NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|226371746|ref|NP_066568|]
View 

solute carrier family 15 member 2 isoform a [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2A1704 super family cl36771
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
58-696 0e+00

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00926:

Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 790.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746   58 FSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILG 137
Cdd:TIGR00926   1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAIPSSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  138 GQVvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG-EDC 216
Cdd:TIGR00926  81 HPL-HDLLDLLGLALIALGTGGIKPCVSAFGGDQFEERQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGCFGcQDC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  217 YALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDipKRQHWLDWAAEKYPKQLIMDV 296
Cdd:TIGR00926 160 YPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKRFSTRSEH--WPLHWLDYAKDKHDIRMIRST 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  297 KALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSS 376
Cdd:TIGR00926 238 KRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRFTS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  377 LRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLH 456
Cdd:TIGR00926 318 LRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFLQVLNTDCTICDFSVLSKRVLPHDVYLHLDKKNTSGDQGLF 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  457 LKTKSQ-----------DFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHK 525
Cdd:TIGR00926 398 TTKSSAkgwtltydlsyDGACGLTGNCPKTTDAHELEPKISYVLLLSQGGYQLTANTDKPTDAKTEKGMGSVRLVNTLNG 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  526 D-VNISLSTDTSLNVGEDYGVSAYRTVQRG-EYPAVHCRTEDKNFSLNLGL--LDFGAAYLFVITNN-TNQGLQAWKIED 600
Cdd:TIGR00926 478 EfGMISLCTSDSDSVTPCNPRDPYDFYFRGtKYPANTCDRIDNAKSSTFLSnqLDMGIYYLIVITENsKIDELQAQIVEL 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  601 IPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGL-VQWAEFILFS 679
Cdd:TIGR00926 558 VSVNTVSILWQIPQYVILTAGEVLFSVTGLEFSYSQAPPNMKSVLQALWLLTVAIGNLIVVVIAEFENFsVQAAEFFLFA 637
                         650
                  ....*....|....*..
gi 226371746  680 CLLLVICLIFSIMGYYY 696
Cdd:TIGR00926 638 SLMLVVMAIFSILAYFY 654
 
Name Accession Description Interval E-value
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
58-696 0e+00

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 790.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746   58 FSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILG 137
Cdd:TIGR00926   1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAIPSSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  138 GQVvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG-EDC 216
Cdd:TIGR00926  81 HPL-HDLLDLLGLALIALGTGGIKPCVSAFGGDQFEERQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGCFGcQDC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  217 YALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDipKRQHWLDWAAEKYPKQLIMDV 296
Cdd:TIGR00926 160 YPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKRFSTRSEH--WPLHWLDYAKDKHDIRMIRST 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  297 KALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSS 376
Cdd:TIGR00926 238 KRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRFTS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  377 LRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLH 456
Cdd:TIGR00926 318 LRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFLQVLNTDCTICDFSVLSKRVLPHDVYLHLDKKNTSGDQGLF 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  457 LKTKSQ-----------DFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHK 525
Cdd:TIGR00926 398 TTKSSAkgwtltydlsyDGACGLTGNCPKTTDAHELEPKISYVLLLSQGGYQLTANTDKPTDAKTEKGMGSVRLVNTLNG 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  526 D-VNISLSTDTSLNVGEDYGVSAYRTVQRG-EYPAVHCRTEDKNFSLNLGL--LDFGAAYLFVITNN-TNQGLQAWKIED 600
Cdd:TIGR00926 478 EfGMISLCTSDSDSVTPCNPRDPYDFYFRGtKYPANTCDRIDNAKSSTFLSnqLDMGIYYLIVITENsKIDELQAQIVEL 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  601 IPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGL-VQWAEFILFS 679
Cdd:TIGR00926 558 VSVNTVSILWQIPQYVILTAGEVLFSVTGLEFSYSQAPPNMKSVLQALWLLTVAIGNLIVVVIAEFENFsVQAAEFFLFA 637
                         650
                  ....*....|....*..
gi 226371746  680 CLLLVICLIFSIMGYYY 696
Cdd:TIGR00926 638 SLMLVVMAIFSILAYFY 654
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
43-702 0e+00

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 570.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:cd17347    1 PRAVPFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHVIKSLGALPILGgqVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFIT 202
Cdd:cd17347   81 LGHIVLAVTAIPPLG--PPHVWGLLIGLLLIAIGTGGIKPCVSAFGGDQFGADQQHLLARFFSWFYFAINAGSLLSTFLT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 203 PMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNkpppegnivaqvfkciwfaisnrfknrsgdipkrqhwld 282
Cdd:cd17347  159 PILRADVQFGGHDCYPLAFGVPGVLMAVATLVFWLGRKHYK--------------------------------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 283 waaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFV 362
Cdd:cd17347  200 ------------DVKALLRVLVLFIPLPVFWALFDQQGSRWTLQAEQMDGLVGGFTILPDQMQALNPILILILIPLFDYV 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 363 IYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVflqvlnladdevkvtvvgnennsllies 442
Cdd:cd17347  268 IYPLLERCGIPLTPLRKMGVGMILAALAFVIAGFLQLRIDGGLPGQPDPGEV---------------------------- 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 443 iksfqktphysklhlktksqdfhfhlkyhnlslytehsvqeknwyslviredgnsissmmvkdtesrttngmttvrfvnt 522
Cdd:cd17347      --------------------------------------------------------------------------------
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 523 lhkdvnislstdtslnvgedygvsayrtvqrgeypavhcrtedknfslnlglldfgaaylfvitnntnqglqaWKIEDIP 602
Cdd:cd17347  320 -------------------------------------------------------------------------TTFEDIE 326
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 603 ANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFS-GLVQWAEFILFSCL 681
Cdd:cd17347  327 PNSVSILWQLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNLIVVIVAELIqFSSQAAEYFFFAGL 406
                        650       660
                 ....*....|....*....|.
gi 226371746 682 LLVICLIFSIMGYYYVPVKTE 702
Cdd:cd17347  407 MLVVAVVFALLARFYKYVTYE 427
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
111-481 2.43e-129

