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Conserved domains on  [gi|83816974|ref|NP_062627|]
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WD repeat and SOCS box-containing protein 1 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-378 6.75e-64

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 6.75e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  38 WTVAFAPDGSYFAWSQGYRIVKLvpWsqcrknfllhgskNVTNSSCLKLARQNSNGgqknkppehvidcgdiVWSLAFGS 117
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRL--W-------------DLATGKLLRTLTGHSGA----------------VTSVAFSP 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 118 SvpekqsrcvniewhrfrfGQdqlLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRV 197
Cdd:COG2319 173 D------------------GK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 198 WDLkDDGNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277
Cdd:COG2319 231 WDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 278 TRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG-- 354
Cdd:COG2319 310 GTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGav 375

                       330       340
                ....*....|....*....|....
gi 83816974 355 LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLW 399
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 382-420 4.24e-20

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03746:

Pssm-ID: 470605  Cd Length: 40  Bit Score: 82.94  E-value: 4.24e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 83816974 382 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYR 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-378 6.75e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 6.75e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  38 WTVAFAPDGSYFAWSQGYRIVKLvpWsqcrknfllhgskNVTNSSCLKLARQNSNGgqknkppehvidcgdiVWSLAFGS 117
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRL--W-------------DLATGKLLRTLTGHSGA----------------VTSVAFSP 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 118 SvpekqsrcvniewhrfrfGQdqlLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRV 197
Cdd:COG2319 173 D------------------GK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 198 WDLkDDGNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277
Cdd:COG2319 231 WDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 278 TRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG-- 354
Cdd:COG2319 310 GTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGav 375

                       330       340
                ....*....|....*....|....
gi 83816974 355 LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-388 9.43e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 183.31  E-value: 9.43e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRVWDLKDdGNMVKVLRAHQ 214
Cdd:cd00200  16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL-ASGSSDKTIRLWDLET-GECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 215 NWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF 294
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 295 -GHlfpsptpifagganDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTH 371
Cdd:cd00200 174 tGH--------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYLLASGSE 239

                       250
                ....*....|....*....
gi 83816974 372 DGSVYFW--ATPRQVPSLQ 388
Cdd:cd00200 240 DGTIRVWdlRTGECVQTLS 258
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 382-420 4.24e-20

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 82.94  E-value: 4.24e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 83816974 382 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 378-420 2.27e-15

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.63  E-value: 2.27e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 83816974    378 WATPRQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 175-291 8.94e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 8.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  175 DLTFAPDGSLLLVSASRDKTLRVWDLKDDG-------NMVKvLRAHQNWVYSCAFSPDC-SMLCSVGASKAVFLWNMDKY 246
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGltqnisdPIVH-LQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERG 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 83816974  247 TMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLL 291
Cdd:PTZ00421 159 KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 2.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.16e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 83816974    249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 2.39e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.39e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 83816974   249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 383-417 4.60e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.00  E-value: 4.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 83816974   383 QVPSLQHICRMSIRRVMST---QEVQKLPVPSKILAFL 417
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-378 6.75e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 6.75e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  38 WTVAFAPDGSYFAWSQGYRIVKLvpWsqcrknfllhgskNVTNSSCLKLARQNSNGgqknkppehvidcgdiVWSLAFGS 117
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRL--W-------------DLATGKLLRTLTGHSGA----------------VTSVAFSP 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 118 SvpekqsrcvniewhrfrfGQdqlLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRV 197
Cdd:COG2319 173 D------------------GK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 198 WDLkDDGNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277
Cdd:COG2319 231 WDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 278 TRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG-- 354
Cdd:COG2319 310 GTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGav 375

                       330       340
                ....*....|....*....|....
gi 83816974 355 LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
136-388 4.36e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 200.52  E-value: 4.36e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRVWDLkDDGNMVKVLRAHQN 215
Cdd:COG2319  86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL-ASGSADGTVRLWDL-ATGKLLRTLTGHSG 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 216 WVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEFG 295
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 296 HlfpsptpifaggaNDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG 373
Cdd:COG2319 244 G-------------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDG 310

                       250
                ....*....|....*..
gi 83816974 374 SVYFW--ATPRQVPSLQ 388
Cdd:COG2319 311 TVRLWdlATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-388 9.43e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 183.31  E-value: 9.43e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRVWDLKDdGNMVKVLRAHQ 214
Cdd:cd00200  16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL-ASGSSDKTIRLWDLET-GECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 215 NWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF 294
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 295 -GHlfpsptpifagganDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTH 371
Cdd:cd00200 174 tGH--------------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYLLASGSE 239

                       250
                ....*....|....*....
gi 83816974 372 DGSVYFW--ATPRQVPSLQ 388
Cdd:cd00200 240 DGTIRVWdlRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
133-389 1.51e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.88  E-value: 1.51e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 133 RFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSlLLVSASRDKTLRVWDLkDDGNMVKVLRA 212
Cdd:COG2319  41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDL-ATGLLLRTLTG 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 213 HQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLM 292
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 293 EF-GHlfpsptpifagganDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAG 369
Cdd:COG2319 199 TLtGH--------------TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASG 264

                       250       260
                ....*....|....*....|..
gi 83816974 370 THDGSVYFW--ATPRQVPSLQH 389
Cdd:COG2319 265 SADGTVRLWdlATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
38-287 3.62e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 3.62e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  38 WTVAFAPDGSYFAWSQGYRIVKLvpWsqcrknfllhgskNVTNSSCLKLarqnsnggqknkPPEHvidcGDIVWSLAFGS 117
Cdd:COG2319 208 RSVAFSPDGKLLASGSADGTVRL--W-------------DLATGKLLRT------------LTGH----SGSVRSVAFSP 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 118 svpekqsrcvniewhrfrfgqDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRV 197
Cdd:COG2319 257 ---------------------DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 198 WDLkDDGNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277
Cdd:COG2319 315 WDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                       250
                ....*....|
gi 83816974 278 TRVYVWDPHN 287
Cdd:COG2319 394 GTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
135-389 7.06e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 7.06e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGsLLLVSASRDKTLRVWDLkDDGNMVKVLRAHQ 214
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDA-AAGALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 215 NWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF 294
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 295 -GHlfpsptpifagganDRWVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTH 371
Cdd:COG2319 159 tGH--------------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGavRSVAFSPDGKLLASGSA 224

                       250       260
                ....*....|....*....|
gi 83816974 372 DGSVYFW--ATPRQVPSLQH 389
Cdd:COG2319 225 DGTVRLWdlATGKLLRTLTG 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-284 2.72e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.38  E-value: 2.72e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLLVSASrDKTLRVWDLkDDGNMVKVLRAHQ 214
Cdd:cd00200 142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDL-STGKCLGTLRGHE 219

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 215 NWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 284
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-378 9.91e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 9.91e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 206 MVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDP 285
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 286 HNGDLLMEF-GHLFP------SPT-PIFAGGANDR---------------------WVRAVSFSHDGLHVASLADDKMVR 336
Cdd:cd00200  81 ETGECVRTLtGHTSYvssvafSPDgRILSSSSRDKtikvwdvetgkclttlrghtdWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 83816974 337 FWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378
Cdd:cd00200 161 LWDLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDGTIKLW 204
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 382-420 4.24e-20

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 82.94  E-value: 4.24e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 83816974 382 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYR 39
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 382-420 8.72e-19

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 79.00  E-value: 8.72e-19
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 83816974 382 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 378-420 2.27e-15

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 69.63  E-value: 2.27e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 83816974    378 WATPRQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 383-420 1.23e-09

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 53.24  E-value: 1.23e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 83816974 383 QVPSLQHICRMSIRRVM---STQEVQKLPVPSKILAFLSYR 420
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 382-420 7.67e-09

