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Conserved domains on  [gi|33620759|ref|NP_060879|]
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LRP2-binding protein isoform 1 [Homo sapiens]

Protein Classification

SEL1-like repeat protein( domain architecture ID 11434924)

SEL1-like repeat family protein may function as an adaptor protein for the assembly of macromolecular complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  16870393
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
40-255 1.07e-33

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 124.66  E-value: 1.07e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  40 ANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKK 119
Cdd:COG0790  13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 120 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 197
Cdd:COG0790  93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 33620759 198 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 255
Cdd:COG0790 162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 297-331 7.32e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 33.69  E-value: 7.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 33620759    297 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 331
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
40-255 1.07e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 124.66  E-value: 1.07e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  40 ANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKK 119
Cdd:COG0790  13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 120 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 197
Cdd:COG0790  93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 33620759 198 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 255
Cdd:COG0790 162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 208-242 2.39e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.01  E-value: 2.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 33620759    208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERGN 242
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 208-241 1.18e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.66  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 33620759   208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERG 241
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 36-240 3.24e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759    36 DYTHANLVDKALQLLKERILK--GDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDglgtTLDA 110
Cdd:TIGR02917 440 SYLRSGQFDKALAAAKKLEKKqpDNASLHNLLGAIYLGKGDLAKAREAFEkalSIEPDFFPAAANLARIDIQ----EGNP 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759   111 EKGVDYMKKIL-DSPCPKARHLKFAAAYNlgrayyegkgvKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPK 189
Cdd:TIGR02917 516 DDAIQRFEKVLtIDPKNLRAILALAGLYL-----------RTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLK 584

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 33620759   190 E----LEKAFYWHSEacgngNLESQGALGLMYLygqgIRQDTEAALQCLREAAER 240
Cdd:TIGR02917 585 KalaiLNEAADAAPD-----SPEAWLMLGRAQL----AAGDLNKAVSSFKKLLAL 630
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 297-331 7.32e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 33.69  E-value: 7.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 33620759    297 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 331
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
40-255 1.07e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 124.66  E-value: 1.07e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  40 ANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKK 119
Cdd:COG0790  13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 120 IldspcpkARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYW 197
Cdd:COG0790  93 A-------AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADA----QYNLGLLYLNGEgvPKDPAKAAEW 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 33620759 198 HSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYK 255
Cdd:COG0790 162 YRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
TPR COG0790
TPR repeat [General function prediction only];
44-240 2.33e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 110.40  E-value: 2.33e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  44 DKALQLLKERILKGDTLAYFLRGQLYfEEGW-----YEEALEQFEEIKEKDH-QATYQLGVMYYDGLGTTLDAEKGVDYM 117
Cdd:COG0790  48 AAAAAAAAAAAAAGGAEAQYNLGLMY-AEGRgvpkdYEKALEWFEKAAEQGDaEAQYNLGLMYEEGLGVPQDYAKALEWY 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 118 KKildspcpKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAF 195
Cdd:COG0790 127 EK-------AAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA----QYNLGVLYENGRgvPKDPAKAL 195

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 33620759 196 YWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAER 240
Cdd:COG0790 196 EWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
71-330 3.18e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 110.02  E-value: 3.18e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  71 EEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKILDSPCPKARHLKFAAAYNLGRAYYEGKGVK 150
Cdd:COG0790   1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 151 RSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTE 228
Cdd:COG0790  81 KDYEKALEWFEKAAEQGDAEA----QYNLGLMYEEGLgvPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 229 AALQCLREAAERGNVYAQGNLVEYYYKMKF----FTKCVAFSKRIADydevhdipmiaqvtdclpefigRGMAMASFYHA 304
Cdd:COG0790 157 KAAEWYRKAAEQGDADAQYNLGVLYENGRGvpkdPAKALEWYRKAAE----------------------QGDADAQYNLG 214

                       250       260
                ....*....|....*....|....*.
gi 33620759 305 RCLQLGLGITRDETTAKHYYSKACRL 330
Cdd:COG0790 215 RLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
134-335 1.56e-17

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 80.74  E-value: 1.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 134 AAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKAsvkaQSMLGLYYSTKE--PKELEKAFYWHSEACGNGNLESQG 211
Cdd:COG0790  28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEA----QYNLGLMYAEGRgvPKDYEKALEWFEKAAEQGDAEAQY 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 212 ALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKF----FTKCVAFSKRIADydevhdipmiaqvtdc 287
Cdd:COG0790 104 NLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGvpkdPAKAAEWYRKAAE---------------- 167

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 33620759 288 lpefigRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPALA 335
Cdd:COG0790 168 ------QGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADA 209
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 36-240 3.85e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 3.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  36 DYTHANLVDKALQLLKE--RILKGDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDglgtTLDA 110
Cdd:COG2956  85 DYLKAGLLDRAEELLEKllELDPDDAEALRLLAEIYEQEGDWEKAIEVLErllKLGPENAHAYCELAELYLE----QGDY 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 111 EKGVDYMKKILdspcpKARHLKFAAAYNLGRAYYEGKgvkrSNEEAERLWLIAADNgNPKASVKAQSMLGLYYSTKEPKE 190
Cdd:COG2956 161 DEAIEALEKAL-----KLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQ-DPDYLPALPRLAELYEKLGDPEE 230

