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Conserved domains on  [gi|148539591|ref|NP_060229|]
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INO80 complex subunit D [Homo sapiens]

Protein Classification

zf-C3Hc3H domain-containing protein( domain architecture ID 10620855)

zf-C3Hc3H domain-containing protein may be a DNA-binding protein and is similar to human KAT8 regulatory NSL complex subunit 2 that, as part of the NSL complex, is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 447-511 5.77e-20

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


:

Pssm-ID: 464023  Cd Length: 62  Bit Score: 84.32  E-value: 5.77e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148539591   447 CSGtvkGEQCANKALPFTRHCFQHILLNHSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHA 511
Cdd:pfam13891    1 CSY---GVGCKQKALPGTKYCYRHILEDPNQALFKQCSYVFSGNKRCGNPVLKSDVPSPLCPEHA 62
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 18-79 3.13e-17

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


:

Pssm-ID: 464023  Cd Length: 62  Bit Score: 76.62  E-value: 3.13e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148539591    18 CSYSPKlCKQRRLNGYAFCIRHVLEDKT-APFKQCEYVAKYNSqRCTNPIPKSE-DRRYCNSHL 79
Cdd:pfam13891    1 CSYGVG-CKQKALPGTKYCYRHILEDPNqALFKQCSYVFSGNK-RCGNPVLKSDvPSPLCPEHA 62
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 914-1025 1.14e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539591   914 LSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGlPQTSFSGMGPSAELMASTSPKQQLPQFSAAfghqlsshSGIPKDL 993
Cdd:pfam05109  458 LTAPASTGPTVSTADVTSPTPAGTTSGASPVTPS-PSPRDNGTESKAPDMTSPTSAVTTPTPNAT--------SPTPAVT 528

                           90       100       110
                   ....*....|....*....|....*....|...
gi 148539591   994 QPSHSSIAPPTGFTV-TGATATSTNNASSPFPS 1025
Cdd:pfam05109  529 TPTPNATSPTLGKTSpTSAVTTPTPNATSPTPA 561
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
211-290 3.63e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14971:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539591  211 HLSPLSTSLKPPAPPQGSVCKSPQPQNTSLPMQGVAP----TTHTIAQARQLSHKRPLPLLPSSRAPTVDPPRTDRILMK 286
Cdd:PRK14971  378 HIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPqsatQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKK 457


                  ....
gi 148539591  287 ATAF 290
Cdd:PRK14971  458 IPVS 461
 
Name Accession Description Interval E-value
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 447-511 5.77e-20

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


Pssm-ID: 464023  Cd Length: 62  Bit Score: 84.32  E-value: 5.77e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148539591   447 CSGtvkGEQCANKALPFTRHCFQHILLNHSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHA 511
Cdd:pfam13891    1 CSY---GVGCKQKALPGTKYCYRHILEDPNQALFKQCSYVFSGNKRCGNPVLKSDVPSPLCPEHA 62
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 18-79 3.13e-17

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


Pssm-ID: 464023  Cd Length: 62  Bit Score: 76.62  E-value: 3.13e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148539591    18 CSYSPKlCKQRRLNGYAFCIRHVLEDKT-APFKQCEYVAKYNSqRCTNPIPKSE-DRRYCNSHL 79
Cdd:pfam13891    1 CSYGVG-CKQKALPGTKYCYRHILEDPNqALFKQCSYVFSGNK-RCGNPVLKSDvPSPLCPEHA 62
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 914-1025 1.14e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539591   914 LSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGlPQTSFSGMGPSAELMASTSPKQQLPQFSAAfghqlsshSGIPKDL 993
Cdd:pfam05109  458 LTAPASTGPTVSTADVTSPTPAGTTSGASPVTPS-PSPRDNGTESKAPDMTSPTSAVTTPTPNAT--------SPTPAVT 528

                           90       100       110
                   ....*....|....*....|....*....|...
gi 148539591   994 QPSHSSIAPPTGFTV-TGATATSTNNASSPFPS 1025
Cdd:pfam05109  529 TPTPNATSPTLGKTSpTSAVTTPTPNATSPTPA 561
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
211-290 3.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539591  211 HLSPLSTSLKPPAPPQGSVCKSPQPQNTSLPMQGVAP----TTHTIAQARQLSHKRPLPLLPSSRAPTVDPPRTDRILMK 286
Cdd:PRK14971  378 HIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPqsatQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKK 457


                  ....
gi 148539591  287 ATAF 290
Cdd:PRK14971  458 IPVS 461
 
Name Accession Description Interval E-value
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 447-511 5.77e-20

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


Pssm-ID: 464023  Cd Length: 62  Bit Score: 84.32  E-value: 5.77e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148539591   447 CSGtvkGEQCANKALPFTRHCFQHILLNHSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEEHA 511
Cdd:pfam13891    1 CSY---GVGCKQKALPGTKYCYRHILEDPNQALFKQCSYVFSGNKRCGNPVLKSDVPSPLCPEHA 62
zf-C3Hc3H pfam13891
Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin ...
 18-79 3.13e-17

Potential DNA-binding domain; This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.


Pssm-ID: 464023  Cd Length: 62  Bit Score: 76.62  E-value: 3.13e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148539591    18 CSYSPKlCKQRRLNGYAFCIRHVLEDKT-APFKQCEYVAKYNSqRCTNPIPKSE-DRRYCNSHL 79
Cdd:pfam13891    1 CSYGVG-CKQKALPGTKYCYRHILEDPNqALFKQCSYVFSGNK-RCGNPVLKSDvPSPLCPEHA 62
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 914-1025 1.14e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539591   914 LSTSLSTPPTTSNSETTQPAFATVTPSSSSVLPGlPQTSFSGMGPSAELMASTSPKQQLPQFSAAfghqlsshSGIPKDL 993
Cdd:pfam05109  458 LTAPASTGPTVSTADVTSPTPAGTTSGASPVTPS-PSPRDNGTESKAPDMTSPTSAVTTPTPNAT--------SPTPAVT 528

                           90       100       110
                   ....*....|....*....|....*....|...
gi 148539591   994 QPSHSSIAPPTGFTV-TGATATSTNNASSPFPS 1025
Cdd:pfam05109  529 TPTPNATSPTLGKTSpTSAVTTPTPNATSPTPA 561
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
211-290 3.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148539591  211 HLSPLSTSLKPPAPPQGSVCKSPQPQNTSLPMQGVAP----TTHTIAQARQLSHKRPLPLLPSSRAPTVDPPRTDRILMK 286
Cdd:PRK14971  378 HIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPqsatQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKK 457


                  ....
gi 148539591  287 ATAF 290
Cdd:PRK14971  458 IPVS 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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