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Conserved domains on  [gi|145587671|ref|NP_062799|]
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nuclear receptor coactivator 6 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nucleic_acid_bd pfam13820
Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding ...
 48-189 3.66e-59

Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.


:

Pssm-ID: 463988  Cd Length: 143  Bit Score: 200.35  E-value: 3.66e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671    48 IFVAFKGNIDDkdFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSV 127
Cdd:pfam13820    1 TFLAVKGNLRM--FQEKLDSIRENVAELLRTEKSKLKVRKVEPWNSVRVTFSIPREAALRLRLLAQHNDPRLRDLGILSV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145587671   128 QIEGEGAINLALG---QNRSQDVRMnGPVASGNSVRMEAGFPMASGPGLIRMTSPAAVMTPQGGN 189
Cdd:pfam13820   79 QIEGEGPINLTLAtmvQNPADDIIL-GCSTQLNSQRAEQGWTMLSALGLISDALPLHLRLAESGE 142
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 387-809 7.17e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 67.73  E-value: 7.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   387 QQASQAHTNFPQMSNPGQFTAPQMKGLQGGPSRVPTPlqqPHLTNKSPASSPSSFQQGSPAssptVNQTQQQMGPRPPQN 466
Cdd:pfam09606   60 QQQPQGGQGNGGMGGGQQGMPDPINALQNLAGQGTRP---QMMGPMGPGPGGPMGQQMGGP----GTASNLLASLGRPQM 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   467 NPLSQGFQQPVSSPGRnpmVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPnfMQGQVPSTTAAt 546
Cdd:pfam09606  133 PMGGAGFPSQMSRVGR---MQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGP--MGGQMPPQMGV- 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   547 PGNSGALQLQaNQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGN-----INNQQAGSSGVPQVTLGNMQGQPQQ 621
Cdd:pfam09606  207 PGMPGPADAG-AQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSqlgmgINQMQQMPQGVGGGAGQGGPGQPMG 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   622 GPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPh 701
Cdd:pfam09606  286 PPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANP- 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   702 nqmMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMP------GPAQIMRGPTPNmQGNMVQFTGQMSGQMLPQ 775
Cdd:pfam09606  365 ---MQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPqgpgsqPPQSHPGGMIPS-PALIPSPSPQMSQQPAQQ 440

                          410       420       430
                   ....*....|....*....|....*....|....
gi 145587671   776 QGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHND 809
Cdd:pfam09606  441 RTIGQDSPGGSLNTPGQSAVNSPLNPQEEQLYRE 474
KAR9 super family cl25816
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 1090-1326 3.09e-04

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


The actual alignment was detected with superfamily member pfam08580:

Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 45.98  E-value: 3.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1090 PASVPPSPD-KQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPE-ASGSEV---PSVAGGPNNMPShLVVSQN 1164
Cdd:pfam08580  430 PGSSPPSSViMTPVNKGSKTPSSRRGSSFDFGSSSERVINSKLRRESKLPQiASTLKQtkrPSKIPRASPNHS-GFLSTP 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1165 QLMMTGPKPGPSplsATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRP---------YYPQTPNNRPP 1235
Cdd:pfam08580  509 SNTATSETPTPA---LRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTLTTPSPTPsrssrssstLPPVSPLSRDK 585

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1236 STEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNrgfdqqglNPTTLKAIGQAPSNLTITNPPNFAAPQAHKLDSVV 1315
Cdd:pfam08580  586 SRSPAPTCRSVSRASRRRASRKPTRIGSPNSRTSLLD--------EPPYPKLTLSKGLPRTPRNRQSYAGTSPSRSVSVS 657

                          250
                   ....*....|.
gi 145587671  1316 VNSGKQSNPGT 1326
Cdd:pfam08580  658 SGLGPQTRPGT 668
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1173-1810 7.41e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1173 PGPSPLSATQGATPQQP-PVNSLPSSHGH-HFPNvaAPTQTSRPKTP--------NRASPRPYYPQTPNNRPPSTEPSEI 1242
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPaPRPSEPAVTSRaRRPD--APPQSARPRAPvddrgdprGPAPPSPLPPDTHAPDPPPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1243 SLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPttlkaigQAPSNLTITNPPnfAAPQAhkldsvVVNSGKQS 1322
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA-------QASSPPQRPRRR--AARPT------VGSLTSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1323 NPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTMLQnmelprnVLVGPTPLANPPLPGSFPNNTGl 1402
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPA-------TPGGPARPARPPTTAGPPAPAP- 2771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1403 nPQNPTVPVPAMGTVlednkesvnipqdsdcqnaqgrkeqvnteLKVVPTQEAKMAVPEDQSKKDGQPLDPNKLPSVEEN 1482
Cdd:PHA03247 2772 -PAAPAAGPPRRLTR-----------------------------PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1483 KnlmSPAMREAPTSLSQlldnsGAPNVTIKPPGLTDLEVTPPVVSGEDLRKAsviptlqdPPSKEPSTSLSSPHSSePCS 1562
Cdd:PHA03247 2822 A---SPAGPLPPPTSAQ-----PTAPPPPPGPPPPSLPLGGSVAPGGDVRRR--------PPSRSPAAKPAAPARP-PVR 2884

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1563 TLARSELSEVSSNTA-PSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALPTHLQSALMSTVVTMPNVGN 1641
Cdd:PHA03247 2885 RLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1642 KVMVSeGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPS-TIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSApvTP 1720
Cdd:PHA03247 2965 GALVP-GRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRvSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDA--DS 3041

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1721 NVPSSSPAPNIQTGRPLvlssratpvqlpSPPCTSSPVVAPNPsvqqvkelNPDEASPQTNTSAdQSTLPPSQPTTVVSP 1800
Cdd:PHA03247 3042 LFDSDSERSDLEALDPL------------PPEPHDPFAHEPDP--------ATPEAGARESPSS-QFGPPPLSANAALSR 3100

                         650
                  ....*....|
gi 145587671 1801 LLTNSPGSSA 1810
Cdd:PHA03247 3101 RYVRSTGRSA 3110
 
Name Accession Description Interval E-value
Nucleic_acid_bd pfam13820
Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding ...
 48-189 3.66e-59

Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.


Pssm-ID: 463988  Cd Length: 143  Bit Score: 200.35  E-value: 3.66e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671    48 IFVAFKGNIDDkdFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSV 127
Cdd:pfam13820    1 TFLAVKGNLRM--FQEKLDSIRENVAELLRTEKSKLKVRKVEPWNSVRVTFSIPREAALRLRLLAQHNDPRLRDLGILSV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145587671   128 QIEGEGAINLALG---QNRSQDVRMnGPVASGNSVRMEAGFPMASGPGLIRMTSPAAVMTPQGGN 189
Cdd:pfam13820   79 QIEGEGPINLTLAtmvQNPADDIIL-GCSTQLNSQRAEQGWTMLSALGLISDALPLHLRLAESGE 142
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 387-809 7.17e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 67.73  E-value: 7.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   387 QQASQAHTNFPQMSNPGQFTAPQMKGLQGGPSRVPTPlqqPHLTNKSPASSPSSFQQGSPAssptVNQTQQQMGPRPPQN 466
Cdd:pfam09606   60 QQQPQGGQGNGGMGGGQQGMPDPINALQNLAGQGTRP---QMMGPMGPGPGGPMGQQMGGP----GTASNLLASLGRPQM 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   467 NPLSQGFQQPVSSPGRnpmVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPnfMQGQVPSTTAAt 546
Cdd:pfam09606  133 PMGGAGFPSQMSRVGR---MQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGP--MGGQMPPQMGV- 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   547 PGNSGALQLQaNQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGN-----INNQQAGSSGVPQVTLGNMQGQPQQ 621
Cdd:pfam09606  207 PGMPGPADAG-AQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSqlgmgINQMQQMPQGVGGGAGQGGPGQPMG 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   622 GPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPh 701
Cdd:pfam09606  286 PPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANP- 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   702 nqmMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMP------GPAQIMRGPTPNmQGNMVQFTGQMSGQMLPQ 775
Cdd:pfam09606  365 ---MQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPqgpgsqPPQSHPGGMIPS-PALIPSPSPQMSQQPAQQ 440

                          410       420       430
                   ....*....|....*....|....*....|....
gi 145587671   776 QGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHND 809
Cdd:pfam09606  441 RTIGQDSPGGSLNTPGQSAVNSPLNPQEEQLYRE 474
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 625-776 1.85e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 49.81  E-value: 1.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   625 SQLMGMHQQIVPsqgqMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMtPPKQMLPQQGPQMMAPhnqm 704
Cdd:TIGR01628  369 AHLQDQFMQLQP----RMRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMP-TPMGPGGPLRPNGLAP---- 439

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145587671   705 MGPQGQVLLQQNPMIEQimtNQMQGNKAQFNSQNQSNVMPGPAQimrGPTPNMQGNMvQFTGQMSGQMLPQQ 776
Cdd:TIGR01628  440 MNAVRAPSRNAQNAAQK---PPMQPVMYPPNYQSLPLSQDLPQP---QSTASQGGQN-KKLAQVLASATPQM 504
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 1090-1326 3.09e-04

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 45.98  E-value: 3.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1090 PASVPPSPD-KQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPE-ASGSEV---PSVAGGPNNMPShLVVSQN 1164
Cdd:pfam08580  430 PGSSPPSSViMTPVNKGSKTPSSRRGSSFDFGSSSERVINSKLRRESKLPQiASTLKQtkrPSKIPRASPNHS-GFLSTP 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1165 QLMMTGPKPGPSplsATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRP---------YYPQTPNNRPP 1235
Cdd:pfam08580  509 SNTATSETPTPA---LRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTLTTPSPTPsrssrssstLPPVSPLSRDK 585

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1236 STEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNrgfdqqglNPTTLKAIGQAPSNLTITNPPNFAAPQAHKLDSVV 1315
Cdd:pfam08580  586 SRSPAPTCRSVSRASRRRASRKPTRIGSPNSRTSLLD--------EPPYPKLTLSKGLPRTPRNRQSYAGTSPSRSVSVS 657

                          250
                   ....*....|.
gi 145587671  1316 VNSGKQSNPGT 1326
Cdd:pfam08580  658 SGLGPQTRPGT 668
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1173-1810 7.41e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1173 PGPSPLSATQGATPQQP-PVNSLPSSHGH-HFPNvaAPTQTSRPKTP--------NRASPRPYYPQTPNNRPPSTEPSEI 1242
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPaPRPSEPAVTSRaRRPD--APPQSARPRAPvddrgdprGPAPPSPLPPDTHAPDPPPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1243 SLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPttlkaigQAPSNLTITNPPnfAAPQAhkldsvVVNSGKQS 1322
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA-------QASSPPQRPRRR--AARPT------VGSLTSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1323 NPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTMLQnmelprnVLVGPTPLANPPLPGSFPNNTGl 1402
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPA-------TPGGPARPARPPTTAGPPAPAP- 2771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1403 nPQNPTVPVPAMGTVlednkesvnipqdsdcqnaqgrkeqvnteLKVVPTQEAKMAVPEDQSKKDGQPLDPNKLPSVEEN 1482
Cdd:PHA03247 2772 -PAAPAAGPPRRLTR-----------------------------PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1483 KnlmSPAMREAPTSLSQlldnsGAPNVTIKPPGLTDLEVTPPVVSGEDLRKAsviptlqdPPSKEPSTSLSSPHSSePCS 1562
Cdd:PHA03247 2822 A---SPAGPLPPPTSAQ-----PTAPPPPPGPPPPSLPLGGSVAPGGDVRRR--------PPSRSPAAKPAAPARP-PVR 2884

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1563 TLARSELSEVSSNTA-PSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALPTHLQSALMSTVVTMPNVGN 1641
Cdd:PHA03247 2885 RLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1642 KVMVSeGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPS-TIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSApvTP 1720
Cdd:PHA03247 2965 GALVP-GRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRvSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDA--DS 3041

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1721 NVPSSSPAPNIQTGRPLvlssratpvqlpSPPCTSSPVVAPNPsvqqvkelNPDEASPQTNTSAdQSTLPPSQPTTVVSP 1800
Cdd:PHA03247 3042 LFDSDSERSDLEALDPL------------PPEPHDPFAHEPDP--------ATPEAGARESPSS-QFGPPPLSANAALSR 3100

                         650
                  ....*....|
gi 145587671 1801 LLTNSPGSSA 1810
Cdd:PHA03247 3101 RYVRSTGRSA 3110
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1061-1282 1.62e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1061 PPRGPLNPDSQRMPVQQSgnVPVMVGLQGPASVPPSPDKQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPEA 1140
Cdd:PHA03247 2744 VPAGPATPGGPARPARPP--TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1141 ---SGSEVPSVAGGPNNMPSHLVVSQNQLMMTG--------PKPGPSPLSATQGATPQQPPVNSLPSshghhfPNVAAPT 1209
Cdd:PHA03247 2822 aspAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvapggdvRRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRST 2895

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145587671 1210 QTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLnasiaglfPPQINIPLPPRPNLNRGFDQQGLNP 1282
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSGAVP 2960
 
Name Accession Description Interval E-value
Nucleic_acid_bd pfam13820
Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding ...
 48-189 3.66e-59

Putative nucleic acid-binding region; This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.


Pssm-ID: 463988  Cd Length: 143  Bit Score: 200.35  E-value: 3.66e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671    48 IFVAFKGNIDDkdFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSV 127
Cdd:pfam13820    1 TFLAVKGNLRM--FQEKLDSIRENVAELLRTEKSKLKVRKVEPWNSVRVTFSIPREAALRLRLLAQHNDPRLRDLGILSV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145587671   128 QIEGEGAINLALG---QNRSQDVRMnGPVASGNSVRMEAGFPMASGPGLIRMTSPAAVMTPQGGN 189
Cdd:pfam13820   79 QIEGEGPINLTLAtmvQNPADDIIL-GCSTQLNSQRAEQGWTMLSALGLISDALPLHLRLAESGE 142
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 387-809 7.17e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 67.73  E-value: 7.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   387 QQASQAHTNFPQMSNPGQFTAPQMKGLQGGPSRVPTPlqqPHLTNKSPASSPSSFQQGSPAssptVNQTQQQMGPRPPQN 466
Cdd:pfam09606   60 QQQPQGGQGNGGMGGGQQGMPDPINALQNLAGQGTRP---QMMGPMGPGPGGPMGQQMGGP----GTASNLLASLGRPQM 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   467 NPLSQGFQQPVSSPGRnpmVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPnfMQGQVPSTTAAt 546
Cdd:pfam09606  133 PMGGAGFPSQMSRVGR---MQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGP--MGGQMPPQMGV- 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   547 PGNSGALQLQaNQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGN-----INNQQAGSSGVPQVTLGNMQGQPQQ 621
Cdd:pfam09606  207 PGMPGPADAG-AQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSqlgmgINQMQQMPQGVGGGAGQGGPGQPMG 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   622 GPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPh 701
Cdd:pfam09606  286 PPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANP- 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   702 nqmMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMP------GPAQIMRGPTPNmQGNMVQFTGQMSGQMLPQ 775
Cdd:pfam09606  365 ---MQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPqgpgsqPPQSHPGGMIPS-PALIPSPSPQMSQQPAQQ 440

                          410       420       430
                   ....*....|....*....|....*....|....
gi 145587671   776 QGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHND 809
Cdd:pfam09606  441 RTIGQDSPGGSLNTPGQSAVNSPLNPQEEQLYRE 474
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 289-754 1.80e-08

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 59.64  E-value: 1.80e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   289 QQQQLQTRPLQQHQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQ-GSLGTMTTNQGWKKAP--------LPSPM 359
Cdd:pfam09606   64 QGGQGNGGMGGGQQGMPDPINALQNLAGQGTRPQMMGPMGPGPGGPMGQQmGGPGTASNLLASLGRPqmpmggagFPSQM 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   360 QAQLQARPSLATvqtpsHPPPPYPFGSQQASQAHTNFPQMSnPGQFTAPQMKGLQGGPSRVPTPLQ------------QP 427
Cdd:pfam09606  144 SRVGRMQPGGQA-----GGMMQPSSGQPGSGTPNQMGPNGG-PGQGQAGGMNGGQQGPMGGQMPPQmgvpgmpgpadaGA 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   428 HLTNKSPASSPSSFQQGSPASSPTVNQTQQQMgpRPPQNNPLSQGFQQPVSSPGRNPMVQQGNVPPNFMvmqqqppnqgp 507
Cdd:pfam09606  218 QMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQ--QQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPM----------- 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   508 qslhPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTAATPGNSGALQLQANQNVQHAGGQGAGPPQNQMqvshGPPNMMQ 587
Cdd:pfam09606  285 ----GPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHL----ETWNPGN 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   588 PSLMGIHGNINNQQAGSSGVPQVTLGNMQgqpQQGPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQM 667
Cdd:pfam09606  357 FGGLGANPMQRGQPGMMSSPSPVPGQQVR---QVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQM 433

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   668 MVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQsnvMPGPA 747
Cdd:pfam09606  434 SQQPAQQRTIGQDSPGGSLNTPGQSAVNSPLNPQEEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNK---MKRLL 510


                   ....*..
gi 145587671   748 QIMRGPT 754
Cdd:pfam09606  511 EILSNPS 517
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 440-719 3.83e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 55.43  E-value: 3.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   440 SFQQGSPASSPTVNQTQQQMGPRPPQNNPLSQGFQQPVSSpGRNPMVQQGNVPpnfmvmqqqppnqgpqSLHP--GLGGM 517
Cdd:pfam09770  103 NRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT-GYEKYKEPEPIP----------------DLQVdaSLWGV 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   518 PkrlPPGFSAGQANPnfmqgQVPSTTAATPGNS----------GALQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQ 587
Cdd:pfam09770  166 A---PKKAAAPAPAP-----QPAAQPASLPAPSrkmmsleeveAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFP 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   588 PSlmgihgninnqqagssgvpqvtlgNMQGQPQQGPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQM 667
Cdd:pfam09770  238 PQ------------------------IQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPP 293

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 145587671   668 MVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAP-HNQMMGPQGQVLLQQNPMI 719
Cdd:pfam09770  294 PVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPaPAHQAHRQQGSFGRQAPII 346
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 625-776 1.85e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 49.81  E-value: 1.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   625 SQLMGMHQQIVPsqgqMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMtPPKQMLPQQGPQMMAPhnqm 704
Cdd:TIGR01628  369 AHLQDQFMQLQP----RMRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMP-TPMGPGGPLRPNGLAP---- 439

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145587671   705 MGPQGQVLLQQNPMIEQimtNQMQGNKAQFNSQNQSNVMPGPAQimrGPTPNMQGNMvQFTGQMSGQMLPQQ 776
Cdd:TIGR01628  440 MNAVRAPSRNAQNAAQK---PPMQPVMYPPNYQSLPLSQDLPQP---QSTASQGGQN-KKLAQVLASATPQM 504
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 618-761 2.31e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 49.42  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   618 QPQQGPPSQ-LMGMHQQIVPSQGQMAQQQGTLNPQNPMilsraqLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQ 696
Cdd:TIGR01628  384 QLPMGSPMGgAMGQPPYYGQGPQQQFNGQPLGWPRMSM------MPTPMGPGGPLRPNGLAPMNAVRAPSRNAQNAAQKP 457

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145587671   697 MMAPHNQMMGPQGQVLLQQNPmieqimtnQMQGNKAQFNSqnqsnvMPGPAQIMRGPTPNMQGNM 761
Cdd:TIGR01628  458 PMQPVMYPPNYQSLPLSQDLP--------QPQSTASQGGQ------NKKLAQVLASATPQMQKQV 508
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 632-815 9.41e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 9.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   632 QQIVPSQGQMAQQQGTLNPQNPMILS--------RAQL-MPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPHN 702
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSRKMMSleeveaamRAQAkKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQ 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   703 QMMGPQGQV------LLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMPGPAQIMrgPTPNMQGNMVQftgQMSGQMLPQQ 776
Cdd:pfam09770  250 PQQPQQHPGqghpvtILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIL--QNPNRLSAARV---GYPQNPQPGV 324

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 145587671   777 GPVNNSPSQvmgiqgqvlRPPGPSPHMAQQHNDPVTTAN 815
Cdd:pfam09770  325 QPAPAHQAH---------RQQGSFGRQAPIITHPQQLAQ 354
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 1090-1326 3.09e-04

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 45.98  E-value: 3.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1090 PASVPPSPD-KQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPE-ASGSEV---PSVAGGPNNMPShLVVSQN 1164
Cdd:pfam08580  430 PGSSPPSSViMTPVNKGSKTPSSRRGSSFDFGSSSERVINSKLRRESKLPQiASTLKQtkrPSKIPRASPNHS-GFLSTP 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1165 QLMMTGPKPGPSplsATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRP---------YYPQTPNNRPP 1235
Cdd:pfam08580  509 SNTATSETPTPA---LRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTLTTPSPTPsrssrssstLPPVSPLSRDK 585

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1236 STEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNrgfdqqglNPTTLKAIGQAPSNLTITNPPNFAAPQAHKLDSVV 1315
Cdd:pfam08580  586 SRSPAPTCRSVSRASRRRASRKPTRIGSPNSRTSLLD--------EPPYPKLTLSKGLPRTPRNRQSYAGTSPSRSVSVS 657

                          250
                   ....*....|.
gi 145587671  1316 VNSGKQSNPGT 1326
Cdd:pfam08580  658 SGLGPQTRPGT 668
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 461-662 6.59e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 6.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   461 PRPPQNNPLSQGFQQPVSSPGRN---------PMVQQGNVPPNfmvmQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQAN 531
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSRKmmsleeveaAMRAQAKKPAQ----QPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   532 PNFMQGQVPSTTAATPGNSgalQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPslMGIHGNINNQQAGSSGVPQVT 611
Cdd:pfam09770  246 PQQQPQQPQQHPGQGHPVT---ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQP--TQILQNPNRLSAARVGYPQNP 320

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 145587671   612 LGNMQGQPQQgppsqlmgmhqqivpsqgQMAQQQGTLNPQNPMILSRAQLM 662
Cdd:pfam09770  321 QPGVQPAPAH------------------QAHRQQGSFGRQAPIITHPQQLA 353
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1173-1810 7.41e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 7.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1173 PGPSPLSATQGATPQQP-PVNSLPSSHGH-HFPNvaAPTQTSRPKTP--------NRASPRPYYPQTPNNRPPSTEPSEI 1242
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPaPRPSEPAVTSRaRRPD--APPQSARPRAPvddrgdprGPAPPSPLPPDTHAPDPPPPSPSPA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1243 SLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPttlkaigQAPSNLTITNPPnfAAPQAhkldsvVVNSGKQS 1322
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA-------QASSPPQRPRRR--AARPT------VGSLTSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1323 NPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTMLQnmelprnVLVGPTPLANPPLPGSFPNNTGl 1402
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPA-------TPGGPARPARPPTTAGPPAPAP- 2771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1403 nPQNPTVPVPAMGTVlednkesvnipqdsdcqnaqgrkeqvnteLKVVPTQEAKMAVPEDQSKKDGQPLDPNKLPSVEEN 1482
Cdd:PHA03247 2772 -PAAPAAGPPRRLTR-----------------------------PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1483 KnlmSPAMREAPTSLSQlldnsGAPNVTIKPPGLTDLEVTPPVVSGEDLRKAsviptlqdPPSKEPSTSLSSPHSSePCS 1562
Cdd:PHA03247 2822 A---SPAGPLPPPTSAQ-----PTAPPPPPGPPPPSLPLGGSVAPGGDVRRR--------PPSRSPAAKPAAPARP-PVR 2884

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1563 TLARSELSEVSSNTA-PSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALPTHLQSALMSTVVTMPNVGN 1641
Cdd:PHA03247 2885 RLARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1642 KVMVSeGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPS-TIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSApvTP 1720
Cdd:PHA03247 2965 GALVP-GRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRvSSWASSLALHEETDPPPVSLKQTLWPPDDTEDSDA--DS 3041

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1721 NVPSSSPAPNIQTGRPLvlssratpvqlpSPPCTSSPVVAPNPsvqqvkelNPDEASPQTNTSAdQSTLPPSQPTTVVSP 1800
Cdd:PHA03247 3042 LFDSDSERSDLEALDPL------------PPEPHDPFAHEPDP--------ATPEAGARESPSS-QFGPPPLSANAALSR 3100

                         650
                  ....*....|
gi 145587671 1801 LLTNSPGSSA 1810
Cdd:PHA03247 3101 RYVRSTGRSA 3110
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1680-1822 1.10e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1680 PSTIPATPLTTNSGLMPPSVAVVGPlhiPQNIKFSSAPVTPNVPSSSPAPniQTGRPLVLSSRATPVQLPSPPCTSS-PV 1758
Cdd:PHA03247 2735 LPAAPAPPAVPAGPATPGGPARPAR---PPTTAGPPAPAPPAAPAAGPPR--RLTRPAVASLSESRESLPSPWDPADpPA 2809

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145587671 1759 VAPNPSVQQVKELNPDEASPQTNTSADQSTLPPSQPTTVVSPLLTN-SPGSSANRRSPVSSSKGK 1822
Cdd:PHA03247 2810 AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvAPGGDVRRRPPSRSPAAK 2874
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1061-1282 1.62e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1061 PPRGPLNPDSQRMPVQQSgnVPVMVGLQGPASVPPSPDKQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPEA 1140
Cdd:PHA03247 2744 VPAGPATPGGPARPARPP--TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1141 ---SGSEVPSVAGGPNNMPSHLVVSQNQLMMTG--------PKPGPSPLSATQGATPQQPPVNSLPSshghhfPNVAAPT 1209
Cdd:PHA03247 2822 aspAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvapggdvRRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRST 2895

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145587671 1210 QTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLnasiaglfPPQINIPLPPRPNLNRGFDQQGLNP 1282
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--------PPRPQPPLAPTTDPAGAGEPSGAVP 2960
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1112-1415 2.68e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1112 SNSRKMVYQENPQNSSSSP-LGEMSSLPEASGSEVPSVAGGPNNMPSHlvVSQNQLMMTGPKPGPSPLSATQGATPQQPP 1190
Cdd:pfam05109  414 TTTHKVIFSKAPESTTTSPtLNTTGFAAPNTTTGLPSSTHVPTNLTAP--ASTGPTVSTADVTSPTPAGTTSGASPVTPS 491

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1191 VNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQ-TPNNRPPS---TEPSEISLSPE-RLNASIAGLFPPQINIPL 1265
Cdd:pfam05109  492 PSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTpTPNATSPTlgkTSPTSAVTTPTpNATSPTPAVTTPTPNATI 571

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1266 P-------------PRPNLNRGF--DQQGLNPTTLKAIGQAPSNLTITNPPNFAAPQAHKLDSVVVNSGKQS---NPGTT 1327
Cdd:pfam05109  572 PtlgktsptsavttPTPNATSPTvgETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSmslRPSSI 651

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671  1328 KRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTMLQNMELPR----NVLVGPTPLANPPLPGSFPNNTGLN 1403
Cdd:pfam05109  652 SETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRpgttSQASGPGNSSTSTKPGEVNVTKGTP 731

                          330
                   ....*....|..
gi 145587671  1404 PQNPTVPVPAMG 1415
Cdd:pfam05109  732 PKNATSPQAPSG 743
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 653-847 2.80e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 2.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   653 PMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAphnqmmGPQGQVLLQQNPMIEQIMTNqmqgnka 732
Cdd:TIGR01628  355 PLYVALAQRKEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQPPYY------GQGPQQQFNGQPLGWPRMSM------- 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   733 qfnsqnqsnvMPGPAQIMRGPTPNMQGNMVQFTGQMSGQM-LPQQGPVNNSPSQVMGIQGQVLRP-PGPSPHMAQQHNDP 810
Cdd:TIGR01628  422 ----------MPTPMGPGGPLRPNGLAPMNAVRAPSRNAQnAAQKPPMQPVMYPPNYQSLPLSQDlPQPQSTASQGGQNK 491

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 145587671   811 VTTAnndvNLSQMMPDVSMQQ-ASMVPPHVQSMQGNSA 847
Cdd:TIGR01628  492 KLAQ----VLASATPQMQKQVlGERLFPLVEAIEPALA 525
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 553-708 3.05e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 3.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   553 LQLQANQNVQhaggQGAGPPQ-NQMQVSHGPPNMMQPslmgihgninNQQAGSSGVPQVTLGNMQGQPQQGPPSQLMGM- 630
Cdd:TIGR01628  371 LQDQFMQLQP----RMRQLPMgSPMGGAMGQPPYYGQ----------GPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNg 436

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671   631 --HQQIVPSQGQMAQQQGTLNPQNPM-------ILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPH 701
Cdd:TIGR01628  437 laPMNAVRAPSRNAQNAAQKPPMQPVmyppnyqSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVLGERLFPL 516


                   ....*..
gi 145587671   702 NQMMGPQ 708
Cdd:TIGR01628  517 VEAIEPA 523
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1706-1909 3.32e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1706 HIPQNIK-FSSAPVTPNVPSSSPAPNiqtgrplvlssraTPVQLPSPPCTSSPVVAPNPSVQQVKELNPDEASPQTNTSA 1784
Cdd:PTZ00449  567 HKPSKIPtLSKKPEFPKDPKHPKDPE-------------EPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSP 633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1785 dQSTLPPSQPTTVVSPLLTNSPGSSANRRSPVSSSKGKGKvDKIGQILLTKACK----KVTGSLEKGEEQYGADGETEGP 1860
Cdd:PTZ00449  634 -KRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFK-EKFYDDYLDAAAKsketKTTVVLDESFESILKETLPETP 711

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 145587671 1861 GLEITTPGLMgteqcsteldsktpTPSAPTLLKMTSSPMG-PSSTSTGPI 1909
Cdd:PTZ00449  712 GTPFTTPRPL--------------PPKLPRDEEFPFEPIGdPDAEQPDDI 747
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1687-1913 4.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 4.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1687 PLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVTPNVPSSSPAPniQTGRPLV--LSSRATPvqlPSPPCTSSPvvAPNPS 1764
Cdd:PHA03247 2643 PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR--RAARPTVgsLTSLADP---PPPPPTPEP--APHAL 2715

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1765 VQQVKELNPDEASPQTNTSADQSTLPPSQPTTVVSPLLTNSPGSSANRRSPVSSSKGKGKVDKIGQILLTKAckkvTGSL 1844
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA----VASL 2791

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145587671 1845 EKGEEQYGADGETEGPGLEITTPGLMGTEQCSTELDSKTPTPSAPTLLKMTSSPMGPSSTSTGPILPGG 1913
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1170-1470 8.45e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1170 GPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPN--------------------VAAPTQTSRPKTPNRASPRPYYPQT 1229
Cdd:PHA03247 2606 GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPhppptvppperprddpapgrVSRPRRARRLGRAAQASSPPQRPRR 2685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1230 PNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNRgfdqQGLNPTTLKAIGQAPSNLTITnPPNFAAPQAH 1309
Cdd:PHA03247 2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAAR----QASPALPAAPAPPAVPAGPAT-PGGPARPARP 2760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1310 KLDSVVVNSGKQSNPGTTKRASPSNSRRSSPGSSRKTTPSPgRQNSKAPKLTLASQTSTTMLQNMELPRNVLVGPTPLAN 1389
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP-WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145587671 1390 PPLPGSFPNNTGLN-------------PQNPTVPVPAMGT----------VLEDNKESVNIPQDSDCQNAQGRKEQVNTE 1446
Cdd:PHA03247 2840 PPPPGPPPPSLPLGgsvapggdvrrrpPSRSPAAKPAAPArppvrrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQP 2919

                         330       340
                  ....*....|....*....|....
gi 145587671 1447 LKVVPTQEAKMAVPEDQSKKDGQP 1470
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQPPL 2943
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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