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Conserved domains on  [gi|31377750|ref|NP_060268|]
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YTH domain-containing family protein 1 [Homo sapiens]

Protein Classification

RPA_2b-aaRSs_OBF_like and YTH domain-containing protein( domain architecture ID 10293492)

protein containing domains PHA03247, RPA_2b-aaRSs_OBF_like, and YTH

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YTH pfam04146
YT521-B-like domain; A protein of the YTH family has been shown to selectively remove ...
 390-523 4.16e-70

YT521-B-like domain; A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. The YTH domain has been identified as part of the PUA superfamily.


:

Pssm-ID: 461195  Cd Length: 135  Bit Score: 221.22  E-value: 4.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   390 RVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRcmsSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVW--SQ 467
Cdd:pfam04146   2 RFFIIKSLNEENIHLSIKYGIWATQPHNNKRLNEAFK---ESKNVYLIFSVNKSGHFQGYARMTSPVDFDPSFIFWeaDS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31377750   468 DKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKII 523
Cdd:pfam04146  79 DKWGGPFKVEWLSVKDLPFSRLRHLRNPLNENKPVKISRDGQEIEPEVGRQLLKLF 134
RPA_2b-aaRSs_OBF_like super family cl09930
Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with ...
 258-311 3.08e-05

Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.; This superfamily includes two oligonucleotide/oligosaccharide binding fold (OBF) domain families. One of these contains the OBF domains of the large (RPA1, 70kDa), middle (RPA2, RPA4, 32kDa) and small (RPA3, 14 kDa) subunits of human heterotrimeric Replication protein A (RPA), and similar domains. RPA is a nuclear single-strand (ss) DNA-binding protein involved in most aspects of DNA metabolism. This family includes the four OBF domains of RPA1 [DNA-binding domain (DBD)-A, DBD-B, DBD-C, and RPA1N], the OBF domain of RPA2 (RPA2 DBD-D), RPA3, and the OBF domain of RPA4. The major DNA binding activity of human RPA and Saccharomyces cerevisiae RPA appears to be associated with DBD-A and -B, of RPA1. RPA1 DBD-C shows only weak ssDNA-binding activity and is involved in trimerization. The other OBF domain family in this superfamily is the N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). aaRSs catalyze the specific attachment of amino acids to their cognate tRNAs during protein biosynthesis. Class 2b aaRSs include the homodimeric aspartyl-, asparaginyl-, and lysyl-tRNA synthetases.


The actual alignment was detected with superfamily member PRK05733:

Pssm-ID: 471953 [Multi-domain]  Cd Length: 172  Bit Score: 44.53  E-value: 3.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 31377750  258 GGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQvaqplPAQPPA 311
Cdd:PRK05733 112 GGRPQGDDQGGQGGGNYNQSAPRQQAQRPQQAAQQQSRPAPQQ-----PAPQPA 160
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 227-364 3.17e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   227 PVSKPTSWAAI-ASKPAKPQPKMKTKSGPVMGGGLPPPPikhnmdigtwdnkgPVPKAPVPQQAPSPQAAPQPQQVAQPL 305
Cdd:PHA03247 2871 PAAKPAAPARPpVRRLARPAVSRSTESFALPPDQPERPP--------------QPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31377750   306 PAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVES 364
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
 
Name Accession Description Interval E-value
YTH pfam04146
YT521-B-like domain; A protein of the YTH family has been shown to selectively remove ...
 390-523 4.16e-70

YT521-B-like domain; A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. The YTH domain has been identified as part of the PUA superfamily.


Pssm-ID: 461195  Cd Length: 135  Bit Score: 221.22  E-value: 4.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   390 RVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRcmsSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVW--SQ 467
Cdd:pfam04146   2 RFFIIKSLNEENIHLSIKYGIWATQPHNNKRLNEAFK---ESKNVYLIFSVNKSGHFQGYARMTSPVDFDPSFIFWeaDS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31377750   468 DKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKII 523
Cdd:pfam04146  79 DKWGGPFKVEWLSVKDLPFSRLRHLRNPLNENKPVKISRDGQEIEPEVGRQLLKLF 134
YTH cd21134
YTH (YT521-B homology) domains are RNA-binding domains that belong to the PUA superfamily; ...
 390-523 6.04e-67

YTH (YT521-B homology) domains are RNA-binding domains that belong to the PUA superfamily; Individual members of the YTH family have been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. In general, eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or in other forms of silencing. The YTH domain is a novel RNA-binding domain that has been shown to bind to short, degenerate, single-stranded RNA motifs that loosely follow a consensus sequence. It belongs to the larger PUA superfamily.


