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Conserved domains on  [gi|8923516|ref|NP_060343|]
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ankyrin repeat and SOCS box protein 6 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-212 6.14e-31

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 6.14e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
Cdd:COG0666  35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   97 FEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALL 176
Cdd:COG0666 115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKLLLEAGADVNARDNDGETPLH 191

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 8923516  177 HAlassdgVQIHNTENIRLLLEGGADVKATTKDGDT 212
Cdd:COG0666 192 LA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 370-413 2.39e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239695  Cd Length: 44  Bit Score: 94.43  E-value: 2.39e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 8923516  370 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEH 413
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-212 6.14e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 6.14e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
Cdd:COG0666  35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   97 FEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALL 176
Cdd:COG0666 115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKLLLEAGADVNARDNDGETPLH 191

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 8923516  177 HAlassdgVQIHNTENIRLLLEGGADVKATTKDGDT 212
Cdd:COG0666 192 LA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 370-413 2.39e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 94.43  E-value: 2.39e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 8923516  370 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEH 413
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-285 4.39e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.44  E-value: 4.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   133 DRIHESSPLD-LASEEPERLPCLQRLLDLGADVNAADKHGKTALlHALASSDGVQIhnTENIRLLLEGGADVKATTKDGD 211
Cdd:PHA03095   8 DIIMEAALYDyLLNASNVTVEEVRRLLAAGADVNFRGEYGKTPL-HLYLHYSSEKV--KDIVRLLLEAGADVNAPERCGF 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8923516   212 TVFTCIIFLlgetvggdKEEAQMInrfcfqvtRLLLAHGAD-PSECPAHESLTHICLKSFKLHFPLLRFLLESGA 285
Cdd:PHA03095  85 TPLHLYLYN--------ATTLDVI--------KLLIKAGADvNAKDKVGRTPLHVYLSGFNINPKVIRLLLRKGA 143
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-168 8.05e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 8.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     73 LLKMAELGLTRAADVLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVELLVHHgADVNRRDriHESSPLDLASEEpERLP 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARS-GHLE 75

                          90
                  ....*....|....*.
gi 8923516    153 CLQRLLDLGADVNAAD 168
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 372-410 4.26e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.78  E-value: 4.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 8923516    372 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLL 410
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLG-AIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 373-412 3.44e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.55  E-value: 3.44e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 8923516     373 PPLKHLCRVAIRLYLQpwpvdvKVKALPLPDRLKWYLLSE 412
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLLYY 34
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 102-179 2.60e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 46.34  E-value: 2.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516  102 TYY---TALHIAVLRNQPDMVELLVHHGADVNRRD-----RIHESSPLDLASEEPERLPCLQRLLDL----------GAD 163
Cdd:cd22196  90 SYYkgqTALHIAIERRNMHLVELLVQNGADVHARAsgeffKKKKGGPGFYFGELPLSLAACTNQLDIvkfllenphsPAD 169

                        90
                ....*....|....*.
gi 8923516  164 VNAADKHGKTaLLHAL 179
Cdd:cd22196 170 ISARDSMGNT-VLHAL 184
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 104-130 4.51e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 4.51e-05
                           10        20
                   ....*....|....*....|....*..
gi 8923516     104 YTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 14-180 7.42e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     14 YQPLVDAILGSLGIQDPERQESLdrpsYVASEESRILVLTELLERKAHSPFyqegVSNALLKMAELGLTRAADVLLRH-- 91
Cdd:TIGR00870  34 YRDLEEPKKLNINCPDRLGRSAL----FVAAIENENLELTELLLNLSCRGA----VGDTLLHAISLEYVDAVEAILLHll 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     92 -----GANLNF---EDPVTYY---TALHIAVLRNQPDMVELLVHHGADVNRR---DRIHESSPLDLASEEPERL------ 151
Cdd:TIGR00870 106 aafrkSGPLELandQYTSEFTpgiTALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSQGVDSFYHGESPLnaaacl 185

                         170       180       190
                  ....*....|....*....|....*....|..
gi 8923516    152 --PCLQRLL-DLGADVNAADKHGKTaLLHALA 180
Cdd:TIGR00870 186 gsPSIVALLsEDPADILTADSLGNT-LLHLLV 216
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-212 6.14e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 6.14e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
Cdd:COG0666  35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   97 FEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALL 176
Cdd:COG0666 115 ARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAAN-GNLEIVKLLLEAGADVNARDNDGETPLH 191

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 8923516  177 HAlassdgVQIHNTENIRLLLEGGADVKATTKDGDT 212
Cdd:COG0666 192 LA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-212 8.13e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.89  E-value: 8.13e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
Cdd:COG0666  68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   97 FEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRiHESSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALL 176
Cdd:COG0666 148 AQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAEN-GHLEIVKLLLEAGADVNAKDNDGKTALD 224

