NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|109948304|ref|NP_060695|]
View 

WD40 repeat-containing protein SMU1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
141-513 3.94e-70

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 229.80  E-value: 3.94e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 141 RRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVK--DVEEEKFPTQLSRHikfgqKSHVE 218
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRlwDLATGLLLRTLTGH-----TGAVR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQaqdnfmmmDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQC 298
Cdd:COG2319  125 SVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH--------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 299 LRRFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Cdd:COG2319  197 LRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 379 KTTECSNTFKslgstaGTDITVNSVILLPkNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSgkrEGGDFVCCALSPRGEWI 457
Cdd:COG2319  276 ATGELLRTLT------GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTG---HTGAVRSVAFSPDGKTL 345

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109948304 458 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 7-36 5.54e-11

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 57.02  E-value: 5.54e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 109948304    7 SSDVIRLIMQYLKENSLHRALATLQEETTV 36
Cdd:pfam17814   1 SQDVVRLILQFLKENGLHRTLQALQTESGV 30
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 40-90 2.32e-06

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 44.87  E-value: 2.32e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 109948304    40 TVDSIESFVADINSGHWDTVLQAIQSLKLPD-----KTLIDLYEQVVLELIELREL 90
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLlernsKLEFELRKQKFLELVRQGKL 56
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
141-513 3.94e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 229.80  E-value: 3.94e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 141 RRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVK--DVEEEKFPTQLSRHikfgqKSHVE 218
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRlwDLATGLLLRTLTGH-----TGAVR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQaqdnfmmmDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQC 298
Cdd:COG2319  125 SVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH--------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 299 LRRFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Cdd:COG2319  197 LRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 379 KTTECSNTFKslgstaGTDITVNSVILLPkNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSgkrEGGDFVCCALSPRGEWI 457
Cdd:COG2319  276 ATGELLRTLT------GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTG---HTGAVRSVAFSPDGKTL 345

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109948304 458 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-512 2.72e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 2.72e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 205 LSRHIKfGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAqdnfmmmdDAVLCMCFSRDTEMLATGAQ 284
Cdd:cd00200    1 LRRTLK-GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 285 DGKIKVWKIQSGQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYI 364
Cdd:cd00200   72 DKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 365 ISASSDGTVKIWNMKTTECSNTFKslgstaGTDITVNSVILLPKNpEHFVVCNRSNTVVIMNMQ-GQIVRSFsSGKREGg 443
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLT------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLStGKCLGTL-RGHENG- 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109948304 444 dFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 512
Cdd:cd00200  222 -VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 7-36 5.54e-11

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 57.02  E-value: 5.54e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 109948304    7 SSDVIRLIMQYLKENSLHRALATLQEETTV 36
Cdd:pfam17814   1 SQDVVRLILQFLKENGLHRTLQALQTESGV 30
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 338-377 2.34e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.34e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 109948304   338 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 184-381 7.20e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 7.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 184 IDLFRGKAAVKDVEEEKFPT-QLSRHIKFGQ-------KSHVECARFspdgqylvtgsvDGFIEVWNFTTGKIRKDLKyQ 255
Cdd:PLN00181 507 IKIFECESIIKDGRDIHYPVvELASRSKLSGicwnsyiKSQVASSNF------------EGVVQVWDVARSQLVTEMK-E 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 256 AQDNFMMMDDAvlcmcfSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERahSKGVTCLSFSKDSSQILS-ASFDQTIRIH 334
Cdd:PLN00181 574 HEKRVWSIDYS------SADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESGRSLAfGSADHKVYYY 645

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 109948304 335 GLKSGKT-LKEFRGHSSFVNEATFTqDGHYIISASSDGTVKIWNMKTT 381
Cdd:PLN00181 646 DLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMS 692
WD40 pfam00400
WD domain, G-beta repeat;
339-377 1.06e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.06e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 109948304  339 GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 5-38 1.84e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 44.35  E-value: 1.84e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 109948304     5 IESSDVIRLIMQYLKENSLHRALATLQEETTVSL 38
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 40-90 2.32e-06

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 44.87  E-value: 2.32e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 109948304    40 TVDSIESFVADINSGHWDTVLQAIQSLKLPD-----KTLIDLYEQVVLELIELREL 90
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLlernsKLEFELRKQKFLELVRQGKL 56
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
141-513 3.94e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 229.80  E-value: 3.94e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 141 RRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVK--DVEEEKFPTQLSRHikfgqKSHVE 218
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRlwDLATGLLLRTLTGH-----TGAVR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQaqdnfmmmDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQC 298
Cdd:COG2319  125 SVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH--------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 299 LRRFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Cdd:COG2319  197 LRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 379 KTTECSNTFKslgstaGTDITVNSVILLPkNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSgkrEGGDFVCCALSPRGEWI 457
Cdd:COG2319  276 ATGELLRTLT------GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTG---HTGAVRSVAFSPDGKTL 345

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109948304 458 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-512 2.72e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 2.72e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 205 LSRHIKfGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAqdnfmmmdDAVLCMCFSRDTEMLATGAQ 284
Cdd:cd00200    1 LRRTLK-GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 285 DGKIKVWKIQSGQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYI 364
Cdd:cd00200   72 DKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 365 ISASSDGTVKIWNMKTTECSNTFKslgstaGTDITVNSVILLPKNpEHFVVCNRSNTVVIMNMQ-GQIVRSFsSGKREGg 443
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLT------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLStGKCLGTL-RGHENG- 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109948304 444 dFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 512
Cdd:cd00200  222 -VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
141-511 8.85e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 8.85e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 141 RRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHikfGQKSHVECA 220
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL---GHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 221 RFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQaqdnfmmmDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLR 300
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH--------TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 301 RFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKT 380
Cdd:COG2319  157 TL-TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 381 TECSNTFKslgstaGTDITVNSVILLPKNpEHFVVCNRSNTVVIMNMQ-GQIVRSFSSgkrEGGDFVCCALSPRGEWIYC 459
Cdd:COG2319  236 GKLLRTLT------GHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLAtGELLRTLTG---HSGGVNSVAFSPDGKLLAS 305

