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Conserved domains on  [gi|11034821|ref|NP_067039|]
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endothelial zinc finger protein induced by tumor necrosis factor alpha isoform 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-479 1.61e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 1.61e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 110 NFSSTSDLSKPPMPC-----EEKKTYDCSECGKAFSRSSSLIKHQRIHTGEKPFEC--DTCGKHFIERSSLTIHQRVHTG 182
Cdd:COG5048   9 SSSNNSVLSSTPKSTlkslsNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 183 EK-------------------------------PYACGDCGKAFSQRMNLTVHQRTHTGEKPY----------------- 214
Cdd:COG5048  89 NPsdlnskslplsnskasssslsssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslh 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 215 ----VCDVCGKAFRKTSSLTQHERIHTGEKPYACGDCGKAFSQNMHLIVHQRTHTgEKPYVCPECGRAFSQnmHLTEHQR 290
Cdd:COG5048 169 pplpANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPK--SLLSQSP 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 291 THTGEKPYA--CKECGKAFNKSSSLTLHQRNHTGE-------KPYVCGECGKAFSQSSYLIQHQR--FHIG--VKPFECS 357
Cdd:COG5048 246 SSLSSSDSSssASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCP 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 358 E--CGKAFSKNSSLTQHQRIHTGEKPYECYI--CKKHFTGRS-----SLIVHQIVHTGEKPYVC--GECGKAFSQSAYLI 426
Cdd:COG5048 326 YslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLS 405

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 11034821 427 EHQRIHTGEKP--YRCGQCGKSFIKNSSLTVHQRIHTGEKPYRCGECGKTFSRNT 479
Cdd:COG5048 406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-479 1.61e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 1.61e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 110 NFSSTSDLSKPPMPC-----EEKKTYDCSECGKAFSRSSSLIKHQRIHTGEKPFEC--DTCGKHFIERSSLTIHQRVHTG 182
Cdd:COG5048   9 SSSNNSVLSSTPKSTlkslsNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 183 EK-------------------------------PYACGDCGKAFSQRMNLTVHQRTHTGEKPY----------------- 214
Cdd:COG5048  89 NPsdlnskslplsnskasssslsssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslh 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 215 ----VCDVCGKAFRKTSSLTQHERIHTGEKPYACGDCGKAFSQNMHLIVHQRTHTgEKPYVCPECGRAFSQnmHLTEHQR 290
Cdd:COG5048 169 pplpANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPK--SLLSQSP 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 291 THTGEKPYA--CKECGKAFNKSSSLTLHQRNHTGE-------KPYVCGECGKAFSQSSYLIQHQR--FHIG--VKPFECS 357
Cdd:COG5048 246 SSLSSSDSSssASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCP 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 358 E--CGKAFSKNSSLTQHQRIHTGEKPYECYI--CKKHFTGRS-----SLIVHQIVHTGEKPYVC--GECGKAFSQSAYLI 426
Cdd:COG5048 326 YslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLS 405

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 11034821 427 EHQRIHTGEKP--YRCGQCGKSFIKNSSLTVHQRIHTGEKPYRCGECGKTFSRNT 479
Cdd:COG5048 406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 7.61e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.61e-05
                          10        20
                  ....*....|....*....|....*.
gi 11034821   284 HLTEHQRTHTGEKPYACKECGKAFNK 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 325-390 6.26e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 6.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 11034821  325 PYVCGECGKAFSQSSYLIQHQRFHIGVKpfECSECGKAFSKNSSLTQHqrihtgekpyecyICKKH 390
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH-------------VCKKH 123
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 132-180 8.20e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.22  E-value: 8.20e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 11034821 132 CSECGKAFSRSSSLIKHQRIHTgekpFECDTCGKHFIERSSLTIH-QRVH 180
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
110-479 1.61e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 1.61e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 110 NFSSTSDLSKPPMPC-----EEKKTYDCSECGKAFSRSSSLIKHQRIHTGEKPFEC--DTCGKHFIERSSLTIHQRVHTG 182
Cdd:COG5048   9 SSSNNSVLSSTPKSTlkslsNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 183 EK-------------------------------PYACGDCGKAFSQRMNLTVHQRTHTGEKPY----------------- 214
Cdd:COG5048  89 NPsdlnskslplsnskasssslsssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslh 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 215 ----VCDVCGKAFRKTSSLTQHERIHTGEKPYACGDCGKAFSQNMHLIVHQRTHTgEKPYVCPECGRAFSQnmHLTEHQR 290
Cdd:COG5048 169 pplpANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPK--SLLSQSP 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 291 THTGEKPYA--CKECGKAFNKSSSLTLHQRNHTGE-------KPYVCGECGKAFSQSSYLIQHQR--FHIG--VKPFECS 357
Cdd:COG5048 246 SSLSSSDSSssASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCP 325

