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Conserved domains on  [gi|224591401|ref|NP_060793|]
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phosphatidylinositol 4-kinase type 2-beta [Homo sapiens]

Protein Classification

phosphatidylinositol 4-kinase( domain architecture ID 10452261)

phosphatidylinositol 4-kinase catalyzes the ATP-dependent phosphorylation of 1-phosphatidyl-1D-myo-inositol to orm 1-phosphatidyl-1D-myo-inositol 4-phosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PI3_PI4_kinase pfam00454
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
129-427 2.28e-54

Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.


:

Pssm-ID: 395364 [Multi-domain]  Cd Length: 241  Bit Score: 182.14  E-value: 2.28e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  129 GSSGSYFVKDPKRK---IIGVFKPKSEEPYGQLNPKWTkyvHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVP 205
Cdd:pfam00454   1 GYGGIYKVGDDLRQdelILQVFKLMDEELSKDNLDLRR---LKPYSVIPLGPKCGIIEWVPNSETLAYILDEYGENGVPP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  206 KTKVVWLvsetfnynaidRAKSRGKKYALEKvpkvgrkFHRIGLPPKIGSFQLFVEGYKEAEYWLRkfeadplpenIRKQ 285
Cdd:pfam00454  78 TAMVKIL-----------HSALNYPKLKLEF-------ESRISLPPKVGLLQWFVKKSPDAEEWGE----------ARKN 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  286 FQSQFERLVILDYIIRNTDRGNDNWLVryekqkcekeidHKESKwiddeefliKIAAIDNGLAFpfkhPDEWRAYPFhwa 365
Cdd:pfam00454 130 FVRSCAGYSVLDYILGNGDRHLDNILV------------DKTTG---------KLFHIDFGLCL----PDAGKDLPF--- 181
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224591401  366 wlPqAKVPFSEEiRNLILPY--ISDMNFVQDLCEDLYELFKTDKGFDKATFEsqMSVMRGQILN 427
Cdd:pfam00454 182 --P-EKVPFRLT-REMVYAMgpSGDEGLFRELCETAYEALRRNLNLLTNLLK--LMVADGLPDW 239
 
Name Accession Description Interval E-value
PI3_PI4_kinase pfam00454
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
129-427 2.28e-54

Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.


Pssm-ID: 395364 [Multi-domain]  Cd Length: 241  Bit Score: 182.14  E-value: 2.28e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  129 GSSGSYFVKDPKRK---IIGVFKPKSEEPYGQLNPKWTkyvHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVP 205
Cdd:pfam00454   1 GYGGIYKVGDDLRQdelILQVFKLMDEELSKDNLDLRR---LKPYSVIPLGPKCGIIEWVPNSETLAYILDEYGENGVPP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  206 KTKVVWLvsetfnynaidRAKSRGKKYALEKvpkvgrkFHRIGLPPKIGSFQLFVEGYKEAEYWLRkfeadplpenIRKQ 285
Cdd:pfam00454  78 TAMVKIL-----------HSALNYPKLKLEF-------ESRISLPPKVGLLQWFVKKSPDAEEWGE----------ARKN 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  286 FQSQFERLVILDYIIRNTDRGNDNWLVryekqkcekeidHKESKwiddeefliKIAAIDNGLAFpfkhPDEWRAYPFhwa 365
Cdd:pfam00454 130 FVRSCAGYSVLDYILGNGDRHLDNILV------------DKTTG---------KLFHIDFGLCL----PDAGKDLPF--- 181
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224591401  366 wlPqAKVPFSEEiRNLILPY--ISDMNFVQDLCEDLYELFKTDKGFDKATFEsqMSVMRGQILN 427
Cdd:pfam00454 182 --P-EKVPFRLT-REMVYAMgpSGDEGLFRELCETAYEALRRNLNLLTNLLK--LMVADGLPDW 239
 
Name Accession Description Interval E-value
PI3_PI4_kinase pfam00454
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
129-427 2.28e-54

Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.


Pssm-ID: 395364 [Multi-domain]  Cd Length: 241  Bit Score: 182.14  E-value: 2.28e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  129 GSSGSYFVKDPKRK---IIGVFKPKSEEPYGQLNPKWTkyvHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVP 205
Cdd:pfam00454   1 GYGGIYKVGDDLRQdelILQVFKLMDEELSKDNLDLRR---LKPYSVIPLGPKCGIIEWVPNSETLAYILDEYGENGVPP 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  206 KTKVVWLvsetfnynaidRAKSRGKKYALEKvpkvgrkFHRIGLPPKIGSFQLFVEGYKEAEYWLRkfeadplpenIRKQ 285
Cdd:pfam00454  78 TAMVKIL-----------HSALNYPKLKLEF-------ESRISLPPKVGLLQWFVKKSPDAEEWGE----------ARKN 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224591401  286 FQSQFERLVILDYIIRNTDRGNDNWLVryekqkcekeidHKESKwiddeefliKIAAIDNGLAFpfkhPDEWRAYPFhwa 365
Cdd:pfam00454 130 FVRSCAGYSVLDYILGNGDRHLDNILV------------DKTTG---------KLFHIDFGLCL----PDAGKDLPF--- 181
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224591401  366 wlPqAKVPFSEEiRNLILPY--ISDMNFVQDLCEDLYELFKTDKGFDKATFEsqMSVMRGQILN 427
Cdd:pfam00454 182 --P-EKVPFRLT-REMVYAMgpSGDEGLFRELCETAYEALRRNLNLLTNLLK--LMVADGLPDW 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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