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Conserved domains on  [gi|157388904|ref|NP_060272|]
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dynein axonemal assembly factor 5 [Homo sapiens]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein similar to Homo sapiens deoxyhypusine hydroxylase (DOHH), which catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor

CATH:  1.25.10.10
Gene Ontology:  GO:0005515
PubMed:  10378263
SCOP:  4001283

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
165-306 1.10e-04

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388904 165 DDALRALRCSLLDPFAAVRREScscAAALAQatpdhfhMQSESLIGPLMQTISHQHWKVRVAAIEATGAVihfgngkSVD 244
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAA---ARALGR-------LGDPRAVPALLEALKDPDPEVRAAAAEALGRI-------GDP 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157388904 245 DVLSHFAQRLFDDVPQVRRAVASVVGgwllCLRDRYSffhklIPLLLSSLNDEVPEVRQLAA 306
Cdd:COG1413   78 EAVPALIAALKDEDPEVRRAAAEALG----RLGDPAA-----VPALLEALKDPDWEVRRAAA 130
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
165-306 1.10e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388904 165 DDALRALRCSLLDPFAAVRREScscAAALAQatpdhfhMQSESLIGPLMQTISHQHWKVRVAAIEATGAVihfgngkSVD 244
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAA---ARALGR-------LGDPRAVPALLEALKDPDPEVRAAAAEALGRI-------GDP 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157388904 245 DVLSHFAQRLFDDVPQVRRAVASVVGgwllCLRDRYSffhklIPLLLSSLNDEVPEVRQLAA 306
Cdd:COG1413   78 EAVPALIAALKDEDPEVRRAAAEALG----RLGDPAA-----VPALLEALKDPDWEVRRAAA 130
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
165-306 1.10e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388904 165 DDALRALRCSLLDPFAAVRREScscAAALAQatpdhfhMQSESLIGPLMQTISHQHWKVRVAAIEATGAVihfgngkSVD 244
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAA---ARALGR-------LGDPRAVPALLEALKDPDPEVRAAAAEALGRI-------GDP 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157388904 245 DVLSHFAQRLFDDVPQVRRAVASVVGgwllCLRDRYSffhklIPLLLSSLNDEVPEVRQLAA 306
Cdd:COG1413   78 EAVPALIAALKDEDPEVRRAAAEALG----RLGDPAA-----VPALLEALKDPDWEVRRAAA 130
HEAT COG1413
HEAT repeat [General function prediction only];
203-307 9.07e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.38  E-value: 9.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388904 203 MQSESLIGPLMQTISHQHWKVRVAAIEATGaviHFGNGKSVDDVLshfaQRLFDDVPQVRRAVASVVGGwllcLRDRysf 282
Cdd:COG1413   12 LGDPAAVPALIAALADEDPDVRAAAARALG---RLGDPRAVPALL----EALKDPDPEVRAAAAEALGR----IGDP--- 77

                         90       100
                 ....*....|....*....|....*
gi 157388904 283 fhKLIPLLLSSLNDEVPEVRQLAAS 307
Cdd:COG1413   78 --EAVPALIAALKDEDPEVRRAAAE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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