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Conserved domains on  [gi|157694513|ref|NP_060960|]
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leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 13320140)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
539-812 0e+00

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320483  Cd Length: 274  Bit Score: 533.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGC 618
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 619 KVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPT 698
Cdd:cd15361   81 KVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 699 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 778
Cdd:cd15361  161 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 157694513 779 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15361  241 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-261 1.34e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 143.54  E-value: 1.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  75 DAFKNFPFLEELQLAGNDLSFIhPKALSGLKELKVLTLQNNQLKTVPSEaIRGLSALQSLRLDANHITSVPEdSFEGLVQ 154
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTN 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 155 LRHLWLDDNSLTEVPvHPLSNLPTLQALTLALNKISSIPDfAFTNLSSLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNY 234
Cdd:COG4886  184 LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSN 259
                        170       180
                 ....*....|....*....|....*..
gi 157694513 235 NNLGEFPqAIKALPSLKELGFHSNSIS 261
Cdd:COG4886  260 NQLTDLP-PLANLTNLKTLDLSNNQLT 285
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
34-443 5.11e-17

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 86.44  E-value: 5.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  34 SCDGDRRVDCSGKGLT-AVPEGLSAFTQALDISMNNIT-QLPED--AFKNFPFL---------------------EELQL 88
Cdd:PLN00113 116 TSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPNDigSFSSLKVLdlggnvlvgkipnsltnltslEFLTL 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  89 AGNDLSFIHPKALSGLKELKVLTLQNNQLK-TVPSEaIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTE 167
Cdd:PLN00113 196 ASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYE-IGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 168 VPVHPLSNLPTLQALTLALNKIS-SIPDFaFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL-GEFPQAIK 245
Cdd:PLN00113 275 PIPPSIFSLQKLISLDLSDNSLSgEIPEL-VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsGEIPKNLG 353
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 246 ALPSLKELGFHSNSIS-VIPDGAFDGNPLLRTIhLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN-LTGTVHLES 323
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSeFTKLPLVYF 432
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 324 LTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR-DLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 157694513 403 EIHSRAFATLGPITNLDVSFNELT--------SFPTEGLNGLNQLKLVG 443
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDLSHNQLSgqipasfsEMPVLSQLDLSQNQLSG 561
 
Name Accession Description Interval E-value
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
539-812 0e+00

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 533.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGC 618
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 619 KVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPT 698
Cdd:cd15361   81 KVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 699 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 778
Cdd:cd15361  161 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 157694513 779 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15361  241 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-261 1.34e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 143.54  E-value: 1.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  75 DAFKNFPFLEELQLAGNDLSFIhPKALSGLKELKVLTLQNNQLKTVPSEaIRGLSALQSLRLDANHITSVPEdSFEGLVQ 154
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTN 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 155 LRHLWLDDNSLTEVPvHPLSNLPTLQALTLALNKISSIPDfAFTNLSSLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNY 234
Cdd:COG4886  184 LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSN 259
                        170       180
                 ....*....|....*....|....*..
gi 157694513 235 NNLGEFPqAIKALPSLKELGFHSNSIS 261
Cdd:COG4886  260 NQLTDLP-PLANLTNLKTLDLSNNQLT 285
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
86-264 3.69e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 81.37  E-value: 3.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  86 LQLAGNDLSFIHpkALSGLKELKVLTLQNNQLKTVpsEAIRGLSALQSLRLDANHITSVpeDSFEGLVQLRHLWLDDNSL 165
Cdd:cd21340    7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 166 TEVpvHPLSNLPTLQALTLALNKISSIPDFAF-----TNLS-SLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNYNNLGE 239
Cdd:cd21340   81 SVV--EGLENLTNLEELHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISD 156
                        170       180
                 ....*....|....*....|....*...
gi 157694513 240 FP---QAIKALPSLKELGFHSNSISVIP 264
Cdd:cd21340  157 LEellDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
34-443 5.11e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 86.44  E-value: 5.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  34 SCDGDRRVDCSGKGLT-AVPEGLSAFTQALDISMNNIT-QLPED--AFKNFPFL---------------------EELQL 88
Cdd:PLN00113 116 TSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPNDigSFSSLKVLdlggnvlvgkipnsltnltslEFLTL 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  89 AGNDLSFIHPKALSGLKELKVLTLQNNQLK-TVPSEaIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTE 167
Cdd:PLN00113 196 ASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYE-IGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 168 VPVHPLSNLPTLQALTLALNKIS-SIPDFaFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL-GEFPQAIK 245
Cdd:PLN00113 275 PIPPSIFSLQKLISLDLSDNSLSgEIPEL-VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsGEIPKNLG 353
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 246 ALPSLKELGFHSNSIS-VIPDGAFDGNPLLRTIhLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN-LTGTVHLES 323
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSeFTKLPLVYF 432
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 324 LTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR-DLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 157694513 403 EIHSRAFATLGPITNLDVSFNELT--------SFPTEGLNGLNQLKLVG 443
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDLSHNQLSgqipasfsEMPVLSQLDLSQNQLSG 561
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
61-426 1.75e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.51  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGL-KELKVLTLQNNQLK-TVPSEAIrglSALQSLRLDA 138
Cdd:PLN00113  73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGSI---PNLETLDLSN 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 139 NHIT-SVPED--SFEglvQLRHLWLDDNSLT-EVPVHpLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIR 214
Cdd:PLN00113 150 NMLSgEIPNDigSFS---SLKVLDLGGNVLVgKIPNS-LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLS 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 215 SLSQHCFDGLDNLETLDLNYNNL-GEFPQAIKALPSLKELGFHSNSIS-VIPDGAFDGNPLLrTIHLYDNPLSfvgnsaf 292
Cdd:PLN00113 226 GEIPYEIGGLTSLNHLDLVYNNLtGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLI-SLDLSDNSLS------- 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 293 hnlSDLHSLVIRGASM--VQQFPN-LTGTV--------HLESLTLTGTKIS-SIPNNLcQEQKMLRTLDLSYNNIRDL-- 358
Cdd:PLN00113 298 ---GEIPELVIQLQNLeiLHLFSNnFTGKIpvaltslpRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGEip 373
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 359 ------------------------PSFNGCHALEEISLQRNQI----------------YQIKEGTFQGLIS-------- 390
Cdd:PLN00113 374 eglcssgnlfklilfsnslegeipKSLGACRSLRRVRLQDNSFsgelpseftklplvyfLDISNNNLQGRINsrkwdmps 453
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513 391 -----------------------LRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELT 426
Cdd:PLN00113 454 lqmlslarnkffgglpdsfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
157-401 7.26e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 7.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 157 HLWLDDNSLTEVPVhpLSNLPTLQALTLALNKISSIPDFAFtnLSSLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNYNn 236
Cdd:cd21340    6 HLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 237 lgefpqaikalpslkelgfhsnSISVIpdgafdgnpllrtihlydnplsfvgnSAFHNLSDLHSLvirgasmvqqfpnlt 316
Cdd:cd21340   79 ----------------------RISVV--------------------------EGLENLTNLEEL--------------- 95
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 317 gtvHLESLTL-TGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE--GTFQGLISLRI 393
Cdd:cd21340   96 ---HIENQRLpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRE 172

                 ....*...
gi 157694513 394 LDLSRNLI 401
Cdd:cd21340  173 LDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
177-237 4.53e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 4.53e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157694513  177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
345-401 4.68e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 4.68e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513  345 LRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLI 401
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
556-801 5.21e-10

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 61.16  E-value: 5.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  556 NLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRfaefgiwWETGS-GCKVAGFLAVFSSESAIF 634
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGSaLCKIVGALFVVNGYASIL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  635 LLMLATVER------SLSAKDIMKNGKSnhlkqfRVAALLAFLGATVAGCFPLFHRGEYSA----SPLCLP-FPTGETPS 703
Cdd:pfam00001  75 LLTAISIDRylaivhPLRYKRRRTPRRA------KVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  704 LGFTVTLVLLNSLA-FLLMAVIYTKLYCNLEK----EDLSENSQSS--MIKHVAWLIFTNCIFFCPVAFFSFAPLITAIS 776
Cdd:pfam00001 149 VSYTLLISVLGFLLpLLVILVCYTLIIRTLRKsaskQKSSERTQRRrkALKTLAVVVVVFILCWLPYHIVNLLDSLALDC 228
                         250       260
                  ....*....|....*....|....*...
gi 157694513  777 ISPEIMK---SVTLIFFPLPACLNPVLY 801
Cdd:pfam00001 229 ELSRLLDkalSVTLWLAYVNSCLNPIIY 256
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
132-444 1.23e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 132 QSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHpLSNLPTLQALTLALNKISSIPDFAFTNLsslVVLHLHNN 211
Cdd:COG5238   88 QLLVVDWEGAEEVSPVALAETATAVATPPPDLRRIMAKTL-EDSLILYLALPRRINLIQVLKDPLGGNA---VHLLGLAA 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 212 KIRSLSQH---CFDGLDNLETLDLNYNNLG-----EFPQAIKALPSLKELGFHSNSISviPDGA------FDGNPLLRTI 277
Cdd:COG5238  164 RLGLLAAIsmaKALQNNSVETVYLGCNQIGdegieELAEALTQNTTVTTLWLKRNPIG--DEGAeilaeaLKGNKSLTTL 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 278 HLYDNPLsfvGNSAFHNLSD-------LHSL-----------VIRGASMVQQFPNLTgTVHLESLTLTGTKISSIPNNLc 339
Cdd:COG5238  242 DLSNNQI---GDEGVIALAEalknnttVETLylsgnqigaegAIALAKALQGNTTLT-SLDLSVNRIGDEGAIALAEGL- 316
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 340 QEQKMLRTLDLSYNNIRDlpsfNGCHALEEiSLQRNQIyqikegtfqglisLRILDLSRNLIHEIHSRAFATL----GPI 415
Cdd:COG5238  317 QGNKTLHTLNLAYNGIGA----QGAIALAK-ALQENTT-------------LHSLDLSDNQIGDEGAIALAKYlegnTTL 378
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 157694513 416 TNLDVSFNELTSFPTEGL------NGLNQLKLVGN 444
Cdd:COG5238  379 RELNLGKNNIGKQGAEALidalqtNRLHTLILDGN 413
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
531-814 3.00e-08

