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Conserved domains on  [gi|8923942|ref|NP_061118|]
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H/ACA ribonucleoprotein complex subunit 3 [Homo sapiens]

Protein Classification

H/ACA ribonucleoprotein complex subunit NOP10( domain architecture ID 10514184)

H/ACA ribonucleoprotein complex subunit Nop10 plays a central role in the assembly and activity of the H/ACA sno(s)RNPs

Gene Ontology:  GO:0003723|GO:0031118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nop10p pfam04135
Nucleolar RNA-binding protein, Nop10p family; Nop10p is a nucleolar protein that is ...
 4-52 3.53e-23

Nucleolar RNA-binding protein, Nop10p family; Nop10p is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA snoRNAs (H/ACA snoRNPs). Nop10p is probably necessary for the stability of these RNPs.


:

Pssm-ID: 427735 [Multi-domain]  Cd Length: 51  Bit Score: 82.23  E-value: 3.53e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 8923942     4 QYYLNEQG-DRVYTLKKFDP-MGQQTCSAHPARFSPDDKYSRHRITIKKRF 52
Cdd:pfam04135  1 KYYLRKCGkCRVYTLKDVCPkCGGPTRSAHPARFSPDDKYGKYRRALKKRF 51
 
Name Accession Description Interval E-value
Nop10p pfam04135
Nucleolar RNA-binding protein, Nop10p family; Nop10p is a nucleolar protein that is ...
 4-52 3.53e-23

Nucleolar RNA-binding protein, Nop10p family; Nop10p is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA snoRNAs (H/ACA snoRNPs). Nop10p is probably necessary for the stability of these RNPs.


Pssm-ID: 427735 [Multi-domain]  Cd Length: 51  Bit Score: 82.23  E-value: 3.53e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 8923942     4 QYYLNEQG-DRVYTLKKFDP-MGQQTCSAHPARFSPDDKYSRHRITIKKRF 52
Cdd:pfam04135  1 KYYLRKCGkCRVYTLKDVCPkCGGPTRSAHPARFSPDDKYGKYRRALKKRF 51
PRK13130 PRK13130
RNA-protein complex protein Nop10;
14-51 6.92e-09

RNA-protein complex protein Nop10;


Pssm-ID: 237287 [Multi-domain]  Cd Length: 56  Bit Score: 46.16  E-value: 6.92e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 8923942   14 VYTLKKFDPM-GQQTCSAHPARFSPDDKYSRHRITIKKR 51
Cdd:PRK13130 13 VYTLKEICPVcGGKTKNPHPPRFSPEDKYGKYRRALKKR 51
Nop10 COG2260
rRNA maturation protein Nop10, contains Zn-ribbon domain [Translation, ribosomal structure and ...
 12-51 5.02e-08

rRNA maturation protein Nop10, contains Zn-ribbon domain [Translation, ribosomal structure and biogenesis]; rRNA maturation protein Nop10, contains Zn-ribbon domain is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 441861 [Multi-domain]  Cd Length: 51  Bit Score: 44.12  E-value: 5.02e-08
                       10        20        30        40
               ....*....|....*....|....*....|....*....|.
gi 8923942  12 DRVYTLKKFDPM-GQQTCSAHPARFSPDDKYSRHRITIKKR 51
Cdd:COG2260 11 CGRYTLKDTCPVcGGPTVVPHPPRFSPEDKYGKYRRKLKKR 51
 
Name Accession Description Interval E-value
Nop10p pfam04135
Nucleolar RNA-binding protein, Nop10p family; Nop10p is a nucleolar protein that is ...
 4-52 3.53e-23

Nucleolar RNA-binding protein, Nop10p family; Nop10p is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA snoRNAs (H/ACA snoRNPs). Nop10p is probably necessary for the stability of these RNPs.


Pssm-ID: 427735 [Multi-domain]  Cd Length: 51  Bit Score: 82.23  E-value: 3.53e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 8923942     4 QYYLNEQG-DRVYTLKKFDP-MGQQTCSAHPARFSPDDKYSRHRITIKKRF 52
Cdd:pfam04135  1 KYYLRKCGkCRVYTLKDVCPkCGGPTRSAHPARFSPDDKYGKYRRALKKRF 51
PRK13130 PRK13130
RNA-protein complex protein Nop10;
14-51 6.92e-09

RNA-protein complex protein Nop10;


Pssm-ID: 237287 [Multi-domain]  Cd Length: 56  Bit Score: 46.16  E-value: 6.92e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 8923942   14 VYTLKKFDPM-GQQTCSAHPARFSPDDKYSRHRITIKKR 51
Cdd:PRK13130 13 VYTLKEICPVcGGKTKNPHPPRFSPEDKYGKYRRALKKR 51
Nop10 COG2260
rRNA maturation protein Nop10, contains Zn-ribbon domain [Translation, ribosomal structure and ...
 12-51 5.02e-08

rRNA maturation protein Nop10, contains Zn-ribbon domain [Translation, ribosomal structure and biogenesis]; rRNA maturation protein Nop10, contains Zn-ribbon domain is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 441861 [Multi-domain]  Cd Length: 51  Bit Score: 44.12  E-value: 5.02e-08
                       10        20        30        40
               ....*....|....*....|....*....|....*....|.
gi 8923942  12 DRVYTLKKFDPM-GQQTCSAHPARFSPDDKYSRHRITIKKR 51
Cdd:COG2260 11 CGRYTLKDTCPVcGGPTVVPHPPRFSPEDKYGKYRRKLKKR 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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