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Conserved domains on  [gi|9790051|ref|NP_062677|]
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ATP-dependent 6-phosphofructokinase, platelet type isoform 1 [Mus musculus]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10092100)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 21-779 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


:

Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1363.74  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   21 GDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAF 100
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  101 RSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGT 180
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  181 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRA 260
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  261 RKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETP 340
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  341 ACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAP 420
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:cd00764 401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  501 ALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 580
Cdd:cd00764 481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  581 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 660
Cdd:cd00764 561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  661 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDF 740
Cdd:cd00764 641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                       730       740       750
                ....*....|....*....|....*....|....*....
gi 9790051  741 EHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQ 779
Cdd:cd00764 721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVT 759
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 21-779 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1363.74  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   21 GDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAF 100
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  101 RSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGT 180
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  181 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRA 260
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  261 RKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETP 340
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  341 ACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAP 420
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:cd00764 401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  501 ALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 580
Cdd:cd00764 481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  581 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 660
Cdd:cd00764 561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  661 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDF 740
Cdd:cd00764 641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                       730       740       750
                ....*....|....*....|....*....|....*....
gi 9790051  741 EHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQ 779
Cdd:cd00764 721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVT 759
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 24-763 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1279.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMT 183
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKK 263
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    264 RLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACV 343
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    344 VSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNC---NVAVINVGAP 420
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    501 ALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 580
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    581 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 660
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    661 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVA-ELKKVTD 739
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720

                         730       740
                  ....*....|....*....|....
gi 9790051    740 FEHRIPKEQWWLKLRPIMKILAKY 763
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGR 744
PFK pfam00365
Phosphofructokinase;
26-329 1.18e-144

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 425.22  E-value: 1.18e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     26 IGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREG 105
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    106 RLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMTIG 185
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    186 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLsENRARKKRL 265
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIE---ELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9790051    266 NIIIVSEGAIDmqnkpitSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 329
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
24-381 1.05e-124

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 375.96  E-value: 1.05e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleeLARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIE---ELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   264 RLNIIIVSEGAIDMqnkpitsEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpETPACV 343
Cdd:PRK03202 214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGGRM 283

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 9790051   344 VSLRGNQAVRLPLMECV-QMTQDVqkamDERRFKEAVKL 381
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPF----DKDLYELAKKL 318
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 24-381 2.17e-122

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 370.94  E-value: 2.17e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:COG0205   2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:COG0205  80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:COG0205 138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLD---KLLEKLKERRKRGK 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  264 RLNIIIVSEGAIDMQNKPI---------------TSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEA 328
Cdd:COG0205 215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 9790051  329 VIALLEatpETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDerRFKEAVKL 381
Cdd:COG0205 295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 21-779 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1363.74  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   21 GDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAF 100
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  101 RSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGT 180
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  181 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRA 260
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  261 RKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETP 340
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  341 ACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAP 420
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:cd00764 401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  501 ALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 580
Cdd:cd00764 481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  581 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 660
Cdd:cd00764 561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  661 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDF 740
Cdd:cd00764 641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                       730       740       750
                ....*....|....*....|....*....|....*....
gi 9790051  741 EHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQ 779
Cdd:cd00764 721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVT 759
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 24-763 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1279.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMT 183
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKK 263
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    264 RLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACV 343
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    344 VSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNC---NVAVINVGAP 420
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    501 ALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 580
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    581 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 660
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    661 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVA-ELKKVTD 739
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720

                         730       740
                  ....*....|....*....|....
gi 9790051    740 FEHRIPKEQWWLKLRPIMKILAKY 763
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGR 744
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 24-380 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 533.41  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:cd00363   1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGlleelarngdidndtvqKYSYLNVVGMVGSIDNDFCGTDMT 183
Cdd:cd00363  79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKK 263
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  264 RLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACV 343
Cdd:cd00363 222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGI 301

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 9790051  344 VSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVK 380
Cdd:cd00363 302 QNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
26-329 1.18e-144

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 425.22  E-value: 1.18e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     26 IGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREG 105
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    106 RLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMTIG 185
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    186 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLsENRARKKRL 265
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIE---ELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9790051    266 NIIIVSEGAIDmqnkpitSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 329
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
24-381 1.05e-124

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 375.96  E-value: 1.05e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleeLARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIE---ELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   264 RLNIIIVSEGAIDMqnkpitsEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpETPACV 343
Cdd:PRK03202 214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGGRM 283