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 109948304 460 VGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
195-380 7.28e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 7.28e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 195 DVEEEKFPTQLSRHikfgqKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQaqdnfmmmDDAVLCMCFSR 274
Cdd:COG2319  232 DLATGKLLRTLTGH-----SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSP 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 275 DTEMLATGAQDGKIKVWKIQSGQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNE 354
Cdd:COG2319  299 DGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS 377

                        170       180
                 ....*....|....*....|....*.
gi 109948304 355 ATFTQDGHYIISASSDGTVKIWNMKT 380
Cdd:COG2319  378 VAFSPDGRTLASGSADGTVRLWDLAT 403
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 7-36 5.54e-11

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 57.02  E-value: 5.54e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 109948304    7 SSDVIRLIMQYLKENSLHRALATLQEETTV 36
Cdd:pfam17814   1 SQDVVRLILQFLKENGLHRTLQALQTESGV 30
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 338-377 2.34e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.34e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 109948304   338 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 184-381 7.20e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 7.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 184 IDLFRGKAAVKDVEEEKFPT-QLSRHIKFGQ-------KSHVECARFspdgqylvtgsvDGFIEVWNFTTGKIRKDLKyQ 255
Cdd:PLN00181 507 IKIFECESIIKDGRDIHYPVvELASRSKLSGicwnsyiKSQVASSNF------------EGVVQVWDVARSQLVTEMK-E 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 256 AQDNFMMMDDAvlcmcfSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERahSKGVTCLSFSKDSSQILS-ASFDQTIRIH 334
Cdd:PLN00181 574 HEKRVWSIDYS------SADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESGRSLAfGSADHKVYYY 645

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 109948304 335 GLKSGKT-LKEFRGHSSFVNEATFTqDGHYIISASSDGTVKIWNMKTT 381
Cdd:PLN00181 646 DLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMS 692
WD40 pfam00400
WD domain, G-beta repeat;
339-377 1.06e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.06e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 109948304  339 GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 232-389 2.01e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 232 GSVDGFIE----VWNFTTGKIRKDLKyqaQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSgqCLRRFERAHS 307
Cdd:PLN00181 450 GWIDPFLEglckYLSFSKLRVKADLK---QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECES--IIKDGRDIHY 524

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 308 KGVTCLSFSKDS---------SQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ-DGHYIISASSDGTVKIWN 377
Cdd:PLN00181 525 PVVELASRSKLSgicwnsyikSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWS 604

                        170
                 ....*....|..
gi 109948304 378 MKTTECSNTFKS 389
Cdd:PLN00181 605 INQGVSIGTIKT 616
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 295-334 4.59e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.59e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 109948304   295 SGQCLRRFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIH 334
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
296-333 1.17e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.17e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 109948304  296 GQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRI 333
Cdd:pfam00400   1 GKLLKTLE-GHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 5-38 1.84e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 44.35  E-value: 1.84e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 109948304     5 IESSDVIRLIMQYLKENSLHRALATLQEETTVSL 38
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 40-90 2.32e-06

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 44.87  E-value: 2.32e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 109948304    40 TVDSIESFVADINSGHWDTVLQAIQSLKLPD-----KTLIDLYEQVVLELIELREL 90
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLlernsKLEFELRKQKFLELVRQGKL 56
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 473-512 4.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 109948304   473 TGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 512
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-242 1.34e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 109948304   212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWN 242
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
212-242 3.07e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.07e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 109948304  212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWN 242
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 264-292 3.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 3.15e-05
                           10        20
                   ....*....|....*....|....*....
gi 109948304   264 DDAVLCMCFSRDTEMLATGAQDGKIKVWK 292
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
474-511 4.60e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 109948304  474 GKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
264-291 1.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.37e-04
                          10        20
                  ....*....|....*....|....*...
gi 109948304  264 DDAVLCMCFSRDTEMLATGAQDGKIKVW 291
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 264-318 8.17e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 8.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 109948304  264 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFeRAHSKGVTCLSFSKD 318
Cdd:pfam12894  38 DLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF-SAGSDLITCLGWGEN 91
PTZ00421 PTZ00421
coronin; Provisional
 209-350 1.42e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304 209 IKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTgkirKDLKYQAQDNFMMM---DDAVLCMCFSRDTE-MLATGA 283
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPE----EGLTQNISDPIVHLqghTKKVGIVSFHPSAMnVLASAG 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 109948304 284 QDGKIKVWKIQSGQCLRRFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSS 350
Cdd:PTZ00421 146 ADMVVNVWDVERGKAVEVI-KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS 211
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 214-382 2.27e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.44  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304  214 KSHVECARFSPDGQYLVTGSVDGFIEVW-----NFTTGKIRKDLKYQAQDNFMMM----------DDAVLCMCFSRDTEM 278
Cdd:pfam20426 124 KDVVSCVAVTSDGSILATGSYDTTVMVWevlrgRSSEKRSRNTQTEFPRKDHVIAetpfhilcghDDIITCLYVSVELDI 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109948304  279 LATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLkSGKTLK--EFRGHssfVNEAT 356
Cdd:pfam20426 204 VISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHLYSI-NGKHIAssESNGR---LNCIE 279

                         170       180
                  ....*....|....*....|....*.
gi 109948304  357 FTQDGHYIISASSDGTVKIWNMKTTE 382
Cdd:pfam20426 280 LSSCGEFLVCAGDQGQIVVRSMNSLE 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH