NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|71143135|ref|NP_066401|]
View 

interferon alpha-7 precursor [Homo sapiens]

Protein Classification

alpha/beta interferon family protein( domain architecture ID 10444641)

alpha/beta interferon family protein produces antiviral and antiproliferative response in cell

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 26-181 6.76e-90

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


:

Pssm-ID: 459689  Cd Length: 160  Bit Score: 259.82  E-value: 6.76e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143135    26 LPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLL 105
Cdd:pfam00143   1 LPQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILSGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71143135   106 EKFSTELYQQLNDLEACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFSTNL 181
Cdd:pfam00143  81 EQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRL 156
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 26-181 6.76e-90

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 259.82  E-value: 6.76e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143135    26 LPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLL 105
Cdd:pfam00143   1 LPQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILSGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71143135   106 EKFSTELYQQLNDLEACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFSTNL 181
Cdd:pfam00143  81 EQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRL 156
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 26-178 3.45e-79

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 232.61  E-value: 3.45e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143135  26 LPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLL 105
Cdd:cd00095   1 LRHQHRLFNRRCLKLLRQMRRLPPQSCLKDRADFGFPQELLQGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71143135 106 EKFSTELYQQLNDLEACVIQEVGVEETPlMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFS 178
Cdd:cd00095  81 ESLLNELHQQLNHLETCLEQEMGEEETP-GPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIMRNFSSI 152
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 59-175 1.30e-57

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 176.73  E-value: 1.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143135     59 FRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMnED 138
Cdd:smart00076   2 FAFPEEILDGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEETPLT-RN 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 71143135    139 FILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSF 175
Cdd:smart00076  81 THLALKKYFQRIQLYLKEKKYSPCAWEVVRVEIRRNF 117
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 26-181 6.76e-90

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 259.82  E-value: 6.76e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143135    26 LPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLL 105
Cdd:pfam00143   1 LPQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILSGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71143135   106 EKFSTELYQQLNDLEACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFSTNL 181
Cdd:pfam00143  81 EQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRL 156
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 26-178 3.45e-79

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 232.61  E-value: 3.45e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143135  26 LPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLL 105
Cdd:cd00095   1 LRHQHRLFNRRCLKLLRQMRRLPPQSCLKDRADFGFPQELLQGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71143135 106 EKFSTELYQQLNDLEACVIQEVGVEETPlMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFS 178
Cdd:cd00095  81 ESLLNELHQQLNHLETCLEQEMGEEETP-GPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIMRNFSSI 152
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 59-175 1.30e-57

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 176.73  E-value: 1.30e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71143135     59 FRFPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMnED 138
Cdd:smart00076   2 FAFPEEILDGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEETPLT-RN 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 71143135    139 FILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSF 175
Cdd:smart00076  81 THLALKKYFQRIQLYLKEKKYSPCAWEVVRVEIRRNF 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH