPYRSIRNKPKVResESLQEIEEESRTHLFASFedSKPDGKASSTLIIhlrtLVIFYNRVCI 585

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1155 MSLLNFLNNFQTAKESLSAATAQAAEraatSVKDLAQRSF-----------RVSINIDLKAPVIVIPQSSISTNA--VVV 1221
Cdd:COG5043  586 LSVLKFFVPSRTKIEHVSEWVYSAAA----TVMTLTRQTRasldsalemhkTSNVTIDLQAPLIVFPEDCTDPKSptLFL 661

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1222 DLGLIRVHNQfsLVSDEDY--------LNPPVIDRM-----DVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNL 1288
Cdd:COG5043  662 DAGRISIHSQ--LVEDAIIkkfrelqtLENLMYDRFtislfNVRCLIGPDYEGKRELPKGKCDYHILKELKLEINVEISI 739

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1289 AASWYhKVPVVEIKGHLDSMNVSLNQEDLNLLFRiLTENLCEGTEDLDKVKPRVQETGEIKEPLEIsisqdvhDSKNTLT 1368
Cdd:COG5043  740 LPKAT-NLPKIKVSGHMPHASLMFSDVQYKVIIN-LMSNILPTISVDEINGDYQQFSSASLPPPFF-------DIKDNFQ 810

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1369 TGVEEIRSVDIINMLLNFEIKEVVVTLMKKSEKKGRPLHEL-----NVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTD 1443
Cdd:COG5043  811 IENHANEQTAAKFHAQQIFAFYFKVDYFICSGLDSRSENYLvpvlrARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPS 890

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1444 SKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPfsepsss 1523
Cdd:COG5043  891 SLCDNLLSRSSPKPKNNFDDTVFIEYKSIDYDVLDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFT------- 963

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1524 ekeselkPLVGESRSIAVKAVSSNIsqKDVFDLKI-----TAELNAFNVFVCDQKCNIADIKIHGMDAS-ISVKPKQTDV 1597
Cdd:COG5043  964 -------SPNDEYMIGEDPELTRKI--SDVENIKIedanvRLDNNDIFLYDCIQLFATVLSYGAFMHMEeREKFFLQLRL 1034

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1598 FA--RLKDIIVMNVDlqsihKKAVSILGDEVFRFQLTLYpdategEAYADMSKVDGKLSFKVGCIqivyvHKFFM-SLLN 1674
Cdd:COG5043 1035 MDleLKNHEKSNNPD-----STIVKIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSL-----HFYFIeSYFN 1098

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1675 FLNNFQTAKEalstaTVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNA---VIADLGLIRVENKFSLVP 1751
Cdd:COG5043 1099 FLSKFKRFKV-----SFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCrmqLIIKPGSFYAFSKCPVVE 1173

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1752 MEHYslppvIDKMNIELTQLKLSRTILQASLPQNDIEILKpVNMLLSIQRNLAAAwyVQIPGMEIKGKLKPMQVALSEDD 1831
Cdd:COG5043 1174 KNSK-----LSIFSCELRKGEFSTAVPSSGHHDVLLEELN-IHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQ 1245

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1832 LTVLMKIL-----LENLGEASSQPSPTQSVQETVRVRkvdvSSVPDHLKEqedwtdSKLSMNQIVSLQFDFHFESLSIIL 1906
Cdd:COG5043 1246 HLILLDLIdvvttFFRIDSSFSTSENLPRELDSEFDR----SGTPVKLKH------SKKTVVETLDILFTFKLPKIRLNL 1315

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1907 YNNDINQESGVAFHNDSFQLGELRLhlmasSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSsmID 1986
Cdd:COG5043 1316 YTGTFGIHGGDLTGLHNILFFEIGL-----DYGFYSSGTVYAEFSIASFRIEDVNPIKDVVFLDVIEYSTNTHNLL--VN 1388

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 1987 ISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVRpnmTLKAMI 2066
Cdd:COG5043 1389 GCLEYDSQGRLLNLVLDIDKMFLNLDYLYSIWSIFVHWLRAYYSHLDYLVEQEYFNMGNPNQVACGEESYK---LYRITI 1465

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2067 TDPEVVFVASLTKADAPALtaSFQCNLSLSTSKLeqMMEASVRDLKVLACPflrEKRGKNITTVLQPCSL---FMEKCtw 2143
Cdd:COG5043 1466 VDTTLVFVRDASDMNSYAI--PFFFGQFLVTQQS--IFTVTANNMGIFACK---MSETANINQLLDDFGIrftISQHC-- 1536

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2144 asgKQNINIM----VKEFIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITE 2219
Cdd:COG5043 1537 ---SEKIQIIttldFDSLLLRISVNDFLLLQTILRRIYNFIYALYDKETTDEELEKRTKDGQLALNPDFLAASVPTAQPS 1613

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2220 SFKGIEHslIEENCGVVVESIQVTLECGLGHRtvPLLLAESK-FSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2298
Cdd:COG5043 1614 SVFGIRL--CSEEFLINVDGIRLILISDLHDL--PLLDINIKpFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE 1689

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2299 rvegkrQWNLRLDVKKNpvqdksllpgddfipEPQMAIHISSGNTMNITISKSCLnvfNNLAKGFSEGTASTFDYSLKDR 2378
Cdd:COG5043 1690 ------PWKVGVHISRN---------------DSKTAVHVFSREIADIVLTPRLI---ATLHFIFTKLISTPFPIERKCD 1745

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2379 APFTVKN----AVGVPIKVKPNCNlrvmgfpEKSDIFDVDAGQNLELEYASmVPSSQGNLSIlsRQESSFFTLTIVPHGY 2454
Cdd:COG5043 1746 APYRIVNytqtAVSVWAQFENAAD-------SVECVRHLPNNTSTPWKFEE-WRQMQDVVSQ--DQDRVYIGVHVSNSKY 1815

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121 2455 TEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGN-KVITLRSPLQIKNHFSIAFiiyKFVKNVKLLER---IGIA 2530
Cdd:COG5043 1816 ESLRHVRVNRVGEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEI---EVVFCDSDGIQrsqIYHI 1892

                       1610      1620      1630      1640
                 ....*....|....*....|....*....|....*....|
gi 42544121 2531 RPEEEFHVPLD-SYRCQLFIQPAGilEHQYKESTTYISWK 2569
Cdd:COG5043 1893 SPEESCSLPIEtAYLYSIRIRPVS--EDKFNWSSQAISWK 1930
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 3464-3539 1.26e-10

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 60.60  E-value: 1.26e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42544121   3464 SRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQ 3539
Cdd:pfam09333    5 ANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1647-1839 9.99e-07

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 52.90  E-value: 9.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   1647 SKVDGKLSFKVGCIQIVYVHKFFMSLLNFL---NNFQTAKEALSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKA 1719
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDFFkppESHLELIGALMAAAEATLEgikeQTRAGLEYALEEHKTLDLDIDLQA 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   1720 PVIIIPQS--SVSPNAVIADLGLIRVENKfsLVPMEHYS--------------LPPVI----DKMNIEL--TQLKLSRTI 1777
Cdd:pfam16910   88 PLIIVPEDytSKDSPCLILDAGHISVTSD--LVDKSTIKeikskqsqqyteedLKELEslmyDKFSLKLsdTQVLIGPSG 165

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42544121   1778 --LQASLPQNDIE---ILKPVNMLLSIQRNLAAAwYVQIPGMEIKGKLKPMQVALSEDDLTVLMKIL 1839
Cdd:pfam16910  166 edWKEALTEDDSSplhILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1132-1324 1.60e-05

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 49.05  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   1132 SKVDGVLSLNVGCIQIVYLHKFLMSLLNFlnnFQTAKESLSAATAQAAERAATsVKDLAQRSF-----------RVSINI 1200
Cdd:pfam16910    8 GSADSRLTVKLRPLEIIYDPHFIEEVIDF---FKPPESHLELIGALMAAAEAT-LEGIKEQTRagleyaleehkTLDLDI 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544121   1201 DLKAPVIVIPQS--SISTNAVVVDLGLIRVH--------------NQFSLVSDEDY--LNPPVIDRMDVQLTKLTLyrtV 1262
Cdd:pfam16910   84 DLQAPLIIVPEDytSKDSPCLILDAGHISVTsdlvdkstikeiksKQSQQYTEEDLkeLESLMYDKFSLKLSDTQV---L 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42544121   1263 IQPGI--------------YHpdiqLLHPINLEFLVNRNLAASwYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRIL 1324
Cdd:pfam16910  161 IGPSGedwkealteddsspLH----ILEPINLDLTLEKSILPK-APRLPKFKVSGHLPSLHINFSDDKYKSLMRLI 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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