Pssm-ID: 410979  Cd Length: 133  Bit Score: 213.20  E-value: 6.04e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750 390 RVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRcmsSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSA--GVWSQ 467
Cdd:cd21134   1 RFFIIKSNNEENIHLSIKYGVWATQPHNEKKLNQAFR---ESGNVYLIFSVNGSGHFQGYARMTSPPDPNRSPswPWWSQ 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 31377750 468 DKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKII 523
Cdd:cd21134  78 DKLGGPFKVEWLRVKDLPFSKLRHLKNPLNENKPVTISRDGQEIEPEVGEQLLKLF 133
PRK05733 PRK05733
single-stranded DNA-binding protein; Provisional
 258-311 3.08e-05

single-stranded DNA-binding protein; Provisional


Pssm-ID: 235585 [Multi-domain]  Cd Length: 172  Bit Score: 44.53  E-value: 3.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 31377750  258 GGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQvaqplPAQPPA 311
Cdd:PRK05733 112 GGRPQGDDQGGQGGGNYNQSAPRQQAQRPQQAAQQQSRPAPQQ-----PAPQPA 160
PHA03247 PHA03247
large tegument protein UL36; Provisional
 227-364 3.17e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   227 PVSKPTSWAAI-ASKPAKPQPKMKTKSGPVMGGGLPPPPikhnmdigtwdnkgPVPKAPVPQQAPSPQAAPQPQQVAQPL 305
Cdd:PHA03247 2871 PAAKPAAPARPpVRRLARPAVSRSTESFALPPDQPERPP--------------QPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31377750   306 PAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVES 364
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
Aim21 pfam11489
Altered inheritance of mitochondria protein 21; This is a family of proteins conserved in ...
 217-309 9.42e-04

Altered inheritance of mitochondria protein 21; This is a family of proteins conserved in yeasts. Saccharomyces cerevisiae Aim21 may be involved in mitochondrial migration along actin filament. It may also interact with ribosomes.


Pssm-ID: 371558 [Multi-domain]  Cd Length: 677  Bit Score: 42.27  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   217 SGNGGTNVNMPVSKPTSWAAIASKPAKP-QPKMKTKSGPVMGGGLPPPPIKhnmdigtwdnkgPVPKAPVPQQAPSPQAA 295
Cdd:pfam11489 497 SQELVTTVETPDEVKSTSPGVPTKPAIPaRPKSGKPTSPTEKRKPPPVPKK------------PKPQIPARPAKAQPQQA 564

                          90
                  ....*....|....
gi 31377750   296 PQPQQVAQPLPAQP 309
Cdd:pfam11489 565 GEEFKPKPRVPARP 578
 
Name Accession Description Interval E-value
YTH pfam04146
YT521-B-like domain; A protein of the YTH family has been shown to selectively remove ...
 390-523 4.16e-70

YT521-B-like domain; A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. The YTH domain has been identified as part of the PUA superfamily.


Pssm-ID: 461195  Cd Length: 135  Bit Score: 221.22  E-value: 4.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   390 RVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRcmsSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVW--SQ 467
Cdd:pfam04146   2 RFFIIKSLNEENIHLSIKYGIWATQPHNNKRLNEAFK---ESKNVYLIFSVNKSGHFQGYARMTSPVDFDPSFIFWeaDS 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31377750   468 DKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKII 523
Cdd:pfam04146  79 DKWGGPFKVEWLSVKDLPFSRLRHLRNPLNENKPVKISRDGQEIEPEVGRQLLKLF 134
YTH cd21134
YTH (YT521-B homology) domains are RNA-binding domains that belong to the PUA superfamily; ...
 390-523 6.04e-67

YTH (YT521-B homology) domains are RNA-binding domains that belong to the PUA superfamily; Individual members of the YTH family have been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. In general, eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or in other forms of silencing. The YTH domain is a novel RNA-binding domain that has been shown to bind to short, degenerate, single-stranded RNA motifs that loosely follow a consensus sequence. It belongs to the larger PUA superfamily.


