|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
74-498 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 743.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 74 AIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANR 153
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 154 VFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLA 233
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 234 GILVQYTGWSSVFYVYGSFGMVWYMFWLLVSyespakhptitdeerryieesigesanllgamekfktpwrkfftsMPVY 313
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLVS---------------------------------------------MPVY 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 314 AIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGF 393
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 394 GMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSR 473
Cdd:cd17382 276 GMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTR 355
|
410 420
....*....|....*....|....*
gi 9966811 474 EEWQYVFLIAALVHYGGVIFYAIFA 498
Cdd:cd17382 356 EEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
74-498 |
1.43e-180 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 514.48 E-value: 1.43e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 74 AIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGK-------VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIA 146
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNtstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 147 SRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGA 226
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 227 VIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWllvsyespakhptitdeerryieesigesanllgamekfktpwrkF 306
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW---------------------------------------------F 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 307 FTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRK 386
Cdd:cd17318 196 FLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRK 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 387 IMNCGGFGMEATLLLVVGY-SHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVG 465
Cdd:cd17318 276 LFTSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVG 355
|
410 420 430
....*....|....*....|....*....|....
gi 9966811 466 AMTKNK-SREEWQYVFLIAALVHYGGVIFYAIFA 498
Cdd:cd17318 356 AIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
73-498 |
3.94e-129 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 383.75 E-value: 3.94e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 73 IAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVI---------------KEKAKFNWDPETVGMIHGSFFWGYII 137
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSnacpehssspsvehnETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 138 TQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATT 217
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 218 SFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWllvsyespakhptitdeerryieesigesanllgame 297
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLW------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 298 kfktpwrkFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQ 377
Cdd:cd17381 204 --------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQ 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 378 ILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGV-AISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLS 456
Cdd:cd17381 276 NFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSlAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIP 355
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 9966811 457 GMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFA 498
Cdd:cd17381 356 GMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
79-498 |
1.39e-100 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 309.10 E-value: 1.39e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 79 LGFCISFGIRCNLGVAIVDMVNnstihrggkvikekaKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAA 158
Cdd:cd17380 6 LATCICYADRVNMPIAIVPMAK---------------EFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 159 ILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ 238
Cdd:cd17380 71 VALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 239 YTGWSSVFYVYGSFGMVWYMFWLLVSyespakhptitdeerryieesigesanllgamekfktpwrkfftsMPVYAIIVA 318
Cdd:cd17380 151 YYGWPSVFYFFGLLGLLWALVWLIYL---------------------------------------------PPVWAIIVA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 319 NFCRSWTFYLLLISQPAYFEEVFGfEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQIlSTTTVRKIMNCGGFGMEAT 398
Cdd:cd17380 186 HFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPAL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 399 LLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA-MTKNKSreeWQ 477
Cdd:cd17380 264 FLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYiLEATGS---WS 340
|
410 420
....*....|....*....|.
gi 9966811 478 YVFLIAALVHYGGVIFYAIFA 498
Cdd:cd17380 341 LVFVLAAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
70-511 |
9.22e-97 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 302.82 E-value: 9.22e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 70 RYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEK-------AKFNWDPETVGMIHGSFFWGYIITQIPG 142
Cdd:TIGR00894 17 RLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENeldniknPNFKWSGALQGLILSSHFYGQIIIQIPV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 143 GYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGS 222
Cdd:TIGR00894 97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 223 YAGAVIAMPLAGILVQYT-GWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESanllGAMEKFKT 301
Cdd:TIGR00894 177 QLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ----KGSTRQSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 302 PWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILST 381
Cdd:TIGR00894 253 PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 382 TTVRKIMN-CGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVC 460
Cdd:TIGR00894 333 TAARKIFNgIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIA 412
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 9966811 461 PIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEET 511
Cdd:TIGR00894 413 STLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
68-498 |
6.03e-48 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 171.21 E-value: 6.03e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 68 PRRYIIAIMSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIAS 147
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL---------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 148 RLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAV 227
Cdd:COG2271 71 RFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 228 IAMPLAGILVQYTGWSSVFYVYGSFGMVW--YMFWLLvsyespakhptitdeerryieesigesanllgamekfktpwrk 305
Cdd:COG2271 149 LAPPLLGWLLAAFGWRAAFLILGLPGLLLalLRFWLL------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 306 fftsmpvyaiIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKqilstttvR 385
Cdd:COG2271 186 ----------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------R 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 386 KIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSGMVCPIIV 464
Cdd:COG2271 248 KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLV 327
|
410 420 430
....*....|....*....|....*....|....
gi 9966811 465 GAMTKNKSreeWQYVFLIAALVHYGGVIFYAIFA 498
Cdd:COG2271 328 GYLLDATG---YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
70-496 |
5.52e-47 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 168.52 E-value: 5.52e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 70 RYIIAIMSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRL 149
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI---------------MKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 150 AANRVFGAAILLTSTLNMLIpSAARVHYGcVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIA 229
Cdd:cd17319 66 GARKVLAVSMLLWSLFTALT-GFATSLTS-LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 230 MPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYEspakhptitdeerryieesigesanllgamekfktpwrkffts 309
Cdd:cd17319 144 PPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 310 mpVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQilstttvRKIMN 389
Cdd:cd17319 181 --VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVI 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 390 CGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPIIVGAM- 467
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLv 331
|
410 420
....*....|....*....|....*....
gi 9966811 468 TKNKSreeWQYVFLIAALVHYGGVIFYAI 496
Cdd:cd17319 332 DATGS---YTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
117-459 |
2.22e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 136.01 E-value: 2.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTYP 196
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 197 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITD 276
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 277 EERRyieesigesanllgameKFKTPWRKFFTSmPVYAIIVANFCRSWTFYLLLISQPAYfEEVFGFEISKVGMLSAVPH 356
Cdd:pfam07690 185 EARL-----------------SLIVAWKALLRD-PVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 357 LVMTIIVPIGGQIADFLRSKQILstttvrkIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLD 436
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....
gi 9966811 437 IAP-RYASILMGISNGVGTLSGMV 459
Cdd:pfam07690 319 LAPkEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
117-498 |
3.80e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.07 E-value: 3.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTYP 196
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--PSFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 197 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQY--TGWSSVFYVYGSFGMVWYMFWLLVsYESPAKHPTI 274
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV-VPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 275 TDEERRYIEesigesanllgamekFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAV 354
Cdd:cd06174 183 KNEEASSKS---------------VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 355 PHLVMTIIVPIGGQIADFLRSkqilstttVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNH 434
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9966811 435 LDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTknKSREEWQYVFLIAALVhyggVIFYAIFA 498
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL--AATFGLTGAFLVLAVL----LLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
69-457 |
2.93e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.84 E-value: 2.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 69 RRYIIAIMSGLGFCISFGIRCnLGVAIVDMVnnstihrggkvikekAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASR 148
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGI-VLPALPLIA---------------ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 149 LAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVI 228
Cdd:COG2814 72 FGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 229 AMPLAGILVQYTGWSSVFYVYGSFGMVwymFWLLVsyespakhptitdeeRRYIEESIGESAnllgamEKFKTPWRKFFT 308
Cdd:COG2814 150 GPLLGGLLADLFGWRWVFLVNAVLALL---ALLLL---------------LRLLPESRPAAR------ARLRGSLRELLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 309 SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILStttvrkim 388
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL-------- 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 389 ncGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSG 457
Cdd:COG2814 278 --IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
68-486 |
6.70e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.97 E-value: 6.70e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 68 PRRYIIAIMSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIAS 147
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL---------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 148 RLAANRVFGAAILLTSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAV 227
Cdd:COG2223 66 RFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 228 IAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTitdeerryieesiGESANLLGAMEKFKTPWrkff 307
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA-------------AAKASLRDQLEALRDPR---- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 308 tsmpVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSkqilstttvRKI 387
Cdd:COG2223 207 ----FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG---------RRV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 388 MNCGGFGMEATLLLVVGYSHTRGVAI-SFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA 466
Cdd:COG2223 274 LLIVFALMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGA 353
|
410 420
....*....|....*....|
gi 9966811 467 MtkNKSREEWQYVFLIAALV 486
Cdd:COG2223 354 L--LDATGSYTAAFLVFAVL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
124-498 |
2.82e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.97 E-value: 2.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 124 VGMIHGSFFWGYIITQIPGGYIASRLAANR--VFGAAILLTSTLnmLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGI 201
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRllLLGLLLLAVSTL--LFAFAT--SYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 202 WSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwyMFWLLVsyespakhptitdeerRY 281
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL--ALVLAL----------------LL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 282 IEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTI 361
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 362 IVPIGGQIAD-FLRSKQILstttvrkimncggFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHL--DIA 438
Cdd:cd17325 251 SQPPAGKLSDrIGRKPLIL-------------IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALlaDIV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9966811 439 PRYA-SILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAALVHYGGVIFYAIFA 498
Cdd:cd17325 318 PPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG---FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
131-463 |
1.56e-14 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 75.75 E-value: 1.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 131 FFWGYIITQIPGGYIASRLAANRVFGAAILLTSTlnMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLE 210
Cdd:cd17327 50 FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL--LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 211 RSRLATTSFCGSYAGAVIamplaGILVQY-----------TGWSSVFYVYG--SFGM-VWYMFWLLVsyeSPAKHPTITD 276
Cdd:cd17327 128 QAKRIAFFYAAAGLGSIF-----GGLLAYgvfkilgvgglAGWRWLFIIEGliTIIIgLVIFFWLPD---NPSKAWFLTE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 277 EERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCrSW-------TFYLLLISQpayfeevFGFEISKVG 349
Cdd:cd17327 200 EEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFC-SQitnngisNFLPLILKS-------LGFYSLQTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 350 MLSAVPHLVMTIIVPIGGQIADFLRSKQILSTttvrkIMNCggFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISG 429
Cdd:cd17327 272 LLSVPIGALGAVSLLIAALLSDRFKKRGLFAI-----FACV--LALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILL 344
|
330 340 350
....*....|....*....|....*....|....*.
gi 9966811 430 FNVNhlDIAPRYAS--ILMGISNGVGTLSGMVCPII 463
Cdd:cd17327 345 SWIS--SNCAGYTKraTVLAIMLIFYNVGNIVAPQI 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
114-467 |
6.96e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.54 E-value: 6.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 114 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLipSAARVHYGCVIFVRILQGLVEGV 193
Cdd:TIGR00895 44 SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLILRFLAGLGLGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 194 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFG--MVWY-MFWLLVSYE-SPA 269
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPllLLLLlMRFLPESIDfLVS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 270 KHPTITDEERRYIEESIGESANLLGAMEKFKTP-WRKFF-------TSMPVYAIIVANFCRSWTFYLLLISQPaYFEEVF 341
Cdd:TIGR00895 202 KRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGtKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 342 GFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILstttvrkimncGGFGMEATLLLVVGYSHTRGVAISFLVLAVG 421
Cdd:TIGR00895 281 GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA-----------LLLLLGAVFAVLVGSTLFSPTLLLLLGAIAG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 9966811 422 FsgFAISGFNVNHLDIAPRYASIL----MGISNGVGTLSGMVCPIIVGAM 467
Cdd:TIGR00895 350 F--FVNGGQSGLYALMALFYPTAIratgVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
154-498 |
2.64e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 2.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 154 VFGAAILLTSTLNMLIpsaarvhygcviFVRILQGLVEGVTYPACHGIWSKWAPPLERSRL-----ATTSFcgsyaGAVI 228
Cdd:cd17473 77 IGGVAGLFLDSLYALL------------ASRALLGIGVAGIMTLATALIGDYFEGEERAKMlglqsAAMSL-----GGVV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 229 AMPLAGILVQYtGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTitdeerryieesigesaNLLGAMEKFKTPWRkfft 308
Cdd:cd17473 140 FLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPARKSKSA-----------------ASPGAATAAALPWK---- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 309 smPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAvphlVMTIIVPIGGQIADFLRSKqilstTTVRKIM 388
Cdd:cd17473 198 --RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALA----IASLAGAIGALLFGRLKRR-----LGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 389 nCGGFGMEATLLLVVGYSHTRGVAISFLVLaVGFsGFAISGFNVNH--LDIAPRYAS-ILMGISNGVGTLSGMVCPIIVG 465
Cdd:cd17473 267 -AIGFALMALGFLLLALASGLWVVLLGAIL-AGL-GFGLLLPTLNSwaMSLVPPELRgRAMGIVTSAFFLGQFLSPLVLG 343
|
330 340 350
....*....|....*....|....*....|...
gi 9966811 466 AMTKNKSREewQYVFLIAALVHYGGVIFYAIFA 498
Cdd:cd17473 344 PLVNLTGGL--SGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
124-308 |
1.09e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 66.63 E-value: 1.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 124 VGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGLVEGVTYPACHGIWS 203
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFF--GFSTSLWVMAALWALNGIFQGMGWPPCGRTVT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 204 KWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ-YTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKhPTITDEERRYI 282
Cdd:TIGR00881 110 KWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMPN 188
|
170 180
....*....|....*....|....*.
gi 9966811 283 EESIGESANllgaMEKFKTPWRKFFT 308
Cdd:TIGR00881 189 EEPDGDAEK----KEEELTKKQIFLQ 210
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
117-263 |
3.14e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.45 E-value: 3.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILL---TSTLNMLIPSAArvhygCVIFVRILQGLVEGV 193
Cdd:COG0477 44 LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLfglASLLCGLAPSPE-----LLIAARALQGIGAGG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 194 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLV 263
Cdd:COG0477 119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
110-467 |
5.28e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.55 E-value: 5.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 110 VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTST---LNMLIPSaarvhYGCVIFVRIL 186
Cdd:cd17316 24 VLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLatlLIGLLPT-----PILLLVLRFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 187 QGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILV----QYTGWSSVFYVYGSFGMVwyMFWLl 262
Cdd:cd17316 99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPALL--ALLL- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 263 vsyespakhptitdeerryieesigesanllgamekfktpwRKFFTsmpvyAIIVANFCRSWTFYLLLISQPAYFEEVFG 342
Cdd:cd17316 176 -----------------------------------------RRRTL-----LLILLWFFISFGYYGLTTFLPTYLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 343 FEISKVGMLSAVPHLVMTIIVPIGGQIADFLRskqilstttvRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVgF 422
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI-L 278
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 9966811 423 SGFAISGFNVNHLDIA----PRYASILMGISNGVGTLSGMVCPIIVGAM 467
Cdd:cd17316 279 SFFVGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
117-485 |
4.53e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 4.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLipSAARVHYGCVIFVRILQGLVEGVTYP 196
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL--AALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 197 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFG---MVWYMFWLlvsyespakhPT 273
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAllaALLLWRLL----------PS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 274 ITDEERRyieeSIGESANLLGAmekFKTPwrKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvfgfeiSKVGMLSA 353
Cdd:cd17324 177 LPPKKPG----SLGLLSSLLLL---LRNP--RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS------SAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 354 VPHLVMTIIVPIGGQIADFLRSKQILSTttvrkimncGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFsGFAISGFNVN 433
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGRRALLIA---------LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF-FAAHSALQTR 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 9966811 434 HLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAAL 485
Cdd:cd17324 312 VLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG---WAGVGWVGAA 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
114-499 |
3.22e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.10 E-value: 3.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 114 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTStLNMLIPSAARvHYGCVIFVRILQGLVEGV 193
Cdd:COG0738 35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA-LGLLLFALAP-SYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 194 TYPACHGIWSKWAPPLERSRLATTSFCGSyAGAVIAMPLAGILVQY---TGWSSVFYVYGSFGMVWYMFWLLVSYespak 270
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL----- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 271 hPTITDEErryiEESIGESANLLGAmekFKTPwrkfftsmPVYAIIVANFC--------RSWTfylllisqPAYFEEVFG 342
Cdd:COG0738 187 -PEIEEEE----EEAAGSAASLKSL---LKNP--------RLLLGGLAIFLyvgaegaiGDWL--------PLYLKDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 343 FEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggfgMEATLLLVVGYSHTRGVAISFLVLAvgf 422
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL----------LAAVGLLLALLAPGPWLALIGLALV--- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 423 sGFAISGF--NVNHL--DIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAALVhYGGVIFYAIFA 498
Cdd:COG0738 310 -GLGLSLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG---LRAAFLVPLVC-YLLILLLALAL 384
|
.
gi 9966811 499 S 499
Cdd:COG0738 385 K 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
210-467 |
5.50e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 5.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 210 ERSRLATTSFCGSYAGAVIAMPLAGILVQY------TGWSSVFYVYGSFGMV--WYMFWLLVSYESPAKHPTitdeerry 281
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLafLLTFFGTKERPVPEEEKV-------- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 282 ieesigesanllgameKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTI 361
Cdd:COG2211 216 ----------------SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 362 IVPIGGQIADFLRSKQILstttvrkimnCGGFGMEATLLLVVGYSHTRGVAISFLVLAVgfSGFAISGFNVNHL----DI 437
Cdd:COG2211 280 GAPLWPRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLGPGNLWLLLVLAAL--AGIGLGAILVLPWamlaDV 347
|
250 260 270
....*....|....*....|....*....|....*...
gi 9966811 438 AP--------RYASILMGISNGVGTLSGMVCPIIVGAM 467
Cdd:COG2211 348 VDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
315-510 |
5.97e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.81 E-value: 5.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 315 IIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRskqilstttVRKIMNCGGFG 394
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG---------RRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 395 MEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSre 474
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-- 149
|
170 180 190
....*....|....*....|....*....|....*.
gi 9966811 475 eWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEE 510
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
120-268 |
4.19e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 55.36 E-value: 4.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 120 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGLVEGVTYPACH 199
Cdd:cd17312 36 SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GFSTSLWFFAVLWGLNGLFQSMGWPPCV 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9966811 200 GIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESP 268
Cdd:cd17312 114 KLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
124-494 |
3.67e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.60 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 124 VGMIHGSFFWGYIITQIPGGYIASRLAANRV--FGAAILLTSTLNMLIPSAARVhygcVIFVRILQGLVEGVTYPACHGI 201
Cdd:cd17489 33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLllIGLLIFALATLLYLLATSVAL----LLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 202 WSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEER-- 279
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRaf 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 280 -RYIEESIGESANLLgamekfktpwrkFFTSMPVYAIIvanfcrswTFYlllisqPAYFEEVFgfeISKVGMLSAVPHLV 358
Cdd:cd17489 189 rRLVEKKVLPPALIL------------FLASIAYGAIS--------TFL------PLYAAERG---ISNAGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 359 MTIIVPIGGQIADFLRskqilstttvRKIMNCGGFGMEATLLLVVGYSHT-RGVAISFLVLAVGFsGFAISGFNVNHLDI 437
Cdd:cd17489 240 LLLSRPFSGKLSDRKG----------PKTVIIPGLLLLALGLLLLSFAGSpWMLLLAAVLYGLGF-GLLFPALQALAVDL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 438 APRYA-SILMGISNGVGTLSGMVCPIIVGAMTknksrEEWQY--VFLIAALVHYGGVIFY 494
Cdd:cd17489 309 VPPHRrGAANGTFFIFFDLGIGLGGLLLGLVA-----ELFGYraMFLLAAVVVLLALVLY 363
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
114-268 |
1.01e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 114 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRL-AANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVrILQGLVEG 192
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPSPALAIALL-FLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9966811 193 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESP 268
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
181-422 |
6.89e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 48.44 E-value: 6.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 181 IFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMpLAGILVQYT---------GWSSVFYVYGS 251
Cdd:cd17367 105 LLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLAL-GVLLVLQHTlgedqmaawGWRIPFLLGGV 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 252 FGMVwyMFWLlvsyespakhptitdeeRRYIEESIgESANLLGAMEKFKTPWRKFFtSMPVYAIIVANFCRSWT--FYLL 329
Cdd:cd17367 184 LAVV--VLWL-----------------RRGLEETE-SFEAIAESNEASAGTLRELR-RHPRELLLVVGLTAGGTlaFYTW 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 330 LISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggFGMEATLLLVVGYSHTR 409
Cdd:cd17367 243 TTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGI--------GGTLATVPLLSALDHTD 314
|
250
....*....|...
gi 9966811 410 GVAISFLVLAVGF 422
Cdd:cd17367 315 SPYTAFALVLVGL 327
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
302-486 |
1.35e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 302 PWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILst 381
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 382 ttvrkimnCGGFGMEATLLLVVGYSHTrgvaISFLVLAVGFSGFAISGFNVNHLDIAPRYAS-----ILMGISNGVGTLS 456
Cdd:COG2814 79 --------LLGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALALIADLVPperrgRALGLLGAGLGLG 146
|
170 180 190
....*....|....*....|....*....|
gi 9966811 457 GMVCPIIVGAMTKNKSreeWQYVFLIAALV 486
Cdd:COG2814 147 PALGPLLGGLLADLFG---WRWVFLVNAVL 173
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
119-496 |
1.70e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 47.24 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 119 WDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFV--RILQGLVEGVTYP 196
Cdd:cd17345 35 LSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFilLFLNGWFQGMGWP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 197 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTG---WSSVFYVYGSFGMVWYMFWLLVSYESPAKH-- 271
Cdd:cd17345 115 PSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEgl 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 272 PTITDEERRYIEESIGEsanllgAMEKFKTPWRKFFTSM----PVYAIIVAN----FCR----SWTfylllisqPAYFEE 339
Cdd:cd17345 195 PPIEEYKGDYPEEADGE------EEEQELSAWEIFVKYVlknkLLWYIAIANvfvyLVRygilDWA--------PTYLSE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 340 VFGFEISKVGM------LSAVPHlvmTIIVpigGQIAD-FLRSKqilstttvRKIMNCggFGMEATLLLVVGYSHTRGVA 412
Cdd:cd17345 261 VKGFSKAQAMWafslfeWAAIPG---TLLA---GWLSDkLFKGR--------RAPTGI--IFMILVIVALIVYWLAPNVL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 413 ISFLVLAvgFSGFAISG----FNVNHLDIAPRYAsilmgisngVGTLSGM--VCPIIVGAMTKN--------KSREEWQY 478
Cdd:cd17345 325 VDLIALI--ALGFLIYGpvmlIGLQALELVPKKA---------AGTAAGLtgLFGYLGGSVLATaligiivdHFGWNGGF 393
|
410
....*....|....*...
gi 9966811 479 VFLIAALVhyGGVIFYAI 496
Cdd:cd17345 394 IVLLASCI--LAIIFLAL 409
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
120-265 |
2.12e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 120 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTYPACH 199
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 200 GIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYV------------------YGSFGMVWYMFWL 261
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLggvpplillpllrgtlllWVTFFMGLLLVYL 189
|
....
gi 9966811 262 LVSY 265
Cdd:cd17365 190 LNSW 193
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
116-255 |
3.37e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 116 KFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTY 195
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL--LLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9966811 196 PACHGIWSKWAPPLERSR-LATTSFCGSyAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMV 255
Cdd:cd17325 307 PATLALLADIVPPEGRGTaMGLFNTAFS-LGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
320-515 |
4.35e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 320 FCRSWTFYLLLISQPAY--FEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADflrskqilsTTTVRKIMNCGGFGMEA 397
Cdd:cd06174 3 LGFFLTGLARGLISPLLpaLLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD---------RFGRRPVLLLGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 398 TLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSrEEWQ 477
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGWR 152
|
170 180 190
....*....|....*....|....*....|....*...
gi 9966811 478 YVFLIAALVhyGGVIFYAIFASGEKQPWADPEETSEEK 515
Cdd:cd06174 153 AVFLIAAAL--ALLAAILLLLVVPDPPESARAKNEEAS 188
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
279-459 |
1.01e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 279 RRYIEESIGESANLLGAMEKFKTPWRkfftsmPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAvpHLV 358
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVWR------ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL--FLF 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 359 MTII-VPIGGQIADFLRSKQILSTTTVrkimncggfgmeATLLLVVGYSHTRGVAISFLVLAVGFsgFAISGFNVNHL-- 435
Cdd:cd17478 242 AGAIgTLIGGPLSDRFGRRRVIIASLL------------LAAPFLLLFLLTPGIWSYILLVLAGF--LLFASFPVTVVla 307
|
170 180
....*....|....*....|....*....
gi 9966811 436 -DIAPRYA----SILMGISNGVGTLSGMV 459
Cdd:cd17478 308 qELLPGNVglasGLMMGLSFGLGGIGAPV 336
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
115-484 |
1.26e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.52 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 115 AKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRV-------FGAAILLTS---TLNMLIpsaarvhygcvIFVR 184
Cdd:cd17353 31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAiliggilFGLGFILSAfaiSLPLLF-----------LGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 185 ILQGLVEGVTYPACHGIWSKWAPplERSRLAT-TSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGS-FGMVWYMFWLL 262
Cdd:cd17353 100 VLGGIGAGIGYITPVSTAVKWFP--DKRGLATgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIiFLIIIVIGAFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 263 VSYESPAKHPTITDEERRYIEESIGEsanllgamekfKTPWRKFFTsmPVYAIIVANFCRSWTFYLLLISQPAYF-EEVF 341
Cdd:cd17353 178 IRDPPKGWVPPGVDPLANNAENSPRD-----------YTPREMLRT--PTFWLLWLMFFLNATAGLMLIGQAKPIgQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 342 GFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimnCGGFGMeatLLLVvgysHTRGVAISFlVLAVG 421
Cdd:cd17353 245 GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL-----IQGVAM---FLLP----FIGSVAVLF-VLGVA 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9966811 422 FSGFAISGFnvnhLDIAPRYASILMGISNgVGT----------LSGMVCPIIVGAMTKNKSreeWQYVFLIAA 484
Cdd:cd17353 312 LIGFCYGGG----FALFPALTADFFGTKN-AGTnygllytakgVGGLIGPIIAAYVLYTGG---YNAAFIIAA 376
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
117-427 |
1.32e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 117 FNWDPETVGMIHGSFFWGYIITqIP-GGYIASRLAANRVFGAAIL---LTSTLNMLIPSAARVhygcvIFVRILQGLVEG 192
Cdd:cd17503 26 LGASLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALAlftLGSLLCGLAPNLASL-----IIFRILQGFGGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 193 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwymfwllvsyespakhp 272
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL----------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 273 titdeerryieesigesANLLGAMEKFKTPWRKFFTSMpVYAIIVANFCRSWTFYLLlisqPAYFEEVFGFEISKVGMLS 352
Cdd:cd17503 163 -----------------ALLLAPLLDLRLFKDRNFTLG-LLLSFLLGLGLFGAMFLL----PLYLQNVLGYSAFESGLVL 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9966811 353 AVPHLVMTIIVPIGGQIADFLrskqilsttTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAI 427
Cdd:cd17503 221 APGGLASAILSPLVGRLLDKF---------GPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGL 286
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
140-467 |
1.93e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.09 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 140 IPGGYIASRLAANRVF--GAAI-LLTSTLNMLIPSAArvhygCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLAT 216
Cdd:cd17321 49 LLAGRLGDRFGRKRVFliGLALfGLASLLCALAPSLA-----FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 217 TSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwyMFWLLvsyespakhptitdeerryieesigesanllgam 296
Cdd:cd17321 124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV--ALLLA---------------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 297 ekfktpwRKFFTSMpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSaVPHLVMTIIV-PIGGQIADflrs 375
Cdd:cd17321 168 -------RTFSGAV------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL-LPLALAMLVAaPLAGRLAD---- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 376 kqilsTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAV-GF-SGFAISGFNVNHLDIAPR-YASILMGISNGV 452
Cdd:cd17321 230 -----RFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLlGLgLGLFATPLTNAALSSVPKeKAGAASGILNTA 304
|
330
....*....|....*
gi 9966811 453 GTLSGMVCPIIVGAM 467
Cdd:cd17321 305 RQLGGALGVALLGAL 319
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
120-497 |
2.13e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 120 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVfgaaILLTSTLNMLI-------PSAARVHYGCVIFVRILQGLVEG 192
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRL----LILADLLRALLaavlallALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 193 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYG-SFGMVWYMFWLLvsyesPAKH 271
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlSFLLSALLLLFI-----RRPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 272 PTITDEERRYIEESIGESanllgamekfktpWRKFFTSMPVYAIIVANFCrSWTFYLLLISQ-PAYFEEVFGFEISKVGM 350
Cdd:cd06173 183 PAAPGESSSLLLRDLREG-------------LRYLRRSPLLRLLLLALAL-FALLGGALTVLlPLLAKEVLGGGAAGYGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 351 LSAVPhlvmtiivPIGGQIADFLRSKqILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGF 430
Cdd:cd06173 249 LLAAF--------GVGALLGALLLGR-LSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9966811 431 NVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTknkSREEWQYVFLIAALVHYGGVIFYAIF 497
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA---DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
117-459 |
4.53e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRV--FGAAI-LLTSTLNMLIPSaarvhYGCVIFVRILQGLVEGV 193
Cdd:cd17320 29 LGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVllAGLLLfILASLLCALASS-----IEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 194 TYPACHGIWSKWAPPLERSRLAttsfcgSYAGAVIAM-----PLAG-ILVQYTGWSSVFYVYGSFGMV---WYMFWLlvs 264
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIF------SLLMMILAIapalaPLLGgLLLLFFGWRAIFVFLALLGLLlllLVLLFL--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 265 yespakhPTITDEERRyieeSIGESANLLGAMEKFKTpwRKFFTSMPVYAIIVAnfcrswTFYLLLISQPAYFEEVFGFE 344
Cdd:cd17320 175 -------PETLPEEKR----KPLLSSLLRAYKRVLKN--RRFLGYALALGLSFA------GLFAYLAAAPFIYIEQLGLS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 345 ISKVGMLsavphLVMTIIVPIGGQIAdflrSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVG--F 422
Cdd:cd17320 236 PAQFGLL-----FALNAIALILGSLL----NGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFliF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 9966811 423 SGFAISGFNVNHLDIAPRY-----ASILMG-ISNGVGTLSGMV 459
Cdd:cd17320 307 FGFGLIFPNATSLALEPFPhvagtASALLGfLQFLIGALAGAL 349
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
180-467 |
4.69e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.56 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 180 VIFVRILQGLVEGVTyPACHGIWSKWAPPlERSRLATTSFCGSYA-GAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwym 258
Cdd:cd17504 87 LIAGRALQGIGGAVF-PLAFALVREEFPP-ERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL--- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 259 FWLLVsyespakhPTITdeeRRYIEESIGESANLLGAMEKfktpwrkfFTSMPVYAIIVAnfcrswtfyllLISQPAYFE 338
Cdd:cd17504 162 LAALV--------PLID---LRLLRRRNVLLANITALLAG--------FGMFMVFQLLPQ-----------LLQLPTPTG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 339 evFGFEISKVGMLSAVPHLVMTIIVPIGGQIAdflrskqilSTTTVRKIMNCGGFGMeATLLLVVGYSHTRGVAISF--L 416
Cdd:cd17504 212 --FGLGITEAGLLLLPGALVMLIAGPLAGRLI---------ARVGPRRVLLIGLVIS-AVGLLLLALLHSSLWALVValL 279
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 9966811 417 VLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM 467
Cdd:cd17504 280 LIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
124-465 |
5.59e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 124 VGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVhYGCVIFVRIL---QGLVEGVTYPACHG 200
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSI-YLFVVLMFLAglgAGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 201 IWSKWAPplerSRLATTSFCGSyAGAVIAMPLAGILV-QYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEER 279
Cdd:cd17333 112 LFEESSA----TRLNVLHGFFG-LGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 280 RYIEESIGESAN---LLGAMEKFktpwrkfftsmpVYAIIVANFCrSWTfylllisqPAYFEEVFGFEISKVGMLSAVPH 356
Cdd:cd17333 187 AFSASASRLLRNpsiILGALALF------------LYVGAETAFS-SWV--------PSYLVEKKHVSDGLAGYLLSGFW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 357 LVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggfgmEATLLLVVGYSHTRGVAISFLVLAVGFSgfaISG----FNV 432
Cdd:cd17333 246 VGITIGRLLGGPISRRIKPHTLLVLSGS-----------GALLGLLILLLAPTLVVGLVATALLGLF---MAAlfptILS 311
|
330 340 350
....*....|....*....|....*....|...
gi 9966811 433 NHLDIAPRYASILMGISNGVGTLSGMVCPIIVG 465
Cdd:cd17333 312 LGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
123-466 |
6.37e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.23 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 123 TVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARvhYGCVIFVRILQGLVEGVTYPACHGIW 202
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS--YPVLLVLLFLVGAGYGSVQPGGGRAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 203 SKWAPPLERSrLAT----TSFcgSYAGAVIAMPLAGILVQYtGWSSVFYVYGSFGMVW-YMFWL-LVSYESPAKHPTITD 276
Cdd:cd17475 110 MRWFPPRERG-LAMgirqTGV--PLGGALAAALLPPLALHY-GWRAAFVVAGLVSILAaVLFWLfYREPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 277 EERRYIEESIGESANLLGAmekfktpWRKFFTSMPVYAIIVanfcrswtfYLLLisqpaYFEEVFGFEISKVGMLsavph 356
Cdd:cd17475 186 TLLRSLKEVLRNRDVWLIA-------IAGALLVAPQFALLT---------FLLL-----FLHDHLGLSVVAAGAL----- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 357 LVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHL- 435
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVa 319
|
330 340 350
....*....|....*....|....*....|..
gi 9966811 436 DIAP-RYASILMGISNGVGTLSGMVCPIIVGA 466
Cdd:cd17475 320 ESAGpEQAGTALGLANTINFIGIAIGPPLFGL 351
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
142-250 |
7.64e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.26 E-value: 7.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 142 GGYIASRLAANRVFGAAILLTSTLNMLIPSAARvhYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCG 221
Cdd:PRK11551 70 GGRLADRIGRKRILIVSVALFGLFSLATAQAWD--FPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCG 147
|
90 100
....*....|....*....|....*....
gi 9966811 222 SYAGAVIAMPLAGILVQYTGWSSVFYVYG 250
Cdd:PRK11551 148 VPFGGALASVIGVLAAGDAAWRHIFYVGG 176
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
117-486 |
9.82e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.78 E-value: 9.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLtstlnMLIPSAARV---HYGCVIFVRILQGLVEGV 193
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL-----LAAGLLLRSlapSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 194 TYPACHGIWSKWAPplERSRLATTSF-CGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHP 272
Cdd:COG2807 123 GNVLLPGLIKRWFP--DRVGLMTGLYtAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 273 TITDEERryieesigesanllgamekFKTPWRkfftSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLS 352
Cdd:COG2807 201 AAPAAAS-------------------LRSLWR----SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 353 AVPHLVMTIIVPIGGQIADFLRSKQILSTTtvrkimnCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGfSGFAISGFNV 432
Cdd:COG2807 257 SLFQLAGIPGSLLVPLLADRLGDRRPLLLL-------LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALTLI 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 9966811 433 NHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM---TKNksreeWQYVFLIAALV 486
Cdd:COG2807 329 GLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALhdaTGS-----WTAALLLLAAL 380
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
114-248 |
1.47e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.13 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 114 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGV 193
Cdd:cd17371 26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ--NYWQLLILRALAGLGFGG 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 9966811 194 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQY----TGWSSVFYV 248
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFLL 162
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
334-500 |
2.30e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 334 PAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQ------ILSTTtvrkIMNCGGFgmeaTLLLVVGYSH 407
Cdd:COG2211 34 LYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwILIGA----IPLALSF----VLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 408 TRGVAISFLVLAVGFsGFAISGFNVNHL----DIAPRYA--SILMGISNGVGTLSGMVCPIIVGAMTKN---KSREEWQY 478
Cdd:COG2211 106 PTGKLIYALVTYLLL-GLAYTLVNIPYSalgaELTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVAAfggDAALGYRL 184
|
170 180
....*....|....*....|..
gi 9966811 479 VFLIAALVhygGVIFYAIFASG 500
Cdd:COG2211 185 TALIFAVL---GLLAFLLTFFG 203
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
110-468 |
3.39e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 110 VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGL 189
Cdd:cd17330 22 YVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL--GLSRNLWLLFLARFLDGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 190 VeGVTYPACHGIWSKWAPPLERSR-LATTSFCGSyAGAVIAMPLAGILVQYTGWSSVFYVYG--SFGMVWYMFWLLvsye 266
Cdd:cd17330 100 T-GGNVSVAQAYIADITDEEERAKaFGIISAAFG-LGFILGPALGGFLSTPYGYALPFLVAAalALLNLVLVLFFL---- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 267 spakhptitdeerryieesigesanllgamekfKTPWRKFFTSMpVYAIIVANFcrSWTFYLLLISQpayfeevFGFEIS 346
Cdd:cd17330 174 ---------------------------------PPLRRLLLVYF-LIALAFAGL--ESVFSLFLKDR-------FGFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 347 KVGMLSAVPHLVMTIIvpiggQIADFLRSKQILSTttvRKIMnCGGFGMEATLLLVVGYSHTRG---VAISFLVLAVGFS 423
Cdd:cd17330 211 QIGLLLALVGIAGILA-----QLLLIPRLAKRLGE---RKLL-RLGLLLAIIGLLLLPFASSVPllvLAAAILAFGTGIV 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 9966811 424 GFAISGFNVNHLDIAPRyaSILMGISNGVGTLSGMVCPIIVGAMT 468
Cdd:cd17330 282 FPALSALLSKSVPSKEQ--GKAQGIIQSLQSLARIIGPLLAGPLY 324
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
114-229 |
4.59e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 114 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGV 193
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGL 312
|
90 100 110
....*....|....*....|....*....|....*.
gi 9966811 194 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIA 229
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
125-497 |
4.84e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 39.63 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 125 GMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVhygcVIFVRI--LQGLVEGVTYPACHGIW 202
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSV----WVFSILwfLNGLAQGLGWPPCAKIL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 203 SKWAPPLE----RSRLATTSfcgSYAGAViAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEE 278
Cdd:cd17343 117 RKWFSPSQfgtwWSVLSTSM---NLAGSL-GPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 279 RRYIEESIGESANLLGAMEKFKTP--WRKFFTSMPVYAIIVAnfCRSWTfYLLLI---SQPAYFE-------EVFGFeis 346
Cdd:cd17343 193 EESKGKKKKSPRGESTLKELLLSPflWLLSLGYLVVFGVKTA--VTDWG-QLFLIqdkGQSALTGssfmsslEVGGF--- 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 347 kVGMLSAvphlvmtiivpigGQIADFLRSKQILST------TTVRKIMncggFGMEATL--LLVVGYSHTRGVAISFLVL 418
Cdd:cd17343 267 -VGSIAA-------------GYLSDWAVAKHGSSSrgnprmPLALVFM----AGLTVSLhlFRVHITSDSSELFILLLGF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 419 AVGFSGFA-ISGFNVNHLDIAPryaSILMGISNGVGTLSGMVCPIIVG-AMTKNKSREEWQYVFLIAALVHYGGVIFYAI 496
Cdd:cd17343 329 LIGFSLYGpIAIFGVIANESAP---SHLCGTSHAIVALAANVGGVLAGlPFSYIAKHYDWRTAFLLLEILCAITVVILFL 405
|
.
gi 9966811 497 F 497
Cdd:cd17343 406 L 406
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
314-501 |
5.75e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.02 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 314 AIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFL-RskqilstttvRKIMNCGG 392
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAAD-LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYgR----------KRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 393 FGMEATLLLvVGYSHTrgvaISFLVLAVGFSGFAISGFNVNHL----DIAP-RYASILMGISNGVGTLSGMVCPIIVGAM 467
Cdd:COG0477 87 LLFGLASLL-CGLAPS----PELLIAARALQGIGAGGLMPGALaliaELFPaRERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190
....*....|....*....|....*....|....
gi 9966811 468 TKNKSreeWQYVFLIAALVhyGGVIFYAIFASGE 501
Cdd:COG0477 162 VAALG---WRWIFLINAPL--GLLALVLRLRLPE 190
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
119-255 |
7.72e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 7.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9966811 119 WDPETVGMIHGSFFWGYIITQIPGGYIASRLAANR---VFGAAILLTSTLNMLI-PSAARVhygcvIFVrILQGLVEGVT 194
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpllLLLGLLGLAGLLGLLLaPGSLPW-----LWA-VLLGLGQGGL 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9966811 195 YPACHGIWSKWAP-PLERSRLATTSFCGSYAGAVIAMPLAGILVQYTG-WSSVFYVYGSFGMV 255
Cdd:COG2807 321 FPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVL 383
|
|
| |