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 8923516  177 HAlassdgVQIHNTENIRLLLEGGADVKATTKDGDT 212
Cdd:COG0666 225 LA------AENGNLEIVKLLLEAGADLNAKDKDGLT 254
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-288 1.40e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.12  E-value: 1.40e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELL 122
Cdd:COG0666  27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516  123 VHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALLHAlassdgVQIHNTENIRLLLEGGAD 202
Cdd:COG0666 107 LEAGADVNARDKDGE-TPLHLAAYN-GNLEIVKLLLEAGADVNAQDNDGNTPLHLA------AANGNLEIVKLLLEAGAD 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516  203 VKATTKDGDTVFTCIIFllgetvGGDKEeaqminrfcfqVTRLLLAHGADPSEcPAHESLTHICLKSFKLHFPLLRFLLE 282
Cdd:COG0666 179 VNARDNDGETPLHLAAE------NGHLE-----------IVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLE 240


                ....*.
gi 8923516  283 SGAAYN 288
Cdd:COG0666 241 AGADLN 246
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 370-413 2.39e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 94.43  E-value: 2.39e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 8923516  370 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEH 413
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-288 2.09e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.01  E-value: 2.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   50 LVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADV 129
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516  130 NRRDRiHESSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALLHAlassdgVQIHNTENIRLLLEGGADVKATTKD 209
Cdd:COG0666  81 NAKDD-GGNTLLHAAARN-GDLEIVKLLLEAGADVNARDKDGETPLHLA------AYNGNLEIVKLLLEAGADVNAQDND 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8923516  210 GDTVFTCIIFllgetvGGDKEeaqminrfcfqVTRLLLAHGADPsECPAHESLTHICLKSFKLHFPLLRFLLESGAAYN 288
Cdd:COG0666 153 GNTPLHLAAA------NGNLE-----------IVKLLLEAGADV-NARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 370-412 3.69e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 63.28  E-value: 3.69e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 8923516  370 SYPPPLKHLCRVAIRLYLQPWPvDVKVKALPLPDRLKWYLLSE 412
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRR-LELIKKLPLPPRLKDYLLYE 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 133-285 4.39e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.44  E-value: 4.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   133 DRIHESSPLD-LASEEPERLPCLQRLLDLGADVNAADKHGKTALlHALASSDGVQIhnTENIRLLLEGGADVKATTKDGD 211
Cdd:PHA03095   8 DIIMEAALYDyLLNASNVTVEEVRRLLAAGADVNFRGEYGKTPL-HLYLHYSSEKV--KDIVRLLLEAGADVNAPERCGF 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8923516   212 TVFTCIIFLlgetvggdKEEAQMInrfcfqvtRLLLAHGAD-PSECPAHESLTHICLKSFKLHFPLLRFLLESGA 285
Cdd:PHA03095  85 TPLHLYLYN--------ATTLDVI--------KLLIKAGADvNAKDKVGRTPLHVYLSGFNINPKVIRLLLRKGA 143
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-219 5.34e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.08  E-value: 5.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    88 LLRHGANLNfedPVTYY--TALHIAVLRNQPD--MVELLVHHGADVNRRDRIhesspldlaseeperlpclQRLLDLGAD 163
Cdd:PHA03100 127 LLDNGANVN---IKNSDgeNLLHLYLESNKIDlkILKLLIDKGVDINAKNRV-------------------NYLLSYGVP 184

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 8923516   164 VNAADKHGKTALLHAlassdgVQIHNTENIRLLLEGGADVKATTKDGDtvfTCIIF 219
Cdd:PHA03100 185 INIKDVYGFTPLHYA------VYNNNPEFVKYLLDLGANPNLVNKYGD---TPLHI 231
PHA03095 PHA03095
ankyrin-like protein; Provisional
 117-285 8.51e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 8.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   117 DMVELLVHHGADVNRRDrIHESSPLD--LASEEPERLPCLQRLLDLGADVNAADKHGKTALlHALASSDgvqihNTEN-I 193
Cdd:PHA03095  28 EEVRRLLAAGADVNFRG-EYGKTPLHlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPL-HLYLYNA-----TTLDvI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   194 RLLLEGGADVKATTKDGDTVFTciIFLLGETVGgdkeeaqminrfcFQVTRLLLAHGADPSECPAHE-SLTHICLKSFKL 272
Cdd:PHA03095 101 KLLIKAGADVNAKDKVGRTPLH--VYLSGFNIN-------------PKVIRLLLRKGADVNALDLYGmTPLAVLLKSRNA 165

                        170
                 ....*....|...
gi 8923516   273 HFPLLRFLLESGA 285
Cdd:PHA03095 166 NVELLRLLIDAGA 178
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 372-412 8.04e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.41  E-value: 8.04e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 8923516  372 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLLSE 412
Cdd:cd03587   2 PRSLQHLCRLAIRRCLGKRRLD-LIDKLPLPPRLKDYLLYK 41
PHA03095 PHA03095
ankyrin-like protein; Provisional
 82-214 1.08e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.20  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    82 TRAADVLLRHGANLNfeDPVTY-YTALHIAVL-RNQPDMVELLVHHGADVNRRDRIHESsPLDLASEEPERLPCLQR-LL 158
Cdd:PHA03095  63 KDIVRLLLEAGADVN--APERCgFTPLHLYLYnATTLDVIKLLIKAGADVNAKDKVGRT-PLHVYLSGFNINPKVIRlLL 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 8923516   159 DLGADVNAADKHGKTAlLHALASSDGVqihNTENIRLLLEGGADVKATTKDGDTVF 214
Cdd:PHA03095 140 RKGADVNALDLYGMTP-LAVLLKSRNA---NVELLRLLIDAGADVYAVDDRFRSLL 191
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-208 1.98e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.46  E-value: 1.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    88 LLRHGANLNFEDpVTYYTALHI-----AVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGA 162
Cdd:PHA03100  54 LLDNGADINSST-KNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGA 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 8923516   163 DVNAADKHGKTaLLHALASSDGVqihNTENIRLLLEGGADVKATTK 208
Cdd:PHA03100 133 NVNIKNSDGEN-LLHLYLESNKI---DLKILKLLIDKGVDINAKNR 174
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 87-271 5.69e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.13  E-value: 5.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    87 VLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIhESSPLDLASEEpERLPCLQRLLDLGADVNA 166
Cdd:PHA02878 152 LLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKT-NNSPLHHAVKH-YNKPIVHILLENGASTDA 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   167 ADKHGKTALLHALASsdgvqIHNTENIRLLLEGGADVKATTkdgdtvftciiFLLGETvggdkeeAQMINRFCFQVTRLL 246
Cdd:PHA02878 230 RDKCGNTPLHISVGY-----CKDYDILKLLLEHGVDVNAKS-----------YILGLT-------ALHSSIKSERKLKLL 286

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 8923516   247 LAHGADP------SECPAHES-------------LTHICLKSFK 271
Cdd:PHA02878 287 LEYGADInslnsyKLTPLSSAvkqylcinigrilISNICLLKRI 330
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-168 8.05e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 8.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     73 LLKMAELGLTRAADVLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVELLVHHgADVNRRDriHESSPLDLASEEpERLP 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARS-GHLE 75

                          90
                  ....*....|....*.
gi 8923516    153 CLQRLLDLGADVNAAD 168
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
107-206 3.45e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.58  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    107 LHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLLDlGADVNAADkHGKTALLHALASsdgvq 186
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR-TALHLAAKN-GHLEIVKLLLE-HADVNLKD-NGRTALHYAARS----- 71

                          90       100
                  ....*....|....*....|
gi 8923516    187 iHNTENIRLLLEGGADVKAT 206
Cdd:pfam12796  72 -GHLEIVKLLLEKGADINVK 90
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 372-410 4.26e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.78  E-value: 4.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 8923516    372 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLL 410
Cdd:pfam07525   2 PRSLQHLCRLAIRRALGKRRLG-AIDKLPLPPLLKDYLL 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 115-288 6.84e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.58  E-value: 6.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   115 QPDMVELLVHHGADVNRRDRIHESSPLDLASEEPE-RLpcLQRLLDLGADVNAADKHGKTALLHAlassdgVQIHNTENI 193
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKGNTALHYATENKDqRL--TELLLSYGANVNIPDKTNNSPLHHA------VKHYNKPIV 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   194 RLLLEGGADVKATTKDGDTVftciiflLGETVGGDKEeaqminrfcFQVTRLLLAHGADPSECPAHESLT--HICLKSFK 271
Cdd:PHA02878 218 HILLENGASTDARDKCGNTP-------LHISVGYCKD---------YDILKLLLEHGVDVNAKSYILGLTalHSSIKSER 281

                        170
                 ....*....|....*..
gi 8923516   272 lhfpLLRFLLESGAAYN 288
Cdd:PHA02878 282 ----KLKLLLEYGADIN 294
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 77-206 7.65e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.77  E-value: 7.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    77 AELGLTRAADVLLRHGANLNFeDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRD----------------------- 133
Cdd:PHA02876 186 AERGNAKMVNLLLSYGADVNI-IALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDlsllkairnedletslllydagf 264

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8923516   134 -----RIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLhaLASSDGvqiHNTENIRLLLEGGADVKAT 206
Cdd:PHA02876 265 svnsiDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLY--LMAKNG---YDTENIRTLIMLGADVNAA 337
PHA03095 PHA03095
ankyrin-like protein; Provisional
 86-213 8.01e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 57.34  E-value: 8.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    86 DVLLRHGANLNFEDPVTYyTALHIAvLRNQ---PDMVELLVHHGADVNRRDrIHESSPLDL------ASEEPERLpclqr 156
Cdd:PHA03095 101 KLLIKAGADVNAKDKVGR-TPLHVY-LSGFninPKVIRLLLRKGADVNALD-LYGMTPLAVllksrnANVELLRL----- 172