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 51.05  E-value: 7.67e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 83816974 382 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:cd03745   1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 383-420 1.09e-08

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 50.67  E-value: 1.09e-08
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 83816974 383 QVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 420
Cdd:cd03717   2 SVRSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
PTZ00421 PTZ00421
coronin; Provisional
 175-291 8.94e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.13  E-value: 8.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  175 DLTFAPDGSLLLVSASRDKTLRVWDLKDDG-------NMVKvLRAHQNWVYSCAFSPDC-SMLCSVGASKAVFLWNMDKY 246
Cdd:PTZ00421  80 DVAFNPFDPQKLFTASEDGTIMGWGIPEEGltqnisdPIVH-LQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERG 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 83816974  247 TMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLL 291
Cdd:PTZ00421 159 KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 249-284 2.16e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.16e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 83816974    249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 284
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-284 2.39e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.39e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 83816974   249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 284
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 385-420 2.64e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.63  E-value: 2.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 83816974    385 PSLQHICRMSIRRVMSTqeVQKLPVPSKILAFLSYR 420
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--IDKLPLPPRLKDYLLYY 34
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
142-288 2.89e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 2.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 142 LLATGLNNGRIKIWDVYTGKLLlNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKdDGNMVKVLRAHqNWVYSCA 221
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVV-ATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTA-TGKVVATIPVG-AGPHGIA 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 222 FSPDCSML--CSVGA---SKAVFLWNMDKYTMIRKLEGHHHdVVACDFSPDGALLATASYDT--------RVYVWDPHNG 288
Cdd:COG3391 159 VDPDGKRLyvANSGSntvSVIVSVIDTATGKVVATIPVGGG-PVGVAVSPDGRRLYVANRGSntsnggsnTVSVIDLATL 237
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 382-420 3.75e-07

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 46.33  E-value: 3.75e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 83816974 382 RQVPSLQHICRMSIRRVM---STQEVQKLPVPSKILAFLSYR 420
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLgrrRLELIKKLPLPPRLKDYLLYE 42
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 383-417 4.60e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.00  E-value: 4.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 83816974   383 QVPSLQHICRMSIRRVMST---QEVQKLPVPSKILAFL 417
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 382-419 2.93e-06

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 43.93  E-value: 2.93e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 83816974 382 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSY 419
Cdd:cd03741   1 KNVQSLQHLCRFVIRKLVRRDHIPALPLPRRLIDYLRE 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 203-242 3.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.56e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 83816974    203 DGNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWN 242
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-199 7.43e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.43e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 83816974    159 TGKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRVWD 199
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 152-259 1.03e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  152 IKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSlLLVSASRDKTLRVWDLKdDGNMVKVLRAHQNW-VYSCAFSPDCSMLC 230
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGS-LLCTTSKDKKLNIIDPR-DGTIVSSVEAHASAkSQRCLWAKRKDLII 227

                         90       100       110
                 ....*....|....*....|....*....|...
gi 83816974  231 SVGASKA----VFLWNmdkytmIRKLEGHHHDV 259
Cdd:PTZ00421 228 TLGCSKSqqrqIMLWD------TRKMASPYSTV 254
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 255-284 2.55e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 2.55e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 83816974   255 HHHDVVAC-DFSPDGALLATASYDTRVYVWD 284
Cdd:pfam20426 122 QHKDVVSCvAVTSDGSILATGSYDTTVMVWE 152
WD40 pfam00400
WD domain, G-beta repeat;
160-199 2.73e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.73e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 83816974   160 GKLLLNLVDHIEMVRDLTFAPDGSLLlVSASRDKTLRVWD 199
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 163-314 2.91e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 2.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  163 LLNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVK-------VLRAHQNWVYSCAFSP-DCSMLCSVGA 234
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIIDWNPmNYYIMCSSGF 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  235 SKAVFLWNMD------KYTMIRKLEGHHHDVvacdfspDGALLATASYDTRVYVWDPHNGDLLMEFghlfpsptPIFAGG 308
Cdd:PTZ00420 147 DSFVNIWDIEnekrafQINMPKKLSSLKWNI-------KGNLLSGTCVGKHMHIIDPRKQEIASSF--------HIHDGG 211