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 388.99  E-value: 2.43e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  111 FKTIIYLSLVYVLGHVIKSLGALPILGGQVvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLS 190
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIPSLRPPV-HVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRRSRFFSIFYFS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  191 INAGSLISTFITPMLRGDVqcfgedCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFK-N 269
Cdd:pfam00854  80 INAGSLISTIITPYLQQNY------GYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAWNKVKlN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  270 RSGDIPKRQHWLDWAAEKY------------------PKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMN 331
Cdd:pfam00854 154 GSSAGIKKLHWLDWARELDaliilgivvpgiffniwcTKTKVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQARTMN 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  332 RNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGP 411
Cdd:pfam00854 234 RKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTGGLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGPEFPIA 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226371746  412 QEVFLQVLNLADDEVkvtVVGNENNSLLIESIKSFQKTPHYSKLHLKT----KSQDFHFHLKYHNLSLYTEHSV 481
Cdd:pfam00854 314 QEVPISVLWLIPQYL---LIGFGELFISIGGLEFFYKLAPKSMTSLITglflLTNALGNFLSGVIATLTAKPTN 384
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
41-385 3.03e-70

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 237.40  E-value: 3.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  41 NYPLSIAFIVVNEFCERFSYYGMKAVLILYFLY-----FLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTII 115
Cdd:COG3104   11 GHPKGLYTLFFTEMWERFSFYGMRAILVLYLTAsladgGLGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 116 YLSLVYVLGHViksLGALPIlggqvvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAeERTRYFSVFYLSINAGS 195
Cdd:COG3104   91 LGGILMALGHF---LLALPG------GVTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDP-RRDAGFTIFYMGINIGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 196 LISTFITPMLRgdvQCFGedcYALAFGVPGLLMVIALVVFAMGSKIY----NKPPPEGN-----------IVAQVFKCIW 260
Cdd:COG3104  161 FLAPLLCGYLG---EKYG---WHYGFGAAAIGMLIGLIIFLLGRKYLgdigLEPDNPLSkkerliavalgALLLVLVLAG 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 261 FAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLImDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRM-NRNLGFFVL 339
Cdd:COG3104  235 LLSNANIANYLLYVIAIIAYFIFILRSKKLTKE-ERKRLLAILILFLFSIVFWALYEQAGTSLNLFADRNvDRSLFGFEI 313
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 226371746 340 QPDQMQVLNPLLVLIFIPLFDFVIYRLvSKCGINFSSLRKMAVGMI 385
Cdd:COG3104  314 PPSWFQSLNPLFIIILAPVFAALWTKL-GKRGKEPSTPTKFALGLL 358
PRK15462 PRK15462
dipeptide permease;
40-240 1.95e-21

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 98.48  E-value: 1.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  40 SNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSL 119
Cdd:PRK15462   5 ASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGAL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 120 VYVLGHVikslgalpILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAeERTRYFSVFYLSINAGSLISt 199
Cdd:PRK15462  85 LMAIGHV--------VLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDP-RRDGGFSLMYAAGNVGSIIA- 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 226371746 200 fitPMLRGDVQcfGEDCYALAFGVPGLLMVIALVVFAMGSK 240
Cdd:PRK15462 155 ---PIACGYAQ--EEYSWAMGFGLAAVGMIAGLVIFLCGNR 190
 
Name Accession Description Interval E-value
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
58-696 0e+00

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 790.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746   58 FSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILG 137
Cdd:TIGR00926   1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAIPSSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  138 GQVvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG-EDC 216
Cdd:TIGR00926  81 HPL-HDLLDLLGLALIALGTGGIKPCVSAFGGDQFEERQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGCFGcQDC 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  217 YALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDipKRQHWLDWAAEKYPKQLIMDV 296
Cdd:TIGR00926 160 YPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKRFSTRSEH--WPLHWLDYAKDKHDIRMIRST 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  297 KALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSS 376
Cdd:TIGR00926 238 KRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRFTS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  377 LRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLH 456
Cdd:TIGR00926 318 LRKMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFLQVLNTDCTICDFSVLSKRVLPHDVYLHLDKKNTSGDQGLF 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  457 LKTKSQ-----------DFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHK 525
Cdd:TIGR00926 398 TTKSSAkgwtltydlsyDGACGLTGNCPKTTDAHELEPKISYVLLLSQGGYQLTANTDKPTDAKTEKGMGSVRLVNTLNG 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  526 D-VNISLSTDTSLNVGEDYGVSAYRTVQRG-EYPAVHCRTEDKNFSLNLGL--LDFGAAYLFVITNN-TNQGLQAWKIED 600
Cdd:TIGR00926 478 EfGMISLCTSDSDSVTPCNPRDPYDFYFRGtKYPANTCDRIDNAKSSTFLSnqLDMGIYYLIVITENsKIDELQAQIVEL 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  601 IPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGL-VQWAEFILFS 679
Cdd:TIGR00926 558 VSVNTVSILWQIPQYVILTAGEVLFSVTGLEFSYSQAPPNMKSVLQALWLLTVAIGNLIVVVIAEFENFsVQAAEFFLFA 637
                         650
                  ....*....|....*..
gi 226371746  680 CLLLVICLIFSIMGYYY 696
Cdd:TIGR00926 638 SLMLVVMAIFSILAYFY 654
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
43-702 0e+00

