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Conserved domains on  [gi|217330644|ref|NP_060726|]
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ribosome biogenesis protein WDR12 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12087049)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
100-409 1.01e-51

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.57  E-value: 1.01e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 100 HDDWISSIK----GaeEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAW-------VkkdslsclllSASMDQTI 167
Cdd:COG2319  119 HTGAVRSVAfspdG--KTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFspdgkllA----------SGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 168 LLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteqlglTR 247
Cdd:COG2319  187 RLW--DLATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--------------------------TG 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 248 TPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD 325
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSpDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 326 PRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRScKAPLYDLAAHEDKVLSVDWTDTG-LLLSGG 404
Cdd:COG2319  317 LAT--GKLLR-TLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSPDGrTLASGS 391


                 ....*
gi 217330644 405 ADNKL 409
Cdd:COG2319  392 ADGTV 396
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 4-70 4.96e-21

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 86.04  E-value: 4.96e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217330644    4 LQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKnEFHKHVEFDFLIKGQFLRMPLDKHM 70
Cdd:pfam08154   1 VQVRFVTKEGELAVPGTPLDVPVSLTRYQLSELVNSLLKNE-ELEKPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
100-409 1.01e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.57  E-value: 1.01e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 100 HDDWISSIK----GaeEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAW-------VkkdslsclllSASMDQTI 167
Cdd:COG2319  119 HTGAVRSVAfspdG--KTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFspdgkllA----------SGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 168 LLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteqlglTR 247
Cdd:COG2319  187 RLW--DLATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--------------------------TG 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 248 TPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD 325
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSpDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 326 PRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRScKAPLYDLAAHEDKVLSVDWTDTG-LLLSGG 404
Cdd:COG2319  317 LAT--GKLLR-TLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSPDGrTLASGS 391


                 ....*
gi 217330644 405 ADNKL 409
Cdd:COG2319  392 ADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-409 4.36e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.68  E-value: 4.36e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 100 HDDWISSIK--GAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDslsCLLLSASMDQTILLWEWnver 176
Cdd:cd00200    8 HTGGVTCVAfsPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADG---TYLASGSSDKTIRLWDL---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 177 NKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteqlgLTRTPIVTLSGH 256
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV--------------------------ETGKCLTTLRGH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 257 MEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWDPRTKDgslV 334
Cdd:cd00200  135 TDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---C 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 217330644 335 SLSLTSHTGWVTSVKWSPtHEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKL 409
Cdd:cd00200  212 LGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLASGSADGTI 285
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 4-70 4.96e-21

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 86.04  E-value: 4.96e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217330644    4 LQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKnEFHKHVEFDFLIKGQFLRMPLDKHM 70
Cdd:pfam08154   1 VQVRFVTKEGELAVPGTPLDVPVSLTRYQLSELVNSLLKNE-ELEKPVPFDFLINGEFLRTSLEEHL 66
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 192-421 1.10e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 192 VDSIAVDGSGTKFCSGSWDKMLKIWstvptdeedEMEESTNRPRKkqkteqlglTRTPIVTLSGHMEaVSSVLWSD--AE 269
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIF---------ECESIIKDGRD---------IHYPVVELASRSK-LSGICWNSyiKS 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 270 EICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCISYSPLCKRLASGSTDRHIRLWDPRTKdgslVSLSLTSHTGWVTS 347
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEkrVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANICC 622

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 217330644 348 VKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHV 421
Cdd:PLN00181 623 VQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGI 696
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 337-371 1.66e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 217330644   337 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 371
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
337-371 8.28e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 8.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 217330644  337 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 371
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
100-409 1.01e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.57  E-value: 1.01e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 100 HDDWISSIK----GaeEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAW-------VkkdslsclllSASMDQTI 167
Cdd:COG2319  119 HTGAVRSVAfspdG--KTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVTSVAFspdgkllA----------SGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 168 LLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteqlglTR 247
Cdd:COG2319  187 RLW--DLATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--------------------------TG 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 248 TPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWD 325
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSpDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 326 PRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRScKAPLYDLAAHEDKVLSVDWTDTG-LLLSGG 404
Cdd:COG2319  317 LAT--GKLLR-TLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSPDGrTLASGS 391


