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Conserved domains on  [gi|149588928|ref|NP_065897|]
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SLAIN motif-containing protein 2 [Homo sapiens]

Protein Classification

SLAIN motif-containing protein( domain architecture ID 12172998)

SLAIN motif-containing protein is a microtubule plus-end tracking protein, similar to human SLAIN2 that binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 130-581 1.78e-167

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


:

Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 482.67  E-value: 1.78e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  130 WLYSSPKKKLtPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSMSytsPYSPNAS-SPY 208
Cdd:pfam15301   1 WLYVSPKKKV-PSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSS---AYSGNAEaSSY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  209 SSGFNSPSSTPVRPpivKQLILPGNSGNLKSSdrnPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEES 288
Cdd:pfam15301  74 SSGLNSPGYLKSTN---KQLLTCGSSGYLRRH---SALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEES 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  289 LRQEYAATTSRRSSGSSCN---STRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNsprpspkqSPRNSPRSR 365
Cdd:pfam15301 148 LRQDYASTSASASRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  366 SPARGIEYSRVSPQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSNTQ-VDSVKSSRS-DSNFQVPNGG 443
Cdd:pfam15301 220 SPSTSQEYSRLSAQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  444 IPRMQPQASAIPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSPGsqeitqltqttSSPGPPMVQSTVSANPPSninSAT 522
Cdd:pfam15301 295 LSRLQQSSSSIPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVAG-----------PSKGLPSSQSLPSGGSSG---SPL 360

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  523 LTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY 581
Cdd:pfam15301 361 PSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESWKDGCY 420
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 130-581 1.78e-167

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 482.67  E-value: 1.78e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  130 WLYSSPKKKLtPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSMSytsPYSPNAS-SPY 208
Cdd:pfam15301   1 WLYVSPKKKV-PSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSS---AYSGNAEaSSY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  209 SSGFNSPSSTPVRPpivKQLILPGNSGNLKSSdrnPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEES 288
Cdd:pfam15301  74 SSGLNSPGYLKSTN---KQLLTCGSSGYLRRH---SALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEES 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  289 LRQEYAATTSRRSSGSSCN---STRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNsprpspkqSPRNSPRSR 365
Cdd:pfam15301 148 LRQDYASTSASASRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  366 SPARGIEYSRVSPQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSNTQ-VDSVKSSRS-DSNFQVPNGG 443
Cdd:pfam15301 220 SPSTSQEYSRLSAQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  444 IPRMQPQASAIPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSPGsqeitqltqttSSPGPPMVQSTVSANPPSninSAT 522
Cdd:pfam15301 295 LSRLQQSSSSIPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVAG-----------PSKGLPSSQSLPSGGSSG---SPL 360

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  523 LTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY 581
Cdd:pfam15301 361 PSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESWKDGCY 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 337-565 1.21e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  337 PAVNRFSPSPRNSPRPSPKQSPR-NSPRSRSPARGIEYSRVSPQPMISRLQQPR-LSLQGHPTDLQTSnvkneekLRRSL 414
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSP-------PQRPR 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  415 PNLSRTSNTQVDSvkSSRSDSNFQVPNggiPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQEITQL 494
Cdd:PHA03247 2685 RRAARPTVGSLTS--LADPPPPPPTPE---PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149588928  495 TQTTSSPGPPMVQSTVSANPPsninsATLTRPAGTTA--MRSGLPRPSAPSAGGIPVPRSKLAQPVRRSlPAP 565
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAGPP-----RRLTRPAVASLseSRESLPSPWDPADPPAAVLAPAAALPPAAS-PAG 2826
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 130-581 1.78e-167