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 570.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:cd17347    1 PRAVPFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHVIKSLGALPILGgqVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFIT 202
Cdd:cd17347   81 LGHIVLAVTAIPPLG--PPHVWGLLIGLLLIAIGTGGIKPCVSAFGGDQFGADQQHLLARFFSWFYFAINAGSLLSTFLT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 203 PMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNkpppegnivaqvfkciwfaisnrfknrsgdipkrqhwld 282
Cdd:cd17347  159 PILRADVQFGGHDCYPLAFGVPGVLMAVATLVFWLGRKHYK--------------------------------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 283 waaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFV 362
Cdd:cd17347  200 ------------DVKALLRVLVLFIPLPVFWALFDQQGSRWTLQAEQMDGLVGGFTILPDQMQALNPILILILIPLFDYV 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 363 IYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVflqvlnladdevkvtvvgnennsllies 442
Cdd:cd17347  268 IYPLLERCGIPLTPLRKMGVGMILAALAFVIAGFLQLRIDGGLPGQPDPGEV---------------------------- 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 443 iksfqktphysklhlktksqdfhfhlkyhnlslytehsvqeknwyslviredgnsissmmvkdtesrttngmttvrfvnt 522
Cdd:cd17347      --------------------------------------------------------------------------------
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 523 lhkdvnislstdtslnvgedygvsayrtvqrgeypavhcrtedknfslnlglldfgaaylfvitnntnqglqaWKIEDIP 602
Cdd:cd17347  320 -------------------------------------------------------------------------TTFEDIE 326
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 603 ANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFS-GLVQWAEFILFSCL 681
Cdd:cd17347  327 PNSVSILWQLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNLIVVIVAELIqFSSQAAEYFFFAGL 406
                        650       660
                 ....*....|....*....|.
gi 226371746 682 LLVICLIFSIMGYYYVPVKTE 702
Cdd:cd17347  407 MLVVAVVFALLARFYKYVTYE 427
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
43-703 0e+00

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 537.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:cd17411    1 PLSIAFIVVNEFCERFSYYGMKAVLTLYFLSFLHWDENLSTAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIYLSIVYV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFIT 202
Cdd:cd17411   81 VGHVIKSVGAIPTVGDQQVHVVLSMIGLFLIALGTGGIKPCVAAFGGDQFEEEHARERSKFFSIFYLSINAGSLISTFVT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 203 PMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNkpppegnivaqvfkciwfaisnrfknrsgdipkrqhwld 282
Cdd:cd17411  161 PILRGDVQCFGGDCYALAFGVPAALMVVALVVFIAGSGMYK--------------------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 283 waaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFV 362
Cdd:cd17411  202 ------------EVKMVTRVLFLYIPLPMFWALFDQQGSRWTLQATRMNDFGGGFVLQPDQMQTLNPLLILVFIPIFDLG 269
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 363 IYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPaqpgpqevflQVLNLADDEVKVTVVGNENnsllies 442
Cdd:cd17411  270 IYPLVSKCKINFTSLRKMATGMILAALAFAVAAAVEIKIAWQLP----------QYVLLSAGEVMFSITGLEF------- 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 443 ikSFQKTPHYSKlhlktksqdfhfhlkyhnlslytehSVQEKNWyslviredgnsissmmvkdtesrttngMTTVRFVNT 522
Cdd:cd17411  333 --SYSQAPASMK-------------------------SVLQAGW---------------------------LLTVAFGNV 358
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 523 lhkdvnislstdtslnvgedygvsayrtvqrgeypavhcrtedknfslnlglldfgaaylfvitnntnqglqawkiedip 602
Cdd:cd17411      --------------------------------------------------------------------------------
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 603 ankmsiawqlpqyalvtagevmfsvtglefsysqapssmksvlqaawlltiavgniIVLVVAQFSGLVQWAEFILFSCLL 682
Cdd:cd17411  359 --------------------------------------------------------IVLIVAQAAGMAQWAEFLLFAALL 382
                        650       660
                 ....*....|....*....|.
gi 226371746 683 LVICLIFSIMGYYYVPVKTED 703
Cdd:cd17411  383 LAVCIIFSIMGYFYVYVDPED 403
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
43-385 4.17e-141

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 420.40  E-value: 4.17e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:cd17412    1 PLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHVIKSLGALPILGGQ---------VVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINA 193
Cdd:cd17412   81 IGQAVMAVSAIHDLTDAnrdgtpdnlTLHVALSMIGLLLIALGTGGIKPCVAAFGGDQFEEHQEKQRSRFFSIFYLSINA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 194 GSLISTFITPMLRGDvQCFG---EDCYALAFGVPGLLMVIALVVFAMGSKIYNKpppegnivaqvfkciwfaisnrfknr 270
Cdd:cd17412  161 GSLLSTIITPILRSQ-ECGIhskQKCYPLAFGVPAALMVVALIVFILGSKMYKQ-------------------------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 271 sgdipkrqhwldwaaekypkqlimdVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPL 350
Cdd:cd17412  214 -------------------------IKMVLKVLFLYIPLPMFWALFDQQGSRWTLQATTMDGNFGAIQIQPDQMQTVNPI 268
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 226371746 351 LVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMI 385
Cdd:cd17412  269 LIIIMVPIFDAVIYPLIKKCKINFTPLRKMTVGMF 303
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
111-481 2.43e-129

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 388.99  E-value: 2.43e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  111 FKTIIYLSLVYVLGHVIKSLGALPILGGQVvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLS 190
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIPSLRPPV-HVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRRSRFFSIFYFS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  191 INAGSLISTFITPMLRGDVqcfgedCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFK-N 269
Cdd:pfam00854  80 INAGSLISTIITPYLQQNY------GYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAWNKVKlN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  270 RSGDIPKRQHWLDWAAEKY------------------PKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMN 331
Cdd:pfam00854 154 GSSAGIKKLHWLDWARELDaliilgivvpgiffniwcTKTKVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQARTMN 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  332 RNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGP 411
Cdd:pfam00854 234 RKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTGGLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGPEFPIA 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226371746  412 QEVFLQVLNLADDEVkvtVVGNENNSLLIESIKSFQKTPHYSKLHLKT----KSQDFHFHLKYHNLSLYTEHSV 481
Cdd:pfam00854 314 QEVPISVLWLIPQYL---LIGFGELFISIGGLEFFYKLAPKSMTSLITglflLTNALGNFLSGVIATLTAKPTN 384
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
41-385 3.03e-70

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 237.40  E-value: 3.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  41 NYPLSIAFIVVNEFCERFSYYGMKAVLILYFLY-----FLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTII 115
Cdd:COG3104   11 GHPKGLYTLFFTEMWERFSFYGMRAILVLYLTAsladgGLGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 116 YLSLVYVLGHViksLGALPIlggqvvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAeERTRYFSVFYLSINAGS 195
Cdd:COG3104   91 LGGILMALGHF---LLALPG------GVTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDP-RRDAGFTIFYMGINIGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 196 LISTFITPMLRgdvQCFGedcYALAFGVPGLLMVIALVVFAMGSKIY----NKPPPEGN-----------IVAQVFKCIW 260
Cdd:COG3104  161 FLAPLLCGYLG---EKYG---WHYGFGAAAIGMLIGLIIFLLGRKYLgdigLEPDNPLSkkerliavalgALLLVLVLAG 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 261 FAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLImDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRM-NRNLGFFVL 339
Cdd:COG3104  235 LLSNANIANYLLYVIAIIAYFIFILRSKKLTKE-ERKRLLAILILFLFSIVFWALYEQAGTSLNLFADRNvDRSLFGFEI 313
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 226371746 340 QPDQMQVLNPLLVLIFIPLFDFVIYRLvSKCGINFSSLRKMAVGMI 385
Cdd:COG3104  314 PPSWFQSLNPLFIIILAPVFAALWTKL-GKRGKEPSTPTKFALGLL 358
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
46-419 4.66e-53

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 189.18  E-value: 4.66e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  46 IAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGH 125
Cdd:cd06175    1 CAMILLIELCERFTFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 126 VIKSLGALPI----LGGQVVH--------TVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINA 193
Cdd:cd06175   81 AILTVSTIPPglrpLRCNPSHceqasgiqLTGFYAALYLIALGTGGVKANVSPLGADQFDERGPSKTQSFFNWFYFCINV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 194 GSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFamgskiynkpppegnivaqvfkciwfaisnrfknrsgd 273
Cdd:cd06175  161 GSLLAMLGTPYIQDNVG------WAAAYGIPFVAILLALVVF-------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 274 ipkrqhwldwaaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVL 353
Cdd:cd06175  197 ---------------------EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVRSTGLFTIPPASMQAFNPILLL 255
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226371746 354 IFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQ-----PGPQEVFLQVL 419
Cdd:cd06175  256 LLIPVLDKVVYPLIRRYGVGLSPLTKIGLGFFFGSLSMFVAGFLELKRLNTAHAHgpvvtTSPLSFWWQIP 326
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
42-385 6.25e-48

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 174.30  E-value: 6.25e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  42 YPLSIAFIVvnEFCERFSYYGMKAVLILYFLY--FLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSL 119
Cdd:cd17346    2 KGLYTLFFT--EMWERFSYYGMRAILILYLTAqlGDGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 120 VYVLGHViksLGALPILGgqvvhTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAeERTRYFSVFYLSINAGSLIST 199
Cdd:cd17346   80 LMALGYL---LLALSPFS-----VSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDP-RRDSGFSIFYMGINLGAFLAP 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 200 FITPMLRgdvQCFGedcYALAFGVPGLLMVIALVVFAMGSKIYnkpppegnivaqvfkciwfaisnrfknrsgdipkrqh 279
Cdd:cd17346  151 LLCGTLG---DNYG---YHYGFGLAAVGMLLGLLIFLLGRKKL------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 280 wldwaAEKypkqlimdvKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIR-MNRNLGFFVLQPDQMQVLNPLLVLIFIPL 358
Cdd:cd17346  188 -----LER---------KKMLAIIILFLFAVVFWAIYEQAGTSLALFADEnVDRLLGGFTIPPSWFQSLNPLFIILLAPI 253
                        330       340
                 ....*....|....*....|....*..
gi 226371746 359 FDFvIYRLVSKCGINFSSLRKMAVGMI 385
Cdd:cd17346  254 LAA-LWTKLGKRGKDPSIPTKFALGLL 279
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
45-385 2.07e-47

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 174.38  E-value: 2.07e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  45 SIAFIVVNEFCERFSYYGMKAVLILYFLYFLHwnEDTSTSI--YHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:cd17417    3 ACSFIIGIEVAERFAYYGIASNLVTYLTTPLH--QSTARAAknVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHVIKSLGA-LPILGGQV----------VHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTR---YFSVFY 188
Cdd:cd17417   81 LGLVLLTLSAsLPSLKPPEcngtcskastLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPKEKKQkssFFNWWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 189 LSINAGSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYnkpppegnivaqvfkciwfaisnRFK 268
Cdd:cd17417  161 FSICAGSLTAVTVLVYIQDNVG------WALGFGIPTIVMALALFVFLLGTPLY-----------------------RYK 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 269 nrsgdipkrqhwldwaaekypkqlIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLG-FFVLQPDQMQVL 347
Cdd:cd17417  212 ------------------------VEEVKLVLRLIPIWFTTLVFTVVFAQSPTFFTKQGVTMDRTIGpNFKIPPASLQSF 267
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 226371746 348 NPLLVLIFIPLFD--FV-IYRLVSK--CGInfSSLRKMAVGMI 385
Cdd:cd17417  268 ITLSILISIPIYDrvFVpIARKITGnpRGI--TLLQRIGIGMF 308
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
48-385 1.41e-46

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 171.65  E-value: 1.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  48 FIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVI 127
Cdd:cd17351    3 FILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLIL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 128 KSLGA-LPIL----GGQVVHTVLS--------LIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEER---TRYFSVFYLSI 191
Cdd:cd17351   83 LTLSAsVPSLrpppCNPDSPCEPAsstqltvlYVGLYLIALGTGGIKPCVSAFGADQFDETDPKEKkqkPSFFNWFYFSI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 192 NAGSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYNkpppegnivaqvfkciwfaisnrfknrs 271
Cdd:cd17351  163 NLGSLLAVTLVVYIQDNVS------WGWGFGIPAAAMALAVIVFVAGTPFYR---------------------------- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 272 gdipkrqhwldwaaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGF-FVLQPDQMQVLNPL 350
Cdd:cd17351  209 -----------------------EVKCLLRLLPIWATTILLSTVYAQMQTFFVQQGLTMDRRLGGsFEIPAASLSVFSTL 265
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 226371746 351 LVLIFIPLFDFVIYRLVSKCGIN---FSSLRKMAVGMI 385
Cdd:cd17351  266 FVLLFIPLYDRVFVPFARRYTGNprgITPLQRIGIGLV 303
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
48-385 1.20e-44

