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Conserved domains on  [gi|46397373|ref|NP_060709|]
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leucine-rich repeat-containing protein 20 isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-107 1.21e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 1.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  17 NETVESGSDTLELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPAL 96
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNL 184

                        90
                ....*....|.
gi 46397373  97 RSINLRFNPLN 107
Cdd:COG4886 185 KELDLSNNQIT 195
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-107 1.21e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 1.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  17 NETVESGSDTLELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPAL 96
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNL 184

                        90
                ....*....|.
gi 46397373  97 RSINLRFNPLN 107
Cdd:COG4886 185 KELDLSNNQIT 195
PLN03150 PLN03150
hypothetical protein; Provisional
 39-110 2.87e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 2.87e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46397373   39 LPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV 110
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
LRR_8 pfam13855
Leucine rich repeat;
47-106 4.92e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 4.92e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46397373    47 QHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 106
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 28-109 9.68e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 9.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  28 ELHLEGNFLH-----RLPSEVSALQHLKAIDLSRNQF-----QDFPEQLTALPALETINLEENEIVDVPVEKLA-AMPA- 95
Cdd:cd00116 169 ELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALAsALLSp 248

                        90
                ....*....|....*..
gi 46397373  96 ---LRSINLRFNPLNAE 109
Cdd:cd00116 249 nisLLTLSLSCNDITDD 265
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-107 1.21e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 1.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  17 NETVESGSDTLELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPAL 96
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNL 184

                        90
                ....*....|.
gi 46397373  97 RSINLRFNPLN 107
Cdd:COG4886 185 KELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-106 2.29e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 2.29e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46397373  28 ELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLRFNPL 106
Cdd:COG4886 163 SLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-106 6.65e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 6.65e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 46397373  28 ELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPveKLAAMPALRSINLRFNPL 106
Cdd:COG4886 186 ELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-107 1.22e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  28 ELHLEGNFLHRLPSEVSALQHLKAIDLSRNQFQDFPEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLRFNPLN 107
Cdd:COG4886 140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLT 218
PLN03150 PLN03150
hypothetical protein; Provisional
 39-110 2.87e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 2.87e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 46397373   39 LPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV 110
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-123 4.13e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 4.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  28 ELHLEGNFLHRLPsEVSALQHLKAIDLSRNQFQDFPEqLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLN 107
Cdd:COG4886 232 TLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309

                        90
                ....*....|....*.
gi 46397373 108 AEVRVIAPPLIKFDML 123
Cdd:COG4886 310 LLELLILLLLLTTLLL 325
LRR_8 pfam13855
Leucine rich repeat;
47-106 4.92e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 4.92e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46397373    47 QHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPL 106
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-110 3.88e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 3.88e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46397373   34 NFLHRLPsEVSALQHLKAIDLSRNQFQD-FPEQLTALPALETINLEENEIVDVPVEKLAAMPALRSINLRFNPLNAEV 110
Cdd:PLN00113 463 KFFGGLP-DSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539
LRR_8 pfam13855
Leucine rich repeat;
28-82 2.13e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46397373    28 ELHLEGNFLHRLPSEV-SALQHLKAIDLSRNQFQDF-PEQLTALPALETINLEENEI 82
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-106 1.27e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 1.27e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46397373  39 LPSEVSALQHLKAIDLSRNqfqdfpEQLTALPALETINLEENEIVDVPVEkLAAMPALRSINLRFNPL 106
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQL 148
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 22-110 5.36e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 5.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373   22 SGSDTLE-LHLEGN-FLHRLPSEVSALQHLKAIDLSRNQFQ-DFPEQLTALPALETINLEENEIVDVPVEKLAAMPALRS 98
Cdd:PLN00113 472 FGSKRLEnLDLSRNqFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ 551

                         90
                 ....*....|..
gi 46397373   99 INLRFNPLNAEV 110
Cdd:PLN00113 552 LDLSQNQLSGEI 563
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 28-109 9.68e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 9.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  28 ELHLEGNFLH-----RLPSEVSALQHLKAIDLSRNQF-----QDFPEQLTALPALETINLEENEIVDVPVEKLA-AMPA- 95
Cdd:cd00116 169 ELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALAsALLSp 248

                        90
                ....*....|....*..
gi 46397373  96 ---LRSINLRFNPLNAE 109
Cdd:cd00116 249 nisLLTLSLSCNDITDD 265
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
24-132 1.17e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 37.45  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373   24 SDTLELHLEGNFLHRLPSEVSALQHLKaidLSRNQFQDFPEQLTALPALETINLEENEIVDvpveklAAMPALRSInlrf 103
Cdd:PRK15387 402 SELKELMVSGNRLTSLPMLPSGLLSLS---VYRNQLTRLPESLIHLSSETTVNLEGNPLSE------RTLQALREI---- 468

                         90       100
                 ....*....|....*....|....*....
gi 46397373  104 nplnAEVRVIAPPLIKFDMlmspEGARAP 132
Cdd:PRK15387 469 ----TSAPGYSGPIIRFDM----AGASAP 489
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 31-106 2.57e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.56  E-value: 2.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  31 LEGNFLHRLPSEVSALQHLKAIDLSRNQFQDF-----PEQLTALPALETINLEENEIVDVPVEKLAA----MPALRSINL 101
Cdd:cd00116 149 LEGASCEALAKALRANRDLKELNLANNGIGDAgiralAEGLKANCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNL 228


                ....*
gi 46397373 102 RFNPL 106
Cdd:cd00116 229 GDNNL 233
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 18-117 2.69e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.31  E-value: 2.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  18 ETVESGSDTLELHLEGNFLHRLPSE--VSALQHLKAI---DLSRNQFQD-----FPEQLTALPALETINLEENEIVDVPV 87
Cdd:COG5238 202 EALTQNTTVTTLWLKRNPIGDEGAEilAEALKGNKSLttlDLSNNQIGDegviaLAEALKNNTTVETLYLSGNQIGAEGA 281

                        90       100       110
                ....*....|....*....|....*....|....*
gi 46397373  88 EKLAAM----PALRSINLRFNPLNAE-VRVIAPPL 117
Cdd:COG5238 282 IALAKAlqgnTTLTSLDLSVNRIGDEgAIALAEGL 316
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 18-111 5.66e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 35.15  E-value: 5.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46397373  18 ETVESGSDTLE-LHLEGNflhRLPS--EVSALQHLKAIDLSRNQFQDFpeqltalpaletinleeNEIVDVpvekLAAMP 94
Cdd:cd21340 113 RSLAALSNSLRvLNISGN---NIDSlePLAPLRNLEQLDASNNQISDL-----------------EELLDL----LSSWP 168

                        90
                ....*....|....*..
gi 46397373  95 ALRSINLRFNPLNAEVR 111
Cdd:cd21340 169 SLRELDLTGNPVCKKPK 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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