                 ....*
gi 217330644 405 ADNKL 409
Cdd:COG2319  392 ADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-409 4.36e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 173.68  E-value: 4.36e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 100 HDDWISSIK--GAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDslsCLLLSASMDQTILLWEWnver 176
Cdd:cd00200    8 HTGGVTCVAfsPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADG---TYLASGSSDKTIRLWDL---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 177 NKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteqlgLTRTPIVTLSGH 256
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV--------------------------ETGKCLTTLRGH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 257 MEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWDPRTKDgslV 334
Cdd:cd00200  135 TDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---C 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 217330644 335 SLSLTSHTGWVTSVKWSPtHEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKL 409
Cdd:cd00200  212 LGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
100-374 4.15e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 4.15e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 100 HDDWISSI----KGaeEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAW-------VkkdslsclllSASMDQTI 167
Cdd:COG2319  161 HSGAVTSVafspDG--KLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFspdgkllA----------SGSADGTV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 168 LLWewNVERNKVKALHccRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteqlglTR 247
Cdd:COG2319  229 RLW--DLATGKLLRTL--TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA--------------------------TG 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 248 TPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIRLWD 325
Cdd:COG2319  279 ELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 217330644 326 PRTKdgsLVSLSLTSHTGWVTSVKWSPtHEQQLISGSLDNIVKLWDTRS 374
Cdd:COG2319  359 LATG---ELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
113-410 6.66e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 6.66e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 113 WILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWvkkDSLSCLLLSASMDQTILLWewNVERNKvkALHCCRGHAGSV 192
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF---SPDGRLLASASADGTVRLW--DLATGL--LLRTLTGHTGAV 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 193 DSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRK--------------KQKTEQL--GLTRTPIVTLSGH 256
Cdd:COG2319  124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSvafspdgkllasgsDDGTVRLwdLATGKLLRTLTGH 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 257 MEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIRLWDPRTkdGSLV 334
Cdd:COG2319  204 TGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT--GELL 281

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217330644 335 SLsLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKLY 410
Cdd:COG2319  282 RT-LTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGkTLASGSDDGTVR 355
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-371 1.86e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.64  E-value: 1.86e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 100 HDDWISSIK--GAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSasmDQTILLWEWNver 176
Cdd:cd00200   50 HTGPVRDVAasADGTYLASGSSDKTIRLWDLEtGECVRTLTGHTSYVSSVAFSPDGRILSSSSR---DKTIKVWDVE--- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 177 nKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeeSTNRPRKkqkteqlgltrtpivTLSGH 256
Cdd:cd00200  124 -TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-----------RTGKCVA---------------TLTGH 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 257 MEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDgslV 334
Cdd:cd00200  177 TGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE---C 253

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 217330644 335 SLSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWD 371
Cdd:cd00200  254 VQTLSGHTNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-413 4.83e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 4.83e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 135 TIVGHTDVVKDVAWvkkDSLSCLLLSASMDQTILLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLK 214
Cdd:cd00200    4 TLKGHTGGVTCVAF---SPDGKLLATGSGDGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 215 IWSTVptdeedemeestnrprkkqkteqlglTRTPIVTLSGHMEAVSSVLWSDAEEI-CSASWDHTIRVWDVESGSLKST 293
Cdd:cd00200   77 LWDLE--------------------------TGECVRTLTGHTSYVSSVAFSPDGRIlSSSSRDKTIKVWDVETGKCLTT 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 294 LTGNKVF-NCISYSPLCKRLASGSTDRHIRLWDPRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDT 372
Cdd:cd00200  131 LRGHTDWvNSVAFSPDGTFVASSSQDGTIKLWDLRT--GKCVA-TLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDL 206

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 217330644 373 RScKAPLYDLAAHEDKVLSVDWTDTGLLL-SGGADNKLYSYR 413
Cdd:cd00200  207 ST-GKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
109-409 6.80e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 6.80e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 109 GAEEWILTGSYDKTSRIWSLE-GKSIMTIVGHTDVVKDVAWVkkdSLSCLLLSASMDQTILLWEWNVERnkvkALHCCRG 187
Cdd:COG2319    4 ADGAALAAASADLALALLAAAlGALLLLLLGLAAAVASLAAS---PDGARLAAGAGDLTLLLLDAAAGA----LLATLLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 188 HAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteqlgLTRTPIVTLSGHMEAVSSVLWS- 266
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDL--------------------------ATGLLLRTLTGHTGAVRSVAFSp 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 267 DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIRLWDPRTkdGSLVsLSLTSHTGWV 345
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLL-RTLTGHTGAV 207

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 217330644 346 TSVKWSPtHEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKL 409
Cdd:COG2319  208 RSVAFSP-DGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGrLLASGSADGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 249-408 6.26e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.35  E-value: 6.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 249 PIVTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWDp 326
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPvRDVAASADGTYLASGSSDKTIRLWD- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 327 rTKDGSLVSlSLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTGLLLSGGAD 406
Cdd:cd00200   80 -LETGECVR-TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155


                 ..
gi 217330644 407 NK 408
Cdd:cd00200  156 DG 157
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 4-70 4.96e-21

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 86.04  E-value: 4.96e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217330644    4 LQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKnEFHKHVEFDFLIKGQFLRMPLDKHM 70
Cdd:pfam08154   1 VQVRFVTKEGELAVPGTPLDVPVSLTRYQLSELVNSLLKNE-ELEKPVPFDFLINGEFLRTSLEEHL 66
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 192-421 1.10e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 192 VDSIAVDGSGTKFCSGSWDKMLKIWstvptdeedEMEESTNRPRKkqkteqlglTRTPIVTLSGHMEaVSSVLWSD--AE 269
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIF---------ECESIIKDGRD---------IHYPVVELASRSK-LSGICWNSyiKS 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 270 EICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCISYSPLCKRLASGSTDRHIRLWDPRTKdgslVSLSLTSHTGWVTS 347
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEkrVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANICC 622

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 217330644 348 VKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHV 421
Cdd:PLN00181 623 VQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGI 696
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 337-371 1.66e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 217330644   337 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 371
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
337-371 8.28e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 8.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 217330644  337 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 371
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 312-408 1.05e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.64  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 312 LASGSTDRHIRLWDPRTKDGSLVSLS-----LTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAhe 386
Cdd:PTZ00420  90 LASGSEDLTIRVWEIPHNDESVKEIKdpqciLKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMP-- 167

                         90       100
                 ....*....|....*....|..
gi 217330644 387 DKVLSVDWTDTGLLLSGGADNK 408
Cdd:PTZ00420 168 KKLSSLKWNIKGNLLSGTCVGK 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 246-284 1.16e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 217330644   246 TRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWD 284
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 244-404 2.74e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 244 GLTRT---PIVTLSGHMEAVSSVLW--SDAEEICSASWDHTIRVWDVESGSLKSTLTgnkvfnCISY-----------SP 307
Cdd:PTZ00421 109 GLTQNisdPIVHLQGHTKKVGIVSFhpSAMNVLASAGADMVVNVWDVERGKAVEVIK------CHSDqitslewnldgSL 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 308 LCkrlaSGSTDRHIRLWDPRtkDGSLVSLSLTSHTGWVTSVKWSptHEQQLI-----SGSLDNIVKLWDTRSCKAPLY-- 380
Cdd:PTZ00421 183 LC----TTSKDKKLNIIDPR--DGTIVSSVEAHASAKSQRCLWA--KRKDLIitlgcSKSQQRQIMLWDTRKMASPYStv 254

                        170       180
                 ....*....|....*....|....
gi 217330644 381 DLAAHEDKVLSVDWTDTGLLLSGG 404
Cdd:PTZ00421 255 DLDQSSALFIPFFDEDTNLLYIGS 278
WD40 pfam00400
WD domain, G-beta repeat;
247-284 6.02e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 217330644  247 RTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWD 284
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 180-217 1.49e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 217330644   180 KALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWS 217
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-325 3.41e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 217330644   287 SGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIRLWD 325
Cdd:smart00320   1 SGELLKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-217 3.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 217330644  180 KALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWS 217
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 206-415 4.17e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 4.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 206 SGSWDKMLKIWStVPTDEEDEMEestnrprkkqkteqlglTRTPIVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVW 283
Cdd:PTZ00420  92 SGSEDLTIRVWE-IPHNDESVKE-----------------IKDPQCILKGHKKKISIIDWNPMNYyiMCSSGFDSFVNIW 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 284 DVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDgslVSLSLTSHTG-------WVTSVKWSPTHeq 356
Cdd:PTZ00420 154 DIENEKRAFQINMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQE---IASSFHIHDGgkntkniWIDGLGGDDNY-- 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217330644 357 QLISG-SLDNI--VKLWDTRSCKAPLYD---------LAAHEDKvlsvdwtDTGLL-LSGGADNKLYSYRYS 415
Cdd:PTZ00420 229 ILSTGfSKNNMreMKLWDLKNTTSALVTmsidnasapLIPHYDE-------STGLIyLIGKGDGNCRYYQHS 293
WD40 pfam00400
WD domain, G-beta repeat;
288-325 2.29e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 217330644  288 GSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWD 325
Cdd:pfam00400   1 GKLLKTLEGHTGSvTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 267-376 2.86e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330644 267 DAEEICSASWDHTIRVWDVESGSLKST-------LTG-NKVFNCISYSPLCKR-LASGSTDRHIRLWDPRTkdGSLVSlS 337
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGhTKKVGIVSFHPSAMNvLASAGADMVVNVWDVER--GKAVE-V 163

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 217330644 338 LTSHTGWVTSVKWSpTHEQQLISGSLDNIVKLWDTRSCK 376
Cdd:PTZ00421 164 IKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGT 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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