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 166.49  E-value: 1.20e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  48 FIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVI 127
Cdd:cd17418    6 FILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYFIGMVL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 128 KSLGA-LPILG-----------GQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTR---YFSVFYLSIN 192
Cdd:cd17418   86 LTLSAsVPGLKpascigslcppATSVQYAVFFLGLYLIALGTGGIKPCVSSFGADQFDDTDPKEKVRkssFFNWFYFSIN 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 193 AGSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYNkpppegnivaqvfkciwfaisnrfknrsg 272
Cdd:cd17418  166 IGALISSSVLVWIQENVG------WGWGFGIPTVFMGIAIVSFFFGTPLYR----------------------------- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 273 dipkrqhwldwaaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLV 352
Cdd:cd17418  211 ----------------------EVKILIRLLPIWASGIVFATVYSQMSTMFVQQGRTMDRMGGNFEIPPASLSLFDTLSV 268
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 226371746 353 LIFIPLFDFVIYRLVSK-CGI--NFSSLRKMAVGMI 385
Cdd:cd17418  269 LIWVPIYDRFIVPLVRKfTGHerGFTQLQRMGIGLF 304
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
605-699 1.87e-37

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 144.99  E-value: 1.87e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 605 KMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGLV-QWAEFILFSCLLL 683
Cdd:cd17412  316 QIQMAWQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAEAGSISeQWAEYVLFAALLV 395
                         90
                 ....*....|....*.
gi 226371746 684 VICLIFSIMGYYYVPV 699
Cdd:cd17412  396 AVCIIFAIMAYFYTYV 411
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
45-405 1.23e-35

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 140.66  E-value: 1.23e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  45 SIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLG 124
Cdd:cd17415    3 TMPFIFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQLG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 125 HVIKSLGA-LPIL------GGQVVHTVLS-------LIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTR---YFSVF 187
Cdd:cd17415   83 MVLLTISAiLPSLrpppcnGHEVCACQASsaqlsilYLSLLLTALGSGGIRPCVVAFGADQFDESDPKQAKQtwnFFNWY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 188 YLSINAGSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYNKpppegnivaqvFKCIWfaisnrf 267
Cdd:cd17415  163 YFCMGIAILLAVTVIVYIQDNVG------WGWGFGIPTIAMAISVIAFVVGSPLYRE-----------LKSII------- 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 268 knRSGDIpkrqhwldWAAEkypkqlIMDVKALTrvlflyiplpmfwalldQQGSRWTLQAIRMNRNLGF-FVLQPDQMQV 346
Cdd:cd17415  219 --RMLPI--------WAAG------ILLVTASS-----------------QQHTFSIQQARTMNRHLTPsFQIPPASMSV 265
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226371746 347 LNPLLVLIFIPLFDFVIYRLVSKC-----GINFssLRKMAVGMILACLAFAVAAAVEIKINEMA 405
Cdd:cd17415  266 FGILSLLTTVPLYDRVLMPVARKFtgnerGITF--LQRMGIGLFISILATVVAAFVEVKRKSVA 327
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
43-418 4.98e-33

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 132.88  E-value: 4.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:cd17419    1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHVIKSLGA-LPIL-----GGQVV--------HTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEE---RTRYFS 185
Cdd:cd17419   81 IGLLLLTLSSaLPSLrppqcGDGDLkcppasaaQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEkasKSAFFS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 186 VFYLSINAGSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYNkpppegnivaqvfkciwfaisn 265
Cdd:cd17419  161 YFYQALNLGSLFSNTILVYFEDNGS------WGLGFGISAGAAFIGLVLFLAGTPFYR---------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 266 rfknrsgdipkrqhwldwaaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQ 345
Cdd:cd17419  213 -----------------------------EVKCILRLLPIWLSTIIYSVVYTQMATLFVEQGAAMDTSFGNFKIPPASMS 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 346 VLNPLLVLIFIPLFDFVIYRLVSKCGIN---FSSLRKMAVGMILACLAFAVAAAVEIKINEMA-------PAQPGPQEVF 415
Cdd:cd17419  264 VFEILSVAVGTVLYRKFLVPLLRKVTGHpkgITELQRMGIGLVIGILAMVVAALVEIQRLKVArpsnlddPTSPSPLSIF 343

                 ...
gi 226371746 416 LQV 418
Cdd:cd17419  344 WQI 346
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
36-385 4.88e-32

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 130.34  E-value: 4.88e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746   36 TICGSNYPLSIAFIVvnEFCERFSYYGMKAVLILYFLY--FLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKT 113
Cdd:TIGR00924   4 TFFGHPKPLFTLFFV--ELWERFSYYGMQGILAVYLVQqaGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  114 IIYLSLVYVLGHVIksLGALPILGGqvvhtvlSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINA 193
Cdd:TIGR00924  82 MVLGGIVLMLGHFM--LAMSIYPDL-------IFYGLGTIAVGSGLFKANPSSMVGKLYERGDMPRRDGGFTLFYMSINI 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  194 GSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGN------------------IVAQV 255
Cdd:TIGR00924 153 GSFISPLLAGVIAENYG------YHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDplsgqgktygklllallaALALV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  256 FKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLIMDVKaltRVLFLYIPL----PMFWALLDQQGSRWTLQAIR-M 330
Cdd:TIGR00924 227 FFCAWLMHHVVIANILLMTVTLAVIIFFFRLAFKPRLDAVAR---NKMYAYIVLfleaVVFWVLYAQMPTSLNFFADNnM 303
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 226371746  331 NRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKcGINFSSLRKMAVGMI 385
Cdd:TIGR00924 304 HHEMLGMSVPVIWFQSLNPFWVVVGSPVLAMIWTRLGRK-GKDPTTPLKFTLGML 357
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
46-385 2.52e-31

