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Conserved domains on  [gi|9945322|ref|NP_064705|]
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vesicular glutamate transporter 1 [Homo sapiens]

Protein Classification

vesicular glutamate transporter( domain architecture ID 13024359)

vesicular glutamate transporter, also called solute carrier family 17 member, mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate; belongs to the Major Facilitator Superfamily

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
66-490 0e+00

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 735.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   66 AIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANR 145
Cdd:cd17382   1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  146 VFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLA 225
Cdd:cd17382  81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  226 GVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSyespalhpsiseeerkyiedaigesaklmnpltkfstpwrrfftsMPVY 305
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLVS---------------------------------------------MPVY 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  306 AIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGF 385
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  386 GMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTR 465
Cdd:cd17382 276 GMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTR 355
                       410       420
                ....*....|....*....|....*
gi 9945322  466 EEWQYVFLIASLVHYGGVIFYGVFA 490
Cdd:cd17382 356 EEWQYVFLIASLVHFFGVIFYAIFA 380
 
Name Accession Description Interval E-value
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
66-490 0e+00

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 735.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   66 AIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANR 145
Cdd:cd17382   1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  146 VFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLA 225
Cdd:cd17382  81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  226 GVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSyespalhpsiseeerkyiedaigesaklmnpltkfstpwrrfftsMPVY 305
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLVS---------------------------------------------MPVY 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  306 AIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGF 385
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  386 GMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTR 465
Cdd:cd17382 276 GMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTR 355
                       410       420
                ....*....|....*....|....*
gi 9945322  466 EEWQYVFLIASLVHYGGVIFYGVFA 490
Cdd:cd17382 356 EEWQYVFLIASLVHFFGVIFYAIFA 380
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
49-502 1.16e-93

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 294.34  E-value: 1.16e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322     49 PPVVDCTCFglpRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQK-------AQFSWDPETVGLIHG 121
Cdd:TIGR00894   7 STKLPYFCS---FRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENeldniknPNFKWSGALQGLILS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    122 SFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPL 201
Cdd:TIGR00894  84 SHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    202 ERSRLATTAFCGSYAGAVVAMPLAGVLVQYS-GWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGE 280
Cdd:TIGR00894 164 ERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    281 SaklmNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQ 360
Cdd:TIGR00894 244 Q----KGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    361 IADFLRSRRIMSTTNVRKLMN-CGGFGMeaTLLLVVGYSHSKGV--AISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 437
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNgIGGLGP--GIFAYALPYLSAAFylTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFI 397
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9945322    438 MGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEE 502
Cdd:TIGR00894 398 KGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEK 462
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-490 1.30e-42

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 156.18  E-value: 1.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   60 PRRYIIAIMSGLGFCISFGIRCNLGVAIVSMvnnstthrgghvvvqKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQ 139
Cdd:COG2271   6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL---------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  140 KFAANRVFGFAIVATSTLNMLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAV 219
Cdd:COG2271  71 RFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGA 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  220 VAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFwllvsyespalhpsiseeerkyiedaigesaklmnpltkfstpwrrff 299
Cdd:COG2271 149 LAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------------------------------------------------ 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  300 tsmPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRrimsttnvRKL 379
Cdd:COG2271 181 ---RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------RKL 249
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  380 MNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSGMVCPIIVGA 458
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGY 329
                       410       420       430
                ....*....|....*....|....*....|..
gi 9945322  459 MTKHKTreeWQYVFLIASLVHYGGVIFYGVFA 490
Cdd:COG2271 330 LLDATG---YQAAFLLLAALALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
108-451 4.16e-32

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 126.76  E-value: 4.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    108 QFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTY 187
Cdd:pfam07690  26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGALF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    188 PACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSIS 267
Cdd:pfam07690 104 PAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    268 EEERKyiedaigesaklmnpltKFSTPWRRFFTSmPVYAIIVANFCRSWTFYLLLISQPAYfEEVFGFEISKVGLVSALP 347
Cdd:pfam07690 184 EEARL-----------------SLIVAWKALLRD-PVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLG 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    348 HLVMTIIVPIGGQIADFLRSRRIMsttnvrkLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHL 427
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
                         330       340
                  ....*....|....*....|....*
gi 9945322    428 DIAP-RYASILMGISNGVGTLSGMV 451
Cdd:pfam07690 318 DLAPkEERGTASGLYNTAGSLGGAL 342
 
Name Accession Description Interval E-value
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
66-490 0e+00

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 735.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   66 AIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANR 145
Cdd:cd17382   1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  146 VFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLA 225
Cdd:cd17382  81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  226 GVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSyespalhpsiseeerkyiedaigesaklmnpltkfstpwrrfftsMPVY 305
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLVS---------------------------------------------MPVY 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  306 AIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGF 385
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  386 GMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTR 465
Cdd:cd17382 276 GMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTR 355
                       410       420
                ....*....|....*....|....*
gi 9945322  466 EEWQYVFLIASLVHYGGVIFYGVFA 490
Cdd:cd17382 356 EEWQYVFLIASLVHFFGVIFYAIFA 380
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
66-490 9.18e-171

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 489.05  E-value: 9.18e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   66 AIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGG-------HVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFIC 138
Cdd:cd17318   1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNntstdkdTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  139 QKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGA 218
Cdd:cd17318  81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  219 VVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWllvsyespalhpsiseeerkyiedaigesaklmnpltkfstpwrrF 298
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW---------------------------------------------F 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  299 FTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRK 378
Cdd:cd17318 196 FLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRK 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  379 LMNCGGFGMEATLLLVVGY-SHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVG 457
Cdd:cd17318 276 LFTSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVG 355
                       410       420       430
                ....*....|....*....|....*....|....
gi 9945322  458 AMTKHK-TREEWQYVFLIASLVHYGGVIFYGVFA 490
Cdd:cd17318 356 AIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
65-490 1.96e-119

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 358.32  E-value: 1.96e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   65 IAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGG--------HVVVQKA-------QFSWDPETVGLIHGSFFWGYIV 129
Cdd:cd17381   1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNnssnacpeHSSSPSVehnetgkKYDWDAETQGWILGSFFYGYII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  130 TQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATT 209
Cdd:cd17381  81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  210 AFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWllvsyespalhpsiseeerkyiedaigesaklmnplt 289
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLW------------------------------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  290 kfstpwrrFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRR 369
Cdd:cd17381 204 --------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQ 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  370 IMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGV-AISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLS 448
Cdd:cd17381 276 NFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSlAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIP 355
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 9945322  449 GMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFA 490
Cdd:cd17381 356 GMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
71-490 1.60e-98

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 303.32  E-value: 1.60e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   71 LGFCISFGIRCNLGVAIVSMVNnstthrgghvvvqkaQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFA 150
Cdd:cd17380   6 LATCICYADRVNMPIAIVPMAK---------------EFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  151 IVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQ 230
Cdd:cd17380  71 VALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  231 YSGWSSVFYVYGSFGIFWYLFWLLVSyespalhpsiseeerkyiedaigesaklmnpltkfstpwrrfftsMPVYAIIVA 310
Cdd:cd17380 151 YYGWPSVFYFFGLLGLLWALVWLIYL---------------------------------------------PPVWAIIVA 185
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  311 NFCRSWTFYLLLISQPAYFEEVFGfEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRiMSTTNVRKLMNCGGFGMEAT 390
Cdd:cd17380 186 HFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRG-WTVTSVRKLMQSIGFLGPAL 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  391 LLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA-MTKHKTreeWQ 469
Cdd:cd17380 264 FLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYiLEATGS---WS 340
                       410       420
                ....*....|....*....|.
gi 9945322  470 YVFLIASLVHYGGVIFYGVFA 490
Cdd:cd17380 341 LVFVLAAVVNLVGAVVFLLFG 361
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
49-502 1.16e-93

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 294.34  E-value: 1.16e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322     49 PPVVDCTCFglpRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQK-------AQFSWDPETVGLIHG 121
Cdd:TIGR00894   7 STKLPYFCS---FRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENeldniknPNFKWSGALQGLILS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    122 SFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPL 201
Cdd:TIGR00894  84 SHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    202 ERSRLATTAFCGSYAGAVVAMPLAGVLVQYS-GWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGE 280
Cdd:TIGR00894 164 ERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQG 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    281 SaklmNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQ 360
Cdd:TIGR00894 244 Q----KGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    361 IADFLRSRRIMSTTNVRKLMN-CGGFGMeaTLLLVVGYSHSKGV--AISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 437
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNgIGGLGP--GIFAYALPYLSAAFylTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFI 397
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9945322    438 MGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEE 502
Cdd:TIGR00894 398 KGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEK 462
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
62-485 6.03e-45

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 162.35  E-value: 6.03e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   62 RYIIAIMSGLGFCISFGIRCNLGVAIVSMvnnstthrgghvvvqKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKF 141
Cdd:cd17319   1 RWRIIPLLFLAYVINYLDRVNISVAAPTI---------------MKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRF 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  142 AANRVFGFAIVATSTLNMLIpSAARVHYGcVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVA 221
Cdd:cd17319  66 GARKVLAVSMLLWSLFTALT-GFATSLTS-LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  222 MPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYEspalhpsiseeerkyiedaigesaklmnpltkfstpwrrffts 301
Cdd:cd17319 144 PPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------------------------------------- 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  302 mpVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRimsttnvRKLMN 381
Cdd:cd17319 181 --VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVI 251
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  382 CGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPIIVGAMT 460
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLV 331
                       410       420
                ....*....|....*....|....*
gi 9945322  461 KHKTREEWQYVFLIASLVHYGGVIF 485
Cdd:cd17319 332 DATGSYTAAFLFLAAVALLAALLVL 356
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-490 1.30e-42

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 156.18  E-value: 1.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   60 PRRYIIAIMSGLGFCISFGIRCNLGVAIVSMvnnstthrgghvvvqKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQ 139
Cdd:COG2271   6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL---------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  140 KFAANRVFGFAIVATSTLNMLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAV 219
Cdd:COG2271  71 RFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGA 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  220 VAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFwllvsyespalhpsiseeerkyiedaigesaklmnpltkfstpwrrff 299
Cdd:COG2271 149 LAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------------------------------------------------ 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  300 tsmPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRrimsttnvRKL 379
Cdd:COG2271 181 ---RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------RKL 249
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  380 MNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSGMVCPIIVGA 458
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGY 329
                       410       420       430
                ....*....|....*....|....*....|..
gi 9945322  459 MTKHKTreeWQYVFLIASLVHYGGVIFYGVFA 490
Cdd:COG2271 330 LLDATG---YQAAFLLLAALALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
108-451 4.16e-32

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 126.76  E-value: 4.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    108 QFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTY 187
Cdd:pfam07690  26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGALF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    188 PACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSIS 267
Cdd:pfam07690 104 PAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    268 EEERKyiedaigesaklmnpltKFSTPWRRFFTSmPVYAIIVANFCRSWTFYLLLISQPAYfEEVFGFEISKVGLVSALP 347
Cdd:pfam07690 184 EEARL-----------------SLIVAWKALLRD-PVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLG 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    348 HLVMTIIVPIGGQIADFLRSRRIMsttnvrkLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHL 427
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
                         330       340
                  ....*....|....*....|....*
gi 9945322    428 DIAP-RYASILMGISNGVGTLSGMV 451
Cdd:pfam07690 318 DLAPkEERGTASGLYNTAGSLGGAL 342
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
108-486 1.58e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 114.06  E-value: 1.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  108 QFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTY 187
Cdd:cd06174  25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--PSFWLLLLGRFLLGLGSGLID 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  188 PACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQY--SGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPS 265
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  266 ISEEERKyiedaigesaklmnplTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSA 345
Cdd:cd06174 183 KNEEASS----------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  346 LPHLVMTIIVPIGGQIADFLRSRrimsttnvRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVN 425
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDRLIGR--------KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9945322  426 HLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTReeWQYVFLIASLVHYGGVIFY 486
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
107-449 9.98e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 108.52  E-value: 9.98e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  107 AQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAArvHYGCVIFVRILQGLVEGVT 186
Cdd:COG2814  38 ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGAL 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  187 YPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIfwyLFWLLVSYESPALHPSI 266
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLAL---LALLLLLRLLPESRPAA 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  267 SeeerkyiedaigesaklmnplTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSAL 346
Cdd:COG2814 193 R---------------------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  347 PHLVMTIIVPIGGQIADFLRSRRIMSttnvrklmncGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNH 426
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLL----------IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
                       330       340
                ....*....|....*....|....
gi 9945322  427 LDIAP-RYASILMGISNGVGTLSG 449
Cdd:COG2814 322 AELAPpEARGRASGLYNSAFFLGG 345
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
60-459 1.26e-24

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 106.12  E-value: 1.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   60 PRRYIIAIMSGLGFCISFGIRCNLGVAIVSMvnnstthrgghvvvqKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQ 139
Cdd:COG2223   1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL---------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  140 KFAANRVFGFAIVATSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAV 219
Cdd:COG2223  66 RFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAA 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  220 VAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPAlhpsiseeerkyiEDAIGESAKLMNPLTKFSTPWrrff 299
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA-------------GAAAAAKASLRDQLEALRDPR---- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  300 tsmpVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVrkl 379
Cdd:COG2223 207 ----FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA--- 279
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  380 mncggfGMEATLLLVVGYSHSKGVAI-SFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA 458
Cdd:COG2223 280 ------LMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGA 353

                .
gi 9945322  459 M 459
Cdd:COG2223 354 L 354
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
116-478 3.38e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 95.34  E-value: 3.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  116 VGLIHGSFFWGYIVTQIPGGFICQKFAANR--VFGFAIVATSTLnmLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGI 193
Cdd:cd17325  33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRllLLGLLLLAVSTL--LFAFAT--SYWQLLLARFLQGLASAAVWPAAMAL 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  194 WSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVsyespalhpsiseeerky 273
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLL------------------ 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  274 IEDAIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTI 353
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  354 IVPIGGQIADFLRSRRIMsttnvrklmncgGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHL--DIAP 431
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLI------------LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALlaDIVP 318
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 9945322  432 RYA-SILMGISNGVGTLSGMVCPIIVGAMTkhkTREEWQYVFLIASLV 478
Cdd:cd17325 319 PEGrGTAMGLFNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAAL 363
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
63-485 1.14e-13

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 73.05  E-value: 1.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   63 YIIAIMSGLGFCISFGIRCNLGVAIVSmvNNST-THRGGHvvvqkaQFSWdpetvglIHGSFFWGYIVTQIPGGFICQKF 141
Cdd:cd17327   4 LFILPLLCILYFLQYLDKSNISNAAVM--GMKEdLKLVGN------QYNW-------GNTVFYVGYIIFELPGNLLLQRF 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  142 AANRVFGFAIVATSTlnMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVa 221
Cdd:cd17327  69 PPSKWLSVFIVLWGL--LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIF- 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  222 mplaGVLVQY-----------SGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMnPLTK 290
Cdd:cd17327 146 ----GGLLAYgvfkilgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGK-GDQK 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  291 FS-TPWRRFFTSMPVYAIIVANFCrSW-------TFYLLLISQpayfeevFGFEISKVGLVSALPHLVMTIIVPIGGQIA 362
Cdd:cd17327 221 FKwKQIKEAFKDPRTWLLFLFFFC-SQitnngisNFLPLILKS-------LGFYSLQTNLLSVPIGALGAVSLLIAALLS 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  363 DFLRSRRImsttnvrklmncggFGMEATLLLVVGYS-------HSKGVAISFLVLAVGFSGFAISGFNVNhlDIAPRYAS 435
Cdd:cd17327 293 DRFKKRGL--------------FAIFACVLALVGSIillaapnPPGAYFAAYILGGGSYAGFPILLSWIS--SNCAGYTK 356
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 9945322  436 --ILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWqyvflIASLVHYGGVIF 485
Cdd:cd17327 357 raTVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGN-----IALLVCACVSIV 403
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
172-490 8.08e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 66.83  E-value: 8.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  172 VIFVRILQGLVEGVTYPACHGIWSKWAPPLERSR---LATTAfcgSYAGAVVAMPLAGVLVQYsGWSSVFYVYGSFGIFW 248
Cdd:cd17473  91 LLASRALLGIGVAGIMTLATALIGDYFEGEERAKmlgLQSAA---MSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVL 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  249 YLFWLLvsyespalhpsISEEERKYIEDAIGESAKLMnpltkfSTPWRRfftsmpVYAIIVANFCRSWTFYLLLISQPAY 328
Cdd:cd17473 167 ILVLLF-----------LPEPARKSKSAASPGAATAA------ALPWKR------VLPIYFLAFLAMLLFYVIPIQLPFL 223
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  329 FEEVFGFEISKVGLVSAlphlVMTIIVPIGGqiadfLRSRRIMSTTNVRKLMnCGGFGMEATLLLVVGYSHSKGVAISFL 408
Cdd:cd17473 224 LQERGGGSAALIGLALA----IASLAGAIGA-----LLFGRLKRRLGKRRLL-AIGFALMALGFLLLALASGLWVVLLGA 293
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  409 VLaVGFsGFAISGFNVNH--LDIAPRYAS-ILMGISNGVGTLSGMVCPIIVGAMTKHKTREewQYVFLIASLVHYGGVIF 485
Cdd:cd17473 294 IL-AGL-GFGLLLPTLNSwaMSLVPPELRgRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL--SGAFLILGVLALVLAIV 369

                ....*
gi 9945322  486 YGVFA 490
Cdd:cd17473 370 LLLLR 374
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
106-459 1.16e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 66.61  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLipSAARVHYGCVIFVRILQGLVEGV 185
Cdd:TIGR00895  44 SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLILRFLAGLGLGG 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    186 TYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPS 265
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVS 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    266 ISEEERKYIEDAIGESAKlMNPLTKFSTP------WRRFF-------TSMPVYAIIVANFCRSWTFYLLLISQPaYFEEV 332
Cdd:TIGR00895 202 KRPETVRRIVNAIAPQMQ-AEAQSALPEQkstqgtKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVE 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    333 FGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMsttnvrklmncgGFGMEATLLLVVGYS--HSKGVAISFLVL 410
Cdd:TIGR00895 280 LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA------------LLLLLGAVFAVLVGStlFSPTLLLLLGAI 347
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 9945322    411 AVGFSGFAISGFNVNHLDIAPRYA-SILMGISNGVGTLSGMVCPIIVGAM 459
Cdd:TIGR00895 348 AGFFVNGGQSGLYALMALFYPTAIrATGVGWAIGIGRLGAIIGPILAGYL 397
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
106-462 9.58e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 60.47  E-value: 9.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIpsAARVHYGCVIFVRILQGLVEGV 185
Cdd:TIGR00881  22 VEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFF--GFSTSLWVMAALWALNGIFQGM 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    186 TYPACHGIWSKWAPPLERSRLATTAFCGS-YAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPaLHP 264
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSP-QSC 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    265 SISEEERKYIEDAIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVS 344
Cdd:TIGR00881 179 GLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAF 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    345 ALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRK-LMNCggfgmeATLLLVVGYSHSKGVAISFLvLAVGFSGFA-ISGF 422
Cdd:TIGR00881 259 TLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMaLIIV------SLLVYWLNPAANPLMDLICL-FALGFLVYGpQMLI 331
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 9945322    423 NVNHLDIAPRYASILM-GISNGVGTLSGMVCPIIVGAMTKH 462
Cdd:TIGR00881 332 GVIASELAPKKAAGTAaGFVGFFAYLGGILAGLPLGYLADG 372
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
60-362 1.18e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.82  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322   60 PRRYIIAIMSGLGFCISFgircnLGVAIVSMVnnstthrgghVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQ 139
Cdd:COG0477  10 RRRRRALLALALGTFLEG-----LDFTIVNVA----------LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  140 KFAANRVFGFAIV---ATSTLNMLIPSAArvhygCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYA 216
Cdd:COG0477  75 RYGRKRVLLIGLLlfgLASLLCGLAPSPE-----LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  217 GAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWyLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPLTKFSTPWR 296
Cdd:COG0477 150 GLALGPLLGGLLVAALGWRWIFLINAPLGLLA-LVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLA 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9945322  297 RFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIA 362
Cdd:COG0477 229 LLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
107-475 2.17e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.49  E-value: 2.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  107 AQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLipSAARVHYGCVIFVRILQGLVEGVT 186
Cdd:cd17324  27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL--AALAPSFALLLLARALAGLAHGGF 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  187 YPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGI--FWYLFWLLvsyespalhP 264
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALlaALLLWRLL---------P 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  265 SISEEERKYIEDAIGESAKLMNPLTkfstpWRRFFTSMpvyaIIVANFCRSWTFYLLLISQPAYFEEvfgfeiSKVGLVS 344
Cdd:cd17324 176 SLPPKKPGSLGLLSSLLLLLRNPRL-----RLAYLITF----LLFGGFFALYTYLAPFLTDVPGFSS------SAIIGLL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  345 ALPHLVMTIIVPIGGQIADFLRSRRIMSTtnvrklmncGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFsGFAISGFNV 424
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIA---------LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF-FAAHSALQT 310
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 9945322  425 NHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHktrEEWQYVFLIA 475
Cdd:cd17324 311 RVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVG 358
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
102-459 3.11e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.77  E-value: 3.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  102 VVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIV---ATSTLNMLIPSaarvhYGCVIFVRIL 178
Cdd:cd17316  24 VLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLlfgLATLLIGLLPT-----PILLLVLRFL 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  179 QGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGwssvfyvyGSFGIFWYLFWLLVsye 258
Cdd:cd17316  99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLS--------GDWGWRILFLIGAL--- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  259 sPALhpsiseeerkyiedaigesaklmnpltkFSTPWRRFFTsmpvyAIIVANFCRSWTFYLLLISQPAYFEEVFGFEIS 338
Cdd:cd17316 168 -PAL----------------------------LALLLRRRTL-----LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPA 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  339 KVGLVSALPHLVMTIIVPIGGQIADFLRsrrimsttnvRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVgFSGFA 418
Cdd:cd17316 214 TSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI-LSFFV 282
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 9945322  419 ISGFNVNHLDIA----PRYASILMGISNGVGTLSGMVCPIIVGAM 459
Cdd:cd17316 283 GGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
106-491 1.36e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 57.17  E-value: 1.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRV--FGFAIVATStlnMLIPSAARvHYGCVIFVRILQGLVE 183
Cdd:COG0738  35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGllLGLLLMALG---LLLFALAP-SYPLLLLALFLLGLGL 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  184 GVTYPACHGIWSKWAPPLERSRLATTAFCGSyAGAVVAMPLAGVLVQYS---GWSSVFYVYGSFGIFWYLFWLLVSYesp 260
Cdd:COG0738 111 GLLDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLALLFLRSKL--- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  261 alhPSISEEERKYIEDAIGESAKLMNPLTKFstpwrrFFTSMPVYAII-VAnfCRSWTfylllisqPAYFEEVFGFEISK 339
Cdd:COG0738 187 ---PEIEEEEEEAAGSAASLKSLLKNPRLLL------GGLAIFLYVGAeGA--IGDWL--------PLYLKDVLGLSEAT 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  340 VGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTtnvrklmnCGGFGmeATLLLVVGYSHSKGVAISFLVLAvgfsGFAI 419
Cdd:COG0738 248 AALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRL--------SALLA--AVGLLLALLAPGPWLALIGLALV----GLGL 313
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9945322  420 SGF--NVNHL--DIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTreeWQYVFLIAsLVHYGGVIFYGVFAS 491
Cdd:COG0738 314 SLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG---LRAAFLVP-LVCYLLILLLALALK 385
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
202-459 2.61e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.45  E-value: 2.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  202 ERSRLATTAFCGSYAGAVVAMPLAGVLVQY------SGWSSVFYVYGSFGIFWYLFWLLVSYESPAlhpsiSEEERKYIE 275
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLAFLLTFFGTKERPV-----PEEEKVSLK 218
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  276 DAIGESAKlmNPltkfstPWRRFFtsmpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIV 355
Cdd:COG2211 219 ESLKALLK--NR------PFLLLL---------LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA 281
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  356 PIGGQIADFLRSRRIMsttnvrklmnCGGFGMEATLLLVVGYSHSKGVAISFLVLAVgfSGFAISGFNVNHL----DIAP 431
Cdd:COG2211 282 PLWPRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLGPGNLWLLLVLAAL--AGIGLGAILVLPWamlaDVVD 349
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 9945322  432 --------RYASILMGISNGVGTLSGMVCPIIVGAM 459
Cdd:COG2211 350 ydewktgrRREGLYFGIFTFAIKLGQALAGALAGLL 385
MFS_1 pfam07690
Major Facilitator Superfamily;
307-502 5.72e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.65  E-value: 5.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    307 IIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSttnvrklmnCGGFG 386
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL---------IGLLL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322    387 MEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTre 466
Cdd:pfam07690  72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-- 149
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 9945322    467 eWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEE 502
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
106-486 5.24e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 48.72  E-value: 5.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARvhYGCVIFVRILQGLVEGV 185
Cdd:cd17474  26 AEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGRALQGIGAAG 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  186 TYPACHGIWSKWAPPLERSRLAttafcGSYAGAV----VAMPLAGVLVQYSGWSSVFYVYGSFGI--FWYLFWLLVSYES 259
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAM-----GLYEAALglgiAVGPLLGGLLAAISWRYPFFLLAALIPvaFLAILFLLPEPKE 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  260 PALHPSiseeerkyiedaigesaklmnplTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISK 339
Cdd:cd17474 179 KAKSSS-----------------------ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPII 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  340 VGLVSALPHLVMTIIVPIGGQI-ADFLRSRRIMsttnvrklmnCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFA 418
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGRLlKKRFGARRIL----------VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLN 305
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9945322  419 ISGFNVNHLDIAPRYA-SILMGISNGVGTLSGMVCPIIVGAMTKHKTreeWQYVFLIASLVHYGGVIFY 486
Cdd:cd17474 306 LPLLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFG---LSAPFLVGAAIALAAAVLL 371
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
112-485 5.82e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 48.81  E-value: 5.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  112 DPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIpsAARVHYGCVIFVRILQGLVEGVTYPACH 191
Cdd:cd17312  36 SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GFSTSLWFFAVLWGLNGLFQSMGWPPCV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  192 GIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPalhpsiseeer 271
Cdd:cd17312 114 KLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP----------- 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  272 KYIedaigesaklmnpltkfstpWRRFFTSMPVYAIIVAnfCRSWTfylllisqPAYFEEVFGFEISKVGLVSALPHLVM 351
Cdd:cd17312 183 PYV--------------------WVLSLAYAFVYIVRYA--CLDWG--------PLYLYEVKGYSLIDAGWFSSLYEVGG 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  352 TIIVPIGGQIAD-FLRSRRimsttnvRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIA 430
Cdd:cd17312 233 IAGTILAGLLSDkLFGGRR-------APIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDI 305
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 9945322  431 PRY--ASILMGISNGVGTLSGMVCPIIVGAMTKHKTreeWQYVFLIASLVHYGGVIF 485
Cdd:cd17312 306 GRKeaAGTATGFVGLFGYLGASLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLL 359
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
172-464 6.91e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 48.34  E-value: 6.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  172 VIFVRILQGLVEGVTyPACHGIWSKWAPPlERSRLATTAFCGSYA-GAVVAMPLAGVLVQYSGWSSVFYVYGSFGIfwyl 250
Cdd:cd17504  87 LIAGRALQGIGGAVF-PLAFALVREEFPP-ERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV---- 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  251 fwLLVsyespALHPSISeeerkyiedaigesaklmnpltkfstpwRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFE 330
Cdd:cd17504 161 --LLA-----ALVPLID----------------------------LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQ 205
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  331 E----VFGFEISKVGLVSALPHLVMTIIVPIGGqiadflrsrRIMSTTNVRKLMNCGGFGMeATLLLVVGYSHSKGVAIS 406
Cdd:cd17504 206 LptptGFGLGITEAGLLLLPGALVMLIAGPLAG---------RLIARVGPRRVLLIGLVIS-AVGLLLLALLHSSLWALV 275
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9945322  407 F--LVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA-MTKHKT 464
Cdd:cd17504 276 ValLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAiLTTYTV 336
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
294-478 2.56e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 2.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  294 PWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMst 373
Cdd:COG2814   2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  374 tnvrklmnCGGFGMEATLLLVVGYSHSkgvaISFLVLAVGFSGFAISGFNVNHLDIAPRYAS-----ILMGISNGVGTLS 448
Cdd:COG2814  79 --------LLGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALALIADLVPperrgRALGLLGAGLGLG 146
                       170       180       190
                ....*....|....*....|....*....|
gi 9945322  449 GMVCPIIVGAMTKHktrEEWQYVFLIASLV 478
Cdd:COG2814 147 PALGPLLGGLLADL---FGWRWVFLVNAVL 173
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
135-419 2.62e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 46.80  E-value: 2.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  135 GFICQKFAANRVFGFAIVA---TSTLNMLIPSAARVhygcvIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAF 211
Cdd:cd17503  52 GWLADRFGTRRLFLTALALftlGSLLCGLAPNLASL-----IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVG 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  212 CGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFwylfwllvsyespalhpsiseeerkyiedaigesAKLMNPLTKF 291
Cdd:cd17503 127 LVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL----------------------------------ALLLAPLLDL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  292 STPWRRFFTSMpVYAIIVANFCRSWTFYLLlisqPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGqiadflrsrRIM 371
Cdd:cd17503 173 RLFKDRNFTLG-LLLSFLLGLGLFGAMFLL----PLYLQNVLGYSAFESGLVLAPGGLASAILSPLVG---------RLL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 9945322  372 STTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAI 419
Cdd:cd17503 239 DKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGL 286
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
106-460 3.68e-05

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 46.08  E-value: 3.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFV--RILQGLVE 183
Cdd:cd17345  30 IEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFilLFLNGWFQ 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  184 GVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSG---WSSVFYVYGSFGIFWYLFWLLVSYESP 260
Cdd:cd17345 110 GMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTP 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  261 ---ALhPSISEEERKYIEDAIGESAKlmNPLTKFSTPWRRFFTSMPVYAIIVAN----FCR----SWTfylllisqPAYF 329
Cdd:cd17345 190 eseGL-PPIEEYKGDYPEEADGEEEE--QELSAWEIFVKYVLKNKLLWYIAIANvfvyLVRygilDWA--------PTYL 258
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  330 EEVFGFEISKVGLVSAL---PHLVMTIIVpigGQIAD-FLRSRRimsttnvrklMNCGGFGMEATLLLVVGYSHSKGVAI 405
Cdd:cd17345 259 SEVKGFSKAQAMWAFSLfewAAIPGTLLA---GWLSDkLFKGRR----------APTGIIFMILVIVALIVYWLAPNVLV 325
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9945322  406 SFLVLAvgFSGFAISG----FNVNHLDIAPRYAsilmgisngVGTLSGM--VCPIIVGAMT 460
Cdd:cd17345 326 DLIALI--ALGFLIYGpvmlIGLQALELVPKKA---------AGTAAGLtgLFGYLGGSVL 375
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
116-486 6.64e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.28  E-value: 6.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  116 VGLIHGSFFWGYIVTQIPGGFICQKFAANRV--FGFAIVATSTLNMLIPSAARVhygcVIFVRILQGLVEGVTYPACHGI 193
Cdd:cd17489  33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLllIGLLIFALATLLYLLATSVAL----LLVLRLIHGIGWGAFTTAAATL 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  194 WSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERky 273
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTR-- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  274 iedaigesaklmnpltkfstPWRRFF--TSMPVYAIIvanFCRSWTFYLLLISQPAYFEEVFgfeISKVGLVSALPHLVM 351
Cdd:cd17489 187 --------------------AFRRLVekKVLPPALIL---FLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIAL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  352 TIIVPIGGQIADFLRSRRIMSTtnvrklmncgGFGMEATLLLVVGYSHSKGVA-ISFLVLAVGFsGFAISGFNVNHLDIA 430
Cdd:cd17489 241 LLSRPFSGKLSDRKGPKTVIIP----------GLLLLALGLLLLSFAGSPWMLlLAAVLYGLGF-GLLFPALQALAVDLV 309
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 9945322  431 PRYA-SILMGISNGVGTLSGMVCPIIVGAMTKHktreeWQY--VFLIASLVHYGGVIFY 486
Cdd:cd17489 310 PPHRrGAANGTFFIFFDLGIGLGGLLLGLVAEL-----FGYraMFLLAAVVVLLALVLY 363
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
106-260 1.05e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVAT-STLNMLIPSAARVHYGCVIFVrILQGLVEG 184
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLlAALALLLLALLPSPALAIALL-FLAGFGLG 286
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9945322  185 VTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESP 260
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
106-462 2.05e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.83  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAArvHYGCVIFVRILQGLVEGV 185
Cdd:cd17371  26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ--NYWQLLILRALAGLGFGG 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  186 TYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYS----GWSSVFYvygsFGIFWYLFWLLVsyespa 261
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLFL----LGALPALLVLFI------ 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  262 lHPSISEEERKYIEDAIG-ESAKLMNPLTKFSTPWRRFFTSMPVYAiIVANFcrswTFYLLLISQPAYFEEVFGFEISKV 340
Cdd:cd17371 174 -RRFVKEPPQWQAARAARrHFADRPSLRELFSPPLLRTTLLASLLA-TGALG----GYYGITTWLPSYLTGERGLSFEGS 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  341 GLVSALPHLVMTIIVPIGGQIADFLRSRRIMSttnvrkLMNCGGFgmeATLLLVVGYSHSKGVaISFLVLAVGFSGFAIS 420
Cdd:cd17371 248 AGYLVVTILGGFLGYLAGGFLADRIGRRNNFA------LFALGSA---ISILLYFFLPLSPTL-ILILGFPLGFFASGPF 317
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 9945322  421 GFNVNHLDIA--PRYASILMGISNGVGTLSGMVCPIIVGAMTKH 462
Cdd:cd17371 318 SGMGAYLTELfpTAVRATAQGFCYNVGRIIGALFPFLVGFLATS 361
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
132-459 2.81e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.32  E-value: 2.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  132 IPGGFICQKFAANRVF--GFAI-VATSTLNMLIPSAArvhygCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLAT 208
Cdd:cd17321  49 LLAGRLGDRFGRKRVFliGLALfGLASLLCALAPSLA-----FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALG 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  209 TAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFwyLFWLLvsyespalhpsiseeerkyiedaigesaklmnpl 288
Cdd:cd17321 124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV--ALLLA---------------------------------- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  289 tkfstpwRRFFTSMpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSaLPHLVMTIIV-PIGGQIADFLRS 367
Cdd:cd17321 168 -------RTFSGAV------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL-LPLALAMLVAaPLAGRLADRFGP 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  368 RRIMSTTnvrklMNCGGFGMeATLLLVVGYSHSKGVAISFLVLAVGFsGFAISGFNVNHLDIAPR-YASILMGISNGVGT 446
Cdd:cd17321 234 RLVLVAG-----LLLTAVGL-LLLALLGADSSVWLLLPGLVLLGLGL-GLFATPLTNAALSSVPKeKAGAASGILNTARQ 306
                       330
                ....*....|...
gi 9945322  447 LSGMVCPIIVGAM 459
Cdd:cd17321 307 LGGALGVALLGAL 319
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
107-459 5.82e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.55  E-value: 5.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  107 AQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVAtstlnMLIPSAARV---HYGCVIFVRILQGLVE 183
Cdd:COG2807  46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL-----LAAGLLLRSlapSVALLLAGTALIGAGI 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  184 GVTYPACHGIWSKWAPplERSRLATTAF-CGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPAL 262
Cdd:COG2807 121 AVGNVLLPGLIKRWFP--DRVGLMTGLYtAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  263 HPSiseeerkyiedaigesaklmnplTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGL 342
Cdd:COG2807 199 AAA-----------------------APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGL 254
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  343 VSALPHLVMTIIVPIGGQIADFLRSRRIMSTTnvrklmnCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGfSGFAISGF 422
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL-------LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALT 326
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 9945322  423 NVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM 459
Cdd:COG2807 327 LIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGAL 363
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
112-242 6.88e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.19  E-value: 6.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  112 DPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTYPACH 191
Cdd:cd17365  32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPNAI 109
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 9945322  192 GIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYG 242
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
296-451 9.48e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.77  E-value: 9.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  296 RRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALphLVMTII-VPIGGQIADFLRSRRIMSTT 374
Cdd:cd17478 189 TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF--LFAGAIgTLIGGPLSDRFGRRRVIIAS 266
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  375 NVrklmncggfgmeATLLLVVGYSHSKGVAISFLVLAVGFsgFAISGFNVNHL---DIAPRYA----SILMGISNGVGTL 447
Cdd:cd17478 267 LL------------LAAPFLLLFLLTPGIWSYILLVLAGF--LLFASFPVTVVlaqELLPGNVglasGLMMGLSFGLGGI 332

                ....
gi 9945322  448 SGMV 451
Cdd:cd17478 333 GAPV 336
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
312-478 9.61e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.64  E-value: 9.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  312 FCRSWTFYLLLISQPAY--FEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADflRSRRimsttnvRKLMNCGGFGMEA 389
Cdd:cd06174   3 LGFFLTGLARGLISPLLpaLLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD--RFGR-------RPVLLLGLLLFAL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  390 TLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTrEEWQ 469
Cdd:cd06174  74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGWR 152

                ....*....
gi 9945322  470 YVFLIASLV 478
Cdd:cd06174 153 AVFLIAAAL 161
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
106-269 4.18e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.59  E-value: 4.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  106 KAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLnmLIPSAARVHYGCVIFVRILQGLVEGV 185
Cdd:cd06180  26 LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLL--LAAMALTSGFAALLALRFLAGAASAF 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  186 TYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYS-GWSSVFYVYG--SFGIFWYLFWLLVSYESPAL 262
Cdd:cd06180 104 VFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlSWRAGWLALAllSAVLLLLSFLLLRRGPSAPT 183

                ....*..
gi 9945322  263 HPSISEE 269
Cdd:cd06180 184 EASAAES 190
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
215-478 9.40e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.37  E-value: 9.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  215 YAGAVVAMPLAGVLVQYSGWSSVFYVYG-SFGIFWYLFWLLvsyesPALHPSISEEERKYIEDAIGESaklmnpltkfst 293
Cdd:cd06173 138 QLARIIGPALGGLLVALLGPGGAFAINAlSFLLSALLLLFI-----RRPPPAAPGESSSLLLRDLREG------------ 200
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  294 pWRRFFTSMPVYAIIVANFCrSWTFYLLLISQ-PAYFEEVFGFEISKVGLVSALPhlvmtiivPIGGQIADFLRSRRIMS 372
Cdd:cd06173 201 -LRYLRRSPLLRLLLLALAL-FALLGGALTVLlPLLAKEVLGGGAAGYGLLLAAF--------GVGALLGALLLGRLSKR 270
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9945322  373 TTNVRKLMncGGFGMEATLLLVVGYSHSKGVAISFLVLAvgfsGFAISGFNVN-----HLDIAPRYASILMGISNGVGTL 447
Cdd:cd06173 271 RRRGRLLL--IGALLLGLALLVLGLSPSLWLLLAALFLL----GLAGGLFNVPlntllQLRVPDELRGRVFSVYNALNSG 344
                       250       260       270
                ....*....|....*....|....*....|.
gi 9945322  448 SGMVCPIIVGAMTKHktrEEWQYVFLIASLV 478
Cdd:cd06173 345 AMPLGALLAGLLADA---LGLSAVFLLAGAL 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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