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 56.71  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 531 PCE-----YLLGSWMIRLTVwFIFLVALFFNLLVIlTTFASCTSLPSSKLFIGLISVSNLfmgIYTGILTF------LDA 599
Cdd:PHA03087  29 DCDlnigyDTNSTILIVVYS-TIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDL---LFVMTLPFqiyyyiLFQ 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 600 VSWGRFAefgiwwetgsgCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAgCF 679
Cdd:PHA03087 104 WSFGEFA-----------CKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIE-TT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 680 PLFHRGEYSA---SPLCLPFPTGETPSLGFTVTLVLlNSLAFLL----MAVIYTKLYCNLEKEDLSENSQSSmIKHVAWL 752
Cdd:PHA03087 172 PILFVYTTKKdheTLICCMFYNNKTMNWKLFINFEI-NIIGMLIpltiLLYCYSKILITLKGINKSKKNKKA-IKLVLII 249
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157694513 753 IFTNCIFFCP---VAFFSFAPLITAISiSPEIMKSVTLIFF------PLPACLNPVLYVF----FNPKFKEDWKL 814
Cdd:PHA03087 250 VILFVIFWLPfnvSVFVYSLHILHFKS-GCKAVKYIQYALHvteiisLSHCCINPLIYAFvsefFNKHKKKSLKL 323
LRRNT smart00013
Leucine rich repeat N-terminal domain;
29-61 1.36e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 1.36e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 157694513    29 CAAPCSCdGDRRVDCSGKGLTAVPEGLSAFTQA 61
Cdd:smart00013   2 CPAPCNC-SGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
539-812 0e+00

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 533.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGC 618
Cdd:cd15361    1 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 619 KVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPT 698
Cdd:cd15361   81 KVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPFPT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 699 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 778
Cdd:cd15361  161 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 157694513 779 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15361  241 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 274
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
539-812 2.08e-164

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 481.66  E-value: 2.08e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGC 618
Cdd:cd15138    1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSLPPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 619 KVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPT 698
Cdd:cd15138   81 KVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFPT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 699 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 778
Cdd:cd15138  161 GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLISIS 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 157694513 779 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15138  241 PEIMKSVLLVVFPLPACLNPLLYVLFNPHFKEDL 274
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
539-811 4.43e-96

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 304.02  E-value: 4.43e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGC 618
Cdd:cd15362    1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 619 KVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPF-- 696
Cdd:cd15362   81 RATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSpl 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 697 PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAIS 776
Cdd:cd15362  161 PDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLFP 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 157694513 777 ISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd15362  241 ISPEVIKSVLLVVLPLPACLNPLLYLLFNPHFRDD 275
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
539-811 4.51e-91

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 290.59  E-value: 4.51e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGC 618
Cdd:cd15363    1 WLIRIGVWTIAVLALVCNALVTATVFRSPLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 619 KVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPT 698
Cdd:cd15363   81 QITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPLPF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 699 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 778
Cdd:cd15363  161 GEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLTFIS 240
                        250       260       270
                 ....*....|....*....|....*....|...
gi 157694513 779 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd15363  241 PEVIKFILLVIVPLPACLNPLLYILFNPHFKED 273
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
539-811 1.03e-62

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 213.62  E-value: 1.03e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGC 618
Cdd:cd15136    1 WWLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 619 KVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPT 698
Cdd:cd15136   81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFET 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 699 GETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQ-SSMIKHVAWLIFTNCIFFCPVAFFSfaplITAIS- 776
Cdd:cd15136  161 ETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSNdTRIAKRMALLVFTDFLCWAPIAFFG----LTAAFg 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 157694513 777 ---ISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd15136  237 lplISVSNAKILLVFFYPLNSCANPFLYAIFTKQFRRD 274
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
539-811 5.76e-52

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 183.98  E-value: 5.76e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILT-TFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSG 617
Cdd:cd14980    1 ISLRIFIWIIGILALIGNILVIIWhISSKKKKKKVPKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 618 CKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGcFPLF-------HRGEYSAS 690
Cdd:cd14980   81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAA-IPILysinqpgDNRLYGYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 691 PLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSS-----MIKHVAWLIFTNCIFFCPVAF 765
Cdd:cd14980  160 SICMPSNVSNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARRSSSkrdkrIAIRLALILITDLICWLPYYI 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 157694513 766 FSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd14980  240 VIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRD 285
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
541-811 3.33e-37

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 141.20  E-value: 3.33e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 541 IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKV 620
Cdd:cd15964    3 LRIVVWFVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCNT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 621 AGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGE 700
Cdd:cd15964   83 AGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTET 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 701 TPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMI-KHVAWLIFTNCIFFCPVAFFSFAPLITAISISP 779
Cdd:cd15964  163 PLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSGDKDTKIaKRMAVLIFTDFICMAPISFYALSAILNKPLITV 242
                        250       260       270
                 ....*....|....*....|....*....|..
gi 157694513 780 EIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd15964  243 SNSKILLVLFYPLNSCANPFLYAIFTKAFRRD 274
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-261 1.34e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 143.54  E-value: 1.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  75 DAFKNFPFLEELQLAGNDLSFIhPKALSGLKELKVLTLQNNQLKTVPSEaIRGLSALQSLRLDANHITSVPEdSFEGLVQ 154
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTN 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 155 LRHLWLDDNSLTEVPvHPLSNLPTLQALTLALNKISSIPDfAFTNLSSLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNY 234
Cdd:COG4886  184 LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSN 259
                        170       180
                 ....*....|....*....|....*..
gi 157694513 235 NNLGEFPqAIKALPSLKELGFHSNSIS 261
Cdd:COG4886  260 NQLTDLP-PLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-338 3.27e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 142.38  E-value: 3.27e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  39 RRVDCSGKGLTAVPEGLSAFT--QALDISMNNITQLPEdAFKNFPFLEELQLAGNDLSFIhPKALSGLKELKVLTLQNNQ 116
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 117 LKTVPsEAIRGLSALQSLRLDANHITSVPEdSFEGLVQLRHLWLDDNSLTEVPVhpLSNLPTLQALTLALNKISSIPDFA 196
Cdd:COG4886  194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 197 ftNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRT 276
Cdd:COG4886  270 --NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157694513 277 IHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNL 338
Cdd:COG4886  348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
540-812 1.16e-35

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 136.91  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 540 MIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCK 619
Cdd:cd15360    2 ILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 620 VAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTG 699
Cdd:cd15360   82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 700 ETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKED-LSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISIS 778
Cdd:cd15360  162 SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNfVSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPLIT 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 157694513 779 PEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15360  242 VSKSKILLVLFYPINSCANPFLYAIFTKTFRRDF 275
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
541-812 1.44e-35

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 136.53  E-value: 1.44e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 541 IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKV 620
Cdd:cd15359    3 LRVLIWFINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCST 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 621 AGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGE 700
Cdd:cd15359   83 AGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIET 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 701 TPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDL-SENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISP 779
Cdd:cd15359  163 LLSQAYILLILVLNVIAFLVICACYIKIYLAVQNPELvAKNKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPLITV 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 157694513 780 EIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15359  243 TNSKILLVLFYPINSCANPFLYAIFTKAFRRDF 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-521 1.78e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.21  E-value: 1.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  83 LEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDD 162
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 163 NSLTEVPVHPLSNLPTLQALTLALNKissipdfAFTNLSSLVVLHLHNNKIRSLSQHcFDGLDNLETLDLNYNNLGEFPQ 242
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 243 AIKALPSLKELGFHSNSISVIPDgAFDGNPLLRTIHLYDNPLSFVGNSafhnLSDLHSlvirgasmvqqfpnltgtvhLE 322
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP----LGNLTN--------------------LE 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 323 SLTLTGTKISSIPNNLCQEQKmLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTfqGLISLRILDLSRNLIH 402
Cdd:COG4886  209 ELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 403 EIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANL 482
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365
                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 157694513 483 NTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIH 521
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
541-810 6.51e-32

