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Conserved domains on  [gi|21361661|ref|NP_060298|]
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COMM domain-containing protein 4 isoform 1 [Homo sapiens]

Protein Classification

COMM domain-containing protein 4( domain architecture ID 10140832)

COMM domain-containing protein 4 (COMMD4) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 25-198 4.65e-105

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 299.34  E-value: 4.65e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661  25 MSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 104
Cdd:cd04752   1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661 105 SLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVL 184
Cdd:cd04752  81 SLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVL 160

                       170
                ....*....|....
gi 21361661 185 LAELKQAQTLMSSL 198
Cdd:cd04752 161 LAELKQAQTLMETL 174
 
Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 25-198 4.65e-105

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 299.34  E-value: 4.65e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661  25 MSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 104
Cdd:cd04752   1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661 105 SLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVL 184
Cdd:cd04752  81 SLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVL 160

                       170
                ....*....|....
gi 21361661 185 LAELKQAQTLMSSL 198
Cdd:cd04752 161 LAELKQAQTLMETL 174
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 127-191 2.95e-12

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 59.10  E-value: 2.95e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361661   127 RMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVaAAPGTPAQPVAMSLSADKFQVLLAELKQA 191
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKL-SDGDGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 25-198 4.65e-105

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 299.34  E-value: 4.65e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661  25 MSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 104
Cdd:cd04752   1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661 105 SLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVL 184
Cdd:cd04752  81 SLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVL 160

                       170
                ....*....|....
gi 21361661 185 LAELKQAQTLMSSL 198
Cdd:cd04752 161 LAELKQAQTLMETL 174
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 127-191 2.95e-12

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 59.10  E-value: 2.95e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21361661   127 RMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVaAAPGTPAQPVAMSLSADKFQVLLAELKQA 191
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKL-SDGDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 19-197 6.71e-08

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 50.14  E-value: 6.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661  19 ISTLAKMSSVKLRLLCSQVLKELLGQGiDYEKIL----KLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQ 94
Cdd:cd04755   1 IQNLNQLSEQQFSRLTEILFEFLLEPK-ESERLLnqldEFAGENGISLGPLKNIVKSILLVPNGALKRNLTAEQLREDLI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661  95 QLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAapGTPAQPVAM 174
Cdd:cd04755  80 QLGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTAGSSELQKVGSIFLQLKLVVRK--GNQTENVYM 157

                       170       180
                ....*....|....*....|...
gi 21361661 175 SLSADKFQVLLAELKQAQTLMSS 197
Cdd:cd04755 158 ELTLPQFYSFLHEMERAKASLEC 180
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 109-192 1.45e-07

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 47.30  E-value: 1.45e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661 109 CYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAEL 188
Cdd:cd04748   1 LLTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSEKICFEMTKEELQNFLNKL 80


                ....
gi 21361661 189 KQAQ 192
Cdd:cd04748  81 KKIK 84
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 53-198 1.71e-06

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 46.22  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661  53 KLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLA 132
Cdd:cd04758  42 KLQEAFKLLSQDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAFVNAWEAEGEDVLEKLRSRILAPNQLE 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21361661 133 GVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTpAQPVAMSLSADKFQVLLAELKQAQTLMSSL 198
Cdd:cd04758 122 DVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEDGN-LEKINLEFNHEELLEFYNQLESIQEQLDSL 186
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 76-198 6.47e-03

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 35.85  E-value: 6.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361661  76 LSSAAKHSVDGESLSSELQQL--GLPKEHAASLCRCYEEKQSPLQKHL--RVCSLRMNRLAGVGWRVDYTLSSSLLQSVE 151
Cdd:cd04756  52 LATLFKQAVGKNSNDEEAKAQlsDLSSSHQEALLKCVKSRKEEIRQALvnKTNSISSAQLQDFDWQLKLALSSDKLSSLQ 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 21361661 152 EPMVHLRLEVAAApGTpAQPVAMSLSADKFQVLLAELKQAQTLMSSL 198
Cdd:cd04756 132 EPLLNLDLDVKEN-GI-LKPVSIEMNKEELQNLISSLEAANKVVLQL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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