                 ....*...
gi 83816974  309 ANDR--WV 314
Cdd:PTZ00420 212 KNTKniWI 219
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 385-420 3.18e-05

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 40.99  E-value: 3.18e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 83816974 385 PSLQHICRMSIRRVmsTQEVQKLPVPSKILAFLS-YR 420
Cdd:cd03736   4 PSLQHLCRITINKC--TRQIQELPLPTRLKDYLTeYT 38
WD40 pfam00400
WD domain, G-beta repeat;
204-242 5.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 5.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 83816974   204 GNMVKVLRAHQNWVYSCAFSPDCSMLCSVGASKAVFLWN 242
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 383-417 1.75e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 38.94  E-value: 1.75e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 83816974 383 QVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFL 417
Cdd:cd03740   2 QVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 384-417 2.12e-04

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 38.41  E-value: 2.12e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 83816974 384 VPSLQHICRMSIRRVmsTQEVQKLPVPSKILAFL 417
Cdd:cd03734   3 ARSLQHLCRLVINRL--VTDVDCLPLPRRMADYL 34
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 380-420 3.17e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 38.23  E-value: 3.17e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 83816974 380 TPRqvpSLQHICRMSIRRVMSTQEVQ---KLPVPSKILAFLSYR 420
Cdd:cd03729   2 TPL---SLQQLCRINLRKALGTRALEkiaKLNIPNRIIDYLSYN 42
PTZ00421 PTZ00421
coronin; Provisional
 143-255 3.24e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974  143 LATGLNNGRIKIWDVYTGKLLLNLVDHI-------EMVRDLTFAPDGSLLLVSASRDKTLRVWDLkDDGNMVKVLRAHQN 215
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEEGLTQNISDPIvhlqghtKKVGIVSFHPSAMNVLASAGADMVVNVWDV-ERGKAVEVIKCHSD 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 83816974  216 WVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 142-284 3.54e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.81  E-value: 3.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83816974 142 LLATGLNNGRIKIW--DVYTGKLLlNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRAHQNWVYS 219
Cdd:COG0823   1 LAFTLSRDGNSDIYvvDLDGGEPR-RLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNAS 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 83816974 220 CAFSPDCSML---CSVGASKAVFLWNMDKYTMIRKLEGHHHDVvacdFSPDGALLATASY---DTRVYVWD 284
Cdd:COG0823  80 PSWSPDGKRLafvSRSDGRFDIYVLDLDGGAPRRLTDGPGSPS----WSPDGRRIVFSSDrggRPDLYVVD 146
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 386-420 1.04e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 37.12  E-value: 1.04e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 83816974 386 SLQHICRMSIRRVMSTQEVQ------KLPVPSKILAFLSYR 420
Cdd:cd03731   5 PLKHLCRLKIRKLMGLQKLQqpssmkKLPLPPALKRYILYK 45
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 380-417 2.03e-03

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 35.88  E-value: 2.03e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 83816974 380 TPRqvpSLQHICRMSIRRVMSTQ---EVQKLPVPSKILAFL 417
Cdd:cd03723   2 TPR---SLQHLCRCAIRKLLGSRchkLVPQLSLPTSLKNYL 39
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 384-419 4.51e-03

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 35.15  E-value: 4.51e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 83816974 384 VPSLQHICRMSIR------RVMSTQEVQKLPVPSKILAFLSY 419
Cdd:cd03722   3 VPSLTHLCRLEIRsslkseRLRSDSFICQLPLPRSLQDYLLY 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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