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Conserved domains on  [gi|145301603|ref|NP_062394|]
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growth arrest-specific protein 6 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 295-447 9.75e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.52  E-value: 9.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603 295 GRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRyNGVGRIT-SSGPTINH 373
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYD-LGSGSLVlSSKTPLND 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145301603 374 GMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLErglYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNW 447
Cdd:cd00110   80 GQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLN---LDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 26-90 1.33e-25

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


:

Pssm-ID: 214503  Cd Length: 65  Bit Score: 100.08  E-value: 1.33e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145301603    26 HTVLLRAREAAQFLRpRQRRAYQV-FEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQ 90
Cdd:smart00069   1 GSVFLSRQEANKVLR-RQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
LamG smart00282
Laminin G domain;
509-647 7.58e-13

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.82  E-value: 7.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603   509 RIRPATDTGVLLALVGDDDVVPISVALVDyhstkklkKQLVV---LAVEDVALALMEIKVCDSQEHTVTVSLREGEATLE 585
Cdd:smart00282   5 SFRTTSPNGLLLYAGSKGGGDYLALELRD--------GRLVLrydLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLS 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145301603   586 VDGTKGQSEVSTAQLQeRLDtLKTHLqgsvhtYVGGLPEVSVISA-PVTAFYRGCM-TLEVNGK 647
Cdd:smart00282  77 VDGGNRVSGESPGGLT-ILN-LDGPL------YLGGLPEDLKLPPlPVTPGFRGCIrNLKVNGK 132
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 157-192 1.30e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 1.30e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145301603  157 CVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTC 192
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-225 6.16e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 6.16e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 145301603   194 DIDECTDSDTCG-DARCKNLPGSYSCLCDEGYT 225
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 244-274 8.75e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 8.75e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 145301603  244 CEQTCVNSPGSYTCHCdgRGGLKLSPDMDTC 274
Cdd:pfam14670   8 CSHLCLNTPGGYTCSC--PEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 295-447 9.75e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.52  E-value: 9.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603 295 GRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRyNGVGRIT-SSGPTINH 373
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYD-LGSGSLVlSSKTPLND 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145301603 374 GMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLErglYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNW 447
Cdd:cd00110   80 GQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLN---LDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
319-451 5.75e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 106.27  E-value: 5.75e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603   319 EFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRY-NGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAV 397
Cdd:smart00282   3 SFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGNR 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 145301603   398 MKIAVAGELFQLERglyHLNLTVGGIPFKESELVQPINPRLDGCMRSWnWLNGE 451
Cdd:smart00282  83 VSGESPGGLTILNL---DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNL-KVNGK 132
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 26-90 1.33e-25

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 100.08  E-value: 1.33e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145301603    26 HTVLLRAREAAQFLRpRQRRAYQV-FEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQ 90
Cdd:smart00069   1 GSVFLSRQEANKVLR-RQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
Laminin_G_1 pfam00054
Laminin G domain;
322-449 2.08e-23

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 96.23  E-value: 2.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  322 FRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRyNGVGRI-TSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKI 400
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYD-LGSGAAvVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 145301603  401 A-VAGELFQL--ERGLYhlnltVGGIP-FKESELVQPINPRLDGCMRSWNWLN 449
Cdd:pfam00054  80 EsPLGATTDLdvDGPLY-----VGGLPsLGVKKRRLAISPSFDGCIRDVIVNG 127
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 50-89 1.27e-20

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 85.28  E-value: 1.27e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145301603   50 FEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRY 89
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
LamG smart00282
Laminin G domain;
509-647 7.58e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.82  E-value: 7.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603   509 RIRPATDTGVLLALVGDDDVVPISVALVDyhstkklkKQLVV---LAVEDVALALMEIKVCDSQEHTVTVSLREGEATLE 585
Cdd:smart00282   5 SFRTTSPNGLLLYAGSKGGGDYLALELRD--------GRLVLrydLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLS 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145301603   586 VDGTKGQSEVSTAQLQeRLDtLKTHLqgsvhtYVGGLPEVSVISA-PVTAFYRGCM-TLEVNGK 647
Cdd:smart00282  77 VDGGNRVSGESPGGLT-ILN-LDGPL------YLGGLPEDLKLPPlPVTPGFRGCIrNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 510-647 3.31e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 60.90  E-value: 3.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  510 IRPATDTGVLLaLVGDDDVVPISVALVDyhstKKLKKQlVVLAVEDVALALMEIKVCDSQEHTVTVSLREGEATLEVDGt 589
Cdd:pfam02210   1 FRTRQPNGLLL-YAGGGGSDFLALELVN----GRLVLR-YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDG- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  590 kgqSEVSTAQLQERLDTLKTHLQgsvhTYVGGLPEVSVISA-PVTAFYRGCM-TLEVNGK 647
Cdd:pfam02210  74 ---QTVVSSLPPGESLLLNLNGP----LYLGGLPPLLLLPAlPVRAGFVGCIrDVRVNGE 126
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 157-192 1.30e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 1.30e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145301603  157 CVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTC 192
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 474-640 2.80e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 58.97  E-value: 2.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603 474 GSFFPGNGFATYRlnytrTSLDVGTETTWEVkvvaRIRPATDTGVLLALVGDDDVVPISVALVDYHstkklkkqlVVLAV 553
Cdd:cd00110    1 GVSFSGSSYVRLP-----TLPAPRTRLSISF----SFRTTSPNGLLLYAGSQNGGDFLALELEDGR---------LVLRY 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603 554 EDVALALM---EIKVCDSQEHTVTVSLREGEATLEVDGTKgQSEVSTAQLQERLDTlKTHLqgsvhtYVGGLPEVS-VIS 629
Cdd:cd00110   63 DLGSGSLVlssKTPLNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNL-DGPL------YLGGLPEDLkSPG 134

                        170
                 ....*....|.
gi 145301603 630 APVTAFYRGCM 640
Cdd:cd00110  135 LPVSPGFVGCI 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-225 6.16e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 6.16e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 145301603   194 DIDECTDSDTCG-DARCKNLPGSYSCLCDEGYT 225
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 194-234 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.06e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 145301603 194 DIDECTDSDTCG-DARCKNLPGSYSCLCDEGYTYsskeKTCQ 234
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG----RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-193 1.32e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 1.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 145301603   153 DVNECVQKNGgCSQ--VCHNKPGSFQCACHSGFslaSDGQTCQ 193
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 153-193 1.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.49e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 145301603 153 DVNECVQKNG-GCSQVCHNKPGSFQCACHSGFSlasdGQTCQ 193
Cdd:cd00054    1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 244-274 8.75e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 8.75e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 145301603  244 CEQTCVNSPGSYTCHCdgRGGLKLSPDMDTC 274
Cdd:pfam14670   8 CSHLCLNTPGGYTCSC--PEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
235-260 3.47e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 3.47e-04
                           10        20
                   ....*....|....*....|....*....
gi 145301603   235 DVDECQQD---RCEQTCVNSPGSYTCHCD 260
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECP 29
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 229-270 6.54e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.60  E-value: 6.54e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 145301603 229 KEKTCQDVDECQQDR--CEQTCVNSPGSYTCHCdgRGGLKLSPD 270
Cdd:cd01475  180 QGKICVVPDLCATLShvCQQVCISTPGSYLCAC--TEGYALLED 221
EGF_CA pfam07645
Calcium-binding EGF domain;
194-223 1.89e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 145301603  194 DIDECTD-SDTC-GDARCKNLPGSYSCLCDEG 223
Cdd:pfam07645   1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 295-447 9.75e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.52  E-value: 9.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603 295 GRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRyNGVGRIT-SSGPTINH 373
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYD-LGSGSLVlSSKTPLND 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145301603 374 GMWQTISVEELERNLVIKVNKDAVMKIAVAGELFQLErglYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNW 447
Cdd:cd00110   80 GQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLN---LDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
319-451 5.75e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 106.27  E-value: 5.75e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603   319 EFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRY-NGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAV 397
Cdd:smart00282   3 SFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGNR 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 145301603   398 MKIAVAGELFQLERglyHLNLTVGGIPFKESELVQPINPRLDGCMRSWnWLNGE 451
Cdd:smart00282  83 VSGESPGGLTILNL---DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNL-KVNGK 132
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 26-90 1.33e-25

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 100.08  E-value: 1.33e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145301603    26 HTVLLRAREAAQFLRpRQRRAYQV-FEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQ 90
Cdd:smart00069   1 GSVFLSRQEANKVLR-RQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
Laminin_G_1 pfam00054
Laminin G domain;
322-449 2.08e-23

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 96.23  E-value: 2.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  322 FRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRyNGVGRI-TSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKI 400
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYD-LGSGAAvVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 145301603  401 A-VAGELFQL--ERGLYhlnltVGGIP-FKESELVQPINPRLDGCMRSWNWLN 449
Cdd:pfam00054  80 EsPLGATTDLdvDGPLY-----VGGLPsLGVKKRRLAISPSFDGCIRDVIVNG 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 322-451 4.72e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 4.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  322 FRTFDPEGVLFFAGGrSDSTWIVLGLRAGRLELQLRY-NGVGRITSSGPTINHGMWQTISVEELERNLVIKVNKDAVMKI 400
Cdd:pfam02210   1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLgSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 145301603  401 AVAGE--LFQLERGLYhlnltVGGIPFKESELVQPINPRLDGCMRSWNwLNGE 451
Cdd:pfam02210  80 LPPGEslLLNLNGPLY-----LGGLPPLLLLPALPVRAGFVGCIRDVR-VNGE 126
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 50-89 1.27e-20

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 85.28  E-value: 1.27e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 145301603   50 FEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRY 89
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
LamG smart00282
Laminin G domain;
509-647 7.58e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.82  E-value: 7.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603   509 RIRPATDTGVLLALVGDDDVVPISVALVDyhstkklkKQLVV---LAVEDVALALMEIKVCDSQEHTVTVSLREGEATLE 585
Cdd:smart00282   5 SFRTTSPNGLLLYAGSKGGGDYLALELRD--------GRLVLrydLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLS 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145301603   586 VDGTKGQSEVSTAQLQeRLDtLKTHLqgsvhtYVGGLPEVSVISA-PVTAFYRGCM-TLEVNGK 647
Cdd:smart00282  77 VDGGNRVSGESPGGLT-ILN-LDGPL------YLGGLPEDLKLPPlPVTPGFRGCIrNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 510-647 3.31e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 60.90  E-value: 3.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  510 IRPATDTGVLLaLVGDDDVVPISVALVDyhstKKLKKQlVVLAVEDVALALMEIKVCDSQEHTVTVSLREGEATLEVDGt 589
Cdd:pfam02210   1 FRTRQPNGLLL-YAGGGGSDFLALELVN----GRLVLR-YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDG- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  590 kgqSEVSTAQLQERLDTLKTHLQgsvhTYVGGLPEVSVISA-PVTAFYRGCM-TLEVNGK 647
Cdd:pfam02210  74 ---QTVVSSLPPGESLLLNLNGP----LYLGGLPPLLLLPAlPVRAGFVGCIrDVRVNGE 126
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 157-192 1.30e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 1.30e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145301603  157 CVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQTC 192
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 474-640 2.80e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 58.97  E-value: 2.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603 474 GSFFPGNGFATYRlnytrTSLDVGTETTWEVkvvaRIRPATDTGVLLALVGDDDVVPISVALVDYHstkklkkqlVVLAV 553
Cdd:cd00110    1 GVSFSGSSYVRLP-----TLPAPRTRLSISF----SFRTTSPNGLLLYAGSQNGGDFLALELEDGR---------LVLRY 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603 554 EDVALALM---EIKVCDSQEHTVTVSLREGEATLEVDGTKgQSEVSTAQLQERLDTlKTHLqgsvhtYVGGLPEVS-VIS 629
Cdd:cd00110   63 DLGSGSLVlssKTPLNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNL-DGPL------YLGGLPEDLkSPG 134

                        170
                 ....*....|.
gi 145301603 630 APVTAFYRGCM 640
Cdd:cd00110  135 LPVSPGFVGCI 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-225 6.16e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 6.16e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 145301603   194 DIDECTDSDTCG-DARCKNLPGSYSCLCDEGYT 225
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 194-234 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 1.06e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 145301603 194 DIDECTDSDTCG-DARCKNLPGSYSCLCDEGYTYsskeKTCQ 234
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG----RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-193 1.32e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 1.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 145301603   153 DVNECVQKNGgCSQ--VCHNKPGSFQCACHSGFslaSDGQTCQ 193
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 176-197 8.72e-06

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 42.78  E-value: 8.72e-06
                          10        20
                  ....*....|....*....|..
gi 145301603  176 QCACHSGFSLASDGQTCQDIDE 197
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 157-192 1.03e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.59  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145301603  157 CVQKNGGCSQ--VCHNKPGSFQCACHSGFSLasDGQTC 192
Cdd:pfam12947   1 CSDNNGGCHPnaTCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 153-193 1.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.49e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 145301603 153 DVNECVQKNG-GCSQVCHNKPGSFQCACHSGFSlasdGQTCQ 193
Cdd:cd00054    1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 244-274 8.75e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 8.75e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 145301603  244 CEQTCVNSPGSYTCHCdgRGGLKLSPDMDTC 274
Cdd:pfam14670   8 CSHLCLNTPGGYTCSC--PEGYELQDDGRTC 36
EGF smart00181
Epidermal growth factor-like domain;
197-234 1.33e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 39.42  E-value: 1.33e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 145301603   197 ECTDSDTCGDARCKNLPGSYSCLCDEGYTYSskeKTCQ 234
Cdd:smart00181   1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGD---KRCE 35
Laminin_G_1 pfam00054
Laminin G domain;
510-650 1.59e-04