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 8923516   157 LLDLGADVNAADKHGKTALLHALASSDGvqihNTENIRLLLEGGADVKATTKDGDTV 213
Cdd:PHA03095 173 LIDAGADVYAVDDRFRSLLHHHLQSFKP----RARIVRELIRAGCDPAATDMLGNTP 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
42-133 1.05e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGanlNFEDPVTYYTALHIAVLRNQPDMVEL 121
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA---DVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 8923516    122 LVHHGADVNRRD 133
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 103-252 3.71e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.06  E-value: 3.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHeSSPLDLASEEPERLPCLQRLLDL----GADVNAADKHGKTALLHA 178
Cdd:PHA03100  35 PVLPLYLAKEARNIDVVKILLDNGADINSSTKNN-STPLHYLSNIKYNLTDVKEIVKLlleyGANVNAPDNNGITPLLYA 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8923516   179 LASSDGvqihNTENIRLLLEGGADVKATTKDGDTvftciifLLGETVGGDKEEAQMInrfcfqvtRLLLAHGAD 252
Cdd:PHA03100 114 ISKKSN----SYSIVEYLLDNGANVNIKNSDGEN-------LLHLYLESNKIDLKIL--------KLLIDKGVD 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-252 9.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 9.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    48 RILVLTELLERKAHSPFYQE-GVSNALLKMAELGLTRAADVLLRHGanlNFEDPVTY---YTALHIAVLRNQPDMVELLV 123
Cdd:PHA02875  46 RDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDVKAVEELLDLG---KFADDVFYkdgMTPLHLATILKKLDIMKLLI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   124 HHGAD--VNRRDRiheSSPLDLASEEPErLPCLQRLLDLGADVNAADKHGKTALLHALASSdgvqihNTENIRLLLEGGA 201
Cdd:PHA02875 123 ARGADpdIPNTDK---FSPLHLAVMMGD-IKGIELLIDHKACLDIEDCCGCTPLIIAMAKG------DIAICKMLLDSGA 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 8923516   202 DVKATTKDGDTVFTCiifllgetvggdkeEAQMINRfcFQVTRLLLAHGAD 252
Cdd:PHA02875 193 NIDYFGKNGCVAALC--------------YAIENNK--IDIVRLFIKRGAD 227
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 73-211 1.88e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.33  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    73 LLKMAELGLTRAADVLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRD------------------- 133
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDS-KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDangntalwnaisakhhkif 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   134 RI-----HESSPL---DLASEEPER--LPCLQRLLDLGADVNAADKHGKTALLHALASSdgvqihNTENIRLLLEGGADV 203
Cdd:PLN03192 608 RIlyhfaSISDPHaagDLLCTAAKRndLTAMKELLKQGLNVDSEDHQGATALQVAMAED------HVDMVRLLIMNGADV 681


                 ....*...
gi 8923516   204 KATTKDGD 211
Cdd:PLN03192 682 DKANTDDD 689
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 81-214 3.97e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.37  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    81 LTRAADVLLRHGANLNFEDpVTYYTALHIaVLRNQPDM--VELLVHHGADVNRRDRIHeSSPLDLASEEPERLPCLQRLL 158
Cdd:PHA02876 286 LSRLVPKLLERGADVNAKN-IKGETPLYL-MAKNGYDTenIRTLIMLGADVNAADRLY-ITPLHQASTLDRNKDIVITLL 362

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 8923516   159 DLGADVNAADKHGKTAlLHALASSDGVQIHNTenirlLLEGGADVKATTKDGDTVF 214
Cdd:PHA02876 363 ELGANVNARDYCDKTP-IHYAAVRNNVVIINT-----LLDYGADIEALSQKIGTAL 412
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 41-273 1.37e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.45  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGL-TRAADVLLRHGANLNFEDPVtYYTALHIA-VLRNQPDM 118
Cdd:PHA02876 279 HASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRL-YITPLHQAsTLDRNKDI 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   119 VELLVHHGADVNRRDrIHESSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQihnteNIRLLLE 198
Cdd:PHA02876 358 VITLLELGANVNARD-YCDKTPIHYAAVR-NNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM-----SVKTLID 430

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   199 GGADVKATTKDGDTV--FTC-------IIFLLGETvGGDKEEAQMINRFCF-------QVTRLLLAHGADPSECPA-HES 261
Cdd:PHA02876 431 RGANVNSKNKDLSTPlhYACkknckldVIEMLLDN-GADVNAINIQNQYPLlialeyhGIVNILLHYGAELRDSRVlHKS 509

