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Conserved domains on  [gi|23510368|ref|NP_067015|]
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homeobox protein Hox-D11 [Homo sapiens]

Protein Classification

DUF3528 and homeodomain domain-containing protein( domain architecture ID 10967557)

DUF3528 and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3528 super family cl13478
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 26-185 2.95e-45

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


The actual alignment was detected with superfamily member pfam12045:

Pssm-ID: 432284  Cd Length: 127  Bit Score: 150.64  E-value: 2.95e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23510368    26 SDFASKPSFLSQPSSCQMTFPYSSNLaPHVQPVREVAFRDYGLERA-KWPYRGGGGGGSAGGGSsgggpggggggaggya 104
Cdd:pfam12045   1 PDFSSLPSFLPQTPSCQMTYPYSSNL-PQVQPVREVAFRDYALDPSsKWHHRGNYASCYSAEEL---------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23510368   105 pyyaaaaaaaaaaaaaeeaaMQRELLPPAGRRPDVLFKApEPVCAapGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEA 184
Cdd:pfam12045  64 --------------------VHRDCLPPSTTRGEMLFKN-ESVYG--HHHHGSSHPSSNFYSSVGRNGVLPQGFDQFFET 120


                  .
gi 23510368   185 A 185
Cdd:pfam12045 121 A 121
Homeodomain pfam00046
Homeodomain;
267-323 2.05e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 2.05e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 23510368   267 RKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 323
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 26-185 2.95e-45

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


Pssm-ID: 432284  Cd Length: 127  Bit Score: 150.64  E-value: 2.95e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23510368    26 SDFASKPSFLSQPSSCQMTFPYSSNLaPHVQPVREVAFRDYGLERA-KWPYRGGGGGGSAGGGSsgggpggggggaggya 104
Cdd:pfam12045   1 PDFSSLPSFLPQTPSCQMTYPYSSNL-PQVQPVREVAFRDYALDPSsKWHHRGNYASCYSAEEL---------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23510368   105 pyyaaaaaaaaaaaaaeeaaMQRELLPPAGRRPDVLFKApEPVCAapGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEA 184
Cdd:pfam12045  64 --------------------VHRDCLPPSTTRGEMLFKN-ESVYG--HHHHGSSHPSSNFYSSVGRNGVLPQGFDQFFET 120


                  .
gi 23510368   185 A 185
Cdd:pfam12045 121 A 121
Homeodomain pfam00046
Homeodomain;
267-323 2.05e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 2.05e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 23510368   267 RKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 323
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 266-322 3.01e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.77  E-value: 3.01e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 23510368    266 SRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEK 322
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 267-323 9.77e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.91  E-value: 9.77e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 23510368 267 RKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 323
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
263-326 5.54e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 65.92  E-value: 5.54e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23510368 263 PQRSRKKRCpyTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNR 326
Cdd:COG5576  50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 26-185 2.95e-45

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


Pssm-ID: 432284  Cd Length: 127  Bit Score: 150.64  E-value: 2.95e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23510368    26 SDFASKPSFLSQPSSCQMTFPYSSNLaPHVQPVREVAFRDYGLERA-KWPYRGGGGGGSAGGGSsgggpggggggaggya 104
Cdd:pfam12045   1 PDFSSLPSFLPQTPSCQMTYPYSSNL-PQVQPVREVAFRDYALDPSsKWHHRGNYASCYSAEEL---------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23510368   105 pyyaaaaaaaaaaaaaeeaaMQRELLPPAGRRPDVLFKApEPVCAapGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEA 184
Cdd:pfam12045  64 --------------------VHRDCLPPSTTRGEMLFKN-ESVYG--HHHHGSSHPSSNFYSSVGRNGVLPQGFDQFFET 120


                  .
gi 23510368   185 A 185
Cdd:pfam12045 121 A 121
Homeodomain pfam00046
Homeodomain;
267-323 2.05e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 2.05e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 23510368   267 RKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 323
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 266-322 3.01e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.77  E-value: 3.01e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 23510368    266 SRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEK 322
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 267-323 9.77e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.91  E-value: 9.77e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 23510368 267 RKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 323
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
263-326 5.54e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 65.92  E-value: 5.54e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23510368 263 PQRSRKKRCpyTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNR 326
Cdd:COG5576  50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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