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 9790051   344 VSLRGNQAVRLPLMECV-QMTQDVqkamDERRFKEAVKL 381
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPF----DKDLYELAKKL 318
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 24-381 2.17e-122

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 370.94  E-value: 2.17e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:COG0205   2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:COG0205  80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:COG0205 138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLD---KLLEKLKERRKRGK 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  264 RLNIIIVSEGAIDMQNKPI---------------TSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEA 328
Cdd:COG0205 215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 9790051  329 VIALLEatpETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDerRFKEAVKL 381
Cdd:COG0205 295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 26-358 5.81e-109

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 334.70  E-value: 5.81e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     26 IGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREG 105
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    106 RLKAACNLARLGITNLCVIGGDGSLTGANLFRKEwsglleelarnGDIdndtvqkysylNVVGMVGSIDNDFCGTDMTIG 185
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE-----------GGI-----------PVIGLPGTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    186 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKKRL 265
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKH 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    266 NIIIVSEGAIDMQNKPItSEKIKELVvknlGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETpacVVS 345
Cdd:TIGR02482 215 SIIIVAEGNIVGSAKEV-AKKIEEKT----GIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MIG 286

                         330
                  ....*....|...
gi 9790051    346 LRGNQAVRLPLME 358
Cdd:TIGR02482 287 IQNNKIVTHPIEE 299
PFK pfam00365
Phosphofructokinase;
411-694 4.30e-108

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 331.23  E-value: 4.30e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    411 NVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGK---YL 487
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKteeGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    488 EKIAEQMHSHSINALLIIGGFEAYLGLLELAAAREkheafcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 567
Cdd:pfam00365  81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    568 SASGTkRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIqrglVLRNESCSvnyTTD 647
Cdd:pfam00365 155 TASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRFSI----IVVAEGAS---DGE 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 9790051    648 FIYQLYsEEGKGvFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 694
Cdd:pfam00365 227 FLAKLI-EEGTG-IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 24-370 2.32e-97

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 305.10  E-value: 2.32e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:cd00763   1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleeLARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:cd00763  79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-----------LTEHG------------FPCVGLPGTIDNDIPGTDYT 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEedwEENMCLKLSENRARKK 263
Cdd:cd00763 136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  264 RLNIIIVSEGAIDmqnkpitSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEAtpeTPACV 343
Cdd:cd00763 213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLA 282

                       330       340
                ....*....|....*....|....*..
gi 9790051  344 VSLRGNQAVRLPLMECVQMTQDVQKAM 370
Cdd:cd00763 283 VGIQNEQLVHHDIIDAIENMKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 26-360 3.60e-83

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 268.02  E-value: 3.60e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     26 IGVLTSGGDAQGMNAAVRAVVRMGIYT-GAKVYFIYEGYQGLVDGGSnIVEAKWDCVSSILQVGGTIIGSARCKAFRS-R 103
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    104 EGRLKAACNLARLGITNLCVIGGDGSLTGANlfrkewsglleELARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPeeDWEEnMCLKLSENRARKK 263
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGK 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    264 RLNIIIVSEGA--------IDMQNKPI--------TSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVE 327
Cdd:TIGR02483 215 RFAIVVVAEGAkpkggemvVQEGVKDAfghvrlggIGNWLAEEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVA 294

                         330       340       350
                  ....*....|....*....|....*....|...
gi 9790051    328 AVIALLEATPETpacVVSLRGNQAVRLPLMECV 360
Cdd:TIGR02483 295 AVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
21-367 6.93e-62

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 212.24  E-value: 6.93e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    21 GDGKAIGVLTSGGDAQGMNAAVRAVVR--MGIYtGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARcK 98
Cdd:PRK14071   2 GEKKRIGILTSGGDCAGLNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTN-K 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    99 ----AFRSREGRLKAACN-----LARLGITNLCVIGGDGSLtganlfrkewsGLLEELARNGDIdndtvqkysylNVVGM 169
Cdd:PRK14071  80 gdpfAFPMPDGSLRDRSQeiidgYHSLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   170 VGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPpeedWE- 248
Cdd:PRK14071 138 PKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIP----YTl 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   249 ENMCLKLSENRARKKRLNIIIVSEGAIDMQNKPITSEK-------------IKELVVKNLGFDTRVTILGHVQRGGTPSA 315
Cdd:PRK14071 214 ENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSP 293

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 9790051   316 FDRILASRMGVEAVIALLEATPETpacVVSLRGNQAVRLPLMECVQMTQDVQ 367
Cdd:PRK14071 294 RDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAVD 342
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 13-350 2.19e-54

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 200.64  E-value: 2.19e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     13 PKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGsnIVEAKWDCVSSILQVGGTII 92
Cdd:TIGR02478 379 DKKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSEL 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     93 GSARCKAFRSREgrlKAACNLARLGITNLCVIGGDGSLTGANLFRKewsglleelARngdidndtvQKYSYLNV--VGMV 170
Cdd:TIGR02478 457 GTNRSLPGDDLG---TIAYYFQQHKIDGLIIIGGFEAFEALYQLDA---------AR---------EKYPAFRIpmVVIP 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    171 GSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQ-SHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEE 249
Cdd:TIGR02478 516 ATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQ 595

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    250 NMCLKLSENRARKKRLNIIIVSEGAIdmqnKPITSEKIKEL---VVKNLgFDTRVTILGHVQRGGTPSAFDRILASRMGV 326
Cdd:TIGR02478 596 EDIEHLKETFAEGRAGKLILRNEKAS----KVYTTDFIARIiseEGKGR-FDARTAVLGHMQQGGSPSPFDRVRATRLAI 670

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 9790051    327 EAVIALLEATP-----------ETPACVVSLRGNQ 350
Cdd:TIGR02478 671 RAVDFIEEKIKankhadklsadDTSAVVIGIRGSN 705
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 411-759 1.18e-53

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 189.13  E-value: 1.18e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  411 NVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGK---YL 487
Cdd:COG0205   3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKteeGR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  488 EKIAEQMHSHSINALLIIGGFEAYLGLLELAAAREkheafcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 567
Cdd:COG0205  83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  568 SASGTkRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLqsnVVHLTEKMKTSIQRGLVL--------RNES 639
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDGEA 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  640 CSVNYTTDFIYQLYSEEGKGV---------FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGsqgtgkkf 710
Cdd:COG0205 233 VLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTG-------- 304

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 9790051  711 vsddsiCVLGICKRDLLFQPvaeLKKVTDFEHRIPKEQWWLKLRPIMKI 759
Cdd:COG0205 305 ------VMVGIRRGEIVLVP---LEEVANKEKPVDPDSPLIQLARELGI 344
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
421-694 1.16e-52

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 185.67  E-value: 1.16e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLE---KIAEQMHSH 497
Cdd:PRK03202  13 APGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgraKAIENLKKL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   498 SINALLIIGGFEAYLGLLELAAARekheafcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASgTKRRVF 577
Cdd:PRK03202  93 GIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS-SHERVF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   578 IIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDlqsnvvhLTEKMKTSIQRG----LVLRNES-CSVNYTTDFIyql 652
Cdd:PRK03202 165 IVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEE-------LCAKIKKGRERGkkhaIIVVAEGvMPAEELAKEI--- 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 9790051   653 yseEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 694
Cdd:PRK03202 235 ---EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVE 273
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 411-694 2.97e-52

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 185.19  E-value: 2.97e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  411 NVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLE-- 488
Cdd:cd00363   2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEgr 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  489 -KIAEQMHSHSINALLIIGGFEAYLGLLELAA-AREKHEAFcvPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIK 566
Cdd:cd00363  82 aKAAENLKKHGIDALVVIGGDGSYTGADLLTEeWPSKYQGF--NVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  567 QSASgTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQsnvvHLTEKMKTSIQRG----LVLRNEScsv 642
Cdd:cd00363 160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEE----EMVDVIKKRRERGkrhgIVIVAEG--- 231

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 9790051  643 nyTTDFIYQLYSEEG-------KGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 694
Cdd:cd00363 232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVE 288
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 412-694 2.12e-51

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 182.22  E-value: 2.12e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  412 VAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLE--- 488
Cdd:cd00763   3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEgqa 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  489 KIAEQMHSHSINALLIIGGFEAYLGLLELAaarekHEAFcvPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQS 568
Cdd:cd00763  83 KAIEQLKKHGIDALVVIGGDGSYMGAMRLT-----EHGF--PCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDT 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051  569 ASgTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSiqrGLVLRNESCsvnYTTDF 648
Cdd:cd00763 156 SS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKH---AIVVVAEGV---YDVDE 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 9790051  649 IYQLYSEEGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 694
Cdd:cd00763 229 LAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYAVE 272
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 11-274 1.96e-25

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 110.52  E-value: 1.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    11 AYPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYT-GAK-VYFIYEGYQGLVDGGSniVEAKWDCVSSILQVG 88
Cdd:PTZ00286  75 AGPRKHLYFNPKEVKAGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDW--IKLDPKDVKTIHRLG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    89 GTIIGSARckafrSREGRLKAACNLARLGITNLCVIGGDGSLTGANlfrkewsGLLEELARNGdidndtvqkySYLNVVG 168
Cdd:PTZ00286 153 GTILGSSR-----GGFDPKVMVDTLIRHGINILFTLGGDGTHRGAL-------AIYKELRRRK----------LNISVVG 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   169 MVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALTCG-ADWVFLPESppeeD 246
Cdd:PTZ00286 211 IPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEF----D 286

                        250       260
                 ....*....|....*....|....*...
gi 9790051   247 WEENMCLKLSENRARKKRLNIIIVSEGA 274
Cdd:PTZ00286 287 IPLEGVLEYIEQRLQKKGHCVIVVAEGA 314
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
27-274 1.60e-21

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 98.40  E-value: 1.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    27 GVLTSGGDAQGMNAAVRAVVrMGIYTGAKVYFIY---EGYQGLV-DGGSNIVEAKWDCVSSILQVGGTIIGSARckafrs 102
Cdd:PRK06830  84 AIVTCGGLCPGLNDVIRAIV-LELHHHYGVRRILgirYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR------ 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   103 reGRLKAAC---NLARLGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGdidndtvQKYSylnVVGMVGSIDNDFCG 179
Cdd:PRK06830 157 --GPQDPEEivdTLERMNINILFVIGGDGTLRGA-------SAIAEEIERRG-------LKIS---VIGIPKTIDNDINF 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   180 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALTCG-ADWVFLPESPPEEDwEENMCLKLSE 257
Cdd:PRK06830 218 IQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLE-GPNGLLAALE 296

                        250
                 ....*....|....*..
gi 9790051   258 NRARKKRLNIIIVSEGA 274
Cdd:PRK06830 297 KRLAERGHAVIVVAEGA 313
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
412-698 2.72e-19

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 90.52  E-value: 2.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   412 VAVINVGAPAAGMNAAVRSAVRVGIAD-GHKMFAIYDGFEGFANG--QIKEIGWADVGGWTGQGGSILGTKR-------- 480
Cdd:PRK14071   7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpfafp 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   481 ----TLPGKYLEkIAEQMHSHSINALLIIGGFEAylglleLAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALN 556
Cdd:PRK14071  87 mpdgSLRDRSQE-IIDGYHSLGLDALIGIGGDGS------LAILRRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   557 TITDTCDRIKQSASgTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKtsiQRGLVLR 636
Cdd:PRK14071 160 IATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENVCKKIRERQEEGK---NFCLVVV 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9790051   637 NESC------SVNYTTDF-------IYQLYSEE--GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISA 698
Cdd:PRK14071 236 SEAVrteegeQVTKTQALgedryggIGQYLAEQiaERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
PLN02884 PLN02884
6-phosphofructokinase
 27-329 2.01e-14

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 76.00  E-value: 2.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    27 GVLTSGGDAQGMNAAVRAVV-RMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSreg 105
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRGGAKTS--- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   106 rlKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleelarngdIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMTIG 185
Cdd:PLN02884 134 --DIVDSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFG 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   186 TDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALTCG-ADWVFLPESPPEEDWEENMcLKLSENRARKK 263
Cdd:PLN02884 195 FDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGV-LRHLEHLIETK 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   264 RLNIIIVSEGA-IDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPS-----------------AFDRILASRMG 325
Cdd:PLN02884 274 GSAVVCVAEGAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLG 353


                 ....
gi 9790051   326 VEAV 329
Cdd:PLN02884 354 QNAV 357
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
156-334 5.29e-14

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 74.90  E-value: 5.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   156 DTVQKYS-------Y-LNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV-----D-AIMTTaqsHQRTFVLEVMGRHCG 221
Cdd:PRK14072 117 DTALKVSqlakkmgYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVleaalDvAAMAN---TSKVFILEVMGRHAG 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   222 YLALVSALTC-----GADWVFLPESPPEedwEENMCLKLSENRARKKRLnIIIVSEGAIDMQNKPITSEK---------- 286
Cdd:PRK14072 194 WLAAAAALAKqnpddAPHLIYLPERPFD---EEKFLADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAGlaedafghaq 269

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 9790051   287 -------IKELVVKNLGFDTRVTILGHVQR--GGTPSAFDRILASRMGVEAVIALLE 334
Cdd:PRK14072 270 lggvapvLANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
PLN02564 PLN02564
6-phosphofructokinase
 28-274 1.06e-13

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 74.40  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    28 VLTSGGDAQGMNAAVRAVVrMGI---YTGAKVYFIYEGYQGLVdgGSNIVEAKWDCVSSILQVGGTIIGSarckafrSRE 104
Cdd:PLN02564  92 IVTCGGLCPGLNTVIREIV-CGLsymYGVTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGT-------SRG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   105 GR--LKAACNLARLGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGdidndtvqkySYLNVVGMVGSIDNDFCGTDM 182
Cdd:PLN02564 162 GHdtSKIVDSIQDRGINQVYIIGGDGTQKGASV-------IYEEIRRRG----------LKVAVAGIPKTIDNDIPVIDK 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   183 TIGTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALTC-GADWVFLPESPPEEDWEENMcLKLSENRA 260
Cdd:PLN02564 225 SFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPFYLEGKGGL-FEFIEKRL 303

                        250
                 ....*....|....
gi 9790051   261 RKKRLNIIIVSEGA 274
Cdd:PLN02564 304 KENGHMVIVVAEGA 317
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 24-274 1.94e-11

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 66.57  E-value: 1.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    24 KAIGVLTSGGDAQGMNAAVRAVVRMgiYT--GAKVYFIY--EGYQGLVDGGS-NIVEAKWDCVSSILQVGGTIIGSARCK 98
Cdd:PRK06555   4 KKVALLTAGGLAPCLSSAVGGLIER--YTeiAPEVEIIAyrSGYQGLLLGDSiEITPAVRANAGLLHRYGGSPIGNSRVK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    99 AFRS---------REGR--LK-AACNLARLGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGdidndtvqkYSyLNV 166
Cdd:PRK06555  82 LTNVadcvkrglvKEGEnpLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENG---------YD-LTV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   167 VGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSA-----LTCGADW----- 235
Cdd:PRK06555 145 VGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATArayreWLDRQEYvpgfg 224

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 9790051   236 ----------VFLPESPPEEDWEENmclKLSENRARKKRLNiIIVSEGA 274
Cdd:PRK06555 225 lsaerwdihaVYLPEMAFDLEAEAE---RLKAVMDEVGNVN-IFLSEGA 269
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 412-590 5.83e-11

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 65.45  E-value: 5.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   412 VAVINVGAPAAGMNAAVRSAVRVGIADGH--KMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTlpGKYLEK 489
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG--GFDPKV 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   490 IAEQMHSHSINALLIIGGFEAYLGLLELA--AAREKHEafcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 567
Cdd:PTZ00286 168 MVDTLIRHGINILFTLGGDGTHRGALAIYkeLRRRKLN---ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244

                        170       180
                 ....*....|....*....|...
gi 9790051   568 SASGTKRRVFIIETMGGYCGYLA 590
Cdd:PTZ00286 245 EAKSAKNGVGIVKLMGRDSGFIA 267
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 26-276 1.41e-09

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 61.98  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     26 IGVLTSGGDAQGMNAAVRavvrmGIYTGAKVYFIYE---GYQGLVDG--GSNIVEAKWDCVSSILQVGG-TIIGSARCKA 99
Cdd:PTZ00287  180 IGIILSGGPAPGGHNVIS-----GIYDYAKRYNEQSqviGFLGGIDGlySKNYVTITDSLMNRFRNLGGfNMLWSGRGKV 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    100 fRSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvQKYSYLNVVGMVGSIDNDFC- 178
Cdd:PTZ00287  255 -RNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALISEYFA-----------------ERQIPISIIGIPKTIDGDLKs 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    179 -GTDMTIGTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEE-----DWEENM 251
Cdd:PTZ00287  317 eAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKEnlslkDIVSNI 396

                         250       260
                  ....*....|....*....|....*
gi 9790051    252 CLKLSENRARKKRLNIIIVSEGAID 276
Cdd:PTZ00287  397 VNTILKRRSLNKNYGVILIPEGLIE 421
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 24-276 1.87e-08