                        250       260
                 ....*....|....*....|...
gi 8923516   262 L-----------THICLKSFKLH 273
Cdd:PHA02876 510 LndnmfsfryiiAHICIQDFIRH 532
PHA03095 PHA03095
ankyrin-like protein; Provisional
 86-221 1.43e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    86 DVLLRHGANLnFEDPVTYYTALHI--AVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGAD 163
Cdd:PHA03095 171 RLLIDAGADV-YAVDDRFRSLLHHhlQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGIS 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 8923516   164 VNAADKHGKTALLHALASSdgvqihNTENIRLLLEGGADVKATTKDGdtvFTCIIFLL 221
Cdd:PHA03095 250 INARNRYGQTPLHYAAVFN------NPRACRRLIALGADINAVSSDG---NTPLSLMV 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-175 1.98e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.18  E-value: 1.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVE 120
Cdd:COG0666 158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIVK 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 8923516  121 LLVHHGADVNRRDRIHESSPLDLASEEPERLpcLQRLLDLGADVNAADKHGKTAL 175
Cdd:COG0666 237 LLLEAGADLNAKDKDGLTALLLAAAAGAALI--VKLLLLALLLLAAALLDLLTLL 289
PHA02798 PHA02798
ankyrin-like protein; Provisional
 96-212 3.21e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 49.06  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    96 NFEDPVTYYTALHIAVLRNQP--DMVELLVHHGADVNRRDRiHESSPL-DLAS---EEPERLPCLQRLLDLGADVNAADK 169
Cdd:PHA02798  29 NPNEIVNEYSIFQKYLQRDSPstDIVKLFINLGANVNGLDN-EYSTPLcTILSnikDYKHMLDIVKILIENGADINKKNS 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 8923516   170 HGKTALLHALASSdgvQIHNTENIRLLLEGGADVKATTKDGDT 212
Cdd:PHA02798 108 DGETPLYCLLSNG---YINNLEILLFMIENGADTTLLDKDGFT 147
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 373-412 3.44e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.55  E-value: 3.44e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 8923516     373 PPLKHLCRVAIRLYLQpwpvdvKVKALPLPDRLKWYLLSE 412
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLLYY 34
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 39-202 4.01e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    39 PSYVASEESRILVLTELLE--RKAHSPFYQEGVSNALL--KMAELGLTRaadVLLRHGANLNFEDpVTYYTALHIAVLRN 114
Cdd:PHA02875  71 ELHDAVEEGDVKAVEELLDlgKFADDVFYKDGMTPLHLatILKKLDIMK---LLIARGADPDIPN-TDKFSPLHLAVMMG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   115 QPDMVELLVHHGADVNRRDrIHESSPLDLASEEPERLPClQRLLDLGADVNAADKHGKTALLhalasSDGVQIHNTENIR 194
Cdd:PHA02875 147 DIKGIELLIDHKACLDIED-CCGCTPLIIAMAKGDIAIC-KMLLDSGANIDYFGKNGCVAAL-----CYAIENNKIDIVR 219


                 ....*...
gi 8923516   195 LLLEGGAD 202
Cdd:PHA02875 220 LFIKRGAD 227
PHA02798 PHA02798
ankyrin-like protein; Provisional
 88-203 4.85e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 48.68  E-value: 4.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    88 LLRHGANLNFEDPvTYYTAL-----HIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLD--LASEEPERLPCLQRLLDL 160
Cdd:PHA02798  57 FINLGANVNGLDN-EYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGE-TPLYclLSNGYINNLEILLFMIEN 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 8923516   161 GADVNAADKHGKTALLHALASSDGVQIhntENIRLLLEGGADV 203
Cdd:PHA02798 135 GADTTLLDKDGFTMLQVYLQSNHHIDI---EIIKLLLEKGVDI 174
PHA02792 PHA02792
ankyrin-like protein; Provisional
 50-218 4.96e-06

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 48.79  E-value: 4.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    50 LVLTELLERkahspfYQEGVSNALLKMAELGLTRAADV--LLRHGANL-NFEDPVTYYTALHiavlRNQPDMVELLVHHG 126
Cdd:PHA02792 293 IIISSILKR------YTDSIQDLLSEYVSYHTVYINVIkcMIDEGATLyRFKHINKYFQKFD----NRDPKVVEYILKNG 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   127 ADV-NRRDRIHESSPL--DLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASsdgvqiHNTENIRLLLEGGADV 203
Cdd:PHA02792 363 NVVvEDDDNIINIMPLfpTLSIHESDVLSILKLCKPYIDDINKIDKHGRSILYYCIES------HSVSLVEWLIDNGADI 436

                        170
                 ....*....|....*.
gi 8923516   204 KATTKDGDTVFT-CII 218
Cdd:PHA02792 437 NITTKYGSTCIGiCVI 452
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 104-134 7.85e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.28  E-value: 7.85e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 8923516    104 YTALHIAVLR-NQPDMVELLVHHGADVNRRDR 134
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
88-144 9.90e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 9.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 8923516     88 LLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRiHESSPLDLA 144
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDE-EGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 74-170 1.29e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    74 LKMAELGLTRAADV--------LLRHGANLNFEDpVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIhESSPLDLAS 145
Cdd:PHA03100 156 LKILKLLIDKGVDInaknrvnyLLSYGVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKY-GDTPLHIAI 233

                         90       100
                 ....*....|....*....|....*
gi 8923516   146 eEPERLPCLQRLLDLGADVNAADKH 170
Cdd:PHA03100 234 -LNNNKEIFKLLLNNGPSIKTIIET 257
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 102-179 2.60e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 46.34  E-value: 2.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516  102 TYY---TALHIAVLRNQPDMVELLVHHGADVNRRD-----RIHESSPLDLASEEPERLPCLQRLLDL----------GAD 163
Cdd:cd22196  90 SYYkgqTALHIAIERRNMHLVELLVQNGADVHARAsgeffKKKKGGPGFYFGELPLSLAACTNQLDIvkfllenphsPAD 169

                        90
                ....*....|....*.
gi 8923516  164 VNAADKHGKTaLLHAL 179
Cdd:cd22196 170 ISARDSMGNT-VLHAL 184
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 104-130 4.51e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 4.51e-05
                           10        20
                   ....*....|....*....|....*..
gi 8923516     104 YTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADIN 29
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 157-239 4.52e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 4.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   157 LLDLGADVNAADKHGKTaLLHaLASSDG-VQIhntenIRLLLEGGADVKATTKDGDTVFTciifLLGETvgGDKEEAQMI 235
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRT-PLH-IACANGhVQV-----VRVLLEFGADPTLLDKDGKTPLE----LAEEN--GFREVVQLL 167