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 482.67  E-value: 1.78e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  130 WLYSSPKKKLtPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSMSytsPYSPNAS-SPY 208
Cdd:pfam15301   1 WLYVSPKKKV-PSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSS---AYSGNAEaSSY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  209 SSGFNSPSSTPVRPpivKQLILPGNSGNLKSSdrnPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEES 288
Cdd:pfam15301  74 SSGLNSPGYLKSTN---KQLLTCGSSGYLRRH---SALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEES 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  289 LRQEYAATTSRRSSGSSCN---STRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNsprpspkqSPRNSPRSR 365
Cdd:pfam15301 148 LRQDYASTSASASRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  366 SPARGIEYSRVSPQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSNTQ-VDSVKSSRS-DSNFQVPNGG 443
Cdd:pfam15301 220 SPSTSQEYSRLSAQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  444 IPRMQPQASAIPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSPGsqeitqltqttSSPGPPMVQSTVSANPPSninSAT 522
Cdd:pfam15301 295 LSRLQQSSSSIPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVAG-----------PSKGLPSSQSLPSGGSSG---SPL 360

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  523 LTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY 581
Cdd:pfam15301 361 PSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESWKDGCY 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 337-565 1.21e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  337 PAVNRFSPSPRNSPRPSPKQSPR-NSPRSRSPARGIEYSRVSPQPMISRLQQPR-LSLQGHPTDLQTSnvkneekLRRSL 414
Cdd:PHA03247 2612 APPSPLPPDTHAPDPPPPSPSPAaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSP-------PQRPR 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  415 PNLSRTSNTQVDSvkSSRSDSNFQVPNggiPRMQPQASAIPSPGKFRSPAAPSPLALRQPVKAFSNHGSGSPGSQEITQL 494
Cdd:PHA03247 2685 RRAARPTVGSLTS--LADPPPPPPTPE---PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149588928  495 TQTTSSPGPPMVQSTVSANPPsninsATLTRPAGTTA--MRSGLPRPSAPSAGGIPVPRSKLAQPVRRSlPAP 565
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAGPP-----RRLTRPAVASLseSRESLPSPWDPADPPAAVLAPAAALPPAAS-PAG 2826
PHA03247 PHA03247
large tegument protein UL36; Provisional
 337-565 2.84e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  337 PAVNRFSPSPRNSPRPSpkqSPRNSPRSRSPArgieysrVSPQPMISRL-----QQPRLSLQGHPTDLQTSNVKNEEKLR 411
Cdd:PHA03247 2562 AAPDRSVPPPRPAPRPS---EPAVTSRARRPD-------APPQSARPRApvddrGDPRGPAPPSPLPPDTHAPDPPPPSP 2631

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  412 RSLPNLSRTSNTQVDSVKSSRSDSnfqvPNGGIPRMQPQASAIPSPGKFRSPA-APSPLALRQPVKAFSNHGS--GSPGS 488
Cdd:PHA03247 2632 SPAANEPDPHPPPTVPPPERPRDD----PAPGRVSRPRRARRLGRAAQASSPPqRPRRRAARPTVGSLTSLADppPPPPT 2707

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149588928  489 QEITQLTQTTSSPGPPMVQSTVSANPPSNINSATLTRPAG--TTAMRSGLPRPSAPSAGGIPVPRSKLAQPVRRSLPAP 565
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP 2786
PHA03247 PHA03247
large tegument protein UL36; Provisional
 344-565 1.22e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  344 PSPRNSPRPSPKQS---PRNSPRSRSPARGIEYSR--VSPQPMISRL-----QQPRLSLQGHPTDLQTSNVKNEEKLRRS 413
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppPRPAPRPSEPAVTSRARRpdAPPQSARPRApvddrGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  414 LPNLSRTSNTQVDSVKSSRSDSnfqvPNGGIPRMQPQASAIPSPGKFRSPA-APSPLALRQPVKAFSNHGS--GSPGSQE 490
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDD----PAPGRVSRPRRARRLGRAAQASSPPqRPRRRAARPTVGSLTSLADppPPPPTPE 2709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149588928  491 ITQLTQTTSSPGPPMVQSTVSANPPSNINSATLTRPAGTT-----------AMRSGLPRPSAPSA------GGIPVPRSK 553
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggparparpPTTAGPPAPAPPAApaagppRRLTRPAVA 2789

                         250
                  ....*....|..
gi 149588928  554 LAQPVRRSLPAP 565
Cdd:PHA03247 2790 SLSESRESLPSP 2801
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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