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603  510 IRPATDTGVLLALVGDDDVVPISVALVD----YHStkKLKKQLVVLAVEDvalalmeiKVCDSQEHTVTVSLREGEATLE 585
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDgrleVSY--DLGSGAAVVRSGD--------KLNDGKWHSVELERNGRSGTLS 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145301603  586 VDGT---KGQSEVSTAQlqeRLDtLKTHLqgsvhtYVGGLPEVSV---ISAPVTAFyRGCM-TLEVNGKILD 650
Cdd:pfam00054  71 VDGEarpTGESPLGATT---DLD-VDGPL------YVGGLPSLGVkkrRLAISPSF-DGCIrDVIVNGKPLD 131
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 147-191 1.81e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 1.81e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 145301603 147 GRLCdKDVNECVQKNGGCSQVCHNKPGSFQCACHSGFSLASDGQT 191
Cdd:cd01475  181 GKIC-VVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
235-260 3.47e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 3.47e-04
                           10        20
                   ....*....|....*....|....*....
gi 145301603   235 DVDECQQD---RCEQTCVNSPGSYTCHCD 260
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECP 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 197-234 4.45e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 4.45e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 145301603 197 ECTDSDTCG-DARCKNLPGSYSCLCDEGYTYSskeKTCQ 234
Cdd:cd00053    1 ECAASNPCSnGGTCVNTPGSYRCVCPPGYTGD---RSCE 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 229-270 6.54e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.60  E-value: 6.54e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 145301603 229 KEKTCQDVDECQQDR--CEQTCVNSPGSYTCHCdgRGGLKLSPD 270
Cdd:cd01475  180 QGKICVVPDLCATLShvCQQVCISTPGSYLCAC--TEGYALLED 221
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 235-260 1.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.22e-03
                         10        20
                 ....*....|....*....|....*....
gi 145301603 235 DVDECQQD---RCEQTCVNSPGSYTCHCD 260
Cdd:cd00054    1 DIDECASGnpcQNGGTCVNTVGSYRCSCP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
194-223 1.89e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 145301603  194 DIDECTD-SDTC-GDARCKNLPGSYSCLCDEG 223
Cdd:pfam07645   1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
153-182 3.18e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 3.18e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 145301603  153 DVNECVQKNGGCSQ--VCHNKPGSFQCACHSG 182
Cdd:pfam07645   1 DVDECATGTHNCPAntVCVNTIGSFECRCPDG 32
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 478-631 4.15e-03

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 38.88  E-value: 4.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603   478 PGNGFATYRLNY-------TRTSLDVGTETTWEVKVVARIRPaTDTGVLLALVGDDDVVPISVAL------VDYHSTKKL 544
Cdd:smart00210  23 PEPGSPAYRLGDpalvpqpTRDLFPSGLPEDFSLLTTFRQTP-KSRGVLFAIYDAQNVRQFGLEVdgrantLLLRYQGVD 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145301603   545 KKQLVVlAVEDVALAlmeikvcDSQEHTVTVSLREGEATLEVDGTKGQSEVSTAQLQERLDTLKTHL---QGSVHTYVGG 621
Cdd:smart00210 102 GKQHTV-SFRNLPLA-------DGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVrgaQAADRKPFQG 173

                          170
                   ....*....|.
gi 145301603   622 -LPEVSVISAP 631
Cdd:smart00210 174 dLQQLKIVCDP 184
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 199-225 6.08e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 34.88  E-value: 6.08e-03
                          10        20
                  ....*....|....*....|....*...
gi 145301603  199 TDSDTCG-DARCKNLPGSYSCLCDEGYT 225
Cdd:pfam12947   3 DNNGGCHpNATCTNTGGSFTCTCNDGYT 30
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 209-233 6.98e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 34.53  E-value: 6.98e-03
                          10        20
                  ....*....|....*....|....*
gi 145301603  209 CKNLPGSYSCLCDEGYTYSSKEKTC 233
Cdd:pfam14670  12 CLNTPGGYTCSCPEGYELQDDGRTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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