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 127.77  E-value: 2.52e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  46 IAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGH 125
Cdd:cd17416    1 MPFIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 126 VIKSLGA-LPIL-------------GGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERT---RYFSVFY 188
Cdd:cd17416   81 VLLTLTAaIPSLrpppcetasslcqSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKTESGKRgleSFFNWYY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 189 LSINAGSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYNkpppegnivaqvfkciwfaisnrfk 268
Cdd:cd17416  161 FTFTVAQIISLTAIVYIQDNVS------WKIGFGIPAALMLLSFILFLAGSRLYV------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 269 nrsgdipkrqhwldwaaekypkqlIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLG-FFVLQPDQMQVL 347
Cdd:cd17416  210 ------------------------VEDLKSLIRVIPIWSTGIILSLAMAQQMSLTVLQALVMDRHLGpSFQIPAGSITVF 265
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 226371746 348 NPLLVLIFIPLFDFVIYRLVSK---CGINFSSLRKMAVGMI 385
Cdd:cd17416  266 LLITLTIFIPLYDRVLVPLLRKitgRGRGLTLLQRVGIGIV 306
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
43-385 8.61e-31

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 126.04  E-value: 8.61e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVVNEFCERFSYYGMKAVLILYFLY--------FLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTI 114
Cdd:cd17350    1 PWSAFLIAIVELCERFSYYGLTGPFQNYMQFgpddstpgALGLGEQGATGLSNFFTFWCYVTPVIGAYVADQFLGRYNTI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 115 IYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERT------------- 181
Cdd:cd17350   81 VCGAVIYFVGILILTCTSIPSVIDAGAGLGGFVVAIIIIGLGTGGIKSNVSPLIADQLPKIKPYVKTlkngervivdpvv 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 182 ---RYFSVFYLSINAGSLiSTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYNKPPpegnivaqvfkc 258
Cdd:cd17350  161 tlsRIYMIFYWAINVGSL-SLLATTYLERTKG------FWYAYLLPLCVFVIPLIILAFGKKFYKIRP------------ 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 259 iwfaisnrfknrsgdipkrQHWLDwaaekypkqlimDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNlgffV 338
Cdd:cd17350  222 -------------------DLFID------------ELKRALRACKVFLFYPIYWVCYGQMTSNFISQAGQMQLH----G 266
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 226371746 339 LQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMI 385
Cdd:cd17350  267 VPNDLFQAFDSIALIIFIPILENIIYPLLRKYNIPFKPITRITLGFM 313
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
44-412 8.94e-30

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 123.33  E-value: 8.94e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  44 LSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVL 123
Cdd:cd17413    2 KSAALILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 124 GHVIKSLGA------LPILGGQVVH----------TVLSLiGLSLIALGTGGIKPCVAAFGGDQFEEKHAEER---TRYF 184
Cdd:cd17413   82 GVLVLTLSTtlpslrPPPCNHTTSHhcepasgiqlTVLYL-ALYLIALGTGGIKSSVSGFGSDQFDENDPKERklmSYFF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 185 SVFYLSINAGSLISTFITPMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYnkpppegnivaqvfkciwfais 264
Cdd:cd17413  161 NRFFFCISVGSLLAVTVLVYIQDNVG------RGWGYGICAAAMVLAIVVFLAGTKRY---------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 265 nRFKNRSGdipkrqhwldwaaekypKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQM 344
Cdd:cd17413  213 -RFKKSIG-----------------STQVEEVKMVVRMLPIWATTILFWTVYAQMTTFSVEQAETMDRNIGSFEIPPASM 274
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226371746 345 QVLNPLLVLIFIPLFDFVIYRLVSKCGIN---FSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQ 412
Cdd:cd17413  275 AVFLVATILLTTAVYDRVIVPLCRKLTGHpqgLTTLQRIGVGLVFSCLAMAVAALVELKRLRIAHAHGKPV 345
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
44-369 3.44e-24

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 106.34  E-value: 3.44e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  44 LSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVL 123
Cdd:cd17414    2 RAAFFVLVVEALENMAYLANANNLVTYLINNMHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 124 GHVIKSLGA-LPILGGQV--------------VHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTR---YFS 185
Cdd:cd17414   82 GLILLTVQAhIPSLQPPScnslgdltckepsgSQAAILFVGLYLVALGVGCIKPNLPSHGADQFDENDPKGRRQlssFFN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 186 VFYLSINAGSLIStfITPMLRGDVQCfgedCYALAFGVPGLLMVIALVVFAMGSKIYNKpppegnivaqvfkciwfaisn 265
Cdd:cd17414  162 WYYFSFSLGALIA--VTLVVWVEENK----GWDWGFGVSAAVIAVGILVFVAGTPFYRN--------------------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 266 rfknrsgdipkrqhwldwaaekypKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNL-GFFVLQPDQM 344
Cdd:cd17414  215 ------------------------KTQVEEVKIVLKMLPIFACTIILNCILAQLQTFSVQQGSTMNRTKiGSFNIPPASL 270
                        330       340
                 ....*....|....*....|....*
gi 226371746 345 QVLNPLLVLIFIPLFDFVIYRLVSK 369
Cdd:cd17414  271 QAIPVIFMLILVPLYDHLLVPFARK 295
PRK15462 PRK15462
dipeptide permease;
40-240 1.95e-21

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 98.48  E-value: 1.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  40 SNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSL 119
Cdd:PRK15462   5 ASQPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGAL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 120 VYVLGHVikslgalpILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAeERTRYFSVFYLSINAGSLISt 199
Cdd:PRK15462  85 LMAIGHV--------VLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDP-RRDGGFSLMYAAGNVGSIIA- 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 226371746 200 fitPMLRGDVQcfGEDCYALAFGVPGLLMVIALVVFAMGSK 240
Cdd:PRK15462 155 ---PIACGYAQ--EEYSWAMGFGLAAVGMIAGLVIFLCGNR 190
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
44-384 6.08e-21