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 358 E--CGKAFSKNSSLTQHQRIHTGEKPYECYI--CKKHFTGRS-----SLIVHQIVHTGEKPYVC--GECGKAFSQSAYLI 426
Cdd:COG5048 326 YslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLS 405

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*
gi 11034821 427 EHQRIHTGEKP--YRCGQCGKSFIKNSSLTVHQRIHTGEKPYRCGECGKTFSRNT 479
Cdd:COG5048 406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-400 1.21e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 140 SRSSSLIKHQRIHTGEKPFECDTCGKHFIERSSLTIHQRVHTGEKPYACGDCGKAFSQrmNLTVHQRTHTGEK--PYVCD 217
Cdd:COG5048 181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLSSSdsSSSAS 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 218 VCGKAFRKTSSLTQHERIHTGE-------KPYACGDCGKAFSQNMHLIVHQRT--HTGE--KPYVCPE--CGRAFSQNMH 284
Cdd:COG5048 259 ESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDA 338

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 285 LTEHQRTHTGEKPYACKEC-------GKAFNKSSSLTLHQRNHTGEKPYVC--GECGKAFSQSSYLIQHQRFHIGVKP-- 353
Cdd:COG5048 339 LKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPyn 418

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 11034821 354 FECSECGKAFSKNSSLTQHQRIHTgEKPYECYICKKHFTGRSSLIVH 400
Cdd:COG5048 419 CKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
142-488 2.16e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 2.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 142 SSSLIKHQRIHTGE----KPFECDTCGKHFIERSSLTIHQRVHTGEKPYACGD--CGKAFSQRMNLTVHQRTHTGEKPYV 215
Cdd:COG5048  14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 216 C-DVCGKAFRKTSSLTQHERIHTGEKPYACGDCGKAFSQN--MHLIVHQRTHTGEKPYvcPECGRAFSQNMHLTEHQRTH 292
Cdd:COG5048  94 NsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRdpQLPDLLSISNLRNNPL--PGNNSSSVNTPQSNSLHPPL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 293 TGEKPYACKECGKAFNKSSSLTLHQRNHtgekpYVCGECGKAFSQSSyLIQHQRFHIGVKPFECSECGKAFSK------N 366
Cdd:COG5048 172 PANSLSKDPSSNLSLLISSNVSTSIPSS-----SENSPLSSSYSIPS-SSSDQNLENSSSSLPLTTNSQLSPKsllsqsP 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 367 SSLTQHQRIHTGEKPYECYICKKHFTGRSSLIVHQIVHTG-EKPYVCGECGKAFSQSAYLIEHQR--IHTGE--KPYRCG 441
Cdd:COG5048 246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCP 325

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 11034821 442 --QCGKSFIKNSSLTVHQRIHTGEKPYRC--GECGKTFSRNTNLTRHLRIH 488
Cdd:COG5048 326 ysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-489 2.75e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 184 KPYACGDCGKAFSQRMNLTVHQRTHTGEKPYVCDV--CGKAFRKTSSLTQHERIHTGEKPYACGDCG------KAFSQNM 255
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 256 HLIVHQRTHTGEKPYVCPEcgrAFSQNMHLTEHQRTHTGEKP-YACKECGKAFNKSSSLTL-HQRNHTGEKPYvcgecgk 333
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPP---SSRDPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHPpLPANSLSKDPS------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 334 afSQSSYLIqHQRFHIGVKPFECSECGKAFSKNSSLTQHQRIHTGEKPYECY----ICKKHFTGRSSLIVHQIVHTGEKP 409
Cdd:COG5048 182 --SNLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTtnsqLSPKSLLSQSPSSLSSSDSSSSAS 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 410 YVCGEC-GKAFSQSAYLIEH-QRIHTG-EKPYRCGQCGKSFIKNSSLTVHQR--IHTGE--KPYRCGE--CGKTFSRNTN 480
Cdd:COG5048 259 ESPRSSlPTASSQSSSPNESdSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDA 338


                ....*....
gi 11034821 481 LTRHLRIHT 489
Cdd:COG5048 339 LKRHILLHT 347
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 210-293 4.77e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 4.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 210 GEKPYVCDV--CGKAFRKTSSLTQHeRIHtgekpyacGDCGKAFSQNMHLIVHQRTHTGEKPYVCPECGRAFSQNMHLTE 287
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 11034821 288 HqRTHT 293
Cdd:COG5189 417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 7.61e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.61e-05
                          10        20
                  ....*....|....*....|....*.
gi 11034821   284 HLTEHQRTHTGEKPYACKECGKAFNK 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-281 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 11034821   256 HLIVHQRTHTGEKPYVCPECGRAFSQ 281
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 294-372 1.75e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 294 GEKPYACK--ECGKAFNKSSSLTLHQRNhtgekpyvcGECGKAFSQSSYLIQHQRFHIGVKPFECSECGKAFSKNSSLTQ 371
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 11034821 372 H 372
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
200-223 1.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.79e-04
                          10        20
                  ....*....|....*....|....
gi 11034821   200 NLTVHQRTHTGEKPYVCDVCGKAF 223
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 466-488 3.21e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.21e-04
                          10        20
                  ....*....|....*....|...
gi 11034821   466 YRCGECGKTFSRNTNLTRHLRIH 488
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 3.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 11034821   228 SLTQHERIHTGEKPYACGDCGKAFSQ 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-477 3.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 11034821   452 SLTVHQRIHTGEKPYRCGECGKTFSR 477
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-447 5.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.15e-04
                          10        20
                  ....*....|....*....|....
gi 11034821   424 YLIEHQRIHTGEKPYRCGQCGKSF 447
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 325-390 6.26e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 6.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 11034821  325 PYVCGECGKAFSQSSYLIQHQRFHIGVKpfECSECGKAFSKNSSLTQHqrihtgekpyecyICKKH 390
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH-------------VCKKH 123
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 130-152 1.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|...
gi 11034821   130 YDCSECGKAFSRSSSLIKHQRIH 152
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 11034821   312 SLTLHQRNHTGEKPYVCGECGKAFSQ 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
144-167 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....
gi 11034821   144 SLIKHQRIHTGEKPFECDTCGKHF 167
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-392 1.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|....*
gi 11034821   368 SLTQHQRIHTGEKPYECYICKKHFT 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 406-484 1.81e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11034821 406 GEKPYVCG--ECGKAFSQSAYLIEHqRIHtgekpyrcGQCGKSFIKNSSLTVHQRIHTGEKPYRCGECGKTFSRNTNLTR 483
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 11034821 484 H 484
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 11034821   340 YLIQHQRFHIGVKPFECSECGKAFSK 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 270-292 2.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.15e-03
                          10        20
                  ....*....|....*....|...
gi 11034821   270 YVCPECGRAFSQNMHLTEHQRTH 292
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 354-376 2.33e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.33e-03
                          10        20
                  ....*....|....*....|...
gi 11034821   354 FECSECGKAFSKNSSLTQHQRIH 376
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
172-197 3.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 11034821   172 SLTIHQRVHTGEKPYACGDCGKAFSQ 197
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 185-232 4.23e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 4.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 11034821  185 PYACGDCGKAFSQRMNLTVHQRTHTGEKpyVCDVCGKAFRKTSSLTQH 232
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 186-208 4.41e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.41e-03
                          10        20
                  ....*....|....*....|...
gi 11034821   186 YACGDCGKAFSQRMNLTVHQRTH 208
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 438-460 5.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.16e-03
                          10        20
                  ....*....|....*....|...
gi 11034821   438 YRCGQCGKSFIKNSSLTVHQRIH 460
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 269-316 5.28e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 5.28e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 11034821  269 PYVCPECGRAFSQNMHLTEHQRTHTGEKpyACKECGKAFNKSSSLTLH 316
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 242-264 5.92e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.92e-03
                          10        20
                  ....*....|....*....|...
gi 11034821   242 YACGDCGKAFSQNMHLIVHQRTH 264
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-421 7.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|....*.
gi 11034821   396 SLIVHQIVHTGEKPYVCGECGKAFSQ 421
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 132-180 8.20e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.22  E-value: 8.20e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 11034821 132 CSECGKAFSRSSSLIKHQRIHTgekpFECDTCGKHFIERSSLTIH-QRVH 180
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 326-348 8.43e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.43e-03
                          10        20
                  ....*....|....*....|...
gi 11034821   326 YVCGECGKAFSQSSYLIQHQRFH 348
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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