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Conserved domains on  [gi|144953907|ref|NP_060164|]
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major facilitator superfamily domain-containing protein 6 isoform a [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 13023754)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
70-622 1.23e-172

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 501.34  E-value: 1.23e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  70 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGI 149
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 150 GFVkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpq 229
Cdd:cd17335   81 FFV----------------------------------------------------------------------------- 83
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 230 tgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVTIV 309
Cdd:cd17335   84 -------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVPLV 108
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 310 DTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIevlidgkgckppeYRNYQIVFIVFGVLMTMALIVATQF 389
Cdd:cd17335  109 DSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLALKF 175
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 390 RFRYNHfknddskgkeveipqvernnstesseetptttsHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLY 469
Cdd:cd17335  176 PFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLF 222
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 470 WHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAA 549
Cdd:cd17335  223 WHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 144953907 550 IWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 622
Cdd:cd17335  303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
70-622 1.23e-172

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 501.34  E-value: 1.23e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  70 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGI 149
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 150 GFVkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpq 229
Cdd:cd17335   81 FFV----------------------------------------------------------------------------- 83
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 230 tgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVTIV 309
Cdd:cd17335   84 -------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVPLV 108
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 310 DTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIevlidgkgckppeYRNYQIVFIVFGVLMTMALIVATQF 389
Cdd:cd17335  109 DSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLALKF 175
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 390 RFRYNHfknddskgkeveipqvernnstesseetptttsHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLY 469
Cdd:cd17335  176 PFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLF 222
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 470 WHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAA 549
Cdd:cd17335  223 WHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 144953907 550 IWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 622
Cdd:cd17335  303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
68-604 8.94e-73

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 241.77  E-value: 8.94e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907   68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNL 147
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  148 GIGFVKPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlq 227
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  228 pqtgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVT 307
Cdd:pfam12832  88 ---------------------------------------------------------SLTFWWLALLVVLFSFFWNAILP 110
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  308 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLidgkgckppeyrnYQIVFIVFGVLMTMALIVat 387
Cdd:pfam12832 111 QFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL-- 175
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  388 qfrfrynhfknddskgkeveipqvernnstesSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 467
Cdd:pfam12832 176 --------------------------------PLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTF 223
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  468 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQGVT 546
Cdd:pfam12832 224 LFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAIS 303
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 144953907  547 HAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 604
Cdd:pfam12832 304 FGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
450-627 6.17e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.10  E-value: 6.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2814   14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 608
Cdd:COG2814   94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168
                        170
                 ....*....|....*....
gi 144953907 609 ACLVILLLFALIQWLAVPD 627
Cdd:COG2814  169 VNAVLALLALLLLLRLLPE 187
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
76-140 6.69e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.07  E-value: 6.69e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRfKKGKIVLLFSLL 140
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADR-KGRKIMLLRSAL 92
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
70-622 1.23e-172

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 501.34  E-value: 1.23e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  70 ISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGI 149
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 150 GFVkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpq 229
Cdd:cd17335   81 FFV----------------------------------------------------------------------------- 83
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 230 tgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVTIV 309
Cdd:cd17335   84 -------------------------------------------------------AQIFWLLLLLVILGAFFSAPVVPLV 108
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 310 DTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIevlidgkgckppeYRNYQIVFIVFGVLMTMALIVATQF 389
Cdd:cd17335  109 DSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST-------------YKNYTIAFYVFAVLMLLALLLALKF 175
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 390 RFRYNHfknddskgkeveipqvernnstesseetptttsHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLY 469
Cdd:cd17335  176 PFRPKH---------------------------------PEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLF 222
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 470 WHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAA 549
Cdd:cd17335  223 WHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 144953907 550 IWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQW 622
Cdd:cd17335  303 VWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
68-604 8.94e-73

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 241.77  E-value: 8.94e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907   68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNL 147
Cdd:pfam12832   1 LWRLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  148 GIGFVKPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlq 227
Cdd:pfam12832  81 SVLFIPI------------------------------------------------------------------------- 87
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  228 pqtgeitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqevEAIFLVILVVVIIGEFFSASSVT 307
Cdd:pfam12832  88 ---------------------------------------------------------SLTFWWLALLVVLFSFFWNAILP 110
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  308 IVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLidgkgckppeyrnYQIVFIVFGVLMTMALIVat 387
Cdd:pfam12832 111 QFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLL-------------PSVLFYLFAALMLLSLLL-- 175
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  388 qfrfrynhfknddskgkeveipqvernnstesSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTF 467
Cdd:pfam12832 176 --------------------------------PLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTF 223
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  468 LYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYL-ENAWTVLPMEVLQGVT 546
Cdd:pfam12832 224 LFLYLENLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFvENPWLVLPIQFLHAIS 303
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 144953907  547 HAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR 604
Cdd:pfam12832 304 FGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTFR 361
MFS_MFSD6L cd17479
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...
71-618 2.52e-44

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341032 [Multi-domain]  Cd Length: 376  Bit Score: 164.02  E-value: 2.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  71 SKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLgig 150
Cdd:cd17479    1 ASLFHFFHSAGKACLLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYL--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 151 fvkpatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptLQPQt 230
Cdd:cd17479   78 ---------------------------------------------------------------------------LYHQ- 81
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 231 geitnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveaIFLVILVVVIIGEFFSASSVTIVD 310
Cdd:cd17479   82 --------------------------------------------------------IFLLVLLVIIIWELLSAPLEKVAD 105
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 311 TVTLQYLGKHR--DRYGLQRMWGSLGwgLAMLSVGIGidythieVLIDGKGCKPPEYRN-YQIVFIVFGVLMTMALIVAT 387
Cdd:cd17479  106 DSLYEYLDFVDatERYGKLKVWSALG--AAFGPCGIT-------LLVDNLDCFLPPKISrILLHFYTYGGFMILTFLLSF 176
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 388 QFrfrynhfknddskgkEVEIPQVERNNStesseetptttSHSQAFNFwdlikLLCSVQ---YGSVLFVawfMGFGYGFV 464
Cdd:cd17479  177 FY---------------PIPVPKKEEHSS-----------KVVKGLRL-----LGGDGRailYALTVFL---VGFVGSTV 222
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 465 FTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQG 544
Cdd:cd17479  223 QNFLFWLMQDKGGSELHMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHA 302
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 144953907 545 VTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFA 618
Cdd:cd17479  303 FSNGALWWAVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
73-622 4.56e-33

