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Conserved domains on  [gi|11024658|ref|NP_067594|]
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prostaglandin E synthase [Rattus norvegicus]

Protein Classification

MAPEG family protein( domain architecture ID 10471516)

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family protein is a membrane associated protein; similar to mammalian prostaglandin E synthase, leukotriene C4 synthase, arachidonate 5-lipoxygenase-activating protein, microsomal glutathione S-transferases, and mitochondrial glutathione S-transferase 3

CATH:  1.20.120.550
Gene Ontology:  GO:0016020
PubMed:  10091672|10673221

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 17-147 4.10e-25

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


:

Pssm-ID: 460074  Cd Length: 127  Bit Score: 93.13  E-value: 4.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11024658    17 FLLCSTLLVIKMYAVAVITGQVRLRKKAfanPEDALKRGGLQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPN 96
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKV---GDGGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 11024658    97 PLIAWIHFLVVLTGRVVHTVAYLGKmNPRIRSGAYVLAQFACFSMALQILW 147
Cdd:pfam01124  78 PGLAALLAWAYVVARVLHALGYATG-NPPLRSLGFLLGFLALLALAVLALL 127
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 17-147 4.10e-25

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 93.13  E-value: 4.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11024658    17 FLLCSTLLVIKMYAVAVITGQVRLRKKAfanPEDALKRGGLQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPN 96
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKV---GDGGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 11024658    97 PLIAWIHFLVVLTGRVVHTVAYLGKmNPRIRSGAYVLAQFACFSMALQILW 147
Cdd:pfam01124  78 PGLAALLAWAYVVARVLHALGYATG-NPPLRSLGFLLGFLALLALAVLALL 127
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
13-147 4.75e-07

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 46.00  E-value: 4.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11024658  13 VLPAFLLCSTLLVIKMYAVAVITGQVRLRKKAfanpedALKRGGlqycrsDPDVERCLRAHRNDMETIYPFLFLGFVYSF 92
Cdd:COG3788   2 TLPITALYAALLALLLLVLSLRVVRLRRKYRV------ALGDGG------DPELQRAIRAHGNFVEYVPLALILLLLLEL 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 11024658  93 LGPNPLIAWIHFLVVLTGRVVHTVAYLGKM-NPRIRSGAYVLAQFACFSMALQILW 147
Cdd:COG3788  70 NGAPAWWLHLLGIALLLGRLLHAYGLSRSKgPSPGRAIGMLLTFLVLLALAVLLLV 125
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 17-147 4.10e-25

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 93.13  E-value: 4.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11024658    17 FLLCSTLLVIKMYAVAVITGQVRLRKKAfanPEDALKRGGLQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPN 96
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKV---GDGGANPERALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 11024658    97 PLIAWIHFLVVLTGRVVHTVAYLGKmNPRIRSGAYVLAQFACFSMALQILW 147
Cdd:pfam01124  78 PGLAALLAWAYVVARVLHALGYATG-NPPLRSLGFLLGFLALLALAVLALL 127
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
13-147 4.75e-07

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 46.00  E-value: 4.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11024658  13 VLPAFLLCSTLLVIKMYAVAVITGQVRLRKKAfanpedALKRGGlqycrsDPDVERCLRAHRNDMETIYPFLFLGFVYSF 92
Cdd:COG3788   2 TLPITALYAALLALLLLVLSLRVVRLRRKYRV------ALGDGG------DPELQRAIRAHGNFVEYVPLALILLLLLEL 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 11024658  93 LGPNPLIAWIHFLVVLTGRVVHTVAYLGKM-NPRIRSGAYVLAQFACFSMALQILW 147
Cdd:COG3788  70 NGAPAWWLHLLGIALLLGRLLHAYGLSRSKgPSPGRAIGMLLTFLVLLALAVLLLV 125
COG3686 COG3686
Uncharacterized conserved protein, MAPEG superfamily [Function unknown];
18-147 6.53e-06

Uncharacterized conserved protein, MAPEG superfamily [Function unknown];


Pssm-ID: 442902  Cd Length: 130  Bit Score: 42.88  E-value: 6.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11024658  18 LLCSTLLVIKMYAVAVITGQVRLRK-KAFANPEDALKRgglqycrSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLG-P 95
Cdd:COG3686   8 LLLAALLPLVQVALAKLARNRQLGGyDWNAGPRDWLAP-------LSGWAARANRAQQNAFEALPLFAAAVLVAHLTGaS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 11024658  96 NPLIAWIhFLVVLTGRVVHTVAYLGKMnPRIRSGAYVLAQFACFSMALQILW 147
Cdd:COG3686  81 SATTALL-AIAFLAARVLYVPAYLAGL-PPLRSLVWAVGFLCTVALFVAALL 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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