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Conserved domains on  [gi|45238858|ref|NP_061918|]
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WD repeat-containing protein 44 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 510-857 3.63e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 3.63e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 510 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 589
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 590 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 667
Cdd:cd00200  47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 668 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 747
Cdd:cd00200 113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 748 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 824
Cdd:cd00200 183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                       330       340       350
                ....*....|....*....|....*....|...
gi 45238858 825 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 857
Cdd:cd00200 254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 510-857 3.63e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 3.63e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 510 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 589
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 590 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 667
Cdd:cd00200  47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 668 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 747
Cdd:cd00200 113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 748 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 824
Cdd:cd00200 183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                       330       340       350
                ....*....|....*....|....*....|...
gi 45238858 825 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 857
Cdd:cd00200 254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
495-815 4.06e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.06e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 495 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 574
Cdd:COG2319 147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 575 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 652
Cdd:COG2319 190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 653 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 732
Cdd:COG2319 252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 733 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 809
Cdd:COG2319 324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                ....*.
gi 45238858 810 VYIWST 815
Cdd:COG2319 396 VRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 638-676 1.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 45238858    638 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 676
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
638-676 6.74e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 45238858   638 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 676
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 596-684 2.69e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858  596 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHISR--------RECLCCFQ-HIDFVTAIAFHPRDDRYFL 664
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMC 142

                         90       100
                 ....*....|....*....|
gi 45238858  665 SGSLDGKLRLWNIPDKKVAL 684
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEKRAF 162
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 510-857 3.63e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 3.63e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 510 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 589
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------------------------------------DLETGELLRT----- 46

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 590 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPrDDRYFLSGS 667
Cdd:cd00200  47 -------------LKGHTGPVRDVAASADgTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSP-DGRILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 668 LDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRNKVgrkITG 747
Cdd:cd00200 113 RDKTIKVWDVETGKCLT--TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLTGHTGE---VNS 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 748 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTS 824
Cdd:cd00200 183 VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS-----VAFSPDGYLLASGSEDGTIRVW----DLRTGEC 253

                       330       340       350
                ....*....|....*....|....*....|...
gi 45238858 825 VRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 857
Cdd:cd00200 254 VQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
495-815 4.06e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.06e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 495 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 574
Cdd:COG2319 147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 575 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 652
Cdd:COG2319 190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 653 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 732
Cdd:COG2319 252 VAFSP-DGRLLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-----TGKLL 323

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 733 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKY 809
Cdd:COG2319 324 RTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgAVTS-----VAFSPDGRTLASGSADGT 395


                ....*.
gi 45238858 810 VYIWST 815
Cdd:COG2319 396 VRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
495-857 7.55e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 7.55e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 495 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 574
Cdd:COG2319 105 WDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLW------------------------------------ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 575 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 652
Cdd:COG2319 148 DLATGKLLRT------------------LTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRS 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 653 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVALwnEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 732
Cdd:COG2319 210 VAFSP-DGKLLASGSADGTVRLWDLATGKLLR--TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-----TGELL 281

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 733 RSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYI 812
Cdd:COG2319 282 RTLTGHS---GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRL 356

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 45238858 813 WstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 857
Cdd:COG2319 357 W----DLATGELLRT--------LTGHTGAVTSVAFSPDGRTLAS 389
WD40 COG2319
WD40 repeat [General function prediction only];
510-857 2.85e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 2.85e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 510 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssksDTDTGVCSGTdedpd 589
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLW------------------------------------DLATGLLLRT----- 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 590 dknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGS 667
Cdd:COG2319 116 -------------LTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 668 LDGKLRLWNIPDKKvaLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHVRSTRGRnkvGRKITG 747
Cdd:COG2319 182 DDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLRTLTGH---SGSVRS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 748 IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRr 827
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLW----DLATGKLLR- 324

                       330       340       350
                ....*....|....*....|....*....|
gi 45238858 828 drndfweGIKAHNAVVTSAIFAPNPSLMLS 857
Cdd:COG2319 325 -------TLTGHTGAVRSVAFSPDGKTLAS 347
WD40 COG2319
WD40 repeat [General function prediction only];
495-773 2.08e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 2.08e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 495 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 574
Cdd:COG2319 189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLW------------------------------------ 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 575 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 652
Cdd:COG2319 232 DLATGKLLRT------------------LTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNS 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 653 IAFHPrDDRYFLSGSLDGKLRLWNIPDKKVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEhlkyhTQIHV 732
Cdd:COG2319 294 VAFSP-DGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-----TGELL 365

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 45238858 733 RSTRGRnkvGRKITGIEPLPGENKILVTSNDSRIRLYDLRD 773
Cdd:COG2319 366 RTLTGH---TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
605-857 1.35e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 1.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 605 GHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDKKv 682
Cdd:COG2319  76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGK- 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 683 aLWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKyhtqiHVRSTRGRNKVgrkITGIEPLPGENKILVTSN 762
Cdd:COG2319 154 -LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----LLRTLTGHTGA---VRSVAFSPDGKLLASGSA 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 763 DSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAV 842
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSV--AFSPDGRLLASGSADGTVRLW----DLATGELLRT--------LTGHSGG 290