                 ....
gi 8923516   236 NRFC 239
Cdd:PTZ00322 168 SRHS 171
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 14-180 7.42e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 7.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     14 YQPLVDAILGSLGIQDPERQESLdrpsYVASEESRILVLTELLERKAHSPFyqegVSNALLKMAELGLTRAADVLLRH-- 91
Cdd:TIGR00870  34 YRDLEEPKKLNINCPDRLGRSAL----FVAAIENENLELTELLLNLSCRGA----VGDTLLHAISLEYVDAVEAILLHll 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     92 -----GANLNF---EDPVTYY---TALHIAVLRNQPDMVELLVHHGADVNRR---DRIHESSPLDLASEEPERL------ 151
Cdd:TIGR00870 106 aafrkSGPLELandQYTSEFTpgiTALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSQGVDSFYHGESPLnaaacl 185

                         170       180       190
                  ....*....|....*....|....*....|..
gi 8923516    152 --PCLQRLL-DLGADVNAADKHGKTaLLHALA 180
Cdd:TIGR00870 186 gsPSIVALLsEDPADILTADSLGNT-LLHLLV 216
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 372-411 1.42e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 39.12  E-value: 1.42e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 8923516  372 PPPLKHLCRVAIRLYLqpwPVDvKVKALPLPDRLKWYLLS 411
Cdd:cd03717   3 VRSLQHLCRFVIRQCT---RRD-LIDQLPLPRRLKDYLKE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 37-180 1.52e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   37 DRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEdPVT--YY---TALHIA 110
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALyDNLEAAVVLMEAAPELVNE-PMTsdLYqgeTALHIA 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516  111 VLRNQPDMVELLVHHGADVNR--------RDRIHE-----SSPLDLA----SEEPERLpclqrLLDLGADVNAADKHGKT 173
Cdd:cd22192  97 VVNQNLNLVRELIARGADVVSpratgtffRPGPKNliyygEHPLSFAacvgNEEIVRL-----LIEHGADIRAQDSLGNT 171


                ....*..
gi 8923516  174 aLLHALA 180
Cdd:cd22192 172 -VLHILV 177
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 103-130 1.62e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 1.62e-04
                          10        20
                  ....*....|....*....|....*...
gi 8923516    103 YYTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 83-189 1.84e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    83 RAADVLLRHGANLNFEDpVTYYTALHIAVlrNQP---DMVELLVHHGADVNRRDRIHEsSPLDLASEEPERLPCLQRLLD 159
Cdd:PHA02874 235 RSAIELLINNASINDQD-IDGSTPLHHAI--NPPcdiDIIDILLYHKADISIKDNKGE-NPIDTAFKYINKDPVIKDIIA 310

                         90       100       110
                 ....*....|....*....|....*....|
gi 8923516   160 LGADVNAADKHGKTALLHALASSDGVQIHN 189
Cdd:PHA02874 311 NAVLIKEADKLKDSDFLEHIEIKDNKEFSD 340
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 117-213 2.01e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 42.50  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   117 DMVELLVHHGADVNRRDRIHESSPLD--LASEEPERLPCLQRLLDLGADVNAADKHGKTaLLHALASSDGVQIhntENIR 194
Cdd:PHA02859  67 EILKFLIENGADVNFKTRDNNLSALHhyLSFNKNVEPEILKILIDSGSSITEEDEDGKN-LLHMYMCNFNVRI---NVIK 142

                         90
                 ....*....|....*....
gi 8923516   195 LLLEGGADVKATTKDGDTV 213
Cdd:PHA02859 143 LLIDSGVSFLNKDFDNNNI 161
Ank_5 pfam13857
Ankyrin repeats (many copies);
121-178 2.17e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 2.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 8923516    121 LLVHHGADVNRRDRiHESSPLDLASEEPeRLPCLQRLLDLGADVNAADKHGKTALLHA 178
Cdd:pfam13857   1 LLEHGPIDLNRLDG-EGYTPLHVAAKYG-ALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 105-205 3.35e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.13  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   105 TALHIAVlrNQPDMVEL---LVHHGADVNRRDrIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTAlLHALAS 181
Cdd:PHA02876 275 TPLHHAS--QAPSLSRLvpkLLERGADVNAKN-IKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITP-LHQAST 350

                         90       100
                 ....*....|....*....|....
gi 8923516   182 SDgvqiHNTENIRLLLEGGADVKA 205
Cdd:PHA02876 351 LD----RNKDIVITLLELGANVNA 370
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 373-409 6.70e-04

