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Conserved domains on  [gi|157388917|ref|NP_060478|]
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fez family zinc finger protein 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-395 2.20e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388917 289 HYNLTRHMPVHTG--ARPFVCKVCGKGFRQASTLCRHKIIHT-------QEKPHKCNQCGKAFNRSSTLNTHIR--IH-- 355
Cdd:COG5048  237 PKSLLSQSPSSLSssDSSSSASESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHsg 316

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157388917 356 AGYKPFVC--EFCGKGFHQKGNYKNHKLTHSGEKQYKCTICN 395
Cdd:COG5048  317 ESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLN 358
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 385-441 8.99e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.99e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157388917 385 GEKQYKCTI--CNKAFHQVYNLTFHM-HTHNDK------------------KPFTCATCGKGFCRNFDLKKHVRKLHD 441
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSHD 423
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-395 2.20e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388917 289 HYNLTRHMPVHTG--ARPFVCKVCGKGFRQASTLCRHKIIHT-------QEKPHKCNQCGKAFNRSSTLNTHIR--IH-- 355
Cdd:COG5048  237 PKSLLSQSPSSLSssDSSSSASESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHsg 316

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157388917 356 AGYKPFVC--EFCGKGFHQKGNYKNHKLTHSGEKQYKCTICN 395
Cdd:COG5048  317 ESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-344 6.49e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 6.49e-05
                          10        20
                  ....*....|....*....|...
gi 157388917  322 RHKIIHTQEKPHKCNQCGKAFNR 344
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 385-441 8.99e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.99e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157388917 385 GEKQYKCTI--CNKAFHQVYNLTFHM-HTHNDK------------------KPFTCATCGKGFCRNFDLKKHVRKLHD 441
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSHD 423
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-395 2.20e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388917 289 HYNLTRHMPVHTG--ARPFVCKVCGKGFRQASTLCRHKIIHT-------QEKPHKCNQCGKAFNRSSTLNTHIR--IH-- 355
Cdd:COG5048  237 PKSLLSQSPSSLSssDSSSSASESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHsg 316

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157388917 356 AGYKPFVC--EFCGKGFHQKGNYKNHKLTHSGEKQYKCTICN 395
Cdd:COG5048  317 ESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-344 6.49e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 6.49e-05
                          10        20
                  ....*....|....*....|...
gi 157388917  322 RHKIIHTQEKPHKCNQCGKAFNR 344
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 333-355 3.30e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.30e-04
                          10        20
                  ....*....|....*....|...
gi 157388917  333 HKCNQCGKAFNRSSTLNTHIRIH 355
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
269-435 6.65e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388917 269 SADGKPKNFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCK--VCGKGFRQASTLCRHKIIHTQEKPHKcnqcgkafnrss 346
Cdd:COG5048  316 GESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKN------------ 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388917 347 tlnthirihagYKPFVCE--FCGKGFHQKGNYKNHKLTH--SGEKQYKCTICNKAFHQVYNLTFHMHTHNDKKPFTCATC 422
Cdd:COG5048  384 -----------DKKSETLsnSCIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452

                        170
                 ....*....|...
gi 157388917 423 GKgFCRNFDLKKH 435
Cdd:COG5048  453 KS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 385-441 8.99e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 8.99e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157388917 385 GEKQYKCTI--CNKAFHQVYNLTFHM-HTHNDK------------------KPFTCATCGKGFCRNFDLKKHVRKLHD 441
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
329-400 1.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.36e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157388917 329 QEKPHKCNQCGKAFNRSSTLNTHIRIHAGYKPFVCEF--CGKGFHQKGNYKNHKLTHSGEKQYKCTICNKAFHQ 400
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS 103
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 305-327 4.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.35e-03
                          10        20
                  ....*....|....*....|...
gi 157388917  305 FVCKVCGKGFRQASTLCRHKIIH 327
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-417 4.96e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 4.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388917 303 RPFVCKVCGKGFRQASTLCRHKIIHTQEKPHKCNQCGKAFNRSSTLN--THIRIHAGYKPFVCEFCGKGFHQK-GNYKNH 379
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLS 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157388917 380 KLTHSGEKQYKCTICNKAFHQVYNLT--FHMHTHNDKKPF 417
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPL 151
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-370 5.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.81e-03
                          10        20
                  ....*....|....*....|...
gi 157388917  348 LNTHIRIHAGYKPFVCEFCGKGF 370
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-316 7.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 157388917  291 NLTRHMPVHTGARPFVCKVCGKGFRQ 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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