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Conserved domains on  [gi|42476024|ref|NP_060206|]
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THUMP domain-containing protein 1 [Homo sapiens]

Protein Classification

THUMP domain-containing protein( domain architecture ID 10185044)

THUMP domain-containing protein similar to human THUMP domain-containing protein 1 (THUMPD1) that functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation

CATH:  3.30.2300.10
Gene Ontology:  GO:0006400|GO:0003723
PubMed:  11295541
SCOP:  4002010

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 45-254 1.03e-57

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


:

Pssm-ID: 212586  Cd Length: 158  Bit Score: 184.32  E-value: 1.03e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024  45 GILITCNM-NERKCVEEAYSLLneygddmygpekftdkdqqpsgsegedddaeaalkkevgdikastemrlrrfQSVESG 123
Cdd:cd11717   1 GILVTCNRgKERKAIRELYNLL----------------------------------------------------QSVETG 28

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024 124 ANNVVFIRT-LGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKG-TFQIVYK 201
Cdd:cd11717  29 VKNVVFIKTrPPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEPPkTFAVECK 108

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 42476024 202 SRNNSHVNREEVIRELAGIVctlNSENKVDLTNPQYTVVVEIIKAVCCLSVVK 254
Cdd:cd11717 109 SRNNNKLSRDEVIKAVAELV---PEIHKVDLKNPDKVILVEVIKNVCGISVVK 158
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 45-254 1.03e-57

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 184.32  E-value: 1.03e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024  45 GILITCNM-NERKCVEEAYSLLneygddmygpekftdkdqqpsgsegedddaeaalkkevgdikastemrlrrfQSVESG 123
Cdd:cd11717   1 GILVTCNRgKERKAIRELYNLL----------------------------------------------------QSVETG 28

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024 124 ANNVVFIRT-LGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKG-TFQIVYK 201
Cdd:cd11717  29 VKNVVFIKTrPPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEPPkTFAVECK 108

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 42476024 202 SRNNSHVNREEVIRELAGIVctlNSENKVDLTNPQYTVVVEIIKAVCCLSVVK 254
Cdd:cd11717 109 SRNNNKLSRDEVIKAVAELV---PEIHKVDLKNPDKVILVEVIKNVCGISVVK 158
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 96-254 1.08e-19

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 84.03  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024    96 EAALKKEVGDIKastemrlrrfqsVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKtrvilrMLPISGTCKAFLED 175
Cdd:pfam02926   4 EELLKKGGINVE------------VVRSGRGRILVVLKGENPEEDRELLKEALEKAPGIE------RFPVAETCEADLED 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024   176 MKKYAETFLEPWFKAPNKgTFQIVYKSRN-NSHVNREEVIRELAGIVCTLNSEnKVDLTNPQYTVVVEIIKAVCCLSVVK 254
Cdd:pfam02926  66 ILELAKEIIKDKFKKEGE-TFAVRVKRRGkNHEFTSLEINREVGKAIVEKTGL-KVDLENPDIVVHVEIIKDKAYISIDR 143
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
 90-260 2.00e-17

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 78.39  E-value: 2.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024  90 GEDDDAEAALKK--EVGDIKAstemrlrrfQSVESGANNVVFIRTLGiEPEKLVHHIlqdmyKTKKKKTRVILRMLPISG 167
Cdd:COG1818  10 GRERDAIEELRDilEEGDPNA---------EVVPTGFSGVLLVKTSL-DPYEAVEKL-----KEEPWEPRYILRVIPVDR 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024 168 TCKAFLEDMKKYAETFLEPwfKAPNKGTFQIVYKSRNNSHVNREEVIRELAGIVctlNSENKVDLTNPQYTVVVEIIKAV 247
Cdd:COG1818  75 VVKTDLEEIVEAAKELAKK--KIPEGETFAVRCEKRGKSKLSSREVIRAIGEAI---KRGAKVDLENPDWVVLVEILGDK 149

                       170
                ....*....|...
gi 42476024 248 CCLSVVKDYMLFR 260
Cdd:COG1818 150 AGISVLKPEDIFS 162
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 173-253 9.89e-13

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 63.06  E-value: 9.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024    173 LEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSH-VNREEVIRELAGIVCTLNSENKVDLTNPQYTVVVEIIKAVCCLS 251
Cdd:smart00981   2 LEDLYETALELIRWEKIFKEGKTFAVRAKRRGKNHeFTSLEVKRAIGDKLLEKTGGRKVDLKNPDVVIRVELRKDKAYLS 81


                   ..
gi 42476024    252 VV 253
Cdd:smart00981  82 ID 83
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 45-254 1.03e-57

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 184.32  E-value: 1.03e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024  45 GILITCNM-NERKCVEEAYSLLneygddmygpekftdkdqqpsgsegedddaeaalkkevgdikastemrlrrfQSVESG 123
Cdd:cd11717   1 GILVTCNRgKERKAIRELYNLL----------------------------------------------------QSVETG 28

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024 124 ANNVVFIRT-LGIEPEKLVHHILQDMYKTKKKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPWFKAPNKG-TFQIVYK 201
Cdd:cd11717  29 VKNVVFIKTrPPVDPVELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKELLKKHFPTAEPPkTFAVECK 108

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 42476024 202 SRNNSHVNREEVIRELAGIVctlNSENKVDLTNPQYTVVVEIIKAVCCLSVVK 254
Cdd:cd11717 109 SRNNNKLSRDEVIKAVAELV---PEIHKVDLKNPDKVILVEVIKNVCGISVVK 158
THUMP pfam02926
THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and ...
 96-254 1.08e-19

THUMP domain; The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterized RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 460749  Cd Length: 143  Bit Score: 84.03  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024    96 EAALKKEVGDIKastemrlrrfqsVESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKKKtrvilrMLPISGTCKAFLED 175
Cdd:pfam02926   4 EELLKKGGINVE------------VVRSGRGRILVVLKGENPEEDRELLKEALEKAPGIE------RFPVAETCEADLED 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024   176 MKKYAETFLEPWFKAPNKgTFQIVYKSRN-NSHVNREEVIRELAGIVCTLNSEnKVDLTNPQYTVVVEIIKAVCCLSVVK 254
Cdd:pfam02926  66 ILELAKEIIKDKFKKEGE-TFAVRVKRRGkNHEFTSLEINREVGKAIVEKTGL-KVDLENPDIVVHVEIIKDKAYISIDR 143
Tan1 COG1818
tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure ...
 90-260 2.00e-17

tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain [Translation, ribosomal structure and biogenesis]; tRNA(Ser,Leu) C12 N-acetylase TAN1, contains THUMP domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441423  Cd Length: 162  Bit Score: 78.39  E-value: 2.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024  90 GEDDDAEAALKK--EVGDIKAstemrlrrfQSVESGANNVVFIRTLGiEPEKLVHHIlqdmyKTKKKKTRVILRMLPISG 167
Cdd:COG1818  10 GRERDAIEELRDilEEGDPNA---------EVVPTGFSGVLLVKTSL-DPYEAVEKL-----KEEPWEPRYILRVIPVDR 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024 168 TCKAFLEDMKKYAETFLEPwfKAPNKGTFQIVYKSRNNSHVNREEVIRELAGIVctlNSENKVDLTNPQYTVVVEIIKAV 247
Cdd:COG1818  75 VVKTDLEEIVEAAKELAKK--KIPEGETFAVRCEKRGKSKLSSREVIRAIGEAI---KRGAKVDLENPDWVVLVEILGDK 149

                       170
                ....*....|...
gi 42476024 248 CCLSVVKDYMLFR 260
Cdd:COG1818 150 AGISVLKPEDIFS 162
THUMP smart00981
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP ...
 173-253 9.89e-13

The THUMP domain is named after after thiouridine synthases, methylases and PSUSs; The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 214952 [Multi-domain]  Cd Length: 83  Bit Score: 63.06  E-value: 9.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024    173 LEDMKKYAETFLEPWFKAPNKGTFQIVYKSRNNSH-VNREEVIRELAGIVCTLNSENKVDLTNPQYTVVVEIIKAVCCLS 251
Cdd:smart00981   2 LEDLYETALELIRWEKIFKEGKTFAVRAKRRGKNHeFTSLEVKRAIGDKLLEKTGGRKVDLKNPDVVIRVELRKDKAYLS 81


                   ..
gi 42476024    252 VV 253
Cdd:smart00981  82 ID 83
THUMP cd11688
THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, ...
 153-248 3.09e-07

THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, RNA Methyltransferases and Pseudo-uridine synthases. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212583  Cd Length: 148  Bit Score: 49.41  E-value: 3.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024 153 KKKTRVILRMLPISGTCKAFLEDMKKYAETFLEPwfKAPNKG-TFQIVYKSRNNSHVNREEVIRELAGIVctLNSEN-KV 230
Cdd:cd11688  52 VMWSRLISRIMPPLGECKADLEDLYETALEINEP--EMGNEGaKFAVRARRRNKTILNSQEIAMKVGDAI--VDAFNpEV 127

                        90
                ....*....|....*...
gi 42476024 231 DLTNPQYTVVVEIIKAVC 248
Cdd:cd11688 128 DLDNPDIVVNVEVHKEIA 145
THUMP_ThiI cd11716
THUMP domain of thiamine biosynthesis protein ThiI; ThiI is an enzyme responsible for the ...
 159-243 8.28e-05

THUMP domain of thiamine biosynthesis protein ThiI; ThiI is an enzyme responsible for the formation of the modified base S(4)U (4-thiouridine) found at position 8 in some prokaryotic tRNAs. This modification acts as a signal for UV exposure, triggering a response that provides protection against its damaging effects. ThiI consists of an N-terminal THUMP domain, followed by an NFLD domain, and a C-terminal PP-loop pyrophosphatase domain. The N-terminal THUMP domain has been implicated in the recognition of the acceptor-stem region. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212585  Cd Length: 166  Bit Score: 42.43  E-value: 8.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476024 159 ILRMLP-ISGTCKAF-----LEDMKKYAETFLEPWFKAPnkGTFQIVYKSRNNSH-VNREEVIRELAGIVCTLNSENKVD 231
Cdd:cd11716  61 RLKKVFgIVSFSPAVevekdLEDIKEAALELLKEELKKG--KTFKVRAKRADKSFpFTSMEINREVGAALLENTPDLKVD 138

                        90
                ....*....|..
gi 42476024 232 LTNPQYTVVVEI 243
Cdd:cd11716 139 LKNPDVTIRVEI 150
ThiI COG0301
Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme ...
 173-243 9.99e-04

Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]; Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis) is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440070 [Multi-domain]  Cd Length: 382  Bit Score: 40.84  E-value: 9.99e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42476024 173 LEDMKKYAETFLEPWFKApnkGTFQIVYKsRNNSHV--NREEVIRELAGIVCTLNSENKVDLTNPQYTVVVEI 243
Cdd:COG0301  83 LEDIKEAALELAKEELKG---KTFKVRAK-RAGKHFpfTSPELEREVGGALLENTPGLKVDLKNPDVTIRVEV 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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