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Conserved domains on  [gi|108936950|ref|NP_060716|]
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coiled-coil domain-containing protein 25 isoform 1 [Homo sapiens]

Protein Classification

CCDC25 family protein( domain architecture ID 10529311)

CCDC25 family protein such as vertebrate coiled-coil domain-containing protein 25 and yeast protein JLP2

PubMed:  32528174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-112 6.20e-50

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


:

Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 157.78  E-value: 6.20e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108936950    1 MVFYFTSSSVnssaYTIYMGKDKYENEDLIKHGWPE-DIWFHVDKLSSAHVYLRLHKGeniEDIPKEVLMDCAHLVKANS 79
Cdd:pfam05670   1 KFYWFVSSEG----YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEG---EDIPPETLEEAAQLAKANS 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 108936950   80 IQ-GCKMNNVNVVYTPWSNLKKTAD---MDVGQIGFH 112
Cdd:pfam05670  74 IAwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFK 110
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-112 6.20e-50

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 157.78  E-value: 6.20e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108936950    1 MVFYFTSSSVnssaYTIYMGKDKYENEDLIKHGWPE-DIWFHVDKLSSAHVYLRLHKGeniEDIPKEVLMDCAHLVKANS 79
Cdd:pfam05670   1 KFYWFVSSEG----YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEG---EDIPPETLEEAAQLAKANS 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 108936950   80 IQ-GCKMNNVNVVYTPWSNLKKTAD---MDVGQIGFH 112
Cdd:pfam05670  74 IAwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFK 110
RqcH COG1293
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ...
 12-100 3.16e-08

Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440904 [Multi-domain]  Cd Length: 578  Bit Score: 52.92  E-value: 3.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108936950  12 SSAYTIYMGKDKYENEDLI-KHGWPEDIWFHVDKLSSAHVYLRLHKgeniEDIPKEVLMDCAHLVKANSiQGCKMNNVNV 90
Cdd:COG1293  464 SDGFLILVGRNNRQNDELTkKYARKNDIWFHAKDIPGSHVIIKTEG----KEPPEETLEEAAQLAAYYS-KARKSGSVPV 538

                         90
                 ....*....|
gi 108936950  91 VYTPWSNLKK 100
Cdd:COG1293  539 DYTEPKQVSK 548
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-112 6.20e-50

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 157.78  E-value: 6.20e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108936950    1 MVFYFTSSSVnssaYTIYMGKDKYENEDLIKHGWPE-DIWFHVDKLSSAHVYLRLHKGeniEDIPKEVLMDCAHLVKANS 79
Cdd:pfam05670   1 KFYWFVSSEG----YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEG---EDIPPETLEEAAQLAKANS 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 108936950   80 IQ-GCKMNNVNVVYTPWSNLKKTAD---MDVGQIGFH 112
Cdd:pfam05670  74 IAwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFK 110
RqcH COG1293
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ...
 12-100 3.16e-08

Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440904 [Multi-domain]  Cd Length: 578  Bit Score: 52.92  E-value: 3.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108936950  12 SSAYTIYMGKDKYENEDLI-KHGWPEDIWFHVDKLSSAHVYLRLHKgeniEDIPKEVLMDCAHLVKANSiQGCKMNNVNV 90
Cdd:COG1293  464 SDGFLILVGRNNRQNDELTkKYARKNDIWFHAKDIPGSHVIIKTEG----KEPPEETLEEAAQLAAYYS-KARKSGSVPV 538

                         90
                 ....*....|
gi 108936950  91 VYTPWSNLKK 100
Cdd:COG1293  539 DYTEPKQVSK 548
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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