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 126.16  E-value: 6.51e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 541 IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKV 620
Cdd:cd15137    3 LRVFIWVVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSWLCTF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 621 AGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNhLKQFRVAALLAFLGATVAGCFPL----FHRGEYSASPLCLPF 696
Cdd:cd15137   83 AGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRLG-LRRAIIVLACIWLIGLLLAVLPLlpwdYFGNFYGRSGVCLPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 697 PTGETPSLGF---TVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQS-----SMIKHVAWLIFTNCIFFCPVAFFSF 768
Cdd:cd15137  162 HITDERPAGWeysVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKskrdmAVAKRFFLIVLTDFLCWIPIIVIGI 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 157694513 769 APLiTAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 810
Cdd:cd15137  242 LAL-SGVPIPGEVYAWVAVFVLPINSALNPILYTLSTPKFRK 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-295 2.89e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.70  E-value: 2.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  39 RRVDCSGKGLTAVPEGLSAFT--QALDISMNNITQLPEdAFKNFPFLEELQLAGNDLSFIhPKALSGLKELKVLTLQNNQ 116
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 117 LKTVPSEaIRGLSALQSLRLDANHITSVPE--------------------DSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
Cdd:COG4886  217 LTDLPEP-LANLTNLETLDLSNNQLTDLPElgnltnleeldlsnnqltdlPPLANLTNLKTLDLSNNQLTDLKLKELELL 295
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFH 256
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 157694513 257 SNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
Cdd:COG4886  376 EATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
547-805 3.55e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 82.72  E-value: 3.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLdavswgrFAEFGIWWETGSGCKVAGFLAV 626
Cdd:cd00637    7 LIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLV-------SLLLGRWWFGDALCKLLGFLQS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 627 FSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRG--EYSASPLCLPFPTGETPSL 704
Cdd:cd00637   80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGvyDYGGYCCCCLCWPDLTLSK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 705 GFTVTLVLLN-SLAFLLMAVIYTKLYCNLEKEDLSENSQSS-------------MIKHVAWLIFTNCIFFCPVAFFSFAP 770
Cdd:cd00637  160 AYTIFLFVLLfLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSnssrrrrrrrerkVTKTLLIVVVVFLLCWLPYFILLLLD 239
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 157694513 771 LITAI-SISPEIMKSVTLIFFPLPACLNPVLYVFFN 805
Cdd:cd00637  240 VFGPDpSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
86-264 3.69e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 81.37  E-value: 3.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  86 LQLAGNDLSFIHpkALSGLKELKVLTLQNNQLKTVpsEAIRGLSALQSLRLDANHITSVpeDSFEGLVQLRHLWLDDNSL 165
Cdd:cd21340    7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 166 TEVpvHPLSNLPTLQALTLALNKISSIPDFAF-----TNLS-SLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNYNNLGE 239
Cdd:cd21340   81 SVV--EGLENLTNLEELHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISD 156
                        170       180
                 ....*....|....*....|....*...
gi 157694513 240 FP---QAIKALPSLKELGFHSNSISVIP 264
Cdd:cd21340  157 LEellDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
34-443 5.11e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 86.44  E-value: 5.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  34 SCDGDRRVDCSGKGLT-AVPEGLSAFTQALDISMNNIT-QLPED--AFKNFPFL---------------------EELQL 88
Cdd:PLN00113 116 TSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPNDigSFSSLKVLdlggnvlvgkipnsltnltslEFLTL 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  89 AGNDLSFIHPKALSGLKELKVLTLQNNQLK-TVPSEaIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTE 167
Cdd:PLN00113 196 ASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYE-IGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 168 VPVHPLSNLPTLQALTLALNKIS-SIPDFaFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL-GEFPQAIK 245
Cdd:PLN00113 275 PIPPSIFSLQKLISLDLSDNSLSgEIPEL-VIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsGEIPKNLG 353
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 246 ALPSLKELGFHSNSIS-VIPDGAFDGNPLLRTIhLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN-LTGTVHLES 323
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSeFTKLPLVYF 432
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 324 LTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIR-DLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIH 402
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 157694513 403 EIHSRAFATLGPITNLDVSFNELT--------SFPTEGLNGLNQLKLVG 443
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDLSHNQLSgqipasfsEMPVLSQLDLSQNQLSG 561
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
547-810 1.31e-16

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 81.10  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFldavswgrFAEFGIWWETGS-GCKVAGFLA 625
Cdd:cd14969    9 LIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSF--------YSNLSGRWSFGDpGCVIYGFAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 626 VFSSESAIFLLMLATVERSLSakdIMKNGKSNHLKQFRVAALLAF--LGATVAGCFPLFHRGEYSASPL---CLP-FPTG 699
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLV---IVRPLKAFRLSKRRALILIAFiwLYGLFWALPPLFGWSSYVPEGGgtsCSVdWYSK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 700 ETPSLGFTVTL-VLLNSLAFLLMAVIYTKLYCNLEK-----EDLSENSQSSMI----KHVAWLIFTNCIFFC----PVAF 765
Cdd:cd14969  158 DPNSLSYIVSLfVFCFFLPLAIIIFCYYKIYRTLRKmskraARRKNSAITKRTkkaeKKVAKMVLVMIVAFLiawtPYAV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 157694513 766 FSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 810
Cdd:cd14969  238 VSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRR 282
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
61-426 1.75e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.51  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGL-KELKVLTLQNNQLK-TVPSEAIrglSALQSLRLDA 138
Cdd:PLN00113  73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGSI---PNLETLDLSN 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 139 NHIT-SVPED--SFEglvQLRHLWLDDNSLT-EVPVHpLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIR 214
Cdd:PLN00113 150 NMLSgEIPNDigSFS---SLKVLDLGGNVLVgKIPNS-LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLS 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 215 SLSQHCFDGLDNLETLDLNYNNL-GEFPQAIKALPSLKELGFHSNSIS-VIPDGAFDGNPLLrTIHLYDNPLSfvgnsaf 292
Cdd:PLN00113 226 GEIPYEIGGLTSLNHLDLVYNNLtGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLI-SLDLSDNSLS------- 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 293 hnlSDLHSLVIRGASM--VQQFPN-LTGTV--------HLESLTLTGTKIS-SIPNNLcQEQKMLRTLDLSYNNIRDL-- 358
Cdd:PLN00113 298 ---GEIPELVIQLQNLeiLHLFSNnFTGKIpvaltslpRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGEip 373
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 359 ------------------------PSFNGCHALEEISLQRNQI----------------YQIKEGTFQGLIS-------- 390
Cdd:PLN00113 374 eglcssgnlfklilfsnslegeipKSLGACRSLRRVRLQDNSFsgelpseftklplvyfLDISNNNLQGRINsrkwdmps 453
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513 391 -----------------------LRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELT 426
Cdd:PLN00113 454 lqmlslarnkffgglpdsfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS 512
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
157-401 7.26e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.52  E-value: 7.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 157 HLWLDDNSLTEVPVhpLSNLPTLQALTLALNKISSIPDFAFtnLSSLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNYNn 236
Cdd:cd21340    6 HLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 237 lgefpqaikalpslkelgfhsnSISVIpdgafdgnpllrtihlydnplsfvgnSAFHNLSDLHSLvirgasmvqqfpnlt 316
Cdd:cd21340   79 ----------------------RISVV--------------------------EGLENLTNLEEL--------------- 95
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 317 gtvHLESLTL-TGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKE--GTFQGLISLRI 393
Cdd:cd21340   96 ---HIENQRLpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRE 172

                 ....*...
gi 157694513 394 LDLSRNLI 401
Cdd:cd21340  173 LDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
177-237 4.53e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 4.53e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157694513  177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
48-288 2.60e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 2.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  48 LTAVPEGLSAFTQALDISMNNITQLPEdafkNFP-FLEELQLAGNDLSFIhPKALSglKELKVLTLQNNQLKTVPSEAIr 126
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELPE----RLPsALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHLP- 303
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 127 glSALQSLRLDANHITSVPEDSFEGlvqLRHLWLDDNSLTEVPVhplSNLPTLQALTLALNKISSIPDfafTNLSSLVVL 206
Cdd:PRK15370 304 --SGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTSLPA---SLPPELQVLDVSKNQITVLPE---TLPPTITTL 372
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 207 HLHNNKIRSLSQHCFDGLDNLETldlNYNNLGEFPQaikALPSLKELGFHSNSISVipdgafDGNPLL-RTIHLYDNPLS 285
Cdd:PRK15370 373 DVSRNALTNLPENLPAALQIMQA---SRNNLVRLPE---SLPHFRGEGPQPTRIIV------EYNPFSeRTIQNMQRLMS 440

                 ...
gi 157694513 286 FVG 288
Cdd:PRK15370 441 SVG 443
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
540-810 2.74e-13

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 71.44  E-value: 2.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 540 MIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCK 619
Cdd:cd15965    2 VQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLHAMSIISLCCADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 620 VAGFLAVFSSESAIFLLMLATVERSLSAK---DIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPF 696
Cdd:cd15965   82 LVGSLAILSTEVSVLLLTYLTLEKYICIVypfRCLTPGKCRTITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 697 PTGETPSLG---FTVTLVL-LNSLAFLLMAVIYTKLYCNLEKE-----DLSENSQSSMI--KHVAWLIFTNCIFFCPVAF 765
Cdd:cd15965  162 HSEQPESTGaqiYSVVIFLgLNLAAFIIIVFSYGSMFYSIHQTaimatEISNHIKKEMTlaKRFFFIVFTDALCWIPIFI 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 157694513 766 FSFAPLITaISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 810
Cdd:cd15965  242 LKLLSLLQ-VEIPGTISSWVVIFILPINSALNPILYTLTTRPFKE 285
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
33-293 6.38e-13

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 72.89  E-value: 6.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAfknfPFLEELQLAGNDLSFIhPKALSGLKELKVLTL 112
Cdd:PRK15387 198 CLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSL-PVLPPGLLELSIFSN 272
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 113 QNNQLKTVPS---------EAIRGL----SALQSLRLDANHITSVPEDSFEglvqLRHLWLDDNSLTEVPVHPlsnlPTL 179
Cdd:PRK15387 273 PLTHLPALPSglcklwifgNQLTSLpvlpPGLQELSVSDNQLASLPALPSE----LCKLWAYNNQLTSLPTLP----SGL 344
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 180 QALTLALNKISSIPDFAftnlSSLVVLHLHNNKIRSLSQHCfdglDNLETLDLNYNNLGEFPqaikALPS-LKELGFHSN 258
Cdd:PRK15387 345 QELSVSDNQLASLPTLP----SELYKLWAYNNRLTSLPALP----SGLKELIVSGNRLTSLP----VLPSeLKELMVSGN 412
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 157694513 259 ---SISVIPDGafdgnplLRTIHLYDNPLSFVGNSAFH 293
Cdd:PRK15387 413 rltSLPMLPSG-------LLSLSVYRNQLTRLPESLIH 443
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-284 8.19e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 8.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  47 GLTAVPEGLSAFTQALDISMNNITQLPEDAFKNfpfLEELQLAGNDLSFIhPKALSglKELKVLTLQNNQLKTVPSeaiR 126
Cdd:PRK15370 189 GLTTIPACIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSI-PATLP--DTIQEMELSINRITELPE---R 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 127 GLSALQSLRLDANHITSVPEDSFEGlvqLRHLWLDDNSLTEVPVHplsnLPtlqaltlalnkissipdfaftnlSSLVVL 206
Cdd:PRK15370 260 LPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAH----LP-----------------------SGITHL 309
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157694513 207 HLHNNKIRSLSQHCfdgLDNLETLDLNYNNLGEFPQAIKalPSLKELGFHSNSISVIPDGAfdgNPLLRTIHLYDNPL 284
Cdd:PRK15370 310 NVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL---PPTITTLDVSRNAL 379
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
540-810 1.18e-12

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 69.43  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 540 MIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCK 619
Cdd:cd15966    2 ILRVFVWVMAFITCFGNLFVIGMRSFIRAENKTHAMCIKILCCADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 620 VAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAgCFPLFHR----GEYSASPLCLP 695
Cdd:cd15966   82 IIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPFSNIRPGKCQTLIILISIWLVGFIIA-VIPFWNEdffgNYYGKNGVCFP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 696 F---PTGETPSLGFTVTLVL-LNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMI-KHVA------WLIFTNCIFFCPVA 764
Cdd:cd15966  161 LhsdQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQKTGLQTTEVRSHIhRDVAvanrffFIVFSDAICWIPIF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 157694513 765 FFSFAPLITaISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 810
Cdd:cd15966  241 LLKILSLFQ-VEIPGTITSWIVIFILPINSALNPILYTLTTSFFKE 285
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
48-285 1.11e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.96  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  48 LTAVPEGLSAFTQALDISMNNITQLPEdafkNFP-FLEELQLAGNDLSFIhPKALSglKELKVLTLQNNQLKTVPSEAIR 126
Cdd:PRK15370 211 LKSLPENLQGNIKTLYANSNQLTSIPA----TLPdTIQEMELSINRITEL-PERLP--SALQSLDLFHNKISCLPENLPE 283
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 127 GLSALQSLRldaNHITSVPEDSFEGLVqlrHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKI-SSIPdfaftnlSSLVV 205
Cdd:PRK15370 284 ELRYLSVYD---NSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPPGLKTLEAGENALTSLpASLP-------PELQV 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 206 LHLHNNKIRSLSQHCfdgLDNLETLDLNYNNLGEFPQAIKAlpSLKELGFHSNSISVIPDG--AFDGN-PLLRTIHLYDN 282
Cdd:PRK15370 351 LDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLPA--ALQIMQASRNNLVRLPESlpHFRGEgPQPTRIIVEYN 425

                 ...
gi 157694513 283 PLS 285
Cdd:PRK15370 426 PFS 428
LRR_8 pfam13855
Leucine rich repeat;
83-141 3.86e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 3.86e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513   83 LEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHI 141
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
345-401 4.68e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 4.68e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513  345 LRTLDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLI 401
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
556-801 5.21e-10

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 61.16  E-value: 5.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  556 NLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRfaefgiwWETGS-GCKVAGFLAVFSSESAIF 634
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-------WPFGSaLCKIVGALFVVNGYASIL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  635 LLMLATVER------SLSAKDIMKNGKSnhlkqfRVAALLAFLGATVAGCFPLFHRGEYSA----SPLCLP-FPTGETPS 703
Cdd:pfam00001  75 LLTAISIDRylaivhPLRYKRRRTPRRA------KVLILVIWVLALLLSLPPLLFGWTLTVpegnVTVCFIdFPEDLSKP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  704 LGFTVTLVLLNSLA-FLLMAVIYTKLYCNLEK----EDLSENSQSS--MIKHVAWLIFTNCIFFCPVAFFSFAPLITAIS 776
Cdd:pfam00001 149 VSYTLLISVLGFLLpLLVILVCYTLIIRTLRKsaskQKSSERTQRRrkALKTLAVVVVVFILCWLPYHIVNLLDSLALDC 228
                         250       260
                  ....*....|....*....|....*...
gi 157694513  777 ISPEIMK---SVTLIFFPLPACLNPVLY 801
Cdd:pfam00001 229 ELSRLLDkalSVTLWLAYVNSCLNPIIY 256
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
274-444 6.67e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 6.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 274 LRTIHLYDNPLSfvgnsafhnlsdlhslvirgasmvqQFPNLTGTVHLESLTLTGTKISSIPN--NLcqeqKMLRTLDLS 351
Cdd:cd21340   26 LKVLYLYDNKIT-------------------------KIENLEFLTNLTHLYLQNNQIEKIENleNL----VNLKKLYLG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 352 YNNIRDLPSFNGCHALEEISLQrNQiyQIKEGtfQGLI-----------SLRILDLSRNLIHEIHSraFATLGPITNLDV 420
Cdd:cd21340   77 GNRISVVEGLENLTNLEELHIE-NQ--RLPPG--EKLTfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDA 149
                        170       180
                 ....*....|....*....|....*....
gi 157694513 421 SFNELTSFP--TEGLNGLNQLK---LVGN 444
Cdd:cd21340  150 SNNQISDLEelLDLLSSWPSLReldLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
62-117 7.26e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 7.26e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 157694513   62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQL 117
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
106-165 9.55e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 9.55e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  106 ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSL 165
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
44-239 9.75e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.22  E-value: 9.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  44 SGKGLTAVPEGLSAFT--QALDISMNNITQLPEDAFKNF---PFLEELQLAGNDLSFIHPKALS-GLKE----LKVLTLQ 113
Cdd:cd00116   66 IPRGLQSLLQGLTKGCglQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAkGLKDlppaLEKLVLG 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 114 NNQLKTVPSEAI----RGLSALQSLRLDANHITsvpEDSFEGLVQ-------LRHLWLDDNSLTEVPV----HPLSNLPT 178
Cdd:cd00116  146 RNRLEGASCEALakalRANRDLKELNLANNGIG---DAGIRALAEglkancnLEVLDLNNNGLTDEGAsalaETLASLKS 222
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157694513 179 LQALTLALNKISSIPDFAF-----TNLSSLVVLHLHNNKI-----RSLSQHCFDGLDnLETLDLNYNNLGE 239
Cdd:cd00116  223 LEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDItddgaKDLAEVLAEKES-LLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
201-284 2.28e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  201 SSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNlgefpqaikalpslkelgfhsnsISVIPDGAFDGNPLLRTIHLY 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-----------------------LTTLSPGAFSGLPSLRYLDLS 57

                  ....
gi 157694513  281 DNPL 284
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
367-425 3.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.58e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513  367 LEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNEL 425
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-194 3.60e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 3.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  41 VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEdafkNFPF-LEELQLAGNDLSFIhPKALSglKELKVLTLQNNQLKT 119
Cdd:PRK15370 267 LDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA----HLPSgITHLNVQSNSLTAL-PETLP--PGLKTLEAGENALTS 339
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157694513 120 VPSEAIrglSALQSLRLDANHITSVPEDSFEglvQLRHLWLDDNSLTEVPvhplSNLP-TLQALTLALNKISSIPD 194
Cdd:PRK15370 340 LPASLP---PELQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLP----ENLPaALQIMQASRNNLVRLPE 405
LRR_8 pfam13855
Leucine rich repeat;
154-213 1.17e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  154 QLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKI 213
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
132-444 1.23e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 132 QSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHpLSNLPTLQALTLALNKISSIPDFAFTNLsslVVLHLHNN 211
Cdd:COG5238   88 QLLVVDWEGAEEVSPVALAETATAVATPPPDLRRIMAKTL-EDSLILYLALPRRINLIQVLKDPLGGNA---VHLLGLAA 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 212 KIRSLSQH---CFDGLDNLETLDLNYNNLG-----EFPQAIKALPSLKELGFHSNSISviPDGA------FDGNPLLRTI 277
Cdd:COG5238  164 RLGLLAAIsmaKALQNNSVETVYLGCNQIGdegieELAEALTQNTTVTTLWLKRNPIG--DEGAeilaeaLKGNKSLTTL 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 278 HLYDNPLsfvGNSAFHNLSD-------LHSL-----------VIRGASMVQQFPNLTgTVHLESLTLTGTKISSIPNNLc 339
Cdd:COG5238  242 DLSNNQI---GDEGVIALAEalknnttVETLylsgnqigaegAIALAKALQGNTTLT-SLDLSVNRIGDEGAIALAEGL- 316
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 340 QEQKMLRTLDLSYNNIRDlpsfNGCHALEEiSLQRNQIyqikegtfqglisLRILDLSRNLIHEIHSRAFATL----GPI 415
Cdd:COG5238  317 QGNKTLHTLNLAYNGIGA----QGAIALAK-ALQENTT-------------LHSLDLSDNQIGDEGAIALAKYlegnTTL 378
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 157694513 416 TNLDVSFNELTSFPTEGL------NGLNQLKLVGN 444
Cdd:COG5238  379 RELNLGKNNIGKQGAEALidalqtNRLHTLILDGN 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
83-375 1.44e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.37  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  83 LEELQLAGNDLSFIHPKALSglkelKVLTLQnnqlktvPSEAIRGLSALQSLRLDANhiTSVPEDSFEGLVQLRHLWLDD 162
Cdd:cd00116   25 LQVLRLEGNTLGEEAAKALA-----SALRPQ-------PSLKELCLSLNETGRIPRG--LQSLLQGLTKGCGLQELDLSD 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 163 NSLTEVPVHPLSnlptlqaltlalnkissipdfAFTNLSSLVVLHLHNNKI---------RSLSQHCFDgldnLETLDLN 233
Cdd:cd00116   91 NALGPDGCGVLE---------------------SLLRSSSLQELKLNNNGLgdrglrllaKGLKDLPPA----LEKLVLG 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 234 YNNLG-----EFPQAIKALPSLKELGFHSNSISviPDG------AFDGNPLLRTIHLYDNPLSFVGNSAF-HNLSDLHSL 301
Cdd:cd00116  146 RNRLEgasceALAKALRANRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNGLTDEGASALaETLASLKSL 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157694513 302 VirgasmvqqfpnltgTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRN 375
Cdd:cd00116  224 E---------------VLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLE 282
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
548-809 1.47e-08