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 96.40  E-value: 6.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  44 LSIAFIVVNEFCERFSYYGMKAVLILYF-LYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:cd17348    2 AACAAVLLVELLERAAFYGITSNLVLFLnGSPFNWEGTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGhviksLGALPILGGQVVHTvlsliGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFIT 202
Cdd:cd17348   82 LG-----MLLFPATAAPALYA-----GLLLVGLGVGSVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 203 PMLRGDVQcfgedcYALAFGVPGLLMVIALVVFAMGSKIYnkpppegnivaqvfkciwfaisnrfknrsgdipkrqhwld 282
Cdd:cd17348  152 AYIQQNVS------FLIGYSIPAVCVGLAFLVFLCGQPVF---------------------------------------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 283 waaekypkqliMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAI-----------RMNRNLGFFVLQPDQMQVLNPLL 351
Cdd:cd17348  186 -----------IDVKALVKILPVFLALIPYWTVYFQMQTTYVLQSLhlkipnifisnIAGITNSSHTFPAAWLTMFDAVL 254
                        330       340       350
                 ....*....|....*....|....*....|...
gi 226371746 352 VLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGM 384
Cdd:cd17348  255 ILILIPLKDKLVDPFLKRRGLLPSSLKRIAVGM 287
tppB PRK09584
dipeptide/tripeptide permease DtpA;
43-385 5.23e-16

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 81.34  E-value: 5.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:PRK09584  20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHvikslgALPILGGQVVHTVlsLIGLSLIALGTGGIKPCVAAFGGDQFeEKHAEERTRYFSVFYLSINAGSLISTFIT 202
Cdd:PRK09584 100 IGY------ALVAWSGHDAGIV--YMGMATIAVGNGLFKANPSSLLSTCY-EKDDPRLDGAFTMYYMSINIGSFFSMLAT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 203 PMLRGDvqcFGedcYALAFGVPGLLMVIALVVFAM--------GSKIYNKPPPEGN-------IVAQVFKCIWFAISNRF 267
Cdd:PRK09584 171 PWLAAK---YG---WSVAFALSVVGMLITVVNFAFcqrwvkqyGSKPDFEPINYRKllltivgVVALIAIATWLLHNQEI 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 268 KNRSGDIPKRQHWLDWAAEKYPKQLIMDVKALTRVLfLYIPLPMFWALLDQQGSRWTLQAIR-MNRNLGFFVLQPDQMQV 346
Cdd:PRK09584 245 ARMALGVVALGIVVIFGKEAFAMKGAARRKMIVAFI-LMLEAIIFFVLYSQMPTSLNFFAIRnVEHSILGIAVEPEQYQA 323
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 226371746 347 LNPLLVLIFIPLFDfVIYrlvSKCGINFSSLRKMAVGMI 385
Cdd:PRK09584 324 LNPFWIMIGSPILA-AIY---NKMGDRLPMPHKFAIGMV 358
PRK10207 PRK10207
dipeptide/tripeptide permease DtpB;
43-260 7.64e-14

dipeptide/tripeptide permease DtpB;


Pssm-ID: 182306  Cd Length: 489  Bit Score: 74.47  E-value: 7.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  43 PLSIAFIVvnEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYV 122
Cdd:PRK10207  15 PFFMIFFV--ELWERFGYYGVQGILAVFFVKQLGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRTIVLGAIVLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 123 LGHVIKSLGALpilggqvvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAeERTRYFSVFYLSINAGSLISTFIT 202
Cdd:PRK10207  93 IGYFMTGMSLL--------KPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDP-RLDGAFTLFYMSINIGSLISLSLA 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 226371746 203 PMLrgdVQCFGedcYALAFGVPGLLMVIALVVF--------AMGSKIYNKPPPEGNI-------VAQVFKCIW 260
Cdd:PRK10207 164 PVI---ADKFG---YSVTYNLCGAGLIIALLVYfacrgmvkDIGSEPDHKPMSFSKLllvllgsVVMIFVCAW 230
MFS_SLC15A5 cd17349
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ...
53-385 9.75e-10

Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340907 [Multi-domain]  Cd Length: 437  Bit Score: 61.31  E-value: 9.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  53 EFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGA 132
Cdd:cd17349   11 ELCERFTFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHFLGTALLPVVA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 133 LP-----ILGGQVVHT-------VLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLIS-- 198
Cdd:cd17349   91 FPfedfyIDTHHIIHTlakreqtLLFYVALLTASLGTGGIRAIVCPLSAYGLQDYGSRKLMSFFNWFYWLVNLNSAVVfv 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 199 --TFITPMLRGdvqcfgedcyALAFGVPGLLMVIALVVFAMgskIYNKpppegnivaqvfkciwfaisnrfknrsgdipk 276
Cdd:cd17349  171 giSYIQQSVAK----------NLGFLIPFMSVLMALITLHM---VRND-------------------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 277 rqhwldwaaekypkqlIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFI 356
Cdd:cd17349  206 ----------------LINTKNLVRLFPLFAFQILYRTCIMQIPSGYYLQTMNSNLNLGGFLLPIAAMNVISIIPLLILA 269
                        330       340
                 ....*....|....*....|....*....
gi 226371746 357 PLFDFVIYRLVSKCGINFSSLRKMAVGMI 385
Cdd:cd17349  270 PFLEYFSSCLFSSKRYGPFLSACIIAGHL 298
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
61-253 7.79e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.13  E-value: 7.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  61 YGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKfktiiylsLVYVLGHVIKSLGALpiLGGQV 140
Cdd:cd06174   12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRR--------PVLLLGLLLFALGAL--LFAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 141 VHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEkhaEERTRYFSVFYLSINAGSLISTFITPMLrgdVQCFGEDcYALA 220
Cdd:cd06174   82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPE---RERGRALGLLQAFGSVGGILGPLLGGIL---ASSLGFG-WRAV 154
                        170       180       190
                 ....*....|....*....|....*....|...
gi 226371746 221 FGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVA 253
Cdd:cd06174  155 FLIAAALALLAAILLLLVVPDPPESARAKNEEA 187
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
58-235 2.38e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.59  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  58 FSYYGMKAVLILYFLYFLHwNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGhviksLGALPILG 137
Cdd:COG2211  242 LALALVAALLLYYFKYVLG-LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG-----LLLLFFLG 315
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 138 GQvvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTR----YFSVFYLSINAGSLISTFITPMLrgdVQCFG 213
Cdd:COG2211  316 PG--NLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRreglYFGIFTFAIKLGQALAGALAGLL---LALFG 390
                        170       180       190
                 ....*....|....*....|....*....|....
gi 226371746 214 ED------------CYALAFGVPGLLMVIALVVF 235
Cdd:COG2211  391 YVagaaqspsaltgIRLLFFLLPAVLLLLAALLL 424
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
58-235 1.16e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.11  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  58 FSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIksLGALPILG 137
Cdd:cd06174  213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL--GLALLLLA 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 138 GqvvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEkhaEERTRYFSVFYLSINAGSLISTFITPMLRGDVqcfgeDCY 217
Cdd:cd06174  291 P---SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPP---EIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT-----FGL 359
                        170
                 ....*....|....*...
gi 226371746 218 ALAFGVPGLLMVIALVVF 235
Cdd:cd06174  360 TGAFLVLAVLLLLAAILL 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
45-239 2.12e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.10  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  45 SIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWlGKFKTIIYLSLVYVLG 124
Cdd:cd17325  200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPLILIGLLLSAVA 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 125 hviksLGALPILGGQvvhtVLSLIGLSLIALGTGGIKPCVAAFGGDQFeekHAEERTRYFSVFYLSINAGSLISTFITPM 204
Cdd:cd17325  279 -----LLLLPLATSF----WLLLLLLALLGLGLGLVFPATLALLADIV---PPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 226371746 205 LrgdVQCFGedcYALAFGVPGLLMVIALVVFAMGS 239
Cdd:cd17325  347 L---YDAFG---FATPFLAAAALLLLAAVLFLLLR 375
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
46-236 2.20e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.14  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  46 IAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWlGKFKTIIylslvyvLGH 125
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRF-GRKPVML-------AGL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 126 VIKSLGALPILggqVVHTVLSL-IGLSLIALGTGGIKPCVAAFGGDQFEEkhaEERTRYFSVFYLSINAGSLIStfitPM 204
Cdd:cd17329   73 LLRALGFALLG---FAHSPWLFaIALVLTGFGGGLFEPASEAMIADVTTP---ENRTRAFSLLYWAINLGVAIG----PL 142
                        170       180       190
                 ....*....|....*....|....*....|..
gi 226371746 205 LRGdvqCFGEDCYALAFGVPGLLMVIALVVFA 236
Cdd:cd17329  143 LGG---LLLLYSFRLLFLAAAVLFLLAALVLL 171
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
178-260 4.00e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 4.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 178 EERTRYFSVFYLSINAGSLISTFITPMLrgdVQCFGEDC---YALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQ 254
Cdd:COG2211  143 EERTRLSSWRFAFAGLGGLLASVLPPPL---VAAFGGDAalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKE 219

                 ....*.
gi 226371746 255 VFKCIW 260
Cdd:COG2211  220 SLKALL 225
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
44-237 5.48e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 5.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  44 LSIAFIVVNefcerFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVyvl 123
Cdd:COG2271  185 LALAYFLVY-----FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLL--- 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746 124 ghviksLGALPILGGQVVHTV-LSLIGLSLIALGTGGIKPCVAAFGGDQFeekHAEERTRYFSVFYLSINAGSLISTFIT 202
Cdd:COG2271  257 ------LAALALLLLALLPSPaLAIALLFLAGFGLGGAFGLLWALAAELF---PKKARGTASGLVNTFGFLGGALGPLLV 327
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 226371746 203 PMLrgdVQCFGedcYALAFGVPGLLMVIALVVFAM 237
Cdd:COG2271  328 GYL---LDATG---YQAAFLLLAALALLAALLALL 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-237 6.87e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  83 TSIYHAFSSLcyFTPILGAaIADSWlGKFKTIIYLSLVYVLGHViksLGALpilggqvVHTVLSLIGLSLI-ALGTGGIK 161
Cdd:COG2814   51 VTAYLLGAAL--GAPLAGR-LADRF-GRRRVLLLGLLLFALGSL---LCAL-------APSLWLLLAARFLqGLGAGALF 116
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226371746 162 PCVAAFGGDQFEekhAEERTRYFSVFYLSINAGSLISTFITPMLrgdVQCFGedcYALAFGVPGLLMVIALVVFAM 237
Cdd:COG2814  117 PAALALIADLVP---PERRGRALGLLGAGLGLGPALGPLLGGLL---ADLFG---WRWVFLVNAVLALLALLLLLR 183
MFS_1 pfam07690
Major Facilitator Superfamily;
54-237 1.43e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746   54 FCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWlGKfKTIIYLSLVyvlghviksLGAL 133
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GR-RRVLLIGLL---------LFAL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  134 PILGGQVVHTVLSLIGLSLIA-LGTGGIKPCVAAFGGDQFEEkhaEERTRYFSVFYLSINAGSLISTFITPMLrgdVQCF 212
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQgLGAGALFPAALALIADWFPP---EERGRALGLVSAGFGLGAALGPLLGGLL---ASLF 148
                         170       180
                  ....*....|....*....|....*
gi 226371746  213 GedcYALAFGVPGLLMVIALVVFAM 237
Cdd:pfam07690 149 G---WRAAFLILAILSLLAAVLLLL 170
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
54-195 2.48e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.73  E-value: 2.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371746  54 FCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADsWLGKFKTIIYLSLVYVLGhviksLGAL 133
Cdd:COG2814  217 FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD-RFGRRRLLLIGLLLLALG-----LLLL 290
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226371746 134 PILGgqvvHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFeekHAEERTRYFSVFYLSINAGS 195
Cdd:COG2814  291 ALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELA---PPEARGRASGLYNSAFFLGG 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH