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Conserved domains on  [gi|11036654|ref|NP_061756|]
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protocadherin beta-13 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 2.67e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 148.44  E-value: 2.67e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    31 PRSYSVVEETEGSSFVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEPCVLRFQVL 110
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 11036654   111 LE 112
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-344 1.61e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 1.61e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 248 YRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLfqASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT 327
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 11036654 328 --FSGKCTVLIQVIDVNDH 344
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-768 7.47e-32

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 118.78  E-value: 7.47e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   686 LTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCLVPEGPLPGHLVDMSGTRTLSQSYQYEVCLAGGSGTNEFK 765
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSEFK 81


                  ...
gi 11036654   766 FLK 768
Cdd:pfam16492  82 FLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 5.62e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 5.62e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 455 SYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLpltslVSINADNGHLFALRSLDYEALQGFQFRVGAS 534
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11036654 535 DHGSPALSSEALVRVVVLDANDN 557
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-239 1.24e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 141 VKVSESSPPGTTFPLKNAEDLDVGQNNIENYIIS---PNSYFRVltrKRSDGrkypELVLDKALDREEEAELRLTLTALD 217
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 11036654 218 GGSPPRSGTAQVYIEVLDVNDN 239
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-664 3.18e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 3.18e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 655
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 11036654 656 ATLHVLLVD 664
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 357-447 5.70e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 5.70e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 357 IPENAPE-TVVALFSVSDLDSGENGKISCSIQ---EDLPFLLKSaeNFYTLLTERPLDRESRAEYNITITVTDLGTPMLI 432
Cdd:cd11304   6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 11036654 433 TQLNMTVLIADVNDN 447
Cdd:cd11304  84 STATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 2.67e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 148.44  E-value: 2.67e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    31 PRSYSVVEETEGSSFVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEPCVLRFQVL 110
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 11036654   111 LE 112
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-344 1.61e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 1.61e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 248 YRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLfqASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT 327
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 11036654 328 --FSGKCTVLIQVIDVNDH 344
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-768 7.47e-32

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 118.78  E-value: 7.47e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   686 LTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCLVPEGPLPGHLVDMSGTRTLSQSYQYEVCLAGGSGTNEFK 765
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSEFK 81


                  ...
gi 11036654   766 FLK 768
Cdd:pfam16492  82 FLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 5.62e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 5.62e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 455 SYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLpltslVSINADNGHLFALRSLDYEALQGFQFRVGAS 534
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11036654 535 DHGSPALSSEALVRVVVLDANDN 557
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-239 1.24e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 141 VKVSESSPPGTTFPLKNAEDLDVGQNNIENYIIS---PNSYFRVltrKRSDGrkypELVLDKALDREEEAELRLTLTALD 217
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 11036654 218 GGSPPRSGTAQVYIEVLDVNDN 239
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 1.61e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 1.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    474 SATDRDSGTNAQVTYSLLPPQDPHLpltslVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLD 553
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL-----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 11036654    554 ANDNSP 559
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-346 2.03e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 2.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    266 SATDVDTGVNGEISYSLfqASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT--FSGKCTVLIQVIDVND 343
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 11036654    344 HAP 346
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-664 3.18e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 3.18e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 655
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 11036654 656 ATLHVLLVD 664
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 357-447 5.70e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 5.70e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 357 IPENAPE-TVVALFSVSDLDSGENGKISCSIQ---EDLPFLLKSaeNFYTLLTERPLDRESRAEYNITITVTDLGTPMLI 432
Cdd:cd11304   6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 11036654 433 TQLNMTVLIADVNDN 447
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-339 2.68e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 2.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   248 YRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLfqASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 11036654   328 F--SGKCTVLIQVI 339
Cdd:pfam00028  79 PplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-241 3.22e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 3.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    157 NAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGrkypELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDV 236
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 11036654    237 NDNAP 241
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
456-552 8.61e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 8.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   456 YTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLpltslVSINADNGHLFALRSLDYEALQGFQFRVGASD 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 11036654   536 HGSPALSSEALVRVVVL 552
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 370-449 3.46e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 3.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    370 SVSDLDSGENGKISCSIQ---EDLPFLLKSaeNFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVND 446
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDP--ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 11036654    447 NAP 449
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-664 2.77e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 2.77e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 11036654    590 VAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 34-130 6.09e-14

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 68.14  E-value: 6.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654  34 YSVVEETEGSSFVTNLAKDLGleqrEFSRRGVRVVSRGNKLH---LQLNQETADLLLNEKLDREDLcghtepCVLRFQVL 110
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEALpswLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                        90       100
                ....*....|....*....|....*
gi 11036654 111 LESPF-----EFFQAELQVIDINDH 130
Cdd:cd00031  74 AASLGanvpqTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
353-440 1.23e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   353 FTSPIPENAPE-TVVALFSVSDLDSGENGKISCSIQEDLPfllksAENFY------TLLTERPLDRESRAEYNITITVTD 425
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGP-----GGNFRidpdtgDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 11036654   426 LGTPML--ITQLNMTVL 440
Cdd:pfam00028  76 SGGPPLssTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
576-662 1.57e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 655
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 11036654   656 ATLHVLL 662
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
143-234 3.67e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   143 VSESSPPGTTFPLKNAEDLDVGQN-NIENYIISPNSY--FRVLTRKRsdgrkypELVLDKALDREEEAELRLTLTALDGG 219
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNgRIFYSILGGGPGgnFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 11036654   220 SPPRSGTAQVYIEVL 234
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 31-112 2.67e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 148.44  E-value: 2.67e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    31 PRSYSVVEETEGSSFVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEPCVLRFQVL 110
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 11036654   111 LE 112
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-344 1.61e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 1.61e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 248 YRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLfqASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT 327
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 11036654 328 --FSGKCTVLIQVIDVNDH 344
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-768 7.47e-32

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 118.78  E-value: 7.47e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   686 LTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCLVPEGPLPGHLVDMSGTRTLSQSYQYEVCLAGGSGTNEFK 765
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSEFK 81


                  ...
gi 11036654   766 FLK 768
Cdd:pfam16492  82 FLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 455-557 5.62e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 5.62e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 455 SYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLpltslVSINADNGHLFALRSLDYEALQGFQFRVGAS 534
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL-----FSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11036654 535 DHGSPALSSEALVRVVVLDANDN 557
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-239 1.24e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 141 VKVSESSPPGTTFPLKNAEDLDVGQNNIENYIIS---PNSYFRVltrKRSDGrkypELVLDKALDREEEAELRLTLTALD 217
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 11036654 218 GGSPPRSGTAQVYIEVLDVNDN 239
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 474-559 1.61e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 1.61e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    474 SATDRDSGTNAQVTYSLLPPQDPHLpltslVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLD 553
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGL-----FSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 11036654    554 ANDNSP 559
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-346 2.03e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 2.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    266 SATDVDTGVNGEISYSLfqASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT--FSGKCTVLIQVIDVND 343
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 11036654    344 HAP 346
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 576-664 3.18e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 3.18e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 655
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 11036654 656 ATLHVLLVD 664
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 357-447 5.70e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 5.70e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 357 IPENAPE-TVVALFSVSDLDSGENGKISCSIQ---EDLPFLLKSaeNFYTLLTERPLDRESRAEYNITITVTDLGTPMLI 432
Cdd:cd11304   6 VPENAPPgTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 11036654 433 TQLNMTVLIADVNDN 447
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-339 2.68e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 2.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   248 YRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLfqASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGT 327
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 11036654   328 F--SGKCTVLIQVI 339
Cdd:pfam00028  79 PplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-241 3.22e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 3.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    157 NAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGrkypELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDV 236
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 11036654    237 NDNAP 241
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
456-552 8.61e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 8.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   456 YTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLpltslVSINADNGHLFALRSLDYEALQGFQFRVGASD 535
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 11036654   536 HGSPALSSEALVRVVVL 552
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 370-449 3.46e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 3.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654    370 SVSDLDSGENGKISCSIQ---EDLPFLLKSaeNFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVND 446
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSIDP--ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 11036654    447 NAP 449
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-664 2.77e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 2.77e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 11036654    590 VAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 34-130 6.09e-14

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 68.14  E-value: 6.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654  34 YSVVEETEGSSFVTNLAKDLGleqrEFSRRGVRVVSRGNKLH---LQLNQETADLLLNEKLDREDLcghtepCVLRFQVL 110
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEALpswLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                        90       100
                ....*....|....*....|....*
gi 11036654 111 LESPF-----EFFQAELQVIDINDH 130
Cdd:cd00031  74 AASLGanvpqTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
353-440 1.23e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   353 FTSPIPENAPE-TVVALFSVSDLDSGENGKISCSIQEDLPfllksAENFY------TLLTERPLDRESRAEYNITITVTD 425
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGP-----GGNFRidpdtgDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 11036654   426 LGTPML--ITQLNMTVL 440
Cdd:pfam00028  76 SGGPPLssTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
576-662 1.57e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   576 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSAT 655
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 11036654   656 ATLHVLL 662
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
143-234 3.67e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654   143 VSESSPPGTTFPLKNAEDLDVGQN-NIENYIISPNSY--FRVLTRKRsdgrkypELVLDKALDREEEAELRLTLTALDGG 219
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNgRIFYSILGGGPGgnFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 11036654   220 SPPRSGTAQVYIEVL 234
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-130 1.93e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.45  E-value: 1.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654  31 PRSYSVVEETEGSSFVTNL-AKDLGLEqrEFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTepcvlrFQV 109
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVsATDPDSG--ENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYT------LTV 72

                        90       100
                ....*....|....*....|....*.
gi 11036654 110 L-----LESPFEFFQAELQVIDINDH 130
Cdd:cd11304  73 TatdggGPPLSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-447 4.98e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 37.32  E-value: 4.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11036654 353 FTSPIPENAPETVVALFSVSDLDSGENGKISCSIQEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLI 432
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQ 83

                        90
                ....*....|....*
gi 11036654 433 TQLNMTVLIADVNDN 447
Cdd:cd00031  84 TSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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