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 57.00  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 548 IFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLfmgiytgilTFLDAVS-WGRFAEFGIWWETGSG-CKVAGFLA 625
Cdd:cd14985   10 IFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADL---------VFVLTLPlWATYTANQYDWPFGAFlCKVSSYVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 626 VFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRG----EYSASPLCLPFPTGET 701
Cdd:cd14985   81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSlqaiENLNKTACIMLYPHEA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 702 PSLGFTVTLvllNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMI----KHVAWLIFTNCIFF----CPVAFFSF-APLI 772
Cdd:cd14985  161 WHFGLSLEL---NILGFVLPLLIILTCYFHIARSLRKRYERTGKNgrkrRKSLKIIFALVVAFlvcwLPFHFFKFlDFLA 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 157694513 773 TAISISP--------EIMKSVTLIFFpLPACLNPVLYVFFNPKFK 809
Cdd:cd14985  238 QLGAIRPcfwelfldLGLPIATCLAF-TNSCLNPFIYVFVDRRFR 281
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
37-370 2.48e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.49  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  37 GDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLP-EDAFKNFPFLEELQLAGNDLSFIHPKALSGlKELKVLTLQNN 115
Cdd:COG5238  112 VATPPPDLRRIMAKTLEDSLILYLALPRRINLIQVLKdPLGGNAVHLLGLAARLGLLAAISMAKALQN-NSVETVYLGCN 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 116 QLKtvpSEAIRGL-------SALQSLRLDANHITsvpEDSFEGLVQ-------LRHLWLDDNSLTEVPVHPLSNL----P 177
Cdd:COG5238  191 QIG---DEGIEELaealtqnTTVTTLWLKRNPIG---DEGAEILAEalkgnksLTTLDLSNNQIGDEGVIALAEAlknnT 264
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 178 TLQALTLALNKISsipdfaftnlsslvvlhlhNNKIRSLSQHcFDGLDNLETLDLNYNNLGE-----FPQAIKALPSLKE 252
Cdd:COG5238  265 TVETLYLSGNQIG-------------------AEGAIALAKA-LQGNTTLTSLDLSVNRIGDegaiaLAEGLQGNKTLHT 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 253 LGFHSNSISviPDG------AFDGNPLLRTIHLYDNPLSfvgnsafhnlsdlhslvIRGASMVQQFPNLTGTVHleSLTL 326
Cdd:COG5238  325 LNLAYNGIG--AQGaialakALQENTTLHSLDLSDNQIG-----------------DEGAIALAKYLEGNTTLR--ELNL 383
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 157694513 327 TGTKISSI-PNNLCQEQKM--LRTLDLSYNNIRDLPSFNGCHALEEI 370
Cdd:COG5238  384 GKNNIGKQgAEALIDALQTnrLHTLILDGNLIGAEAQQRLEQLLERI 430
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
531-814 3.00e-08

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 56.71  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 531 PCE-----YLLGSWMIRLTVwFIFLVALFFNLLVIlTTFASCTSLPSSKLFIGLISVSNLfmgIYTGILTF------LDA 599
Cdd:PHA03087  29 DCDlnigyDTNSTILIVVYS-TIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDL---LFVMTLPFqiyyyiLFQ 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 600 VSWGRFAefgiwwetgsgCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAgCF 679
Cdd:PHA03087 104 WSFGEFA-----------CKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIE-TT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 680 PLFHRGEYSA---SPLCLPFPTGETPSLGFTVTLVLlNSLAFLL----MAVIYTKLYCNLEKEDLSENSQSSmIKHVAWL 752
Cdd:PHA03087 172 PILFVYTTKKdheTLICCMFYNNKTMNWKLFINFEI-NIIGMLIpltiLLYCYSKILITLKGINKSKKNKKA-IKLVLII 249
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157694513 753 IFTNCIFFCP---VAFFSFAPLITAISiSPEIMKSVTLIFF------PLPACLNPVLYVF----FNPKFKEDWKL 814
Cdd:PHA03087 250 VILFVIFWLPfnvSVFVYSLHILHFKS-GCKAVKYIQYALHvteiisLSHCCINPLIYAFvsefFNKHKKKSLKL 323
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
221-426 3.70e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 221 FDGLDNLETLDLNYNNLGE-----FPQAIKALPSLKELGFHSNSISVIPDG------AFDGNPLLRTIHLYDNPLSFVGN 289
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGC 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 290 SAFHNL---SDLHSLVIRGASMVQQFPNLTGTV------HLESLTLTGTKISSIP----NNLCQEQKMLRTLDLSYNNIR 356
Cdd:cd00116   99 GVLESLlrsSSLQELKLNNNGLGDRGLRLLAKGlkdlppALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIG 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 357 D---------LPSFngCHaLEEISLQRNQIY----QIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITN-----L 418
Cdd:cd00116  179 DagiralaegLKAN--CN-LEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNislltL 255

                 ....*...
gi 157694513 419 DVSFNELT 426
Cdd:cd00116  256 SLSCNDIT 263
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
543-810 1.85e-07

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 53.34  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 543 LTVWFIFLVALFFNLLVILTtFASCTSLPS-SKLFIGLISVSNLFMGIYTGILTFLDAVswgrfaeFGIWWETGSGCKVA 621
Cdd:cd14967    4 VFLSLIILVTVFGNLLVILA-VYRNRRLRTvTNYFIVSLAVADLLVALLVMPFSAVYTL-------LGYWPFGPVLCRFW 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 622 GFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKqfRVAALLAF--LGATVAGCFPLF---HRGEYSASPLCLPF 696
Cdd:cd14967   76 IALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKK--RALIMIAAvwVYSLLISLPPLVgwrDETQPSVVDCECEF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 697 ptgeTPSLGFTVTLVLLN-SLAFLLMAVIYTKLYCNLEKEdlsensqssmIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 775
Cdd:cd14967  154 ----TPNKIYVLVSSVISfFIPLLIMIVLYARIFRVARRE----------LKAAKTLAIIVGAFLLCWLPFFIIYLVSAF 219
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 157694513 776 SISPEIMKSVTLIFFPLP---ACLNPVLYVFFNPKFKE 810
Cdd:cd14967  220 CPPDCVPPILYAVFFWLGylnSALNPIIYALFNRDFRR 257
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
547-811 2.09e-07

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 53.76  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSwgRFAEFGIWWetgsgCKVAGFL-- 624
Cdd:cd15203    9 LIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLT--KNWPFGSIL-----CKLVPSLqg 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 625 -AVFSSesaIFLLMLATVERSLSAKDIMKNGKSNhlkqfRVAALLAFLGATVAG--CFPLF-----HRGEYSASPLCLPF 696
Cdd:cd15203   82 vSIFVS---TLTLTAIAIDRYQLIVYPTRPRMSK-----RHALLIIALIWILSLllSLPLAifqelSDVPIEILPYCGYF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 697 PTGETPSLGF-----TVTLVLLNSLAFLLMAVIYTKLYCNLEK--------EDLSENSQSSMIKHvawLIFTNCIFFCPV 763
Cdd:cd15203  154 CTESWPSSSSrliytISVLVLQFVIPLLIISFCYFRISLKLRKrvkkkrgkRTLSSRRRRSELRR---KRRTNRLLIAMV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157694513 764 AFF--SFAPL-----ITAISISPEIMKSVTLIFFPL-------PACLNPVLYVFFNPKFKED 811
Cdd:cd15203  231 VVFavCWLPLnlfnlLRDFEPLPQIDGRHFYLIFLIchliamsSACVNPLLYGWLNDNFRKE 292
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
547-811 2.75e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 53.04  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNL--LVILTTFASCTSlPSSKLFIGLiSVSNLfmgIYTGILTFLDAVSWGRFaefgiWWETGSG-CKVAGF 623
Cdd:cd14982    9 LIFILGLLGNIlaLWVFLRKMKKRS-PTTIYMINL-ALADL---LFVLTLPFRIYYYLNGG-----WWPFGDFlCRLTGL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 624 LAVFSSESAIFLLMLATVERSLSakdIMKNGKSNHLKQFRVAALL-AFLGATVAGC---FPLFHRGEY--SASPLCLPF- 696
Cdd:cd14982   79 LFYINMYGSILFLTCISVDRYLA---VVHPLKSRRLRRKRYAVGVcAGVWILVLVAsvpLLLLRSTIAkeNNSTTCFEFl 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 697 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKhVAWLIFTN----CIFFCPVAFFSFAPL 771
Cdd:cd14982  156 sEWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRK-ALRMILIVlavfLVCFLPYHVTRILYL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 157694513 772 ITAISISPE--------IMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd14982  235 LVRLSFIADcsarnslyKAYRITLCLASLNSCLDPLIYYFLSKTFRKR 282
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
225-429 3.10e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 225 DNLETLDLNYNNLGEFPQAIKAlpSLKELGFHSNSISVIPDGAFDgnpllrTIHLYDnpLSFvgnsafHNLSDLHslvir 304
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPD------TIQEME--LSI------NRITELP----- 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 305 gasmvQQFPNLtgtvhLESLTLTGTKISSIPNNLCQEqkmLRTLDLSYNNIRDLPSfngcH---ALEEISLQRNQIYQIK 381
Cdd:PRK15370 258 -----ERLPSA-----LQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPA----HlpsGITHLNVQSNSLTALP 320
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157694513 382 EGTFQGL------------------ISLRILDLSRNLIHEIHSrafaTLGP-ITNLDVSFNELTSFP 429
Cdd:PRK15370 321 ETLPPGLktleagenaltslpaslpPELQVLDVSKNQITVLPE----TLPPtITTLDVSRNALTNLP 383
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
547-811 3.55e-07

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 53.05  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVsWGRfaefgiwWETGS-GCKVAGFLA 625
Cdd:cd15074    9 VIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAF-AHR-------WLFGDiGCVFYGFCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 626 VFSSESAIFLLMLATVERSLSakdIMKNGKSNHLKQFRVAALLAF--LGATVAGCFPLFHRGEYSasplclPFPTGETPS 703
Cdd:cd15074   81 FLFGCCSINTLTAISIYRYLK---ICHPPYGPKLSRRHVCIVIVAiwLYALFWAVAPLVGWGSYG------PEPFGTSCS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 704 LGFTVTLVLLNSLAF-------------LLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLI-------FTNCIFF--- 760
Cdd:cd15074  152 IDWTGASASVGGMSYiisififcyllpvLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIErkvtkvaVLICAGFlia 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513 761 -CPVAFFSFapliTAISISPEimkSVTLIFFPLPACL-------NPVLYVFFNPKFKED 811
Cdd:cd15074  232 wTPYAVVSM----WSAFGSPD---SVPILASILPALFaksscmyNPIIYLLFSSKFRQD 283
LRR_9 pfam14580
Leucine-rich repeat;
306-456 3.73e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 51.30  E-value: 3.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  306 ASMVQQFPNLTGTVHLESLTLTGTKISSIpNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTF 385
Cdd:pfam14580   6 AELIEQSAQYTNPVRERELDLRGYKIPII-ENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLG 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157694513  386 QGLISLRILDLSRNLIHEIHS-RAFATLGPITNLDVSFNELTSFPTEGL---NGLNQLKLVG--NFKLKEALAAKDF 456
Cdd:pfam14580  85 EALPNLTELILTNNNLQELGDlDPLASLKKLTFLSLLRNPVTNKPHYRLyviYKVPQLRLLDfrKVKQKERQAAEKM 161
LRR_8 pfam13855
Leucine rich repeat;
248-305 1.02e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 1.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157694513  248 PSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRG 305
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
198-445 2.34e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 198 TNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL-GEFPQAIKALP-SLKELGFHSNSIS-VIPDGAFdgnPLL 274
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLsGPIPDDIFTTSsSLRYLNLSNNNFTgSIPRGSI---PNL 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 275 RTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPN-LTGTVHLESLTLTGTK-ISSIPNNLCQeQKMLRTLDLSY 352
Cdd:PLN00113 143 ETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNsLTNLTSLEFLTLASNQlVGQIPRELGQ-MKSLKWIYLGY 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 353 NNIR-DLPsfngchaleeislqrnqiYQIKegtfqGLISLRILDLS-RNLIHEIHSrafaTLGPITNLDVSF---NELT- 426
Cdd:PLN00113 222 NNLSgEIP------------------YEIG-----GLTSLNHLDLVyNNLTGPIPS----SLGNLKNLQYLFlyqNKLSg 274
                        250       260
                 ....*....|....*....|.
gi 157694513 427 SFPTE--GLNGLNQLKLVGNF 445
Cdd:PLN00113 275 PIPPSifSLQKLISLDLSDNS 295
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
540-810 3.64e-06

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 49.74  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 540 MIRLTVWFIFLVALFFNLLVILTTFAsctslpssklFIGLISVSNLF-MGIYTGILTFLDAVS-WGRFAEFGIWWETGSG 617
Cdd:cd15192    2 MIPTVYSIIFVVGIFGNSLVVIVIYC----------YMKLKTVANIFlLNLALADLCFLITLPlWAAYTAMEYHWPFGNF 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 618 -CKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSAS----PL 692
Cdd:cd15192   72 lCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIEntniTV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 693 C-LPFPTGETPslgFTVTLVLL-NSLAFLLMAVIYTKLYCNLEKEDLSENSQSS----------MIKHVAwLIFtnciFF 760
Cdd:cd15192  152 CaFHYPSQNST---LLVGLGLMkNLLGFLIPFLIILTCYTLIGKALKKAYEIQRnkprndeifkMIMAVV-LFF----FF 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 761 C--PVAFFSFAPLITAISIS-----PEIMKS---VTLIFFPLPACLNPVLYVFFNPKFKE 810
Cdd:cd15192  224 CwiPHQIFTFLDVLIQLKVIqdchiADIVDTampFTICIAYFNSCLNPILYGFVGKNFRK 283
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
547-812 4.29e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 49.52  E-value: 4.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLdavswgrfAEFGIWWETGS-GCKVAGFLA 625
Cdd:cd15401    9 FTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILL--------AIFHNGWTLGNiHCQISGFLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 626 VFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLgATVAGCFPLFHRGEYSASPLCLPFPTGETPSLG 705
Cdd:cd15401   81 GLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWV-LTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 706 FTVTLVLLNslaFLLMAVIYTklYCNLE------------KEDLSENSQSSMIKH-----VAWLIFTNCifFCPVAFFSF 768
Cdd:cd15401  160 YTITVVVVH---FIVPLSIVT--FCYLRiwvlviqvkhrvRQDSKQKLKANDIRNfltmfVVFVLFAVC--WGPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 157694513 769 APLITAISISPEI-----MKSVTLIFFplPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15401  233 AVAINPLKVAPKIpewlfVLSYFMAYF--NSCLNAVIYGVLNQNFRKEY 279
LRRNT smart00013
Leucine rich repeat N-terminal domain;
29-61 1.36e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 1.36e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 157694513    29 CAAPCSCdGDRRVDCSGKGLTAVPEGLSAFTQA 61
Cdd:smart00013   2 CPAPCNC-SGTAVDCSGRGLTEVPLDLPPDTTL 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-190 1.47e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  36 DGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNfpfLEELQLAGNDLSFIhPKALSglKELKVLTLQNN 115
Cdd:PRK15370 283 EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTSL-PASLP--PELQVLDVSKN 356
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157694513 116 QLKTVPsEAIRglSALQSLRLDANHITSVPEDSfegLVQLRHLWLDDNSLTEVP---VHPLSNLPTLQALTLALNKIS 190
Cdd:PRK15370 357 QITVLP-ETLP--PTITTLDVSRNALTNLPENL---PAALQIMQASRNNLVRLPeslPHFRGEGPQPTRIIVEYNPFS 428
LRR_8 pfam13855
Leucine rich repeat;
390-444 1.64e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.64e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157694513  390 SLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTE---GLNGLNQLKLVGN 444
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsGLPSLRYLDLSGN 59
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
544-811 2.48e-05

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 47.37  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 544 TVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTgILTFLDavswgrFAEFGIWWETGSGCKVAGF 623
Cdd:cd14986    6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFT-VLTQII------WEATGEWVAGDVLCRIVKY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 624 LAVFSSESAIFLLMLATVERSLSAKDIMKngKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSAS---PLCLP-FPTG 699
Cdd:cd14986   79 LQVVGLFASTYILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGdgvHQCWSsFYTP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 700 ETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNL-----EKEDLSENSQSSMIKHVAW------LI---------FTNCI- 758
Cdd:cd14986  157 WQRKVYITWLATYVFVIPLIILSYCYGRILRTIwirsrQKTDRPIAPTAMSCRSVSCvssrvsLIsrakiktikMTLVIi 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157694513 759 --FFC---PVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd14986  237 laFILcwtPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLSFE 294
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
609-809 2.70e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 47.04  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 609 GIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHlKQFRVAALLAFLGATVAGCFPLFHRGEYS 688
Cdd:cd15073   64 GSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRKMTT-NTYTVMILLAWTNAFFWAAMPLVGWASYA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 689 ASP---LC-LPFPTGETPSLGFTVTLVLLN-SLAFLLMAVIYTKLYCNLEK---EDL--SENSQSSMIKHVAWLIFTNCI 758
Cdd:cd15073  143 LDPtgaTCtINWRKNDSSFVSYTMSVIVVNfIVPLAVMFYCYYNVSRFVKKvlaSDCleSVNIDWTDQNDVTKMSVIMIV 222
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 157694513 759 FFCpVAF--FSFAPLITAISISPEIMKSVTLI---FFPLPACLNPVLYVFFNPKFK 809
Cdd:cd15073  223 MFL-VAWspYSIVCLWASFGEPKKIPPWMAIIpplFAKSSTFYNPCIYVIANKKFR 277
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
548-809 3.18e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 46.82  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 548 IFLVALFFNLLVILTTFAScTSLPS-SKLFIGLISVSNLFMGIYTGILTFLDAVSwgrfaefgIWWETGSG-CKVAGFL- 624
Cdd:cd14993   10 VFLLALVGNSLVIAVVLRN-KHMRTvTNYFLVNLAVADLLVSLFCMPLTLLENVY--------RPWVFGEVlCKAVPYLq 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 625 --AVFSSesaIFLLMLATVERSLSAKDIMKNGKSNHLKQFR--------VAALLAFLGATVAGCFPLFHRGEYSAS-PLC 693
Cdd:cd14993   81 gvSVSAS---VLTLVAISIDRYLAICYPLKARRVSTKRRARiiivaiwvIAIIIMLPLLVVYELEEIISSEPGTITiYIC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 694 LP-FPTGETPSLGFTVTLVLLNSLAFLLMAVIYT----KLYCNLEKEDLSENSQSSMIKH------VAWLIFTNCIFFcp 762
Cdd:cd14993  158 TEdWPSPELRKAYNVALFVVLYVLPLLIISVAYSligrRLWRRKPPGDRGSANSTSSRRIlrskkkVARMLIVVVVLF-- 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 763 vaFFSFAPL-ITAISI---SPEIMKSVTLIFFPLP---------ACLNPVLYVFFNPKFK 809
Cdd:cd14993  236 --ALSWLPYyVLSILLdfgPLSSEESDENFLLILPfaqllgysnSAINPIIYCFMSKKFR 293
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
343-375 6.01e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 6.01e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 157694513  343 KMLRTLDLSYNNIRDLPSFNGCHALEEISLQRN 375
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
547-810 9.35e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 45.30  E-value: 9.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFigLISVSNLFMGIYTGILTFLDAVSWgrfaeFGIWWETGSGCKVAGFLAV 626
Cdd:cd15321   15 FLILFTIFGNVLVIIAVLTSRSLRAPQNLF--LVSLAAADILVATLIIPFSLANEL-----MGYWYFRKTWCEIYLALDV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 627 FSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPfptgeTPSLGF 706
Cdd:cd15321   88 LFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLP-----QCKLNE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 707 TVTLVLLNSLAF-----LLMAVIYTKLYC---NLEKedlsensQSSMIKHVAWLIFTNCIFfcPVaFFSFapliTAISIS 778
Cdd:cd15321  163 EAWYILSSSIGSffapcLIMILVYLRIYLiakNREK-------RFTFVLAVVIGVFVLCWF--PF-FFSY----SLGAIC 228
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 157694513 779 PEIMK---SVTLIFFPLPAC---LNPVLYVFFNPKFKE 810
Cdd:cd15321  229 PELCKvphSLFQFFFWIGYCnssLNPVIYTIFNQDFRR 266
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
29-56 1.01e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.30  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|....*...
gi 157694513   29 CAAPCSCdGDRRVDCSGKGLTAVPEGLS 56
Cdd:pfam01462   2 CPVPCHC-SATVVNCSDRGLTAVPRDLP 28
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
545-809 1.59e-04