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 58.06  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     24 KAIGVLTSGGDAQGMNAAVravvrMGIYTGAKVYFIYEGYQGLVDGGSNI-----VEAKWDCVSSILQVGG-TIIGSARC 97
Cdd:PTZ00468  103 RRIGVVLSGGQASGGHNVI-----AGLMSYIKLCNQSSQLFGFLGGPEGVyseryRELTEDDINGILNQGGfNIICSGRH 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051     98 KAfrSREGRLKAACNLA-RLGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGdidndtvqkySYLNVVGMVGSIDND 176
Cdd:PTZ00468  178 KI--ETEEQMRASLEICeKLKLHGLVVIGGDDSNTNAAV-------LAEYFKRNS----------SSTVVVGCPKTIDGD 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    177 FCG--TDMTIGTDSALHRIIEVVDAIMTTAQSHQ-RTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEE-------- 245
Cdd:PTZ00468  239 LKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEEnrslmsiv 318

                         250       260       270
                  ....*....|....*....|....*....|.
gi 9790051    246 DWEENMCLKlseNRARKKRLNIIIVSEGAID 276
Cdd:PTZ00468  319 DEIVEMILK---RDSLGKKHGIVLLPEGLIE 346
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 17-290 2.75e-05

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 47.61  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    17 EHLSGDGKAIGVLTSGGDAQG-MNaavravVRMGIYTGAKVY--------FIyEGYQGLVDGgsNIVEAKWDCVSSILQV 87
Cdd:PRK07085  64 SESSSKPLKVGVILSGGQAPGgHN------VIAGLFDGLKKLnpdsklfgFI-GGPLGLLNG--KYIEITEEVIDEYRNT 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051    88 GG-TIIGSARCKaFRSREGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGdidNDTVqkysylnV 166
Cdd:PRK07085 135 GGfDMIGSGRTK-IETEEQKEACLETVKKLKLDGLVIIGGDDSNTNAAI-------LAEYFAKHG---CKTQ-------V 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   167 VGMVGSIDNDFCGT--DMTIGTDSALHRIIEVVDAIMTTAQSHQRT--FVlEVMGRHCGYLALVSALTCGADWVFLpesp 242
Cdd:PRK07085 197 IGVPKTIDGDLKNEfiETSFGFDTATKTYSEMIGNISRDALSAKKYwhFI-KLMGRSASHIALECALQTHPNICLI---- 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 9790051   243 PEEDWEENMCLK-LSE-------NRARK-KRLNIIIVSEGAIDMqnKPITSEKIKEL 290
Cdd:PRK07085 272 SEEVAEKKMSLQdIVHyiasviaDRAAKgKNYGVILIPEGLIEF--IPEMKSLIKEL 326
PLN02564 PLN02564
6-phosphofructokinase
 423-590 3.73e-05

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 47.05  E-value: 3.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   423 GMNAAVRSAVrVGIADG---HKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTlpGKYLEKIAEQMHSHSI 499
Cdd:PLN02564 101 GLNTVIREIV-CGLSYMygvTRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSRG--GHDTSKIVDSIQDRGI 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   500 NALLIIGGFEAYLGllelaaAREKHE-----AFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKR 574
Cdd:PLN02564 178 NQVYIIGGDGTQKG------ASVIYEeirrrGLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVEN 251

                        170
                 ....*....|....*.
gi 9790051   575 RVFIIETMGGYCGYLA 590
Cdd:PLN02564 252 GIGLVKLMGRYSGFIA 267
PLN02884 PLN02884
6-phosphofructokinase
 401-590 4.38e-05

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 46.73  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   401 PDEKIV--KSNCNVAVINVGAPAAGMNAAVRSAV-RVGIADGHKMFAIYDGFEGFANGQIKEIGWAD--VGGWTGQGGSI 475
Cdd:PLN02884  43 PRKKIYfePEEVKAAIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRkvVQNIHLSGGSL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9790051   476 LGTKRTlpGKYLEKIAEQMHSHSINALLIIGGFEAYLGllELAAAREKHE-AFCVPMVMVPATVSNNVPGSDFSIGADTA 554
Cdd:PLN02884 123 LGVSRG--GAKTSDIVDSIEARGINMLFVLGGNGTHAG--ANAIHNECRKrKMKVSVVGVPKTIDNDILLMDKTFGFDTA 198

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 9790051   555 LNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLA 590
Cdd:PLN02884 199 VEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIA 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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