                       250
                ....*....|....*
gi 45238858 843 VTSAIFAPNPSLMLS 857
Cdd:COG2319 291 VNSVAFSPDGKLLAS 305
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 603-905 1.19e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.03  E-value: 1.19e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 603 YKGHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWNIPDK 680
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 681 KVAlwNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYhtqihVRSTRGRNkvgrkitgieplpgenkilvt 760
Cdd:cd00200  84 ECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-----LTTLRGHT--------------------- 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 761 sndsrirlydlrdlslsmkykGYVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHN 840
Cdd:cd00200 136 ---------------------DWVNS-----VAFSPDGTFVASSSQDGTIKLW----DLRTGKCVAT--------LTGHT 177

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45238858 841 AVVTSAIFAPNPSLMLS---------LDVQSEKSEGNEKSEDAEVLDATPSgimktDNTEVLLSADFTGAIKVF 905
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSsssdgtiklWDLSTGKCLGTLRGHENGVNSVAFS-----PDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 687-905 6.50e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 6.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 687 EVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDTEHLKYHTQIHVRStrgrnkvgRKITGIEPLPGENKILVTSNDSRI 766
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 767 RLYDLRDLSLSMKYKG---YVNSssqikASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVV 843
Cdd:cd00200  76 RLWDLETGECVRTLTGhtsYVSS-----VAFSPDGRILSSSSRDKTIKVW----DVETGKCLTT--------LRGHTDWV 138

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45238858 844 TSAIFAPNPSLMLS---------LDVQSEKSEGNEKSEDAEVLDATPSGimktDNTEVLLSADfTGAIKVF 905
Cdd:cd00200 139 NSVAFSPDGTFVASssqdgtiklWDLRTGKCVATLTGHTGEVNSVAFSP----DGEKLLSSSS-DGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 638-676 1.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 45238858    638 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 676
Cdd:smart00320   2 GELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 501-538 2.67e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 45238858    501 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 538
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
638-676 6.74e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 45238858   638 RECLCCFQ-HIDFVTAIAFHPrDDRYFLSGSLDGKLRLWN 676
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 596-684 2.69e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 2.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858  596 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHISR--------RECLCCFQ-HIDFVTAIAFHPRDDRYFL 664
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEIPHndesvkeiKDPQCILKgHKKKISIIDWNPMNYYIMC 142

                         90       100
                 ....*....|....*....|
gi 45238858  665 SGSLDGKLRLWNIPDKKVAL 684
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEKRAF 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 598-634 3.93e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.93e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 45238858    598 RPFCKYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWH 634
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 623-817 3.98e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858  623 SSSMDKTVRLWHISRRECLCCF-QHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIpDKKVALwnevdGQTKliTAANFC 701
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMkEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVSI-----GTIK--TKANIC 621

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858  702 ------QNGKYAVIGTYDGRCIFYDTEHLKyhtqIHVRSTRGRNKVGRKITGIEplpgENKILVTSNDSRIRLYDLrDLS 775
Cdd:PLN00181 622 cvqfpsESGRSLAFGSADHKVYYYDLRNPK----LPLCTMIGHSKTVSYVRFVD----SSTLVSSSTDNTLKLWDL-SMS 692

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 45238858  776 LS-------MKYKGYVNSSSQIKASFSHDftYLVSGSEDKYVYIwstYH 817
Cdd:PLN00181 693 ISginetplHSFMGHTNVKNFVGLSVSDG--YIATGSETNEVFV---YH 736
WD40 pfam00400
WD domain, G-beta repeat;
501-538 4.67e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.67e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 45238858   501 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 538
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
602-633 1.20e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.20e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 45238858   602 KYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLW 633
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 781-814 4.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 45238858    781 KGYVNSssqikASFSHDFTYLVSGSEDKYVYIWS 814
Cdd:smart00320  12 TGPVTS-----VAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 659-815 4.86e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 40.29  E-value: 4.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 659 DDRYFLSGsldGK---LRLWNIPDKKVALW-------NEVDGQTKL-ITAANFcqngkyavIGTYDGRCIFYDTEHlkyH 727
Cdd:cd22857 137 NENYFAFG---GKeveLNVWDLEEKPGKIWraknvpnDSLGLRVPVwVTDLTF--------LSKDDHRKIVTGTGY---H 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45238858 728 tQIHVRSTR-GR----NKVGRK--ITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYvnSSSQIKASFSH-DFT 799
Cdd:cd22857 203 -QVRLYDTRaQRrpvvSVDFGEtpIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGK--CGGSIRSIARHpELP 279

                       170
                ....*....|....*.
gi 45238858 800 YLVSGSEDKYVYIWST 815
Cdd:cd22857 280 LIASCGLDRYLRIWDT 295
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 495-539 8.33e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 8.33e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 45238858 495 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWA 539
Cdd:cd00200 246 WDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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