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Conserved domains on  [gi|150378439|ref|NP_064611|]
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PR domain zinc finger protein 8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 6-138 1.79e-67

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


:

Pssm-ID: 380969  Cd Length: 131  Bit Score: 217.30  E-value: 1.79e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439   6 IQRGIWDGDAKAVqqcLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDsIAFIALKSTDKRTVPYIFRVDTSAANGSSEG 85
Cdd:cd19192    2 SHRSLWRGGSKSV---LTDIFTSVVTTTDIPAGTIFGPCVLSFTLGYD-IADIALKTTDKRVVPYIFRVDTGACNGSSEP 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 150378439  86 LMWLRLVQSARDKEEQNLEAYIKN-GQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19192   78 SDWLRLVQPARDRHEQNLEAFRKNeGQVYFRTLRRIRKGEELLVWYSDELAELL 131
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 667-688 3.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 3.44e-04
                          10        20
                  ....*....|....*....|..
gi 150378439  667 KCPICNESFRERHHLSRHMTSH 688
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 6-138 1.79e-67

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 217.30  E-value: 1.79e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439   6 IQRGIWDGDAKAVqqcLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDsIAFIALKSTDKRTVPYIFRVDTSAANGSSEG 85
Cdd:cd19192    2 SHRSLWRGGSKSV---LTDIFTSVVTTTDIPAGTIFGPCVLSFTLGYD-IADIALKTTDKRVVPYIFRVDTGACNGSSEP 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 150378439  86 LMWLRLVQSARDKEEQNLEAYIKN-GQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19192   78 SDWLRLVQPARDRHEQNLEAFRKNeGQVYFRTLRRIRKGEELLVWYSDELAELL 131
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 29-131 3.38e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 43.67  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439   29 VYTTCDIPENAIFGP----CVLSHTSLYDSIAFIALKSTDKRTVPYIFRVDTSA-----ANGSSEGLmWLRLVQSARDke 99
Cdd:pfam00856   4 LFATEDIPKGEFIGEyvevLLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSeycidARALYYGN-WARFINHSCD-- 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 150378439  100 eQNLEAYI----KNGQLFYRSLRRIAKDEELLVWYG 131
Cdd:pfam00856  81 -PNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDYG 115
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 667-688 3.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 3.44e-04
                          10        20
                  ....*....|....*....|..
gi 150378439  667 KCPICNESFRERHHLSRHMTSH 688
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 29-134 1.60e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 38.85  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439    29 VYTTCDIPENAIFGPC---VLSHTSLYDSIAFIALKSTDKrtvPYIFRVDTSAANGSSEGLMWLRLV------QSARDKE 99
Cdd:smart00317  15 VRATEDIPKGEFIGEYvgeIITSEEAEERPKAYDTDGAKA---FYLFDIDSDLCIDARRKGNLARFInhscepNCELLFV 91

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 150378439   100 EQNLEAYIkngqlFYRSLRRIAKDEELLVWYGKEL 134
Cdd:smart00317  92 EVNGDDRI-----VIFALRDIKPGEELTIDYGSDY 121
ZnF_C2H2 smart00355
zinc finger;
666-688 2.12e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 2.12e-03
                           10        20
                   ....*....|....*....|...
gi 150378439   666 LKCPICNESFRERHHLSRHMTSH 688
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 6-138 1.79e-67

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 217.30  E-value: 1.79e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439   6 IQRGIWDGDAKAVqqcLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDsIAFIALKSTDKRTVPYIFRVDTSAANGSSEG 85
Cdd:cd19192    2 SHRSLWRGGSKSV---LTDIFTSVVTTTDIPAGTIFGPCVLSFTLGYD-IADIALKTTDKRVVPYIFRVDTGACNGSSEP 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 150378439  86 LMWLRLVQSARDKEEQNLEAYIKN-GQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19192   78 SDWLRLVQPARDRHEQNLEAFRKNeGQVYFRTLRRIRKGEELLVWYSDELAELL 131
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 18-131 2.44e-20

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 85.71  E-value: 2.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  18 VQQCLTDIFTSVYTTCDIPENAIFGPCVLShtslydsiafialkstdkrtvpyifrvdtsaangssegLMWLRLVQSARD 97
Cdd:cd10534    8 VLSSIPEGGLGVFARRTIPAGTRFGPLEGV--------------------------------------VNWMRFVRPARN 49

                         90       100       110
                 ....*....|....*....|....*....|....
gi 150378439  98 KEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYG 131
Cdd:cd10534   50 EEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 29-138 5.06e-16

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 74.96  E-value: 5.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  29 VYTTCDIPENAIFGPC---VLSHTSLYDSIAFIALKSTDKRTVpYIFRVDTSAANgsseglmWLRLVQSARDKEEQNLEA 105
Cdd:cd19193   22 VWAEAPIPKGMVFGPYegeIVEDEEAADSGYSWQIYKGGKLSH-YIDAKDESKSN-------WMRYVNCARNEEEQNLVA 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 150378439 106 YIKNGQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19193   94 FQYRGKIYYRTCKDIAPGTELLVWYGDEYAKEL 126
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 66-134 1.73e-14

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 69.85  E-value: 1.73e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 150378439  66 RTVPYIFRVDTSAangsSEGLMWLRLVQSARDKEEQNLEAY--IKNGQLFYRSLRRIAKDEELLVWYGKEL 134
Cdd:cd19197   33 RRVRGDYLVDESG----SPATEWIGLVRAARNNQEQNLEAIadLPGGQIFYRALRDIQPGEELTVWYSNSL 99
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 74-138 4.94e-14

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 69.31  E-value: 4.94e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 150378439  74 VDTSAANGSSeglmWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19196   67 IDASQENHRS----WMTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFL 127
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 88-130 5.83e-11

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 60.15  E-value: 5.83e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 150378439  88 WLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWY 130
Cdd:cd19188   76 WLRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 28-134 6.15e-11

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 60.05  E-value: 6.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  28 SVYTTCDIPENAIFGPcvlshtslYDsiAFIALKSTDKRTVPYIFRVDTSAANG----SSEGLMWLRLVQSARDKEEQNL 103
Cdd:cd19201   21 GVWAKQPLPEGTRFGP--------YP--GKLVKEPLDPSYEWKVEAQGSKGGEGllllTEDSGTWLKLVRSADDEDEANL 90

                         90       100       110
                 ....*....|....*....|....*....|.
gi 150378439 104 EAYIKNGQLFYRSLRRIAKDEELLVWYGKEL 134
Cdd:cd19201   91 ILYFKGGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 25-131 1.05e-09

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 57.02  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  25 IFTSVYTTCDIPENAIFGPCV--LSHTS---LYDSIAFIALKSTDKRTVPYIfrvdtsAANGSSEGlmWLRLVQSARDKE 99
Cdd:cd19198   18 PHYGVFCKKTIPKGTRFGPFRgrVVNTSeikTYDDNSFMWEIFEDGKLSHFI------DGRGSTGN--WMSYVNCARYAE 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 150378439 100 EQNLEAYIKNGQLFYRSLRRIAKDEELLVWYG 131
Cdd:cd19198   90 EQNLIAIQCQGQIFYESCKEILQGQELLVWYG 121
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 29-133 1.21e-09

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 56.70  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  29 VYTTCDIPENAIFGPCVLSH------TSLYDSIAF-IALKSTDKRTVPYIFRVDTSAANgsseglmWLRLVQSARDKEEQ 101
Cdd:cd19189   23 VWTKETIPVRTCFGPLIGQQshsaevADWTDKAAPhIWKIYHNDVLEFCIITTDENECN-------WMMFVRKARTREEQ 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 150378439 102 NLEAYIKNGQLFYRSLRRIAKDEELLVWYGKE 133
Cdd:cd19189   96 NLVAYPHDGKIYFCTSRDIPPDQELLFYYSRD 127
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 88-138 1.68e-09

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 56.33  E-value: 1.68e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 150378439  88 WLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19191   78 WMRYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 40-131 5.50e-09

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 54.73  E-value: 5.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  40 IFGPCVLSHTSLYDSIAFIALKSTDKRTVPYIFrvDTSaangSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRR 119
Cdd:cd19199   34 QFGPFEAKRVARLDGFAVFPLKVFEKDGSVVYL--DTS----NEDDCNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRD 107

                         90
                 ....*....|..
gi 150378439 120 IAKDEELLVWYG 131
Cdd:cd19199  108 IQPGAELRVWYA 119
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 28-138 2.64e-08

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 52.71  E-value: 2.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  28 SVYTTCDIPENAIFGPCVlshtslydsiAFIALKSTDKRTV--PYIFRV-----DTSAANGSSEGLM-WLRLVQSARDKE 99
Cdd:cd19187   20 GVWSSDYIPRGTRFGPLV----------GEIYTNDPVPKGAnrKYFWRIysngeFYHYIDGFDPSKSnWMRYVNPAHSLQ 89

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 150378439 100 EQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19187   90 EQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 29-138 6.31e-08

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 51.58  E-value: 6.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  29 VYTTCDIPENAIFGPCV---LSHTSLYDSIAFIALKSTDKRTVPYIfrvDTSAANGSSeglmWLRLVQSARDKEEQNLEA 105
Cdd:cd19194   22 VFAKRRIPKRTQFGPLEgplVKKSELKDNKIHPLELEEDDGEDLYF---DLSDENKCN----WMMFVRPAQNHLEQNLVA 94

                         90       100       110
                 ....*....|....*....|....*....|...
gi 150378439 106 YIKNGQLFYRSLRRIAKDEELLVWYGKELTELL 138
Cdd:cd19194   95 YQYGQEIYFTTIKNIEPKQELKVWYAASYAEFL 127
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 35-133 6.72e-08

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 51.78  E-value: 6.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  35 IPENAIFGPCVLSHTSLYDSIAFIALKSTDK-RTVPYIFRVDTSAANgsseglmWLRLVQSARDKEEQNLEAYIKNGQLF 113
Cdd:cd19195   28 IPKGHIFGPYEGQICTQDKSSGFFSWLIVDKnNRYKSIDGSDETKAN-------WMRYVVISREEREQNLLAFQHSEQIY 100

                         90       100
                 ....*....|....*....|
gi 150378439 114 YRSLRRIAKDEELLVWYGKE 133
Cdd:cd19195  101 FRACRDIRPGEKLRVWYSED 120
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 29-128 2.14e-07

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 50.44  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439  29 VYTTCDIPENAIFGPCV-LSHTSLYDSIAFIALKSTDKRTVpyiFRVDTSAANGSSeglmWLRLVQSARDKEEQNLEAYI 107
Cdd:cd19200   28 VWTKVRIEVGEKFGPFVgVQRSSVKDPTYAWEIVDEFGKVK---FWIDASEPGTGN----WMKYIRSAPSCEQQNLMACQ 100

                         90       100
                 ....*....|....*....|.
gi 150378439 108 KNGQLFYRSLRRIAKDEELLV 128
Cdd:cd19200  101 IDEQIYYKVVRDIQPGEELLL 121
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 72-129 5.23e-06

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 47.18  E-value: 5.23e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 150378439  72 FRVDTSAANGSSeglmWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVW 129
Cdd:cd19213   96 FCVDAGQAGAGS----WLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 29-131 3.38e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 43.67  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439   29 VYTTCDIPENAIFGP----CVLSHTSLYDSIAFIALKSTDKRTVPYIFRVDTSA-----ANGSSEGLmWLRLVQSARDke 99
Cdd:pfam00856   4 LFATEDIPKGEFIGEyvevLLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSeycidARALYYGN-WARFINHSCD-- 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 150378439  100 eQNLEAYI----KNGQLFYRSLRRIAKDEELLVWYG 131
Cdd:pfam00856  81 -PNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDYG 115
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 667-688 3.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 3.44e-04
                          10        20
                  ....*....|....*....|..
gi 150378439  667 KCPICNESFRERHHLSRHMTSH 688
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 666-688 7.60e-04

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.24  E-value: 7.60e-04
                          10        20
                  ....*....|....*....|...
gi 150378439  666 LKCPICNESFRERHHLSRHMTSH 688
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 29-134 1.60e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 38.85  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 150378439    29 VYTTCDIPENAIFGPC---VLSHTSLYDSIAFIALKSTDKrtvPYIFRVDTSAANGSSEGLMWLRLV------QSARDKE 99
Cdd:smart00317  15 VRATEDIPKGEFIGEYvgeIITSEEAEERPKAYDTDGAKA---FYLFDIDSDLCIDARRKGNLARFInhscepNCELLFV 91

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 150378439   100 EQNLEAYIkngqlFYRSLRRIAKDEELLVWYGKEL 134
Cdd:smart00317  92 EVNGDDRI-----VIFALRDIKPGEELTIDYGSDY 121
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 88-130 1.81e-03

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 38.81  E-value: 1.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 150378439  88 WLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWY 130
Cdd:cd19190   80 WLRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
ZnF_C2H2 smart00355
zinc finger;
666-688 2.12e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 2.12e-03
                           10        20
                   ....*....|....*....|...
gi 150378439   666 LKCPICNESFRERHHLSRHMTSH 688
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 88-129 5.09e-03

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 37.40  E-value: 5.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 150378439  88 WLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVW 129
Cdd:cd10520   74 WMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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