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Conserved domains on  [gi|1934152514|ref|NP_060176|]
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WD repeat-containing protein 55 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-332 3.08e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  39 APASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 119 ERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319   155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1934152514 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVV 332
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-332 3.08e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  39 APASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 119 ERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319   155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1934152514 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVV 332
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-324 5.17e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 5.17e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  83 HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPL 161
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 162 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNG 241
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 242 FGaTSDRFALRAESIDCMVPV-TESLLCTGSTDGVIRAVNILPNRVVGSVGQHTgEPVEELALSHCGRFLASSGHDQRLK 320
Cdd:cd00200   167 GK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE-NGVNSVAFSPDGYLLASGSEDGTIR 244


                  ....
gi 1934152514 321 FWDM 324
Cdd:cd00200   245 VWDL 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-323 2.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1934152514  283 PNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWD 323
Cdd:smart00320   1 SGELLKTLKGHTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 44-118 8.14e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1934152514  44 LAFHPARDLLAAGDVDGDVFVFSYSCQEgetkeLWS---SGHHLKAcRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQR-----VWTlspDKEDLEV-TSLAWRPDGKLLAVGYSDGTVRLLDAENGKI 72
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-332 3.08e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 3.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  39 APASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLA----TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 119 ERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319   155 LRTL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAfsP-DGKLLASGSDDGT 311

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1934152514 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVVV 332
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
38-325 8.35e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 8.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  38 EAPASGLAFHPARDLLAAGDVDGDVFVFSyscqEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQ 117
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLWD----LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 118 LERRVsKAHGAPINSL-LLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFN 196
Cdd:COG2319   196 LLRTL-TGHTGAVRSVaFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 197 IKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PVTESLLcTGSTDG 274
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAfsPDGKTLA-SGSDDG 352

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1934152514 275 VIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMA 325
Cdd:COG2319   353 TVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-324 5.17e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 5.17e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  83 HLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVsKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPL 161
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 162 MDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNG 241
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 242 FGaTSDRFALRAESIDCMVPV-TESLLCTGSTDGVIRAVNILPNRVVGSVGQHTgEPVEELALSHCGRFLASSGHDQRLK 320
Cdd:cd00200   167 GK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE-NGVNSVAFSPDGYLLASGSEDGTIR 244


                  ....
gi 1934152514 321 FWDM 324
Cdd:cd00200   245 VWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-323 1.40e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 1.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  38 EAPASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKElwsSGHHLKAcRAVAFSEDGQKLITVSKDKAIHVLDVEQGQ 117
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPV-RDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 118 LERRVsKAHGAPINSL-LLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFN 196
Cdd:cd00200    85 CVRTL-TGHTSYVSSVaFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 197 IKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLfnWN-GFGATSDRFALRAESIDCMVP-VTESLLCTGSTDG 274
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL--WDlSTGKCLGTLRGHENGVNSVAFsPDGYLLASGSEDG 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1934152514 275 VIRAVNILPNRVVGSVGQHTgEPVEELALSHCGRFLASSGHDQRLKFWD 323
Cdd:cd00200   242 TIRVWDLRTGECVQTLSGHT-NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-330 1.17e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 1.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  39 APASGLAFHPARDLLAAGDVDGDVFVFSyscqEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:COG2319    37 AAVASLAASPDGARLAAGAGDLTLLLLD----AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 119 eRRVSKAHGAPINSLLL-VDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNI 197
Cdd:COG2319   113 -LRTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 198 KRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGV 275
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAfsP-DGRLLASGSADGT 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1934152514 276 IRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLRAV 330
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323
WD40 COG2319
WD40 repeat [General function prediction only];
38-241 4.07e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.07e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  38 EAPASGLAFHPARDLLAAGDVDGDVFVFSYScqegETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQ 117
Cdd:COG2319   204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLA----TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 118 LeRRVSKAHGAPINSLLLV-DENVLATGDDTGGICLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFN 196
Cdd:COG2319   280 L-LRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1934152514 197 IKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNG 241
Cdd:COG2319   359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
76-356 5.18e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 5.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  76 ELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQ 155
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 156 RKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIY 235
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 236 LFNWNGfGATSDRFALRAESIDCMV--PvTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASS 313
Cdd:COG2319   188 LWDLAT-GKLLRTLTGHTGAVRSVAfsP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASG 264

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1934152514 314 GHDQRLKFWDmaqlravvVDDYRRRKKKGGPLRALSSKTWSTD 356
Cdd:COG2319   265 SADGTVRLWD--------LATGELLRTLTGHSGGVNSVAFSPD 299
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 167-330 1.93e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 1.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 167 HEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATS 246
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 247 DRFALRAESIDCMVPV-TESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMA 325
Cdd:cd00200    87 RTLTGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD-WVNSVAFSPDGTFVASSSQDGTIKLWDLR 165


                  ....*
gi 1934152514 326 QLRAV 330
Cdd:cd00200   166 TGKCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
91-330 5.92e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 5.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514  91 AFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGPLMDMRQHEEY 170
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 171 IADMALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGfGATSDRFA 250
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1934152514 251 LRAESIDCMV--PVTESLLcTGSTDGVIRAVNILPNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWDMAQLR 328
Cdd:COG2319   160 GHSGAVTSVAfsPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237


                  ..
gi 1934152514 329 AV 330
Cdd:COG2319   238 LL 239
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-323 2.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1934152514  283 PNRVVGSVGQHTGePVEELALSHCGRFLASSGHDQRLKFWD 323
Cdd:smart00320   1 SGELLKTLKGHTG-PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 75-112 6.95e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 6.95e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1934152514   75 KELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLD 112
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 44-118 8.14e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.33  E-value: 8.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1934152514  44 LAFHPARDLLAAGDVDGDVFVFSYSCQEgetkeLWS---SGHHLKAcRAVAFSEDGQKLITVSKDKAIHVLDVEQGQL 118
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQR-----VWTlspDKEDLEV-TSLAWRPDGKLLAVGYSDGTVRLLDAENGKI 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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