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Conserved domains on  [gi|1519313667|ref|NP_060328|]
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TIMELESS-interacting protein isoform 1 [Homo sapiens]

Protein Classification

replication fork protection complex subunit Csm3/Swi3 family protein( domain architecture ID 10546341)

replication fork protection complex subunit Csm3/Swi3 family protein plays an important role in DNA replication, similar to vertebrate TIMELESS-interacting protein and fungal Csm3/Swi3, a component of the fork protection complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Swi3 pfam07962
Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a ...
 66-148 1.72e-39

Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling


:

Pssm-ID: 462324  Cd Length: 83  Bit Score: 133.39  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313667  66 KLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRL 145
Cdd:pfam07962   1 KLDEERLLSPKGLPYLRKNFKKFKFKGKGHEYEDLGRLLQFYQLWAHDLFPKAKFKDFIERVEKLGKKKRVRTYRRELRD 80


                  ...
gi 1519313667 146 DLP 148
Cdd:pfam07962  81 EEK 83
 
Name Accession Description Interval E-value
Swi3 pfam07962
Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a ...
 66-148 1.72e-39

Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling


Pssm-ID: 462324  Cd Length: 83  Bit Score: 133.39  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313667  66 KLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRL 145
Cdd:pfam07962   1 KLDEERLLSPKGLPYLRKNFKKFKFKGKGHEYEDLGRLLQFYQLWAHDLFPKAKFKDFIERVEKLGKKKRVRTYRRELRD 80


                  ...
gi 1519313667 146 DLP 148
Cdd:pfam07962  81 EEK 83
 
Name Accession Description Interval E-value
Swi3 pfam07962
Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a ...
 66-148 1.72e-39

Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling


Pssm-ID: 462324  Cd Length: 83  Bit Score: 133.39  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519313667  66 KLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRL 145
Cdd:pfam07962   1 KLDEERLLSPKGLPYLRKNFKKFKFKGKGHEYEDLGRLLQFYQLWAHDLFPKAKFKDFIERVEKLGKKKRVRTYRRELRD 80


                  ...
gi 1519313667 146 DLP 148
Cdd:pfam07962  81 EEK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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