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 131.78  E-value: 4.56e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  73 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd06174    3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 153 KPatlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpqtge 232
Cdd:cd06174   82 PS------------------------------------------------------------------------------ 83
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 233 itnrmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveaiFLVILVVVIIGEFFSASSVTIVDTV 312
Cdd:cd06174   84 -------------------------------------------------------FWLLLLGRFLLGLGSGLIDPAVLAL 108
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 313 TLQYLGKHR--DRYGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppeyrnYQIVFIVFGVLMTMALIVATQFR 390
Cdd:cd06174  109 IADLFPERErgRALGLLQAFGSVGGILGPLLGGILASSL------------------GFGWRAVFLIAAALALLAAILLL 170
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 391 FRYNHFKNDDSKGKEVEipqvernnstesseetptttshSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYW 470
Cdd:cd06174  171 LVVPDPPESARAKNEEA----------------------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 471 HLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIE-LIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHA 548
Cdd:cd06174  229 FLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144953907 549 AIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIGGVLVNYFGAAAT-FRGIGMACLVILLLFALIQW 622
Cdd:cd06174  309 GLLPLSFALIAELFPPEIRGTAFGL-----LNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
76-620 8.39e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 92.25  E-value: 8.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVkpa 155
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGR-KRLLLLGLLLLAVSTLLFAFA--- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 156 tlrcvpkirptthptnashqltilptnssftsfltispkmrekrnlletrlnvsdtvtlptapnmnseptlqpqtgeitn 235
Cdd:cd17325      --------------------------------------------------------------------------------
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 236 rmmdltlnsstatpvspgsvtketttvivtttkslpsdqvmlvydqqeveAIFLVILVVVIIGEFFSASSVT-----IVD 310
Cdd:cd17325   82 --------------------------------------------------TSYWQLLLARFLQGLASAAVWPaamalIAD 111
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 311 TVTLQYLGKhrdRYGLqrMWGSLGWGlAMLSVGIGIdythieVLIDGKGckppeyrnYQIVFIVFGVLMTMALIVATQFR 390
Cdd:cd17325  112 IAPPEERGR---AMGI--FSSAIGLG-FLIGPLLGG------LLADALG--------YRAPFLVCAALALLALVLALLLL 171
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 391 frynhfknddskgkeveipqvernnstESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYW 470
Cdd:cd17325  172 ---------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 471 HLEDLNGTTT-----LFGVcSVLSHVseLTAYFFShKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGV 545
Cdd:cd17325  225 YAAELGGLSPaqiglLFGA-QGLASA--LSQPPAG-KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGL 300
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144953907 546 THAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17325  301 GLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
450-627 6.17e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.10  E-value: 6.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2814   14 ALALGAFLsGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigM 608
Cdd:COG2814   94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWRWVF----L 168
                        170
                 ....*....|....*....
gi 144953907 609 ACLVILLLFALIQWLAVPD 627
Cdd:COG2814  169 VNAVLALLALLLLLRLLPE 187
MFS_1 pfam07690
Major Facilitator Superfamily;
450-630 4.03e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.54  E-value: 4.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  450 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGaaatFRGIGM 608
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV-SAGFGLGAALGPLLGGLLASLFG----WRAAFL 155
                         170       180
                  ....*....|....*....|..
gi 144953907  609 ACLVILLLFALIQWLAVPDEEE 630
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPES 177
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
450-630 2.16e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 72.61  E-value: 2.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFrgigMA 609
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSA-IGLGFLIGPLLGGLLADALGYRAPF----LV 155
                        170       180
                 ....*....|....*....|.
gi 144953907 610 CLVILLLFALIQWLAVPDEEE 630
Cdd:cd17325  156 CAALALLALVLALLLLPEPRP 176
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
450-649 2.88e-12

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 69.12  E-value: 2.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRtsaqGILQGLHlGLGRGCGAMIGGVLVNYFG-AAATFRGIGM 608
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR----GRVLGLY-STVLGLGFALGPLLLALVGtAGALPFLIAA 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 144953907 609 ACLVILLLFALIQWLAVPDEEEDKTMLAERIpVPSSPVPIA 649
Cdd:cd17477  156 VLLLLALVPLLLTRRAAPEIEEAESISLRRL-LRIAPLALL 195
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
287-583 1.35e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 66.92  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 287 IFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKhrdRYGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppeyr 366
Cdd:COG2814  102 LAARFLQGLGAGALFPAALALIADLVPPERRGR---ALGLLGAGLGLGPALGPLLGGLLADLF----------------- 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 367 NYQIVFIVFGVLMTMALIVATQFrfrynhfknddskgkeveIPqvernnstesseETPTTTSHSQAFNFWDLIKllcSVQ 446
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRL------------------LP------------ESRPAARARLRGSLRELLR---RPR 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 447 YGSVLFVAWFMGFGYGFVFTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI 525
Cdd:COG2814  209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 144953907 526 YISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGR 583
Cdd:COG2814  289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
421-620 2.96e-11

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 66.05  E-value: 2.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 421 EETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvsELT 495
Cdd:cd17474  174 PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPiiiglLFAGWSVLL---ALG 250
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 496 AYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ 575
Cdd:cd17474  251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 144953907 576 GLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17474  331 FV-RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_1 pfam07690
Major Facilitator Superfamily;
287-590 1.27e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 63.59  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  287 IFLVILVVVIIGeFFSASSVTIVDTVTLQYLGK-HRDR-YGLQRMWGSLGWGLAMLSVGIGIDYThievlidgkgckppe 364
Cdd:pfam07690  85 LWLLLVLRVLQG-LGAGALFPAALALIADWFPPeERGRaLGLVSAGFGLGAALGPLLGGLLASLF--------------- 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  365 yrNYQIVFIVFGVLMTMALIVAtqFRFRYNHFKNDDSKGKEVEIPQVErnnstesseetptttshsqafnfwdLIKLLCS 444
Cdd:pfam07690 149 --GWRAAFLILAILSLLAAVLL--LLPRPPPESKRPKPAEEARLSLIV-------------------------AWKALLR 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  445 VQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN---T 521
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLilaA 279
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907  522 ARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQglhlgLGRGCGAMIG 590
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYN-----TAGSLGGALG 343
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
450-625 1.67e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.35  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:COG2271   14 LLFLAYFLNYLDRSNLSVAAPPLqADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGM 608
Cdd:COG2271   94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGG-PLGGALAPPLLGWLLAAFGWRAAFLILGL 172
                        170
                 ....*....|....*..
gi 144953907 609 ACLVILLLFALIQWLAV 625
Cdd:COG2271  173 PGLLLALLRFWLLALAY 189
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
452-619 3.36e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 62.61  E-value: 3.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 452 FVAWFMGFGYGFVFTFLYWHLEDLNGTT-----TLFGVCSVLSHvseltayFFSHKLIELIGHIRVLYIGLACNTARYIY 526
Cdd:cd17489  201 LILFLASIAYGAISTFLPLYAAERGISNaglffTVYAIALLLSR-------PFSGKLSDRKGPKTVIIPGLLLLALGLLL 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 527 ISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGI 606
Cdd:cd17489  274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIF-FDLGIGLGGLLLGLVAELFGYRAMFLLA 352
                        170
                 ....*....|...
gi 144953907 607 GMACLVILLLFAL 619
Cdd:cd17489  353 AVVVLLALVLYIF 365
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
449-620 9.25e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.07  E-value: 9.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 449 SVLFVawFMGFGYGFVFTFLYwhLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:cd17489    4 ANFFF--FLSFYLLLPVLPLY--AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGM 608
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYY-GLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
                        170
                 ....*....|..
gi 144953907 609 ACLVILLLFALI 620
Cdd:cd17489  159 LALLALLLVFLV 170
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
457-616 1.09e-09

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 61.08  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 457 MGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSE-LTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWT 535
Cdd:cd17490  207 QMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNaLASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL 286
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 536 VLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILL 615
Cdd:cd17490  287 LYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY-ALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAI 365

                 .
gi 144953907 616 L 616
Cdd:cd17490  366 L 366
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
450-651 1.35e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.90  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGlhlglGRGCGAMIGGVLVNYFGAA--ATFRGIG 607
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQA-----FGSVGGILGPLLGGILASSlgFGWRAVF 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 144953907 608 MACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATI 651
Cdd:cd06174  156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV 199
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
450-619 2.19e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.44  E-value: 2.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFM-GFGYGFVFTFLYWHLEDLNGTTTLFGVcsVLShvseltAYFFSH--------KLIELIGHIRVLYIGLACN 520
Cdd:COG0477   18 ALALGTFLeGLDFTIVNVALPSIAADLGASSAQLGW--IVS------AYLLGRaiglllfgRLGDRYGRKRVLLIGLLLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG0477   90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALGWR 168
                        170
                 ....*....|....*....
gi 144953907 601 ATFrGIGMACLVILLLFAL 619
Cdd:COG0477  169 WIF-LINAPLGLLALVLRL 186
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
450-620 2.47e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 59.94  E-value: 2.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISY 529
Cdd:cd06173  214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 530 LENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMA 609
Cdd:cd06173  294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL-NSGAMPLGALLAGLLADALGLSAVFLLAGAL 372
                        170
                 ....*....|.
gi 144953907 610 CLVILLLFALI 620
Cdd:cd06173  373 LLLAALLLLLL 383
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
324-620 2.58e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 60.30  E-value: 2.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 324 YGLQRMWGSLGWGLAMLSVGIgidythievLIDGKGCKPPEyrNYQIVFIVFGVLMTMALIVAtqFRFRynhfknddskg 403
Cdd:COG2211  149 SSWRFAFAGLGGLLASVLPPP---------LVAAFGGDAAL--GYRLTALIFAVLGLLAFLLT--FFGT----------- 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 404 KEVEIPQVERnnstesseetptttshsqaFNFWDLIKLLCSV-QYGSVLFVAWFMGFGYGFVFT-FLYWHLEDLNGTTTL 481
Cdd:COG2211  205 KERPVPEEEK-------------------VSLKESLKALLKNrPFLLLLLAYLLFFLALALVAAlLLYYFKYVLGLSAAL 265
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 482 FGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYI--YISYLENAWTVLPMEVLQGVTHAAIWAACISYLS 559
Cdd:COG2211  266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLllFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLA 345
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 144953907 560 AAVPP-ELRT--SAQGILQGLH---LGLGRGCGAMIGGVLVNYFG-------AAATFRGIGMACLVILLLFALI 620
Cdd:COG2211  346 DVVDYdEWKTgrRREGLYFGIFtfaIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPAVLLLL 419
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
458-617 3.38e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 59.51  E-value: 3.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 458 GFGYGFVFTFLYWHLEDLNGT----------TTLFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17330    9 ALGFGIVFPVLPFYVREFNKLgasgyyvgllQSSYSLGQFLA------SPLWG-RLSDRYGRKPVLLLSLAGSAVSYVLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 528 SYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFGAAATF---R 604
Cdd:cd17330   82 GLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGII-SAAFGLGFILGPALGGFLSTPYGYALPFlvaA 159
                        170
                 ....*....|...
gi 144953907 605 GIGMACLVILLLF 617
Cdd:cd17330  160 ALALLNLVLVLFF 172
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
450-619 6.64e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.74  E-value: 6.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFmgfgyGFVFTFLYWHL---------EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACN 520
Cdd:COG2223    6 VLLLATL-----AFFLAFGVWYLwsvlapplaEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGG-GNLGAAVAAFLAPLLIAAFGWR 159
                        170
                 ....*....|....*....
gi 144953907 601 ATFRGIGMACLVILLLFAL 619
Cdd:COG2223  160 NAFLILGILLLVVAVLAWL 178
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-152 1.36e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.57  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  73 VFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkkG-KIVLLFSLLCWVLFNLGIGF 151
Cdd:COG2271   17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF--GrRRVLAIGLLLWGLATLLFGF 94

                 .
gi 144953907 152 V 152
Cdd:COG2271   95 A 95
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
68-157 2.00e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.22  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  68 LLISKVFYFFFYSAYGSLYPLLPVYYkqLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNL 147
Cdd:COG2211  233 LLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLL 309
                         90
                 ....*....|
gi 144953907 148 GIGFVKPATL 157
Cdd:COG2211  310 LLFFLGPGNL 319
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
456-633 2.94e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 56.47  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 456 FMGFGYGFVFTFLYWHL-EDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAW 534
Cdd:cd17329   10 LNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 535 TVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCGAMIGGVLVNYFgaaatFRGIGMACLVIL 614
Cdd:cd17329   90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL-YWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLF 163
                        170
                 ....*....|....*....
gi 144953907 615 LLFALIQWLAVPDEEEDKT 633
Cdd:cd17329  164 LLAALVLLFLLPETRPKRR 182
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
450-620 5.81e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.69  E-value: 5.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACnTARYIYIS 528
Cdd:cd17316  182 LILLWFFISFGYYGLTTFLpTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL-SGILALPL 260
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 529 YL---ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAqgilqglhLGLGRGCGAMIGGVLVNYFGAAATFRG 605
Cdd:cd17316  261 FYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG--------VGLSYNLGRLGGGGAPPLIALLLASTG 332
                        170
                 ....*....|....*
gi 144953907 606 IGMACLVILLLFALI 620
Cdd:cd17316  333 GTGVPALILALLAIV 347
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
502-618 7.80e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 55.26  E-value: 7.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 502 KLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILqGLHLGL 581
Cdd:cd17321   53 RLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW-GAVVGI 131
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 144953907 582 GRGCGAMIGGVLVNYFGAAATF--------------RGIGMACLVILLLFA 618
Cdd:cd17321  132 GAALGPLLGGLLLELFGWRWIFlinvpiglvalllaRTFSGAVLAAFLLGA 182
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
450-617 7.91e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 55.24  E-value: 7.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYgFVFTFLYWHLEDLNGTTTLFGVCSVLSH-VSELTAYFFSHkLIELIGHIRVLYIGLACNTARYIYIS 528
Cdd:cd17370  205 YLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYALFNlVYALAAYPAGR-LSDRIGRKKLLILGYLSLALAYLGFA 282
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 529 YLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGIlqglhLGLGRGCGAMIG----GVLVNYFGAAATFR 604
Cdd:cd17370  283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL-----FNTVVGIGWLLAsliaGYLWDLISPSAAFL 357
                        170
                 ....*....|....
gi 144953907 605 -GIGMACLVILLLF 617
Cdd:cd17370  358 fSAVLALIALLLLL 371
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
287-621 1.97e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 54.16  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 287 IFLVILVVVIIGE--FFSASSVTIVDTVTlqylGKHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYthievlidgkgckpp 363
Cdd:cd17329   90 LFAIALVLTGFGGglFEPASEAMIADVTT----PENRTRaFSLLYWAINLGVAIGPLLGGLLLLY--------------- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 364 eyrNYQIVFIVFGVLMTM-ALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNnstesseetptttshsQAFnfwdlikll 442
Cdd:cd17329  151 ---SFRLLFLAAAVLFLLaALVLLFLLPETRPKRRAAEKTEILRGYKIVLRD----------------RAF--------- 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 443 csvqygsVLFVAWFMG--FGYGFVFTFLYWHLEDLNGTTT-----LFGVCSVLShvseLTAYFFSHKLIELIGHIRVLYI 515
Cdd:cd17329  203 -------LLFLLASFLisLIYFQLESTLPVYVVEILGLGEsllglLLALNALLI----VLLQFPVARLVERFRLRKILMI 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 516 GLACNTARYIyISYLENAWTVLPM--------EVLqGVTHAAIWAACISylsaavPPELRTSAQGiLQGLHLGLGRGCGA 587
Cdd:cd17329  272 GILLFAIGFA-VLAFANTLAVLILamivltlgEML-VFPAVQTLVAALA------PPDKRGSYMG-FYALAWGLGRAIGP 342
                        330       340       350
                 ....*....|....*....|....*....|....
gi 144953907 588 MIGGVLVNYFGAAATFRGIGMACLVILLLFALIQ 621
Cdd:cd17329  343 LVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
450-621 2.59e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 53.73  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLF--GVCSVLSHVSELTAYFFShKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17473  202 IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALigLALAIASLAGAIGALLFG-RLKRRLGKRRLLAIGFALMALGFLLL 280
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 528 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVN-YFGAAATFRGI 606
Cdd:cd17473  281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA-FFLGQFLSPLVLGPLVNlTGGLSGAFLIL 359
                        170
                 ....*....|....*
gi 144953907 607 GMACLVILLLFALIQ 621
Cdd:cd17473  360 GVLALVLAIVLLLLR 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
65-157 2.70e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.58  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  65 NNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGM-SPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWV 143
Cdd:cd06174  202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMA 281
                         90
                 ....*....|....
gi 144953907 144 LFNLGIGFVKPATL 157
Cdd:cd06174  282 LGLALLLLAPSLLL 295
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
503-627 4.18e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 52.94  E-value: 4.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 503 LIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQ-GLHLG- 580
Cdd:cd17324   57 LSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFsGLTLGl 136
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 144953907 581 -LGRgcgaMIGGVLVNYFGAAATFRGIGmaclVILLLFALIQWLAVPD 627
Cdd:cd17324  137 vLGR----PLGGLLGQLLGWRAAFLAIA----VLALLAALLLWRLLPS 176
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
488-619 6.22e-07

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 52.63  E-value: 6.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 488 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYL---ENAWTVLPMEVLQGVTHAAIWAACISYLSA 560
Cdd:cd06177  242 LGQISEilfmLAIPFFLKRL----GIKKVMLIGMLAWVLRFGLFAYGdpsPGVWMLVLSIILHGVCYDFFFVTGYIYVDK 317
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 144953907 561 AVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAAT---FRGI-----GMAcLVILLLFAL 619
Cdd:cd06177  318 KAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVEGtkdWQTIwlvpaIYA-LVLAILFAL 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
68-157 6.47e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.58  E-value: 6.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkKGKIVLLFSLLCWVLFNL 147
Cdd:COG2223    7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRF-GPRRVLLIGLLLLGIGLL 85
                         90
                 ....*....|
gi 144953907 148 GIGFVKPATL 157
Cdd:COG2223   86 LLALAVSYWL 95
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
31-152 7.12e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.19  E-value: 7.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  31 REPEPPSNETPSSTETSAIPEEEIdwiekhcvKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQL-GMSPSQSGLLVGI 109
Cdd:cd17325  172 PEPRPPPNKRAVSAARLRSGLRLL--------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGA 243
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 144953907 110 RYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17325  244 QGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLA 285
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
450-620 7.28e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.18  E-value: 7.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWF-MGFGYGFVFTFLYWHLEDLNG--------TTTLFGVCSVlshVSELTAYFFSHKLIEliGHIRVLYIGLACN 520
Cdd:COG2271  184 LLALAYFlVYFALYGFLTWLPTYLVEVRGlslaqaglLLSLPFLAGI---VGSLLGGWLSDRLGR--RRKLVLAIGLLLA 258
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAA 600
Cdd:COG2271  259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLDATGYQ 337
                        170       180
                 ....*....|....*....|
gi 144953907 601 ATFrGIGMACLVILLLFALI 620
Cdd:COG2271  338 AAF-LLLAALALLAALLALL 356
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
494-620 1.17e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 51.42  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 494 LTAYF--------FSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIwAACISYLSAAVPPE 565
Cdd:cd17504   37 LTAYLlvgavstpILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPE 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 144953907 566 LRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17504  116 RVPVAQGILSAT-FGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
73-152 1.25e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  73 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIV---LLFSLLCWVLFNLG 148
Cdd:COG2814  214 LLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLligLLLLALGLLLLALA 293

                 ....
gi 144953907 149 IGFV 152
Cdd:COG2814  294 GSLW 297
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-157 1.46e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  73 VFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRF-KKGKIVLLFSLLCWVLFNLGIG 150
Cdd:COG2271  187 LAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLA 266

                 ....*..
gi 144953907 151 FVKPATL 157
Cdd:COG2271  267 LLPSPAL 273
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
64-152 1.50e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.06  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  64 INNDLLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCW 142
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILS 253
                         90
                 ....*....|
gi 144953907 143 VLFNLGIGFV 152
Cdd:cd17316  254 GILALPLFYL 263
MFS_1 pfam07690
Major Facilitator Superfamily;
36-156 1.58e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.88  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907   36 PSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFyFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEF 115
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 144953907  116 CSAPFWGVVADRFKKGKIVLLFSLLCwVLFNLGIGFVKPAT 156
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLL-ILAALGLLLLSLTL 289
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
73-157 1.76e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.03  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  73 VFYFFFYSA-YGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGF 151
Cdd:COG2807  221 TLFFGLQSLlYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL 300

                 ....*.
gi 144953907 152 VkPATL 157
Cdd:COG2807  301 A-PGSL 305
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
460-617 5.42e-06

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 49.65  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 460 GYGFVFTFLYWHL---------EDLNGTTTLFGVcsvlsHVSELTAYFFSHKLIELIGHIRVLYIGLaCNTARYIYISYL 530
Cdd:cd17338    5 SFGFLLIFLAYSAlqnlqtslhENGLGSISLGIL-----YSSFAVSSFIAPLLVKLLGEKITLVLGG-LGYAIFIASNIF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 531 ENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAA-------ATF 603
Cdd:cd17338   79 PIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSI-FQLSQVFGNLISLALLNHSKGSsgttilfIVF 157
                        170
                 ....*....|....
gi 144953907 604 RGIgMACLVILLLF 617
Cdd:cd17338  158 MAI-MLVGIILLFF 170
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
76-152 6.39e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 6.39e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 144953907  76 FFFYSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17329    9 FLNRLGFFMVWPFMAIYlHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGFALLGFA 85
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
450-620 6.94e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.11  E-value: 6.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGY-GFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAY-FFSHKLIELIGHIRVLYIGLACNTARYIYI 527
Cdd:cd17330  179 LLLVYFLIALAFaGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 528 SYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGAAATFrGIG 607
Cdd:cd17330  259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ-SLARIIGPLLAGPLYSFLGPGVPF-LLA 336
                        170
                 ....*....|...
gi 144953907 608 MACLVILLLFALI 620
Cdd:cd17330  337 AGLLLIALFLLSL 349
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
73-145 1.55e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 1.55e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 144953907  73 VFYFFFYSAYGSLYPLLPVYYK-QLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLF 145
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGL 285
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
452-639 3.10e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.22  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 452 FVAWFMG-----FGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLyigLACNTAR--- 523
Cdd:cd06173    1 FRLLWLAqllsaLGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL---ILADLLRall 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 524 -----YIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFG 598
Cdd:cd06173   78 aavlaLLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLA-TQLARIIGPALGGLLVALLG 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 144953907 599 AAATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERI 639
Cdd:cd06173  157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDL 197
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
76-152 3.20e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.87  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIG 150
Cdd:cd17391    6 FFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGR-KPMLLRASLGMAIVIGLMA 84

                 ..
gi 144953907 151 FV 152
Cdd:cd17391   85 FV 86
Nuc_H_symport pfam03825
Nucleoside H+ symporter;
488-619 3.83e-05

Nucleoside H+ symporter;


Pssm-ID: 461066 [Multi-domain]  Cd Length: 399  Bit Score: 46.69  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  488 LSHVSE----LTAYFFSHKLieliGHIRVLYIGLACNTARYIYISYLEN------AWTVLPMeVLQGVTHAAIWAACISY 557
Cdd:pfam03825 251 LGQISEilfmLTLPFFLKRF----GIKNVMLIGIVAWALRFAFFAYGADptpfgtALLLLSM-IVHGVAYDFFNITGYIF 325
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907  558 LSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFR-------GIGMAcLVILLLFAL 619
Cdd:pfam03825 326 VDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDwqtvwlvFAGMA-LVLAVLFMA 393
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
507-633 5.05e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 46.44  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 507 IGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVthAAIWAACISYLSAAVPPELRTSAQGILqGLHLGLGRGCG 586
Cdd:cd17472   59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI-GASIGIAFAIS 135
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 144953907 587 AMIGGVLVNYFGAAATFrgIGMACLVILLLFalIQWLAVPDEEEDKT 633
Cdd:cd17472  136 MVLGPLLAAHLGVSGLF--LITAILSLVSLL--ILLFFVPDPPKIVQ 178
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
76-140 6.69e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.07  E-value: 6.69e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQ-----SGLLVGIRYFIEFCSAPFWGVVADRfKKGKIVLLFSLL 140
Cdd:PRK09874  24 FLTGAAFSLVMPFLPLYVEQLGVTGHSalnmwSGLVFSITFLFSAIASPFWGGLADR-KGRKIMLLRSAL 92
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
292-620 6.94e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.00  E-value: 6.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 292 LVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRM-WGSLGWGL-AMLSVGIGIdythieVLIDGKGckPPEYRnyq 369
Cdd:COG0738   96 YPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnLLHAFFSLgALLGPLLGG------LLILLGL--SLSWH--- 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 370 IVFIVFGVLMTMALIVATQFRFrynhfknddskgkeveiPQVErnnsTESSEETPTTTSHSQAFNFwdlikllcsvqygS 449
Cdd:COG0738  165 LPYLILAVLLLLLALLFLRSKL-----------------PEIE----EEEEEAAGSAASLKSLLKN-------------P 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGFV----FTFLYWHLEDLNG-TTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARY 524
Cdd:COG0738  211 RLLLGGLAIFLYVGAegaiGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 525 IYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPelRTSAQGilqGLHLGLGrGCGAMIG----GVLVNYFGAA 600
Cdd:COG0738  291 LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK--RTAAAV---SAVLIMG-IVGGAIGppliGFLADAFGLR 364
                        330       340
                 ....*....|....*....|
gi 144953907 601 ATFrGIGMACLVILLLFALI 620
Cdd:COG0738  365 AAF-LVPLVCYLLILLLALA 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
450-618 7.02e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 7.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 450 VLFVAWFMGFGYGF-VFTFLYWHLEDLNGTTT--------LFGVCSVLShvseltAYFFShKLIELIGHIRVLYIGLACN 520
Cdd:cd17324  202 LAYLITFLLFGGFFaLYTYLAPFLTDVPGFSSsaiiglllLFGVAGVVG------SPLAG-RLADRGGRRALLIALLLLA 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 521 TARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPpelrtSAQGILQGLHLG---LGRGCGAMIGGVLVNYF 597
Cdd:cd17324  275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-----EARGLASSLYLAaynLGGALGAALGGLVLDHG 349
                        170       180
                 ....*....|....*....|.
gi 144953907 598 GAAATFRGIGMACLVILLLFA 618
Cdd:cd17324  350 GWAGVGWVGAALLLLALLLAL 370
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
81-154 8.39e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.65  E-value: 8.39e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 144953907  81 AYGSLYPLLPVY---YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVKP 154
Cdd:cd17330   11 GFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGR-KPVLLLSLAGSAVSYVLLGLSRN 86
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
514-619 8.60e-05

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 45.73  E-value: 8.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 514 YIGLACNTARYIYISYLENAWTV---LPMEVLQGVT--HAAIWAACISYLSAAVPPELRTSAQGILQGLhLGLGRGCGAM 588
Cdd:cd17386   67 LVGLLLSSLILVLIVYFTTVPSVwwfYLSAIPLALFggFTAFLSASFAYISDISSEKKRTYRMAILEVA-LGLGGFLGSL 145
                         90       100       110
                 ....*....|....*....|....*....|.
gi 144953907 589 IGGVLVNYFGAAATFrGIGMACLVILLLFAL 619
Cdd:cd17386  146 LSGHLFKALGYAWSF-SISAALLLIALLYIL 175
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
68-151 2.11e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.03  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCS-APFWGVVADRFkkG-KIVLLFSLLCWVLF 145
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSA-YLLGRAIgLLLFGRLGDRY--GrKRVLLIGLLLFGLA 92

                 ....*.
gi 144953907 146 NLGIGF 151
Cdd:COG0477   93 SLLCGL 98
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
325-626 2.77e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 2.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 325 GLQRMWGSLGWGLAMLSVGigidythieVLIDGKGckppeyrnYQIVFIVFGVLMTMALIVATQFrfrynhfknddskgk 404
Cdd:COG2223  132 GLAAGGGNLGAAVAAFLAP---------LLIAAFG--------WRNAFLILGILLLVVAVLAWLF--------------- 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 405 eveipqvernnstesSEETPTTTSHSQAFNFWDLIKLLCSVQYGsVLFVAWFMGFGYGFVFTF---LYWHLE---DLNGT 478
Cdd:COG2223  180 ---------------LRDPPAGAAAAAKASLRDQLEALRDPRFW-LLSLLYFGTFGSFIGFSSwlpPYLVDQfglSAATA 243
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 479 TTLFGVCSVLSHVSELTAYFFSHKlielIGHIRVLYIGLACNTARYIYISY-LENAWTVLPMEVLQGVTHAAIWAACISY 557
Cdd:COG2223  244 GLLAALFALLGALGRPLGGWLSDR----IGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLFLLLGLALGGGNGAVFAL 319
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907 558 LSAAVPPELRTSAQGILqglhlGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQWLAVP 626
Cdd:COG2223  320 VPDIFPTKNAGAVYGLV-----GAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
87-152 3.65e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.69  E-value: 3.65e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 144953907  87 PLLPVYYKQLGMSPSQSGLLVGIrYFIEFC-SAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17324   20 GLLPDIARDFGVSVAQAGLLVSA-YALGYAlGALLLGPLSDRIER-RRLLLVLLLLFILGNLLAALA 84
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
408-623 3.70e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 43.75  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 408 IPQVERNNSTESSEETPTTTShsqAFNFWDLIKLLCSVQYGSVLFVAWFMGFG---YGFVFTFL---YWHL--EDLNGTT 479
Cdd:cd17331  173 IPSNTKSKREKEAKESASPPS---VFNLKEILRLLRLPGVAFLLLVKLLSGLPigmFQSMFSLVamdFFGLtpEENGYLM 249
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 480 TLFGVCSVLSH---VSELTAYFFSHKLIEL-IGHIRVLYIGLA-CNTaryIYISYLenawTVLPMEVLQGVTHAAIWAAc 554
Cdd:cd17331  250 SYAGVLGMVVQgllVGPLTKRFGERSLLKLsVALLAIGYLLLAfVTT---VWQLLV----LLLPLVIGGSVLYTVITSL- 321
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907 555 isyLSAAVPPELRTSAQGILQGLHlGLGRGCGAMIGGVLVNYFGaaatFRGIGMACLVILLLFALIQWL 623
Cdd:cd17331  322 ---LTKAVPPEDTGTALGLSHALF-SLVRTVSPTIGGALLQAYG----FPSFGLLGAAINGLLTVYLLL 382
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
62-157 3.97e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 43.75  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  62 VKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLC 141
Cdd:cd17332  217 LLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGK-KKAFFIGLLL 295
                         90
                 ....*....|....*.
gi 144953907 142 WVLFNLGIGFVKPATL 157
Cdd:cd17332  296 AILGLLLLFFLPPGNL 311
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
70-156 4.51e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.33  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  70 ISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkKGKIVLLFSLLCWVLFNLG 148
Cdd:cd17503  182 LGLLLSFLLGLGLFGAMFLLPLYLQNvLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF-GPRLLLLAGLLLLALGTLL 260

                 ....*...
gi 144953907 149 IGFVKPAT 156
Cdd:cd17503  261 LAFLTPDT 268
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
76-137 4.81e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.30  E-value: 4.81e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 144953907  76 FFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLF 137
Cdd:cd17370    9 LFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIL 70
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
69-141 5.70e-04

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 42.95  E-value: 5.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144953907  69 LISKVFYFFF-YSAYGSLYPLLPVY-YKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLC 141
Cdd:PRK05122  17 IVSIVMFTFIsYLTIGLPLAVLPGYvHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGC 91
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
498-633 6.65e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 498 FFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLsAAVPPELRTSAQGILQGL 577
Cdd:COG0738   61 LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV-AALGPETAASRLNLLHAF 139
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907 578 HlGLGRGCGAMIGGVLVNYFGAAAT---FRGIGMACLVILLLFALIQWLAVPDEEEDKT 633
Cdd:COG0738  140 F-SLGALLGPLLGGLLILLGLSLSWhlpYLILAVLLLLLALLFLRSKLPEIEEEEEEAA 197
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
68-157 7.25e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 7.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  68 LLISKVFYFFFYSaygslYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKiVLLFSLLCWVLFNL 147
Cdd:cd17370  206 LLAVALFALGNFS-----FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALAYL 279
                         90
                 ....*....|
gi 144953907 148 GIGFVKPATL 157
Cdd:cd17370  280 GFALGSSLWL 289
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
87-140 9.61e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 9.61e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 144953907  87 PLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLL 140
Cdd:cd17390   17 PLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGR-RPVLLICLL 69
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
69-145 1.05e-03

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 42.22  E-value: 1.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 144953907  69 LISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLF 145
Cdd:cd06172    2 WKFSLFFFLFFFIWSASFSFFPIWLTQiNHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLF 79
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
80-145 1.21e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 41.82  E-value: 1.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  80 SAYGSLYPLLPVYYKQLGMSPSQSGL---LVGIRYFIefcSAPFWGVVADRFKKGKIVLLF-SLLCWVLF 145
Cdd:cd17385  215 VSLGFLDPTLSPHLRQFKLSPGQVGLmflILAGSYAI---SAPLWGWLSDKKKIPKWLMVIgSIITGVGF 281
lacY PRK09528
galactoside permease; Reviewed
65-130 1.34e-03

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 41.81  E-value: 1.34e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907  65 NNDLLISKVFYFFFYSAYGSLYPLLPVYYKQ-LGMSPSQSGLLVGIRYFIEFCSAPFWGVVADR--FKK 130
Cdd:PRK09528   9 NPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDiNGLSGTDTGIIFSANSLFALLFQPLYGLISDKlgLKK 77
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
73-152 1.76e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  73 VFYFFFYSAYGSLYPLLpVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17316    9 FFDAYDFFLIGFVAPVL-AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGR-KKALILTLLLFGLATLLIGLL 86
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
463-619 2.33e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.05  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 463 FVFTFLYW------------HLEDLNGTTTLFGVCsvlshvseLTAYFFSHKLIEL-IG--------HIRVLYIGLACNT 521
Cdd:cd17490    2 LIIVFLFWfsqyvyvpflspYAESLGASLSMIGII--------LGAYGISQMLLRIpLGilsdrigkRKLFIIIGLLFTV 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 522 ARYIYISYLENAWTVLPMEVLQGVThAAIWAACISYLSAAVPPELRTSAQGILQgLHLGLGRGCGAMIGGVLVNYFGAAA 601
Cdd:cd17490   74 LASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLIN-LVNNLGQLIAFLIGGLIAEHFGMRA 151
                        170
                 ....*....|....*....
gi 144953907 602 TFR-GIGMACLVILLLFAL 619
Cdd:cd17490  152 PFLlAALAGVLGFILSLFI 170
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
474-621 2.68e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 474 DLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAA 553
Cdd:cd17391  234 DASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPA 313
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 144953907 554 CISYLSAAVPPELRTSAQGILQGLHLgLGRGCGAMIGGVLVNYFGAAATFRGIGmaclvILLLFALIQ 621
Cdd:cd17391  314 INSLLAKITPKEVAGRIFGYNQSFQY-LGNVAGPLLGSAIAAHFGYRAVFVVTA-----LLVLLNAIW 375
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
473-616 2.71e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 473 EDLNGTTT----LFGVCSVLshvsELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHA 548
Cdd:cd17471  228 NELGGSESwvglLFGLAAAL----EIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG 303
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 144953907 549 AIWAACISYLSAAVPPE------LRTSAQGIlqglhlglgrgcGAMIGGVLVNYFGAAATFRGIGMACLVILLL 616
Cdd:cd17471  304 ITAGLGISYFQDLMPGQpglattLYSNASRI------------GSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
PRK11128 PRK11128
3-phenylpropionate MFS transporter;
292-617 2.80e-03

3-phenylpropionate MFS transporter;


Pssm-ID: 236856 [Multi-domain]  Cd Length: 382  Bit Score: 40.65  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 292 LVVVIIGEF--FSASSVTIVDTV--TLQYLgKHRDrYGLQRMWGSLGWGLAMLSVGIgidythievLIDGKGckppeYRN 367
Cdd:PRK11128  96 LLFVAIGLFnlFFSPLVPLTDALanTWQKQ-IGLD-YGKVRLWGSIAFVIGSALTGK---------LVSWFG-----EQA 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 368 yqIVFIVFGVLMTMALIVATQfrfrynhfknddskgkeveiPQVernnstesseeTPTTTSHSQA----FNFWDLIK--- 440
Cdd:PRK11128 160 --ILWILTAGVASMLLGQLLR--------------------PTI-----------MPQGESRQQEsagwPAWKALLKept 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 441 ----LLCsvqygsvlfVAWFMG--FGYgFVFTFLYW----HLEDLNGTTTLFGVcsvlshVSELTAYFFSHKlieLIGHI 510
Cdd:PRK11128 207 vwrfLLC---------VSLLQGshAAY-YGFSAIYWqaagYSASTIGYLWSLGV------VAEVLIFAFSNR---LFRRW 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 511 RV---LYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAvPPELRTSAQGILQGLHLGLGRGCGA 587
Cdd:PRK11128 268 SArdlLLLSAICGVVRWGLMGSTTALPWLIVIQILHCGTFTVCHLAAMRYIAAR-PGSEVIRLQALYSALAMGGSIAIMT 346
                        330       340       350
                 ....*....|....*....|....*....|
gi 144953907 588 MIGGVLVNYFGaAATFrgIGMACLVILLLF 617
Cdd:PRK11128 347 VLSGFLYQHLG-AGVF--WVMALVALPALF 373
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
451-647 2.96e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.61  E-value: 2.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 451 LFVAWFMGFGYGFVFTFL-YWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVL-YIGLACNTARYIYIS 528
Cdd:cd17471    2 LLATLLTGLAGAFVLPYLsLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLiLLALLAGALGYLLFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 529 YLENAWTVLpmevLQGVTHAAIWAACISYLSA-------AVPPELRTSAQGILQGLhLGLGRGCGAMIGGVLVNYFGAAA 601
Cdd:cd17471   82 FLRNYWVLL----LVGVVLLSLGAAAFPQLFAlareyadRSSGRDATLFNSVLRAA-FSLAWVIGPPLAFLLLDVLGFTG 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 144953907 602 TFRGIGmaclVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVP 647
Cdd:cd17471  157 LFLLAA----LLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVN 198
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
68-152 3.58e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907  68 LLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFkkG-KIVLLFSLLCWVLFN 146
Cdd:COG0738   10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF--GyKRGLLLGLLLMALGL 87

                 ....*.
gi 144953907 147 LGIGFV 152
Cdd:COG0738   88 LLFALA 93
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
83-154 3.83e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 3.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 144953907  83 GSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVKP 154
Cdd:cd17477  205 GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR-RRVLLGCALLGALAALLLPLVPG 275
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
78-152 4.90e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 4.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144953907  78 FYSayGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLfSLLCWVLFNLGIGFV 152
Cdd:cd17478   10 FYQ--GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPL-GPLLTGLGLSLLGFA 81
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
76-152 4.94e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.84  E-value: 4.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907  76 FFFYSAYGSLYPL-LPVYY-KQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKiVLLFSLLCWVLFNLGIGFV 152
Cdd:cd17471  208 FTLLFAANSMYIIaMPLYVtNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRR-LLLAGFLAGVLFYLGLALA 285
PRK11128 PRK11128
3-phenylpropionate MFS transporter;
75-115 5.28e-03

3-phenylpropionate MFS transporter;


Pssm-ID: 236856 [Multi-domain]  Cd Length: 382  Bit Score: 39.88  E-value: 5.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 144953907  75 YFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEF 115
Cdd:PRK11128  13 YFGYFFAYGVFLPFWSVWLKGQGYTPETIGLLLGAGLVARF 53
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
280-581 6.26e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.92  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 280 DQQEVEAIFLVILVVVIIgEFFSAssvtIVDTVTLQYLG-----KHRDR-YGLQRMWGSLGWGLAMLSVGIGIDYTHIEV 353
Cdd:cd17313   98 DGPRTWALVLFVLGIVLL-DFAMN----VCQGPVRALLPdlvppEQRSKaNGIINFMGGLGGVLGYLLGAILWDHNWFGF 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 354 LIDGkgckppeyrNYQIVFIVFGVLMTMALIVaTQFRFRynhfknddskgkeveipqvERNNSTESSEETPTTTSHSQAF 433
Cdd:cd17313  173 ALGG---------NLKVPFYIGAIILLVCVLV-TLFFVK-------------------EPPLSPEAGEHSENPSLGEVLK 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 434 NFWDLIK-------LLCSVQygsvLFvaWFMGFGYGFVFTFLYWHLEDLNGTTTL------------FGVCsVLSHVSEL 494
Cdd:cd17313  224 SLLKLLKimprsllRLLLVI----FF--WWIAFFPFELFFTDYMGEEVYHGTSAAsshygagvrmgaWGLL-IFSLAFLI 296
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 495 TAyFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVPPELRTsaqgil 574
Cdd:cd17313  297 FS-LPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRG------ 369

                 ....*..
gi 144953907 575 QGLHLGL 581
Cdd:cd17313  370 QGTDTGL 376
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
78-153 6.35e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.48  E-value: 6.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 144953907  78 FYSAYGS--LYPLLPVYYKQLGMSPSQSGLLVGIrYFIEFCSAP-FWGVVADRFKKgKIVLLFSLLCWVLFNLGIGFVK 153
Cdd:cd17323    9 FVVTFGSsiYSPALPQIAEDFHVSEEVANLGVSL-FVLGFGLGPlIWAPLSELYGR-RPVYLVSLFIFVIFQIGCALAP 85
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
481-620 7.87e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.54  E-value: 7.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144953907 481 LFGVCSVLSHVseltayFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEV---LQGVTHAAIWAacisY 557
Cdd:cd17388  250 VFGLLHALFQA------FVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILIllaLGGIAGPALQG----L 319
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144953907 558 LSAAVPPElrtsAQGILQGLHLGLgRGCGAMIGGVLVN--YFGAAATFRGIGMACLVILLLFALI 620
Cdd:cd17388  320 LSRQVPEN----EQGELQGVLTSL-TSLTSIIGPLLFTgiFAASPATWPGLAWIIGAALYLICLV 379
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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