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 44.77  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 545 VWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLfmgIYTGILTFLDAVSWGRFAefgiwWETGSG-CKVAGF 623
Cdd:cd15189    7 IFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADL---VFVSGLPFWAMNILNQFN-----WPFGELlCRVVNG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 624 LAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPS 703
Cdd:cd15189   79 VIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNITACVLLYPH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 704 LGFTV-TLVLLNSLAFLL-MAVIytkLYCNLE-------------KEDLSENSQSSMIKHVAWLIFtncIFFCPVAFFSF 768
Cdd:cd15189  159 EAWHFaHIVLLNIVGFLLpLLVI---TFCNYNilqalrtreestrCEDRNDSKATALVLAVTLLFL---VCWGPYHFFTF 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 157694513 769 APLITAISISPE--------IMKSVTLIFFPLPACLNPVLYVFFNPKFK 809
Cdd:cd15189  233 LDFLFDVGVLDEcfwehfidIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
547-810 1.78e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 44.36  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGI--LTFLDAVSW--GRFAefgiwwetgsgCKVAG 622
Cdd:cd15012    8 LVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLqnLSIYLIPSWpfGEVL-----------CRMYQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 623 FLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLgATVAGCFPLF----------HRGEYSASPL 692
Cdd:cd15012   77 FVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL-TSAVYNTPYFvfsqtveilvTQDGQEEEIC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 693 CLPFPTGETPSLGfTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLI-FTNCIFFCPVAFF--SFA 769
Cdd:cd15012  156 VLDREMFNSKLYD-TINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVsFALCNLPYHARKMwqYWS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 157694513 770 PLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 810
Cdd:cd15012  235 EPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
546-811 2.17e-04

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 44.13  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 546 WFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIytgILTFldavsWGRFAEFGiwWETGSG-CKVAGFL 624
Cdd:cd14984    8 SLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVL---TLPF-----WAVYAADG--WVFGSFlCKLVSAL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 625 AVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKqFRVAALLAFLGATVAGCFP--LFHR-GEYSASPLCLPFPTGET 701
Cdd:cd14984   78 YTINFYSGILFLACISIDRYLAIVHAVSALRARTLL-HGKLTCLGVWALALLLSLPefIFSQvSEENGSSICSYDYPEDT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 702 PSLGFTVTLVLLNSLAFLL----MAVIYTKLYCNLEKedlSENSQSS-MIKHVAWLIFTNCIFFCP---VAFFSFAPLIT 773
Cdd:cd14984  157 ATTWKTLLRLLQNILGFLLpllvMLFCYSRIIRTLLR---ARNHKKHrALRVIFAVVVVFFLCWLPyniVLLLDTLQLLG 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 157694513 774 AISISPEIMKSV--------TLIFFPlpACLNPVLYVFFNPKFKED 811
Cdd:cd14984  234 IISRSCELSKSLdyalqvteSLAFSH--CCLNPVLYAFVGVKFRKY 277
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
202-252 2.90e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.90e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157694513  202 SLVVLHLHNNKIRSLSQhcFDGLDNLETLDLNYNNLgefpqaIKALPSLKE 252
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK------ITDLSDLAN 44
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
539-809 3.60e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 43.58  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVwfIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSwgrfaefgIWWETGS-G 617
Cdd:cd14992    3 LGVALVV--IILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVS--------LSWEYGHfL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 618 CKVAGFLAVFSSESAIFLLMLATVERSLSakdIMKNGKSNHLKQFRVAALL-------AFLGATVAGCF----PLFHRGE 686
Cdd:cd14992   73 CKIVNYLRTVSVYASSLTLTAIAFDRYFA---IIHPLKPRHRQSYTTTVIIiitiwvvSLLLAIPQLYYatteVLFSVKN 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 687 YSASPLC-LPFPTGETP-SLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMI--------KHVAWLIFTN 756
Cdd:cd14992  150 QEKIFCCqIPPVDNKTYeKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVErkrlkckrRVIKMLVCVV 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157694513 757 CIFF-CPVAFFSFapliTAIS-ISPEIMKSVT--LIFFPL------PACLNPVLYVFFNPKFK 809
Cdd:cd14992  230 VLFViCWLPFHLF----FLLRdFFPLIMKEKHtlQVYYFLhwiamsNSMYNPIIYVTLNNNFR 288
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
539-809 3.91e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 43.61  E-value: 3.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 539 WMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAV--SWgrfaEFGIWWetgs 616
Cdd:cd14971    1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPlpGW----VFGDFM---- 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 617 gCKVAGFLAVFSSESAIFLLMLATVERSLSakdIMKNGKSNHLKQFRVA----ALLAFLGATVAGCFPLFHR-GEYSASP 691
Cdd:cd14971   73 -CKFVHYFQQVSMHASIFTLVAMSLDRFLA---VVYPLRSLHIRTPRNAlaasGCIWVVSLAVAAPVLALHRlRNYTPGN 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 692 L--CLP-FPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEK----EDLSENSQSSMiKHVAWLIFTNCIFFC--- 761
Cdd:cd14971  149 RtvCSEaWPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRvavrPVLSEGSRRAK-RKVTRLVLVVVVLFAacw 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157694513 762 ---------------PVAFFSFAPLITAISISpeIMKSvtliffplpaCLNPVLYVFFNPKFK 809
Cdd:cd14971  228 gpihailllvalgpfPLTYATYALRIWAHCLA--YSNS----------AVNPVLYAFLSEHFR 278
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
547-812 4.75e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 43.35  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGrfaefgiwWETGS-GCKVAGFLA 625
Cdd:cd15402    9 FTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNG--------WNLGYlHCQISGFLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 626 VFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLgATVAGCFPLFHRGEYSASPLCLPFPTGETPSLG 705
Cdd:cd15402   81 GLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWV-LTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSSA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 706 FTVTLVLLNslaFLLMAVIYTklYCNLE--------KEDLSENSQSSMIKH---------VAWLIFTNCifFCPVAFFSF 768
Cdd:cd15402  160 YTIAVVFFH---FILPIIIVT--FCYLRiwilviqvRRRVKPDNKPKLKPHdfrnfvtmfVVFVLFAVC--WAPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 157694513 769 APLITAISISPEI-----MKSVTLIFFplPACLNPVLYVFFNPKFKEDW 812
Cdd:cd15402  233 AVAVDPETIVPRIpewlfVASYYMAYF--NSCLNAIIYGLLNQNFRREY 279
LRR_8 pfam13855
Leucine rich repeat;
272-355 9.49e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 9.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  272 PLLRTIHLYDNPLSFVGNSAFHNLSdlhslvirgasmvqqfpnltgtvHLESLTLTGTKISSIPNNLCQEQKMLRTLDLS 351
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57

                  ....
gi 157694513  352 YNNI 355
Cdd:pfam13855  58 GNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
82-169 1.33e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  82 FLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHIT-SVPEdSFEGLVQLRHLWL 160
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPE-SLGQLTSLRILNL 497
                         90
                 ....*....|
gi 157694513 161 DDNSLT-EVP 169
Cdd:PLN03150 498 NGNSLSgRVP 507
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
541-810 1.38e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 41.56  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 541 IRLTVWFIFLVALFFNLLVILTTFAS----------CTSLPSSKLFIGLI----SVSNLFMGIYTgiltfldavswgrfa 606
Cdd:cd15059    3 ISSIVSVVILLIIVGNVLVIVAVLTSrklrapqnwfLVSLAVADILVGLLimpfSLVNELMGYWY--------------- 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 607 eFGIWWetgsgCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMK-NGKSNHLKQFRVAALLAFLGATVagCFP-LF-- 682
Cdd:cd15059   68 -FGSVW-----CEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEyNLKRTPRRAKAMIAAVWIISAVI--SLPpLFgw 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 683 --HRGEYSASPLClpfptgetpSLGFTVTLVLLNSLA-FLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIF 759
Cdd:cd15059  140 kdEQPWHGAEPQC---------ELSDDPGYVLFSSIGsFYIPLLIMIIVYARIYRAAKRKERRFTLVLGVVMGAFVLCWL 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157694513 760 fcpvAFFSFAPLiTAISISPEIMKSVTLIFFPLPAC---LNPVLYVFFNPKFKE 810
Cdd:cd15059  211 ----PFFFTYPL-VVVCKTCGVPELLFKFFFWLGYCnsaLNPVIYTIFNKDFRR 259
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
249-392 1.43e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  249 SLKELGFhSNSISVIPDGAFDGNPLLRTIHLYDNpLSFVGNSAFHNLSdlhslvirgasmvqqfpnltgtvhLESLTLtG 328
Cdd:pfam13306  12 SLTSITI-PSSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS------------------------LTSITI-P 64
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157694513  329 TKISSIPNNLCQEQKMLRTLDLSyNNIRDLPS--FNGCHaLEEISLQrNQIYQIKEGTFQGLISLR 392
Cdd:pfam13306  65 SSLTSIGEYAFSNCSNLKSITLP-SNLTSIGSyaFSNCS-LKSITIP-SSVTTIGSYAFSNCSNLK 127
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
549-803 2.42e-03

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 40.93  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 549 FLVALFFNLLVILTTFAscTSLPSSklfIGLISVSNLFMgiyTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFS 628
Cdd:cd14975   11 FAIGLPGNSFVIWSILI--KVKQRS---VTMLLVLNLAL---ADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 629 SESAIFLLMLATVERSLS-AKDIMKNGKSNHLKQFRVAA---LLAFLGATVAgcFPLFHRGEYSASPLCLPfptgETPSL 704
Cdd:cd14975   83 MYASVFLITLMSLERFLAvSRPFVSQGWRAKALAHKVLAiiwLLAVLLATPV--IAFRHVEETVENGMCKY----RHYSD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 705 GFTVTLVLLNSLA-----FLLMAVIYTKLYCNLEKEDLSENSQSsmIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISP 779
Cdd:cd14975  157 GQLVFHLLLETVVgfavpFTAVVLCYSCLLRRLRRRRFRRRRRT--GRLIASVVVAFAACWLPYHVGNLLEVVSELIGGS 234
                        250       260       270
                 ....*....|....*....|....*....|....
gi 157694513 780 EIMKSV----TLIFFPLPA------CLNPVLYVF 803
Cdd:cd14975  235 KMAGTLgkvaEAGRPIAGAlaflssSINPLLYAF 268
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
547-811 2.81e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 40.86  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSS--KLFIGLISVSNLFMGIYTGIL--TFLDAVSW--GRFAefgiwwetgsgCKV 620
Cdd:cd15098    9 LIFCLGVLGNSLVITVLARVKPGKRRSttNVFILNLSIADLFFLLFCVPFqaTIYSLPEWvfGAFM-----------CKF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 621 AGFLAVFSSESAIFLLMLATVERSLSakdIMKNGKSNHLKQFRVAAL-------LAFLGAT-VAGCFPLFHRGEYSASPL 692
Cdd:cd15098   78 VHYFFTVSMLVSIFTLVAMSVDRYIA---VVHSRTSSSLRTRRNALLgvlviwvLSLAMASpVAVHQDLVHHWTASNQTF 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 693 CLPFPTGETPSLGFTV-TLVLLNSLAFLLMAVIYTKLYCNLEKE-----DLSENSQSSMIKHVAWLIFTNCIFFCP---- 762
Cdd:cd15098  155 CWENWPEKQQKPVYVVcTFVFGYLLPLLLITFCYAKVLNHLHKKlknmsKKSERSKKKTAQTVLVVVVVFGISWLPhhii 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157694513 763 ---VAFFSFaPLiTAISIspeIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
Cdd:cd15098  235 hlwVEFGDF-PL-TQASF---VLRITAHCLAYANSCVNPIIYAFLSENFRKA 281
PLN03150 PLN03150
hypothetical protein; Provisional
158-283 3.00e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 158 LWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVlhlhnnkirslsqhcfdgldnletLDLNYNNL 237
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEV------------------------LDLSYNSF 478
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157694513 238 -GEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTI-HLYDNP 283
Cdd:PLN03150 479 nGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLLHRASfNFTDNA 526
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
605-810 3.58e-03

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 40.36  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 605 FAEFGIWWETGS-GCKVAGFLAVFSSESAIFLLMLATVERSLSAkdIMKNGKSNH--LKQFRVAALLAFLGAtVAGCFP- 680
Cdd:cd14974   58 YIAMGHHWPFGSvLCKLNSFVISLNMFASVFLLTAISLDRCLLV--LHPVWAQNHrtVRLASVVCVGIWILA-LVLSVPy 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 681 -------LFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLN-SLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIkhVAWL 752
Cdd:cd14974  135 fvfrdtvTHHNGRSCNLTCVEDYDLRRSRHKALTVIRFLCGfLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRV--LLAV 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157694513 753 IftnCIFF---CPVAFFSFApLITAISISPEIMK-----SVTLIFFplPACLNPVLYVFFNPKFKE 810
Cdd:cd14974  213 V---VAFFlcwLPYHVFALL-ELVAAAGLPEVVLlglplATGLAYF--NSCLNPILYVFMGQDFRK 272
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
547-809 3.96e-03

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 40.34  E-value: 3.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIytgILTFLdAVSWGRFAEFGIWWetgsgCKVAGFLAV 626
Cdd:cd15178    9 LVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFAL---TLPFW-AVSVVKGWIFGTFM-----CKLVSLLQE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 627 FSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAgcFP-LFHRGEY----SASPLCLPFPTGET 701
Cdd:cd15178   80 ANFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVCAGVWLLSLLLS--LPaLLNRDAFkppnSGRTVCYENLGNES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 702 PSLGFTVTLVLLNSLAFLL----MAVIYTKLYCNLEKedlSENSQssmiKHVAWLIftncIFFCPVAF-FSFAPLITAIs 776
Cdd:cd15178  158 ADKWRVVLRILRHTLGFLLplvvMLFCYGFTIKTLLQ---TRSFQ----KHRAMRV----IFAVVLAFlLCWLPYNVTV- 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157694513 777 ISPEIMKS------------------VTLIFFPLPACLNPVLYVFFNPKFK 809
Cdd:cd15178  226 LIDTLMRTklitetcelrnhvdvalyVTQILGFLHSCINPVLYAFIGQKFR 276
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
534-810 4.31e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 40.39  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 534 YLLGSWMIrltvwFIFLVALFFNLLVILTtFASCTSLPSSK-LFIGLISVSNLFMGIYTGILTFldavsWGRFaeFGIWW 612
Cdd:cd15083    1 YVLGIFIL-----IIGLIGVVGNGLVIYA-FCRFKSLRTPAnYLIINLAISDFLMCILNCPLMV-----ISSF--SGRWI 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 613 ETGSGCKVAGFL-AVFSSESAIFLLMLAtVERSLS-AKDIMKNGKSNHLKQFRVAALLaFLGATVAGCFPLFHRGEYSAS 690
Cdd:cd15083   68 FGKTGCDMYGFSgGLFGIMSINTLAAIA-VDRYLViTRPMKASVRISHRRALIVIAVV-WLYSLLWVLPPLFGWSRYVLE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 691 PL---CLPFPTGETPS----------LGFTVTLVLLN-SLAFLLMAV------IYTKLYCNLEKEDLSENSQSSMIKHVA 750
Cdd:cd15083  146 GLltsCSFDYLSRDDAnrsyviclliFGFVLPLLIIIyCYSFIFRAVrrhekaMKEMAKRFSKSELSSPKARRQAEVKTA 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157694513 751 WLIFTNCIFFC----PVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKE 810
Cdd:cd15083  226 KIALLLVLLFClawtPYAVVALIGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRR 289
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
62-155 5.37e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHI 141
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
                         90
                 ....*....|....*..
gi 157694513 142 T-SVPED--SFEGLVQL 155
Cdd:PLN00113 560 SgEIPKNlgNVESLVQV 576
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
139-275 5.61e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513  139 NHITSVPEDSFEGLVQLRHLWLDdNSLTEVPVHPLSNLPtLQALTLAlNKISSIPDFAFTNLSSLVVLHLhNNKIRSLSQ 218
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLKSITL-PSNLTSIGS 95
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157694513  219 HCFDGLdNLETLDLnynnlgefpqaikalpslkelgfhSNSISVIPDGAFDGNPLLR 275
Cdd:pfam13306  96 YAFSNC-SLKSITI------------------------PSSVTTIGSYAFSNCSNLK 127
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
548-809 7.14e-03

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 39.37  E-value: 7.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 548 IFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLfMGIYTGILTFLDAVS-----WGRFAefgiwwetgsgCKVAG 622
Cdd:cd14988   10 IFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADL-GVVLTLPVWMLEVMLdytwlWGSFL-----------CKFTH 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 623 FLAVFSSESAIFLLMLATVERSLSakdIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEY----SASPLCL---P 695
Cdd:cd14988   78 YFYFANMYSSIFFLTCLSVDRYLT---LTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMqlldGVEPMCLflaP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 696 FPTGETPSLGFTVTLVLLNSLA-FLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITA 774
Cdd:cd14988  155 FETYDEWALAVSLLTLIIGFLIpFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSH 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 157694513 775 ISISPEIMkSVTLIFFPLPACL-------NPVLYVFFNPKFK 809
Cdd:cd14988  235 ISLHCNLV-HFLYFFYDVIDCFsllhcvaNPILYNFLSKSFR 275
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
547-812 7.73e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 39.38  E-value: 7.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 547 FIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILtFLDAVSWGRfaefgiwWETGS-GCKVAGFLA 625
Cdd:cd15209    9 VTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPL-ILHAIFHNG-------WTLGQlHCQASGFIM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 626 VFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLgATVAGCFPLFHRGEYSASPLCLPFPTGETPSLG 705
Cdd:cd15209   81 GLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWL-LTVLAVLPNFFIGSLQYDPRIYSCTFAQTVSTV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 706 FTVTLVLLNslaFLLMAVIYTklYCNLE------------KEDLSENSQSSMIKH-----VAWLIFTNCifFCPVAFFSF 768
Cdd:cd15209  160 YTITVVVIH---FLLPLLIVS--FCYLRiwvlvlqvrqrvKPDQRPKLKPADVRNfltmfVVFVLFAVC--WAPLNFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 157694513 769 APLITAISISPEI-----MKSVTLIFFPlpACLNPVLYVFFNPKFKEDW 812
Cdd:cd15209  233 AVAINPKEMAPKIpewlfVASYFMAYFN--SCLNAIIYGLLNQNFRKEY 279
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
540-810 8.74e-03

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 39.41  E-value: 8.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 540 MIRLTVWFIFLVALFFNLLVI--LTTFASCTSLPSSKLFIGLISVSNLfmgIYTGILTFLDAVSWGRFA-EFGIWWetgs 616
Cdd:cd14976    2 LVSVVYMVVFTVGLLGNLLVLylLKSNKKLRQQSESNKFVFNLALTDL---IFVLTLPFWAVEYALDFVwPFGTAM---- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 617 gCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRvAALLAFLGATVAGCFP--LF--HRGEYSASPL 692
Cdd:cd14976   75 -CKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAF-ATTIAIWAAAALAAIPeaIFstDTWSSVNHTL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157694513 693 C-LPFPTGETPSLGFT------VTLVLlnsLAFLLMAVIYTKLYCNL-----EKEDLSENSQSSMIKHVAWLIFTNCIFF 760
Cdd:cd14976  153 ClLRFPKNSSVTRWYNwlgmyqLQKVV---LGFFLPLGIITLSYLLLlrflqRKRGGSKRRKSRVTKSVFIVVLSFFICW 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157694513 761 CPVAFFSFAPLITAISISPEIMKSVTL--IFFPLP-------ACLNPVLYVFFNPKFKE 810
Cdd:cd14976  230 LPNQALSLWSALIKFDDVPFSDAFFAFqtYAFPVAiclahsnSCLNPVLYCLVRREFRD 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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