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Conserved domains on  [gi|33438586|ref|NP_067040|]
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zinc finger protein 77 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.76e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.76e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 33438586     3 CVIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASLD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-544 1.15e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 237 QKTHACKVCGKTFMYYSYLTRHVRTHTGEKPYEC--KECGKAFSCPSYFREHVRTHTGEKPYECKHCGKSFSCYSSFRDH 314
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 315 VRTHTGE-KPCQCKHCGKAFTCYSSLREHGRTHSGEKPYECKEC-GKAFRYPSSLRAHMRMHTGEkpyvckQCGKAFGCP 392
Cdd:COG5048 111 SSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 393 TYFRRHVKTHSGVKPYQCKECGKAYSFSSSLRIHVRTHTgEKPFECKHCGKAFSCHSSLREHVRTHSGEKP-YECNQCGK 471
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSsSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 472 AFSHAQYFQK-HVRSHSGV-----KPYECTECGKAYSCSSSLRVHVRT--HTGE--RPYEC--KQCGKTFRYLASLQAHV 539
Cdd:COG5048 264 SLPTASSQSSsPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343


                ....*
gi 33438586 540 RTHAG 544
Cdd:COG5048 344 LLHTS 348
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.76e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.76e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 33438586     3 CVIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASLD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.10e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.79  E-value: 3.10e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 33438586      4 VIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASLDC 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 5.02e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.02e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 33438586   4 VIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-544 1.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 237 QKTHACKVCGKTFMYYSYLTRHVRTHTGEKPYEC--KECGKAFSCPSYFREHVRTHTGEKPYECKHCGKSFSCYSSFRDH 314
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 315 VRTHTGE-KPCQCKHCGKAFTCYSSLREHGRTHSGEKPYECKEC-GKAFRYPSSLRAHMRMHTGEkpyvckQCGKAFGCP 392
Cdd:COG5048 111 SSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 393 TYFRRHVKTHSGVKPYQCKECGKAYSFSSSLRIHVRTHTgEKPFECKHCGKAFSCHSSLREHVRTHSGEKP-YECNQCGK 471
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSsSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 472 AFSHAQYFQK-HVRSHSGV-----KPYECTECGKAYSCSSSLRVHVRT--HTGE--RPYEC--KQCGKTFRYLASLQAHV 539
Cdd:COG5048 264 SLPTASSQSSsPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343


                ....*
gi 33438586 540 RTHAG 544
Cdd:COG5048 344 LLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-279 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 33438586   254 YLTRHVRTHTGEKPYECKECGKAFSC 279
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.76e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.76e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 33438586     3 CVIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASLD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.10e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.79  E-value: 3.10e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 33438586      4 VIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASLDC 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 5.02e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.02e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 33438586   4 VIFEEVAVNFTPEEWALLDHAQRSLYRDVMLETCRNLASL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-544 1.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 237 QKTHACKVCGKTFMYYSYLTRHVRTHTGEKPYEC--KECGKAFSCPSYFREHVRTHTGEKPYECKHCGKSFSCYSSFRDH 314
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 315 VRTHTGE-KPCQCKHCGKAFTCYSSLREHGRTHSGEKPYECKEC-GKAFRYPSSLRAHMRMHTGEkpyvckQCGKAFGCP 392
Cdd:COG5048 111 SSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANS------LSKDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 393 TYFRRHVKTHSGVKPYQCKECGKAYSFSSSLRIHVRTHTgEKPFECKHCGKAFSCHSSLREHVRTHSGEKP-YECNQCGK 471
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSsSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 472 AFSHAQYFQK-HVRSHSGV-----KPYECTECGKAYSCSSSLRVHVRT--HTGE--RPYEC--KQCGKTFRYLASLQAHV 539
Cdd:COG5048 264 SLPTASSQSSsPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343


                ....*
gi 33438586 540 RTHAG 544
Cdd:COG5048 344 LLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-398 2.29e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 195 SRTASVTYVKSLSSKKSYECQKCGKAFICPSSFRGHVNSHHGQKT-HACKVCGKTFMYYSYLTRHVRT--HTGE--KPYE 269
Cdd:COG5048 244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFS 323

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 270 CKE--CGKAFSCPSYFREHVRTHTGEKPYECK--HCGKSFS------CYSSFRDHVRTHTGEKPCQCKH-CGKAFTCYSS 338
Cdd:COG5048 324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSN 403

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33438586 339 LREHGRTHSGEKPYECK--ECGKAFRYPSSLRAHMRMHTGEKPYVCKQCGKAFGCPTYFRRH 398
Cdd:COG5048 404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-538 4.28e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 378 KPYVCKQCGKAFGCPTYFRRHVKT--HSG--VKPYQCKE--CGKAYSFSSSLRIHVRTHTGEKPFECK--HCGKAFS--- 446
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 447 --CHSSLREHVRTHSGEKPYEC--NQCGKAFSHAQYFQKHVRSHSGVKPYECT--ECGKAYSCSSSLRVHVRTHTGERPY 520
Cdd:COG5048 368 nnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*...
gi 33438586 521 ECKQCGKtFRYLASLQAH 538
Cdd:COG5048 448 LCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
294-447 5.76e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 294 KPYECKHCGKSFSCYSSFRDHVRT--HTGE--KPCQCKH--CGKAFTCYSSLREHGRTHSGEKPYECKECGKAFRYPSSL 367
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 368 ----RAHMRMHTGEKPYVCKQCGKAFGCPT-----YFRRHVKTHSGVKPYQCK--ECGKAYSFSSSLRIHVRTHTGEKPF 436
Cdd:COG5048 368 nnepPQSLQQYKDLKNDKKSETLSNSCIRNfkrdsNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|.
gi 33438586 437 ECKHCGKAFSC 447
Cdd:COG5048 448 LCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-279 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 33438586   254 YLTRHVRTHTGEKPYECKECGKAFSC 279
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-474 3.16e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 322 KPCQCKHCGKAFTCYSSLREHGRT--HSGE--KPYECKE--CGKAFRYPSSLRAHMRMHTGEKPYVCK--QCGKAFGCPT 393
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33438586 394 YFRRHVKT--HSGVKPYQCKEC-GKAYSFSSSLRIHVRTHT------GEKPFECKHCGKAFSCHSSLREHVRTHSGEKPY 464
Cdd:COG5048 368 NNEPPQSLqqYKDLKNDKKSETlSNSCIRNFKRDSNLSLHIithlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|
gi 33438586 465 ECNQCGKAFS 474
Cdd:COG5048 448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-307 3.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 33438586   282 YFREHVRTHTGEKPYECKHCGKSFSC 307
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
450-475 3.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 33438586   450 SLREHVRTHSGEKPYECNQCGKAFSH 475
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
422-447 4.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 33438586   422 SLRIHVRTHTGEKPFECKHCGKAFSC 447
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-389 5.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.19e-04
                          10        20
                  ....*....|....*....|....
gi 33438586   366 SLRAHMRMHTGEKPYVCKQCGKAF 389
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-531 7.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 33438586   506 SLRVHVRTHTGERPYECKQCGKTFRY 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 352-374 3.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.95e-03
                          10        20
                  ....*....|....*....|...
gi 33438586   352 YECKECGKAFRYPSSLRAHMRMH 374
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-363 6.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.74e-03
                          10        20
                  ....*....|....*....|....*.
gi 33438586   338 SLREHGRTHSGEKPYECKECGKAFRY 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-418 7.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.44e-03
                          10        20
                  ....*....|....*....|....*
gi 33438586   394 YFRRHVKTHSGVKPYQCKECGKAYS 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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