Pssm-ID: 410979  Cd Length: 133  Bit Score: 213.20  E-value: 6.04e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750 390 RVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRcmsSKGPVYLLFSVNGSGHFCGVAEMKSPVDYGTSA--GVWSQ 467
Cdd:cd21134   1 RFFIIKSNNEENIHLSIKYGVWATQPHNEKKLNQAFR---ESGNVYLIFSVNGSGHFQGYARMTSPPDPNRSPswPWWSQ 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 31377750 468 DKWKGKFDVQWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKII 523
Cdd:cd21134  78 DKLGGPFKVEWLRVKDLPFSKLRHLKNPLNENKPVTISRDGQEIEPEVGEQLLKLF 133
EVE-like cd21132
EVE and YTH domains belong to the PUA superfamily; The EVE domain was formerly known as DUF55 ...
 390-522 6.93e-17

EVE and YTH domains belong to the PUA superfamily; The EVE domain was formerly known as DUF55 and is thought to be involved in RNA binding. The YTH (YT521-B homology) domain is a novel RNA-binding domain that has been shown to bind to short, degenerate, single-stranded RNA motifs that loosely follow a consensus sequence. Both domains are part of the larger PUA superfamily.


Pssm-ID: 410977  Cd Length: 138  Bit Score: 77.44  E-value: 6.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750 390 RVFIIKSYSEDDIHR--SIKYSIWCSTEHGNKRLDSafrcmsskgPVYLLFSVNG--------SGHFCGVAEMKSPVDYG 459
Cdd:cd21132   1 AYWIAIVNEDHVRIGvaGGFKQVWGGKEAPKNRIKK---------GDKLLYYSPKealgdkelLQAFTAIGEVKSEPYYD 71

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31377750 460 TSA----GVWSQDKWKGKFDVQWIFVK--DVPNNQLRHIRLENndNKPVTNSRDTQEVPLEKAKQVLKI 522
Cdd:cd21132  72 SKAifspPEMGDGFFPYRRDVEFIKIFedPLSFIELKQDLKFI--WVGHALRRGMFEIPEEDFKLIESL 138
PRK05733 PRK05733
single-stranded DNA-binding protein; Provisional
 258-311 3.08e-05

single-stranded DNA-binding protein; Provisional


Pssm-ID: 235585 [Multi-domain]  Cd Length: 172  Bit Score: 44.53  E-value: 3.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 31377750  258 GGLPPPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQPQQvaqplPAQPPA 311
Cdd:PRK05733 112 GGRPQGDDQGGQGGGNYNQSAPRQQAQRPQQAAQQQSRPAPQQ-----PAPQPA 160
PHA03247 PHA03247
large tegument protein UL36; Provisional
 227-364 3.17e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   227 PVSKPTSWAAI-ASKPAKPQPKMKTKSGPVMGGGLPPPPikhnmdigtwdnkgPVPKAPVPQQAPSPQAAPQPQQVAQPL 305
Cdd:PHA03247 2871 PAAKPAAPARPpVRRLARPAVSRSTESFALPPDQPERPP--------------QPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31377750   306 PAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVES 364
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 278-366 1.28e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750  278 GPVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNA-AFGQSGGAGSDSNSPGNVQP 356
Cdd:PRK07764 411 APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPApAAAPEPTAAPAPAPPAAPAP 490

                         90
                 ....*....|
gi 31377750  357 NSAPSVESHP 366
Cdd:PRK07764 491 AAAPAAPAAP 500
PHA03247 PHA03247
large tegument protein UL36; Provisional
 227-379 3.08e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   227 PVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLPPPPIKHNMDIGtwDNKGPVPKAPVPQQAPSPQAAP-QPQQVAQPL 305
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG--PARPARPPTTAGPPAPAPPAAPaAGPPRRLTR 2785

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31377750   306 PAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPnSAPSVESHPVLEKLKAAHSYNP 379
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP-TAPPPPPGPPPPSLPLGGSVAP 2858
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 278-367 8.67e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 8.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750  278 GPVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRN--RNAAFGQSGGAGSDSNSPGNVQ 355
Cdd:PRK14951 375 PAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAaaAPAAAPAAAPAAVALAPAPPAQ 454

                         90
                 ....*....|..
gi 31377750  356 PnsAPSVESHPV 367
Cdd:PRK14951 455 A--APETVAIPV 464
Aim21 pfam11489
Altered inheritance of mitochondria protein 21; This is a family of proteins conserved in ...
 217-309 9.42e-04

Altered inheritance of mitochondria protein 21; This is a family of proteins conserved in yeasts. Saccharomyces cerevisiae Aim21 may be involved in mitochondrial migration along actin filament. It may also interact with ribosomes.


Pssm-ID: 371558 [Multi-domain]  Cd Length: 677  Bit Score: 42.27  E-value: 9.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   217 SGNGGTNVNMPVSKPTSWAAIASKPAKP-QPKMKTKSGPVMGGGLPPPPIKhnmdigtwdnkgPVPKAPVPQQAPSPQAA 295
Cdd:pfam11489 497 SQELVTTVETPDEVKSTSPGVPTKPAIPaRPKSGKPTSPTEKRKPPPVPKK------------PKPQIPARPAKAQPQQA 564

                          90
                  ....*....|....
gi 31377750   296 PQPQQVAQPLPAQP 309
Cdd:pfam11489 565 GEEFKPKPRVPARP 578
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 234-361 1.39e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 41.62  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750  234 WAAIASKPAKPQPKMKTKSGPVMGGGLP-PPPIKHNMDIGTWDNKGPVPKAPVPQQAPSpQAAP-----QPQQVAQPLPA 307
Cdd:PRK08691 436 WEDAPDEAQTAAGTAQTSAKSIQTASEAeTPPENQVSKNKAADNETDAPLSEVPSENPI-QATPndeavETETFAHEAPA 514

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 31377750  308 QPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNS-PGNVQPNSAPS 361
Cdd:PRK08691 515 EPFYGYGFPDNDCPPEDGAEIPPPDWEHAAPADTAGGGADEEAeAGGIGGNNTPS 569
PHA03247 PHA03247
large tegument protein UL36; Provisional
 209-364 1.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   209 SVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKmKTKSGPVmGGGLPPPPIKHNMDIGTWDNKG---------- 278
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP-PTSAQPT-APPPPPGPPPPSLPLGGSVAPGgdvrrrppsr 2869

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   279 --------------------PVPKAPVPQQAPSPQAAPQPQQVAQPLPAQPPALAQPQYQSPQQPPQTR---WVAPRNRN 335
Cdd:PHA03247 2870 spaakpaaparppvrrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRpqpPLAPTTDP 2949

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 31377750   336 AAFGQSGGAGSDSN----SPGNVQ------PNSAPSVES 364
Cdd:PHA03247 2950 AGAGEPSGAVPQPWlgalVPGRVAvprfrvPQPAPSREA 2988
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 227-311 3.00e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750  227 PVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLPPPPIKHNMDigtwDNKGPVPKAPVP---QQAPSPQAAPQPQQV-- 301
Cdd:PRK14951 389 PAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA----APAAAPAAAPAAvalAPAPPAQAAPETVAIpv 464

                         90
                 ....*....|.
gi 31377750  302 -AQPLPAQPPA 311
Cdd:PRK14951 465 rVAPEPAVASA 475
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 227-366 3.46e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750   227 PVSKPTSWAAIASKPAKP-----QPKMKTKSGPVMGGGLPPPPIKhnmdigtWdNKGPVPKAPVPQQAPSPQAAPQPQQV 301
Cdd:PRK10263  315 PITEPVAVAAAATTATQSwaapvEPVTQTPPVASVDVPPAQPTVA-------W-QPVPGPQTGEPVIAPAPEGYPQQSQY 386

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31377750   302 AQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGNVQPNSAPSVESHP 366
Cdd:PRK10263  387 AQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE 451
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 220-366 3.58e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377750  220 GGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPVMGGGLP--PPPIKHNMDIGTWDNKGPVPKAPVPQQAPSPQAAPQ 297
Cdd:PRK07764 604 ASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPgvAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPP 683

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31377750  298 PQQVAQPLPAQPPALAQPQYQSPQQPPQTRWVAPRNRNAAFGQSGGAGSDSNSPGnVQPNSAPSVESHP 366
Cdd:PRK07764 684 APAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDP-VPLPPEPDDPPDP 751
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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