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 37.02  E-value: 6.70e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 8923516  373 PPLKHLCRVAIRLYLQPWpvdvKVKALPLPDRLKWYL 409
Cdd:cd03733   4 SSLQHLCRMALRRVMTTQ----QVLALPIPKKMKEFL 36
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-162 7.33e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 7.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    32 RQESLDRPSYVASEESRI---LVLTELLERKAHSPFY----QEGVSNALLKM--------AELGLTRAADVLLRHGANLN 96
Cdd:PTZ00322  30 KPISFERMAAIQEEIARIdthLEALEATENKDATPDHnlttEEVIDPVVAHMltvelcqlAASGDAVGARILLTGGADPN 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8923516    97 FEDpvtYY--TALHIAVLRNQPDMVELLVHHGADVNRRDRiHESSPLDLASEEPER------LPCLQRLLDLGA 162
Cdd:PTZ00322 110 CRD---YDgrTPLHIACANGHVQVVRVLLEFGADPTLLDK-DGKTPLELAEENGFRevvqllSRHSQCHFELGA 179
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 370-411 7.39e-04

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.89  E-value: 7.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 8923516     370 SYPPPLKHLCRVAIRLYLQPWpvdvKVKALPLPDRLKWYLLS 411
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTD----QIKTLPLPPKLKDYLSY 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 119-175 8.35e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 8.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 8923516   119 VELLVHHGADVNRRDrIHESSPLDLASEEPeRLPCLQRLLDLGADVNAADKHGKTAL 175
Cdd:PTZ00322  98 ARILLTGGADPNCRD-YDGRTPLHIACANG-HVQVVRVLLEFGADPTLLDKDGKTPL 152
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 7-130 1.00e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.74  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516     7 FRRIIFEYQPLVDAILgSLGIqDPERQESLDRPSYVaseesrilvltellerkahspfyqegvsNALLKMAELGLTRAAD 86
Cdd:PHA02884  38 YSSIKFHYTDIIDAIL-KLGA-DPEAPFPLSENSKT----------------------------NPLIYAIDCDNDDAAK 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 8923516    87 VLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:PHA02884  88 LLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADIN 131
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 69-165 1.03e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.74  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    69 VSNALLKMAELGLTRAADVLLRHGANLNFEDP---VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLaS 145
Cdd:PHA02884  33 IANILYSSIKFHYTDIIDAILKLGADPEAPFPlseNSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYI-S 111

                         90       100
                 ....*....|....*....|
gi 8923516   146 EEPERLPCLQRLLDLGADVN 165
Cdd:PHA02884 112 VLHGCLKCLEILLSYGADIN 131
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 373-409 1.07e-03

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 36.41  E-value: 1.07e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 8923516  373 PPLKHLCRVAIRLYLQPWpvdvKVKALPLPDRLKWYL 409
Cdd:cd03745   4 PSLRHLCRKALRHFLTTY----QVLALPIPKKMKEFL 36
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 105-195 1.14e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516  105 TALHIAVLRNQPDMVELLVHHGADVNRRDR--------IHE-----SSPLDLA--SEEPErlpCLQRLLDLGAD-VNAAD 168
Cdd:cd22194 143 TALNIAIERRQGDIVKLLIAKGADVNAHAKgvffnpkyKHEgfyfgETPLALAacTNQPE---IVQLLMEKESTdITSQD 219

                        90       100
                ....*....|....*....|....*...
gi 8923516  169 KHGKTaLLHALAS-SDGVQIHNTENIRL 195
Cdd:cd22194 220 SRGNT-VLHALVTvAEDSKTQNDFVKRM 246
Ank_4 pfam13637
Ankyrin repeats (many copies);
137-183 1.16e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 8923516    137 ESSPLDLASEEpERLPCLQRLLDLGADVNAADKHGKTALLHALASSD 183
Cdd:pfam13637   1 ELTALHAAAAS-GHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 89-179 1.25e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 40.93  E-value: 1.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   89 LRHGANLNFEDpvTYY---TALHIAVLRNQPDMVELLVHHGADVNRRDR-------------IHESSPLDLA--SEEPER 150
Cdd:cd22193  61 LKRFINAEYTD--EYYegqTALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfYFGELPLSLAacTNQPDI 138

                        90       100
                ....*....|....*....|....*....
gi 8923516  151 LPCLQRLLDLGADVNAADKHGKTaLLHAL 179
Cdd:cd22193 139 VQYLLENEHQPADIEAQDSRGNT-VLHAL 166
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 372-410 1.32e-03

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 36.13  E-value: 1.32e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 8923516  372 PPPLKHLCRVAIRLYLQPWPVDvKVKALPLPDRLKWYLL 410
Cdd:cd03718   3 PLPLMDLCRRRVRVALGRDRLE-EIEQLPLPPSLKNYLL 40
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 108-218 1.66e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   108 HIAVLRNQPDMVELLVH------HGADVNRrDRIHES-SPLDLASE--EPERLPCLQRLLDLGADVNAADKHGKTALLHA 178
Cdd:PHA02876 107 YASIILNKHKLDEACIHilkeaiSGNDIHY-DKINESiEYMKLIKEriQQDELLIAEMLLEGGADVNAKDIYCITPIHYA 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 8923516   179 lassdgVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
Cdd:PHA02876 186 ------AERGNAKMVNLLLSYGADVNIIALDDLSVLECAV 219
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 372-410 1.88e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 36.35  E-value: 1.88e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 8923516  372 PPPLKHLCRVAIRLYLQPWPVD--VKVKALPLPDRLKWYLL 410
Cdd:cd03731   3 PRPLKHLCRLKIRKLMGLQKLQqpSSMKKLPLPPALKRYIL 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-158 1.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 1.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 8923516    103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHEsSPLDLASEEpERLPCLQRLL 158
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE-TALHFAASN-GNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 68-219 2.12e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.33  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    68 GVSNALLKMAELGlTRAADVLLRHGANLNFEDpVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDrIHESSPLDLASEE 147
Cdd:PHA02874  91 GVDTSILPIPCIE-KDMIKTILDCGIDVNIKD-AELKTFLHYAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAIKH 167