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 33620759 191 LEKAFywhsEACGNGNLESQGALGLMYLYGQgiRQDTEAALQCLREAAER 240
Cdd:COG2956 231 ALELL----RKALELDPSDDLLLALADLLER--KEGLEAALALLERQLRR 274
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 44-256 1.70e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 1.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  44 DKALQLLKErILKGD---TLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQ---ATYQLGVMYYDglgtTLDAEKGVDYM 117
Cdd:COG2956  25 DKAIDLLEE-ALELDpetVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDraeALLELAQDYLK----AGLLDRAEELL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 118 KKILDSPcPKARhlkfAAAYNLGRAYYEGKGVKRSNEEAERLwliAADNGNpkaSVKAQSMLG-LYYSTKEPKE----LE 192
Cdd:COG2956 100 EKLLELD-PDDA----EALRLLAEIYEQEGDWEKAIEVLERL---LKLGPE---NAHAYCELAeLYLEQGDYDEaieaLE 168

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33620759 193 KAFYWHSEacgngNLESQGALGLMYLygqgIRQDTEAALQCLREAAER--GNVYAQGNLVEYYYKM 256
Cdd:COG2956 169 KALKLDPD-----CARALLLLAELYL----EQGDYEEAIAALERALEQdpDYLPALPRLAELYEKL 225
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 208-242 2.39e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.01  E-value: 2.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 33620759    208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERGN 242
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 135-168 5.25e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 5.25e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 33620759    135 AAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGN 168
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 208-241 1.18e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.66  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 33620759   208 ESQGALGLMYLYGQGIRQDTEAALQCLREAAERG 241
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 134-167 2.86e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.89  E-value: 2.86e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 33620759   134 AAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNG 167
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 59-273 8.80e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 8.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  59 TLAYFLRGQLYFEEGWYEEALEQFEEIKEKDH---QATYQLGVMYYDgLGttlDAEKGVDYMKKILdspcpKARHLKFAA 135
Cdd:COG2956   8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPetvEAHLALGNLYRR-RG---EYDRAIRIHQKLL-----ERDPDRAEA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 136 AYNLGRAYYEGKGVKRSNEEAERLWLIAADNgnpkasVKAQSMLGLYYSTKepKELEKAFYWHSEACGNGNLESQGALGL 215
Cdd:COG2956  79 LLELAQDYLKAGLLDRAEELLEKLLELDPDD------AEALRLLAEIYEQE--GDWEKAIEVLERLLKLGPENAHAYCEL 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759 216 MYLYGQgiRQDTEAALQCLREA--AERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYD 273
Cdd:COG2956 151 AELYLE--QGDYDEAIEALEKAlkLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
37-165 1.30e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 1.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  37 YTHANLVDKALQLLKE--RILKGDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDgLGttlDAE 111
Cdd:COG0457  52 YLRLGRYEEALADYEQalELDPDDAEALNNLGLALQALGRYEEALEDYDkalELDPDDAEALYNLGLALLE-LG---RYD 127

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33620759 112 KGVDYMKKILdspcpkARHLKFAAAY-NLGRAYYEGKGVKRSNEEAERLWLIAAD 165
Cdd:COG0457 128 EAIEAYERAL------ELDPDDADALyNLGIALEKLGRYEEALELLEKLEAAALA 176
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 36-240 3.24e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759    36 DYTHANLVDKALQLLKERILK--GDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDglgtTLDA 110
Cdd:TIGR02917 440 SYLRSGQFDKALAAAKKLEKKqpDNASLHNLLGAIYLGKGDLAKAREAFEkalSIEPDFFPAAANLARIDIQ----EGNP 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759   111 EKGVDYMKKIL-DSPCPKARHLKFAAAYNlgrayyegkgvKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPK 189
Cdd:TIGR02917 516 DDAIQRFEKVLtIDPKNLRAILALAGLYL-----------RTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLK 584

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 33620759   190 E----LEKAFYWHSEacgngNLESQGALGLMYLygqgIRQDTEAALQCLREAAER 240
Cdd:TIGR02917 585 KalaiLNEAADAAPD-----SPEAWLMLGRAQL----AAGDLNKAVSSFKKLLAL 630
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 44-166 6.48e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.71  E-value: 6.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  44 DKALQLLKE--RILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKE---KDHQATYQLGVMYYDgLGttlDAEKGVDYMK 118
Cdd:COG4783  21 DEAEALLEKalELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEldpDEPEARLNLGLALLK-AG---DYDEALALLE 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33620759 119 KILdspcpKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADN 166
Cdd:COG4783  97 KAL-----KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 297-331 7.32e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 33.69  E-value: 7.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 33620759    297 AMASFYHARCLQLGLGITRDETTAKHYYSKACRLN 331
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 37-140 7.35e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.05  E-value: 7.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  37 YTHANLVDKALQLLkERILK---GDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDgLGttlDA 110
Cdd:COG3914 122 LLALGRLEEALAAL-RRALAlnpDFAEAYLNLGEALRRLGRLEEAIAALRralELDPDNAEALNNLGNALQD-LG---RL 196

                        90       100       110
                ....*....|....*....|....*....|..
gi 33620759 111 EKGVDYMKKI--LDSPCPKARHLKFAAAYNLG 140
Cdd:COG3914 197 EEAIAAYRRAleLDPDNADAHSNLLFALRQAC 228
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 90-119 8.24e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 33.69  E-value: 8.24e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 33620759     90 HQATYQLGVMYYDGLGTTLDAEKGVDYMKK 119
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKK 30
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
44-145 9.23e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.29  E-value: 9.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33620759  44 DKALQLLKE--RILKGDTLAYFLRGQLYFEEGWYEEALEQFE---EIKEKDHQATYQLGVMYYDgLGttlDAEKGVDYMK 118
Cdd:COG0457  25 EEAIEDYEKalELDPDDAEALYNLGLAYLRLGRYEEALADYEqalELDPDDAEALNNLGLALQA-LG---RYEEALEDYD 100

                        90       100
                ....*....|....*....|....*..
gi 33620759 119 KILdspcpKARHLKFAAAYNLGRAYYE 145
Cdd:COG0457 101 KAL-----ELDPDDAEALYNLGLALLE 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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