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Conserved domains on  [gi|126723149|ref|NP_067054|]
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splicing factor Cactin [Homo sapiens]

Protein Classification

cactin family protein( domain architecture ID 10563375)

cactin family protein may be involved in the regulation of innate immune response, and may act as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF), and canonical NF-kappa-B signaling pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CactinC_cactus pfam09732
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 634-758 9.63e-93

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain pfam10312 further upstream.


:

Pssm-ID: 401611  Cd Length: 125  Bit Score: 284.87  E-value: 9.63e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  634 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAG 713
Cdd:pfam09732   1 WSDKYRPRKPRYFNRVKTGYEWNKYNQTHYDSDNPPPKVVQGYKFNIFYPDLIDKTKTPTYKIEKDPNEPDTCLIRFHAG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 126723149  714 PPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 758
Cdd:pfam09732  81 PPYEDIAFRIVNKEWDYSHKRGFKSSFDRGVLQLYFNFKRSRYRR 125
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 270-457 7.97e-76

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


:

Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 242.85  E-value: 7.97e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  270 REKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 343
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  344 LLEDIQVYMELEQ-GKNADFWRDMTTITEDEISKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 422
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 126723149  423 GKIRAGGPnLDMGYWESLLQQLRAHMARARLRERH 457
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKARLREVH 186
PTZ00266 super family cl31758
NIMA-related protein kinase; Provisional
 214-272 9.68e-03

NIMA-related protein kinase; Provisional


The actual alignment was detected with superfamily member PTZ00266:

Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 39.34  E-value: 9.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126723149  214 KALEKKGISHLEEKEL----KERNKRIQ----EDNRLELQKVKQLRLEREREKAMREQELEMLQREK 272
Cdd:PTZ00266  453 KILEKKRIERLEREERerleRERMERIErerlERERLERERLERDRLERDRLDRLERERVDRLERDR 519
 
Name Accession Description Interval E-value
CactinC_cactus pfam09732
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 634-758 9.63e-93

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain pfam10312 further upstream.


Pssm-ID: 401611  Cd Length: 125  Bit Score: 284.87  E-value: 9.63e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  634 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAG 713
Cdd:pfam09732   1 WSDKYRPRKPRYFNRVKTGYEWNKYNQTHYDSDNPPPKVVQGYKFNIFYPDLIDKTKTPTYKIEKDPNEPDTCLIRFHAG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 126723149  714 PPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 758
Cdd:pfam09732  81 PPYEDIAFRIVNKEWDYSHKRGFKSSFDRGVLQLYFNFKRSRYRR 125
CactinC_cactus smart01050
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 634-758 9.45e-77

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain further upstream.


Pssm-ID: 214996  Cd Length: 129  Bit Score: 243.03  E-value: 9.45e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149   634 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEAC----ADNKDFAILR 709
Cdd:smart01050   1 WEDKYRLRKPRYFNRVKTGYDWNKYNQTHYDNDNPPPKIVQGYKFNIFYPDLIDKGKAPRYRIESSfeieKPDDDTCLLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 126723149   710 FHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 758
Cdd:smart01050  81 FSAGPPYEDIAFKIVNREWDYSHRGGFKSSFDNGILQLQFNFKKTRYRR 129
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 270-457 7.97e-76

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 242.85  E-value: 7.97e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  270 REKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 343
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  344 LLEDIQVYMELEQ-GKNADFWRDMTTITEDEISKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 422
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 126723149  423 GKIRAGGPnLDMGYWESLLQQLRAHMARARLRERH 457
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKARLREVH 186
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
 214-272 9.68e-03

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 39.34  E-value: 9.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126723149  214 KALEKKGISHLEEKEL----KERNKRIQ----EDNRLELQKVKQLRLEREREKAMREQELEMLQREK 272
Cdd:PTZ00266  453 KILEKKRIERLEREERerleRERMERIErerlERERLERERLERDRLERDRLDRLERERVDRLERDR 519
 
Name Accession Description Interval E-value
CactinC_cactus pfam09732
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 634-758 9.63e-93

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain pfam10312 further upstream.


Pssm-ID: 401611  Cd Length: 125  Bit Score: 284.87  E-value: 9.63e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  634 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAG 713
Cdd:pfam09732   1 WSDKYRPRKPRYFNRVKTGYEWNKYNQTHYDSDNPPPKVVQGYKFNIFYPDLIDKTKTPTYKIEKDPNEPDTCLIRFHAG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 126723149  714 PPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 758
Cdd:pfam09732  81 PPYEDIAFRIVNKEWDYSHKRGFKSSFDRGVLQLYFNFKRSRYRR 125
CactinC_cactus smart01050
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 634-758 9.45e-77

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain further upstream.


Pssm-ID: 214996  Cd Length: 129  Bit Score: 243.03  E-value: 9.45e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149   634 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEAC----ADNKDFAILR 709
Cdd:smart01050   1 WEDKYRLRKPRYFNRVKTGYDWNKYNQTHYDNDNPPPKIVQGYKFNIFYPDLIDKGKAPRYRIESSfeieKPDDDTCLLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 126723149   710 FHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 758
Cdd:smart01050  81 FSAGPPYEDIAFKIVNREWDYSHRGGFKSSFDNGILQLQFNFKKTRYRR 129
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 270-457 7.97e-76

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 242.85  E-value: 7.97e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  270 REKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 343
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126723149  344 LLEDIQVYMELEQ-GKNADFWRDMTTITEDEISKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 422
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 126723149  423 GKIRAGGPnLDMGYWESLLQQLRAHMARARLRERH 457
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKARLREVH 186
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
 214-272 9.68e-03

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 39.34  E-value: 9.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126723149  214 KALEKKGISHLEEKEL----KERNKRIQ----EDNRLELQKVKQLRLEREREKAMREQELEMLQREK 272
Cdd:PTZ00266  453 KILEKKRIERLEREERerleRERMERIErerlERERLERERLERDRLERDRLDRLERERVDRLERDR 519
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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