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8923516   148 pERLPCLQRLLDLGADVNAADKHGKTALLHALASSDgvqihnTENIRLLLEGGADVKATTKDGDT-VFTCIIF 219
Cdd:PHA02874 168 -NFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGD------YACIKLLIDHGNHIMNKCKNGFTpLHNAIIH 233
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 372-410 2.67e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 35.98  E-value: 2.67e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 8923516  372 PPPLKHLCRVAI-----RLYLQpwpVDVKVKALPLPDRLKWYLL 410
Cdd:cd03730   3 PRSLKHLCRLKIracmgRLRLR---CPVFMSFLPLPNRLKAYIL 43
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-143 2.72e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.24  E-value: 2.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8923516    75 KMAELGLTRAadvLLRHGANLNFEDPvTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDL 143
Cdd:PLN03192 631 KRNDLTAMKE---LLKQGLNVDSEDH-QGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPTEL 695
TRPV4 cd22195
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed ...
 89-179 2.80e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed broadly in neuronal and non-neuronal cells. It is activated by various stimuli, including hypo-osmolarity, warm temperature, and chemical ligands. TRPV4 acts in physiological functions such as osmoregulation and thermoregulation. It also has a role in mechanosensation in the vascular endothelium and urinary tract, and in cell barrier formation in vascular and epidermal tissues. Knockout mice studies suggested the functional importance of TRPV4 in the central nervous system, nociception, and bone formation. TRPV4 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411979 [Multi-domain]  Cd Length: 733  Bit Score: 39.83  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   89 LRHGANLNFEDpvTYY---TALHIAVLRNQPDMVELLVHHGADVN--RRDRIHESS-----------PLDLA--SEEPER 150
Cdd:cd22195 122 LREFINSPFRD--VYYrgqTALHIAIERRCKHYVELLVEKGADVHaqARGRFFQPKdeggyfyfgelPLSLAacTNQPDI 199

                        90       100
                ....*....|....*....|....*....
gi 8923516  151 LPCLQRLLDLGADVNAADKHGKTaLLHAL 179
Cdd:cd22195 200 VHYLTENAHKKADLRRQDSRGNT-VLHAL 227
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 68-130 3.34e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 3.34e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8923516    68 GVSNALLKMAElGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
Cdd:PHA02875 168 GCTPLIIAMAK-GDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 373-409 4.67e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.82  E-value: 4.67e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 8923516  373 PPLKHLCRVAIRlylqpwPVDVKVKALPLPDRLKWYL 409
Cdd:cd03736   4 PSLQHLCRITIN------KCTRQIQELPLPTRLKDYL 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 122-184 5.10e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.85  E-value: 5.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8923516   122 LVHHGADVNRRDRiHESSPLDLASEEPERLPCLqRLLDLGADVNAADKHGKTALLHALASSDG 184
Cdd:PHA03095 243 LLIAGISINARNR-YGQTPLHYAAVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNG 303
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 370-410 5.71e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 34.43  E-value: 5.71e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 8923516  370 SYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLL 410
Cdd:cd03727   1 SAPGTLKALARYAVRRSLGVQYLPEAVKQLPLPRSVKEYLL 41
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 88-175 6.32e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 38.74  E-value: 6.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516    88 LLRHGANLNFEDPVTYyTALHIAVLRN--QPDMVELLVHHGADVNRRDRIHES------------SPLDLASEEPERLPC 153
Cdd:PHA02716 303 FLQPGVKLHYKDSAGR-TCLHQYILRHniSTDIIKLLHEYGNDLNEPDNIGNTvlhtylsmlsvvNILDPETDNDIRLDV 381

                         90       100
                 ....*....|....*....|..
gi 8923516   154 LQRLLDLGADVNAADKHGKTAL 175
Cdd:PHA02716 382 IQCLISLGADITAVNCLGYTPL 403
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 115-204 8.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 38.57  E-value: 8.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923516   115 QPDMVELLVHHGADVNRRDRIheSSPL-------DLASEEPERLpcLQRLLDLGADVNAADKHGKTALLHALASSDgvqI 187
Cdd:PHA02989  49 KIKIVKLLIDNGADVNYKGYI--ETPLcavlrnrEITSNKIKKI--VKLLLKFGADINLKTFNGVSPIVCFIYNSN---I 121

                         90
                 ....*....|....*..
gi 8923516   188 HNTENIRLLLEGGADVK 204
Cdd:PHA02989 122 NNCDMLRFLLSKGINVN 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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