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Conserved domains on  [gi|31317239|ref|NP_067081|]
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interleukin-22 receptor subunit alpha-1 precursor [Homo sapiens]

Protein Classification

Tissue_fac domain-containing protein( domain architecture ID 10471408)

Tissue_fac domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 4-107 1.27e-35

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 129.04  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239     4 LLTILTVGSLAAHA-PEDPSDLL--QHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQRITRKSCN 80
Cdd:pfam01108   1 LLTLLLGLLLLALAsAAGGPSLPapQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECD 80

                          90       100
                  ....*....|....*....|....*..
gi 31317239    81 LTVETGNLTELYYARVTAVSAGGRSAT 107
Cdd:pfam01108  81 LTDETSDLTETYYARVRAVSGGGTSSW 107
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 290-527 4.00e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   290 SGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPPPQILSPLSYAPNAAPEVGPPSYAPQVT 369
Cdd:pfam03154 132 SDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   370 PEAQFPfyAPQAISKVQPSSYApQATPDSWP---PSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQKEPPAGSCMLGGLS 446
Cdd:pfam03154 212 PATSQP--PNQTQSTAAPHTLI-QQTPTLHPqrlPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   447 LQEVTSlameesqeakslHQPLGIctdrtsdpnvlhsgeegTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSPSDQG 526
Cdd:pfam03154 289 MQHPVP------------PQPFPL-----------------TPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP 339


                  .
gi 31317239   527 P 527
Cdd:pfam03154 340 P 340
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 4-107 1.27e-35

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 129.04  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239     4 LLTILTVGSLAAHA-PEDPSDLL--QHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQRITRKSCN 80
Cdd:pfam01108   1 LLTLLLGLLLLALAsAAGGPSLPapQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECD 80

                          90       100
                  ....*....|....*....|....*..
gi 31317239    81 LTVETGNLTELYYARVTAVSAGGRSAT 107
Cdd:pfam01108  81 LTDETSDLTETYYARVRAVSGGGTSSW 107
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 290-527 4.00e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   290 SGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPPPQILSPLSYAPNAAPEVGPPSYAPQVT 369
Cdd:pfam03154 132 SDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   370 PEAQFPfyAPQAISKVQPSSYApQATPDSWP---PSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQKEPPAGSCMLGGLS 446
Cdd:pfam03154 212 PATSQP--PNQTQSTAAPHTLI-QQTPTLHPqrlPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   447 LQEVTSlameesqeakslHQPLGIctdrtsdpnvlhsgeegTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSPSDQG 526
Cdd:pfam03154 289 MQHPVP------------PQPFPL-----------------TPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP 339


                  .
gi 31317239   527 P 527
Cdd:pfam03154 340 P 340
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 293-401 1.06e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   293 SSLAQPVQYSQiRVSGPR--EPAGAPQRHSLSEITYLGQPDISILQPSNVPPPQilSPLSYAPNAAPEVGPPSYAPQVTP 370
Cdd:PRK10263  351 VPPAQPTVAWQ-PVPGPQtgEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQP--QQPYYAPAAEQPAQQPYYAPAPEQ 427

                          90       100       110
                  ....*....|....*....|....*....|.
gi 31317239   371 EAQFPFYAPQAISKVQPSSYAPQATPDSWPP 401
Cdd:PRK10263  428 PAQQPYYAPAPEQPVAGNAWQAEEQQSTFAP 458
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 18-106 9.43e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 9.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239  18 PEDPSDLlqHVKFQSSNfeNI-LTWDSGPE-GTPDTVYSIEYKTYGERDWvakKGCQRITRKSCNLTVEtgNLTE--LYY 93
Cdd:cd00063   1 PSPPTNL--RVTDVTST--SVtLSWTPPEDdGGPITGYVVEYREKGSGDW---KEVEVTPGSETSYTLT--GLKPgtEYE 71

                        90
                ....*....|...
gi 31317239  94 ARVTAVSAGGRSA 106
Cdd:cd00063  72 FRVRAVNGGGESP 84
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 4-107 1.27e-35

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 129.04  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239     4 LLTILTVGSLAAHA-PEDPSDLL--QHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQRITRKSCN 80
Cdd:pfam01108   1 LLTLLLGLLLLALAsAAGGPSLPapQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECD 80

                          90       100
                  ....*....|....*....|....*..
gi 31317239    81 LTVETGNLTELYYARVTAVSAGGRSAT 107
Cdd:pfam01108  81 LTDETSDLTETYYARVRAVSGGGTSSW 107
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 290-527 4.00e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   290 SGPSSLAQPVQYSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPPPQILSPLSYAPNAAPEVGPPSYAPQVT 369
Cdd:pfam03154 132 SDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   370 PEAQFPfyAPQAISKVQPSSYApQATPDSWP---PSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQKEPPAGSCMLGGLS 446
Cdd:pfam03154 212 PATSQP--PNQTQSTAAPHTLI-QQTPTLHPqrlPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   447 LQEVTSlameesqeakslHQPLGIctdrtsdpnvlhsgeegTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSPSDQG 526
Cdd:pfam03154 289 MQHPVP------------PQPFPL-----------------TPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP 339


                  .
gi 31317239   527 P 527
Cdd:pfam03154 340 P 340
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 293-401 1.06e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   293 SSLAQPVQYSQiRVSGPR--EPAGAPQRHSLSEITYLGQPDISILQPSNVPPPQilSPLSYAPNAAPEVGPPSYAPQVTP 370
Cdd:PRK10263  351 VPPAQPTVAWQ-PVPGPQtgEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQP--QQPYYAPAAEQPAQQPYYAPAPEQ 427

                          90       100       110
                  ....*....|....*....|....*....|.
gi 31317239   371 EAQFPFYAPQAISKVQPSSYAPQATPDSWPP 401
Cdd:PRK10263  428 PAQQPYYAPAPEQPVAGNAWQAEEQQSTFAP 458
PHA03247 PHA03247
large tegument protein UL36; Provisional
 305-529 3.43e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   305 RVSGPREPAGAPQRHSLSEITYLGQPdisilQPSNVPPPQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFPFYAPQAISK 384
Cdd:PHA03247 2864 RRPPSRSPAAKPAAPARPPVRRLARP-----AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239   385 VQPSSyAPQATPDSWP-PSYGVCMEGSGKDSPtGTLSSPKHLRPKGQLQKEPPAGSC-MLGGLSLQEVT----SLAMEES 458
Cdd:PHA03247 2939 PQPPL-APTTDPAGAGePSGAVPQPWLGALVP-GRVAVPRFRVPQPAPSREAPASSTpPLTGHSLSRVSswasSLALHEE 3016

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31317239   459 QEAK--SLHQPLGIC--TDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSPSDQGPSP 529
Cdd:PHA03247 3017 TDPPpvSLKQTLWPPddTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPP 3091
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 18-106 9.43e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 35.94  E-value: 9.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31317239  18 PEDPSDLlqHVKFQSSNfeNI-LTWDSGPE-GTPDTVYSIEYKTYGERDWvakKGCQRITRKSCNLTVEtgNLTE--LYY 93
Cdd:cd00063   1 PSPPTNL--RVTDVTST--SVtLSWTPPEDdGGPITGYVVEYREKGSGDW---KEVEVTPGSETSYTLT--GLKPgtEYE 71

                        90
                ....*....|...
gi 31317239  94 ARVTAVSAGGRSA 106
Cdd:cd00063  72 FRVRAVNGGGESP 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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